Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway.

Mroueh A, Fakih W, Carmona A, Trimaille A, Matsushita K, Marchandot B, Qureshi AW, Gong DS, Auger C, Sattler L, Reydel A, Hess S, Oulehri W, Vollmer O, Lessinger JM, Meyer N, Pieper MP, Jesel L, Bäck M, Schini-Kerth V, Morel O

J Thromb Haemost. 2023 10 3;:

γ-Oryzanol ameliorates fine dust-induced premature endothelial senescence and dysfunction via attenuating oxidative stress.

Shiwakoti S, Gong D, Sharma K, Kang KW, Schini-Kerth VB, Kim HJ, Ko JY, Oak MH

Food Chem Toxicol. 2023 08 5;:113981

Determinants and treatments of heart failure after transcatheter aortic valve implantation: moving up a notch.

Matsushita K, Marchandot B, Trimaille A, Hmadeh S, Kibler M, Heger J, Carmona A, Hess S, Reydel A, Jesel L, Ohlmann P, Schini-Kerth V, Morel O

ESC Heart Fail. 2023 07 10;:

SGLT2 inhibition ameliorates nano plastics-induced premature endothelial senescence and dysfunction.

Dhakal B, Shiwakoti S, Park EY, Kang KW, Schini-Kerth VB, Park SH, Ji HY, Park JS, Ko JY, Oak MH

Sci Rep. 2023 04 17;13(1):6256

Empagliflozin prevents angiotensin II-induced hypertension related micro and macrovascular endothelial cell activation and diastolic dysfunction in rats despite persistent hypertension: Role of endothelial SGLT1 and 2.

Bruckert C, Matsushita K, Mroueh A, Amissi S, Auger C, Houngue U, Remila L, Chaker AB, Park SH, Algara-Suarez P, Belcastro E, Jesel L, Ohlmann P, Morel O, Schini-Kerth VB

Vascul Pharmacol. 2022 08 6;:107095

Carissa edulis Vahl (Apocynaceae) extract, a medicinal plant of Benin pharmacopoeia, induces potent endothelium-dependent relaxation of coronary artery rings involving nitric oxide.

Hounguè U, Villette C, Tokoudagba JM, Chaker AB, Remila L, Auger C, Heintz D, Gbaguidi FA, Schini-Kerth VB

Phytomedicine. 2022 08 5;105:154370

The Conundrum of Occult Cancer Screening in Venous Thromboembolism: Lessons from the REMOTEV Registry.

Cordeanu EM, Jambert L, Tousch J, Mirea C, Delatte A, Younes W, Woehl B, Harter C, Frantz AS, Hamade A, Schini-Kerth V, Ohlmann P, Andres E, Stephan D

Medicina (Kaunas). 2022 07 9;58(7):

Effects of polystyrene nanoplastics on endothelium senescence and its underlying mechanism.

Shiwakoti S, Ko JY, Gong D, Dhakal B, Lee JH, Adhikari R, Gwak Y, Park SH, Jun Choi I, Schini-Kerth VB, Kang KW, Oak MH

Environ Int. 2022 Apr 15;164:107248

Long-term cardiovascular complications following sepsis: is senescence the missing link?

Merdji H, Schini-Kerth V, Meziani F, Toti F

Ann Intensive Care. 2021 Dec 1;11(1):166

Septic shock as a trigger of arterial stress-induced premature senescence: A new pathway involved in the post sepsis long-term cardiovascular complications.

Merdji H, Kassem M, Chomel L, Clere-Jehl R, Helms J, Kurihara K, Chaker AB, Auger C, Schini-Kerth V, Toti F, Meziani F

Vascul Pharmacol. 2021 Sep 27;:106922

Molecular Mechanisms Responsible for In Vitro Cytotoxic Attributes of Conyza bonariensis Extract against Lymphoblastic Leukaemia Jurkat Cells.

Saleem M, Schini-Kerth VB, Hussain K, Khalid SH, Asif M, Alhosin M, Akhtar MF, Ahmad B, Raza A, Mahrukh

Anticancer Agents Med Chem. 2021 Sep 5;:

Transient endothelial injury and release of lupus anticoagulant in COVID-19.

Trimaille A, Marchandot B, Oulehri W, Carmona A, Vollmer O, Poindron V, Matsushita K, Sattler L, Grunebaum L, Korganow AS, Schini-Kerth V, Morel O

J Thromb Thrombolysis. 2021 May 28;:

In Vitro Impact of Pro-Senescent Endothelial Microvesicles on Isolated Pancreatic Rat Islets Function.

Kassem M, El Habhab A, Kreutter G, Amoura L, Baltzinger P, Abbas M, Sbat N, Zobairi F, Schini-Kerth VB, Kessler L, Toti F

Transplant Proc. 2021 Apr 30;:

Microparticles in COVID-19 as a link between lung injury extension and thrombosis.

Morel O, Marchandot B, Jesel L, Sattler L, Trimaille A, Curtiaud A, Ohana M, Fafi-Kremer S, Schini-Kerth V, Grunebaum L, Freyssinet JM

ERJ Open Res. 2021 Apr;7(2):

Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle-stimulated endothelial senescence and dysfunction: protective effect of gliflozins.

Park SH, Belcastro E, Hasan H, Matsushita K, Marchandot B, Abbas M, Toti F, Auger C, Jesel L, Ohlmann P, Morel O, Schini-Kerth VB

Cardiovasc Diabetol. 2021 Mar 16;20(1):65

Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells.

Belcastro E, Rehman AU, Remila L, Park SH, Gong DS, Anton N, Auger C, Lefebvre O, Goetz JG, Collot M, Klymchenko AS, Vandamme TF, Schini-Kerth VB

Nanomedicine. 2021 Mar 10;:102379

Involvement of Muscarinic Receptors in Hypotensive and Diuretic Effects of Aqueous Soluble Fraction from Cav.

Younis W, Alamgeer, Schini-Kerth VB, Nocchi SR, Silva DB, de Souza P, Bukhari IA, Vohra F, Afzal S, Gasparotto Junior A

Evid Based Complement Alternat Med. 2021 ;2021:6653270

Prognostic Value of Troponin Elevation in COVID-19 Hospitalized Patients.

Cordeanu EM, Duthil N, Severac F, Lambach H, Tousch J, Jambert L, Mirea C, Delatte A, Younes W, Frantz AS, Merdji H, Schini-Kerth V, Bilbault P, Ohlmann P, Andres E, Stephan D

J Clin Med. 2020 Dec 17;9(12):

Endothelium-independent vasorelaxant effect of Asphodelus tenuifolius Cav. via inhibition of myosin light chain kinase activity in the porcine coronary artery.

Younis W, Alamgeer, Schini-Kerth VB, Junior AG, Nocchi SR, Silva DB, Roberts RE

J Ethnopharmacol. 2020 Dec 13;:113693

Outcomes of COVID-19 Hospitalized Patients Previously Treated with Renin-Angiotensin System Inhibitors.

Cordeanu EM, Jambert L, Severac F, Lambach H, Tousch J, Heitz M, Mirea C, Hamadé A, Younes W, Frantz AS, Merdji H, Schini-Kerth V, Bilbault P, Meziani F, Ohlmann P, Andres E, Stephan D

J Clin Med. 2020 Oct 28;9(11):

Significance of neutrophil microparticles in ischaemia-reperfusion: Pro-inflammatory effectors of endothelial senescence and vascular dysfunction.

El Habhab A, Altamimy R, Abbas M, Kassem M, Amoura L, Qureshi AW, El Itawi H, Kreutter G, Khemais-Benkhiat S, Zobairi F, Schini-Kerth VB, Kessler L, Toti F

J. Cell. Mol. Med.. 2020 Jun 10;:

COVID-19 Related Coagulopathy: A Distinct Entity?

Marchandot B, Sattler L, Jesel L, Matsushita K, Schini-Kerth V, Grunebaum L, Morel O

J Clin Med. 2020 May 31;9(6):

Biochanin A, the Most Potent of 16 Isoflavones, Induces Relaxation of the Coronary Artery Through the Calcium Channel and cGMP-dependent Pathway.

Migkos T, Pourová J, Vopršalová M, Auger C, Schini-Kerth V, Mladěnka P

Planta Med.. 2020 May 14;:

Red Wine Extract Disrupts Th17 Lymphocyte Differentiation in a Colorectal Cancer Context.

Chalons P, Courtaut F, Limagne E, Chalmin F, Cantos-Villar E, Richard T, Auger C, Chabert P, Schini-Kerth V, Ghiringhelli F, Aires V, Delmas D

Mol Nutr Food Res. 2020 Apr 18;:e1901286

Preventive beneficial effect of an aqueous extract of Phyllanthus amarus Schum. & Thonn. (Euphorbiaceae) on DOCA-salt-induced hypertension, cardiac hypertrophy and dysfunction, and endothelial dysfunction in rats.

Yao NA, Niazi ZR, Najmanová I, Kamagaté M, Said A, Chabert P, Auger C, Die-Kakou H, Schini-Kerth V

J. Cardiovasc. Pharmacol.. 2020 Mar 12;:

Empagliflozin improved systolic blood pressure, endothelial dysfunction and heart remodeling in the metabolic syndrome ZSF1 rat.

Park SH, Farooq MA, Gaertner S, Bruckert C, Qureshi AW, Lee HH, Benrahla D, Pollet B, Stephan D, Ohlmann P, Lessinger JM, Mayoux E, Auger C, Morel O, Schini-Kerth VB

Cardiovasc Diabetol. 2020 Feb 18;19(1):19

The difficult balance between thrombosis and bleeding after transcatheter aortic valve replacement: A translational review.

Trimaille A, Marchandot B, Park SH, Schini-Kerth V, Morel O

Arch Cardiovasc Dis. 2020 Feb 10;:

Compared Phenolic Compound Contents of 22 Commercial Fruit and Vegetable Juices: Relationship to ex-vivo Vascular Reactivity and Potential in vivo Projection.

Matute A, Tabart J, Cheramy-Bien JP, Pirotte B, Kevers C, Auger C, Schini-Kerth V, Dommes J, Defraigne JO, Pincemail J

Antioxidants (Basel). 2020 Jan 22;9(2):

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases.

de Almeida AJPO, de Almeida Rezende MS, Dantas SH, de Lima Silva S, de Oliveira JCPL, de Lourdes Assunção Araújo de Azevedo F, Alves RMFR, de Menezes GMS, Dos Santos PF, Gonçalves TAF, Schini-Kerth VB, de Medeiros IA

Oxid Med Cell Longev. 2020 ;2020:1954398

Intake of omega-3 formulation EPA:DHA 6:1 by old rats for 2 weeks improved endothelium-dependent relaxations and normalized the expression level of ACE/AT1R/NADPH oxidase and the formation of ROS in the mesenteric artery.

Farooq MA, Gaertner S, Amoura L, Niazi ZR, Park SH, Qureshi AW, Oak MH, Toti F, Schini-Kerth VB, Auger C

Biochem. Pharmacol.. 2019 Dec 9;:113749

Ageing enhances the shedding of splenocyte microvesicles with endothelial pro-senescent effect that is prevented by a short-term intake of omega-3 PUFA EPA:DHA 6:1.

Qureshi AW, Altamimy R, El Habhab A, El Itawi H, Farooq MA, Zobairi F, Hasan H, Amoura L, Auger C, Schini-Kerth V, Toti F

Biochem. Pharmacol.. 2019 Dec 4;:113734

Role of the NO/cGMP pathway and renin-angiotensin system in the hypotensive and diuretic effects of aqueous soluble fraction from Crataegus songarica K. Koch.

Younis W, Alamgeer, Schini-Kerth VB, Brentan da Silva D, Junior AG, Bukhari IA, Assiri AM

J Ethnopharmacol. 2019 Nov 15;:

Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns.

Hasan H, Park SH, Auger C, Belcastro E, Matsushita K, Marchandot B, Lee HH, Qureshi AW, Kauffenstein G, Ohlmann P, Schini-Kerth VB, Jesel L, Morel O

J Clin Med. 2019 Oct 1;8(10):

Pulmonary Embolism and Coexisting Deep Vein Thrombosis: A Detrimental Association?

Cordeanu EM, Lambach H, Heitz M, Di Cesare J, Mirea C, Faller AM, Cavaro AC, Frantz AS, Gaertner S, Schini-Kerth V, Stephan D

J Clin Med. 2019 Jun 23;8(6):

Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects.

Rouyer O, Auger C, Charles AL, Talha S, Meyer A, Piquard F, Andres E, Schini-Kerth V, Geny B

J Clin Med. 2019 Jun 15;8(6):

Fine air pollution particles induce endothelial senescence via redox-sensitive activation of local angiotensin system.

Sharma K, Lee HH, Gong DS, Park SH, Yi E, Schini-Kerth V, Oak MH

Environ. Pollut.. 2019 May 20;252(Pt A):317-329

Urapidil, but not dihydropyridine calcium channel inhibitors, preserves the hypoxic pulmonary vasoconstriction: an experimental study in pig arteries.

Bopp C, Auger C, Mebazaa A, Joshi GP, Schini-Kerth VB, Diemunsch P

Fundam Clin Pharmacol. 2019 Feb 27;:

Tambulin is a major active compound of a methanolic extract of fruits of Zanthoxylum armatum DC causing endothelium-independent relaxations in porcine coronary artery rings via the cyclic AMP and cyclic GMP relaxing pathways.

Mushtaq MN, Ghimire S, Alamgeer, Akhtar MS, Adhikari A, Auger C, Schini-Kerth VB

Phytomedicine. 2019 Feb;53:163-170

Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages.

Chalons P, Amor S, Courtaut F, Cantos-Villar E, Richard T, Auger C, Chabert P, Schni-Kerth V, Aires V, Delmas D

Nutrients. 2018 Dec 1;10(12):

An aqueous extract of the Anogeissus leiocarpus bark (AEAL) induces the endothelium-dependent relaxation of porcine coronary artery rings involving predominantly nitric oxide.

Belemnaba L, Ouédraogo S, Nitiéma M, Chataigneau T, Guissou IP, Schini-Kerth VB, Bucher B, Auger C

J Basic Clin Physiol Pharmacol. 2018 Nov 27;29(6):599-608

Mechanisms underlying vasorelaxation induced in the porcine coronary arteries by Thymus linearis, Benth.

Alamgeer, Auger C, Chabert P, Lugnier C, Mushtaq MN, Schini-Kerth VB

J Ethnopharmacol. 2018 Oct 28;225:211-219

Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium.

Oak MH, Auger C, Belcastro E, Park SH, Lee HH, Schini-Kerth VB

Free Radic. Biol. Med.. 2018 07;122:161-170

[Significance of hawthorn extract in general practice - a current positioning].

Wegener T, Gündling PW, Holubarsch CJF, Mayer JG, Schini-Kerth VB, Schmidt-Trucksäss A, Stange R

MMW Fortschr Med. 2018 Jul;160(Suppl 4):1-7

Polyphenol-Rich Blackcurrant Juice Prevents Endothelial Dysfunction in the Mesenteric Artery of Cirrhotic Rats with Portal Hypertension: Role of Oxidative Stress and the Angiotensin System.

Rashid S, Idris-Khodja N, Auger C, Kevers C, Pincemail J, Alhosin M, Boehm N, Oswald-Mammosser M, Schini-Kerth VB

J Med Food. 2018 Apr;21(4):390-399

Cardioprotective effect of Asphodelus tenuifolius Cav. on blood pressure and metabolic alterations in glucose-induced metabolic syndrome rats-An ethnopharmacological approach.

Younis W, Alamgeer, Schini-Kerth VB, Junior AG, Majid M

J Ethnopharmacol. 2018 Mar 25;214:168-178

The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins.

Yao AN, Kamagaté M, Amonkan AK, Chabert P, Kpahé F, Koffi C, Kouamé MN, Auger C, Kati-Coulibaly S, Schini-Kerth V, Die-Kakou H

BMC Complement Altern Med. 2018 Mar 15;18(1):94

Increased risk and severity of unprovoked venous thromboembolism with clustering cardiovascular risk factors for atherosclerosis: Results of the REMOTEV registry.

Gaertner S, Cordeanu EM, Mirea C, Frantz AS, Auger C, Bilbault P, Ohlmann P, Schini-Kerth V, Stephan D

Int. J. Cardiol.. 2018 Feb 1;252:169-174

EPA:DHA 6:1 prevents angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase- and COX-derived oxidative stress.

Niazi ZR, Silva GC, Ribeiro TP, León-González AJ, Kassem M, Mirajkar A, Alvi A, Abbas M, Zgheel F, Schini-Kerth VB, Auger C

Hypertens. Res.. 2017 Dec;40(12):966-975

Role of epigenetic regulation on the induction of apoptosis in Jurkat leukemia cells by white grape pomace rich in phenolic compounds.

León-González AJ, Jara-Palacios MJ, Abbas M, Heredia FJ, Schini-Kerth VB

Food Funct. 2017 Nov 15;8(11):4062-4069

Replicative senescence promotes prothrombotic responses in endothelial cells: Role of NADPH oxidase- and cyclooxygenase-derived oxidative stress.

Silva GC, Abbas M, Khemais-Benkhiat S, Burban M, Ribeiro TP, Toti F, Idris-Khodja N, Côrtes SF, Schini-Kerth VB

Exp. Gerontol.. 2017 07;93:7-15

Joint ICMAN and IUPHAR Natural Products Section Meeting. Aberdeen UK 27-29(TH) September 2017.

Zhang Y, Spedding M, Wainwright C, Schini-Kerth V, Bermano G

Biochem. Pharmacol.. 2017 Jun;:

Senescence of Pancreas in Middle-Aged Rats with Normal Vascular Function.

Kassem M, Niazi ZR, Abbas M, El Habhab A, Kreutter G, Khemais-Benkhiat S, Auger C, Antal MC, Schini-Kerth VB, Toti F, Kessler L

Ann. Transplant.. 2017 Mar 31;22:177-186

Lipid Emulsions Containing Medium Chain Triacylglycerols Blunt Bradykinin-Induced Endothelium-Dependent Relaxation in Porcine Coronary Artery Rings.

Amissi S, Boisramé-Helms J, Burban M, Rashid SK, León-González AJ, Auger C, Toti F, Meziani F, Schini-Kerth VB

Lipids. 2017 03;52(3):235-243

Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways.

Abbas M, Jesel L, Auger C, Amoura L, Messas N, Manin G, Rumig C, León-González AJ, Ribeiro TP, Silva GC, Abou-Merhi R, Hamade E, Hecker M, Georg Y, Chakfe N, Ohlmann P, Schini-Kerth VB, Toti F, Morel O

Circulation. 2017 Jan 17;135(3):280-296

Adenylate Cyclase Type III Is Not a Ubiquitous Marker for All Primary Cilia during Development.

Antal MC, Bénardais K, Samama B, Auger C, Schini-Kerth V, Ghandour S, Boehm N

PLoS ONE. 2017 ;12(1):e0170756

Docosahexaenoic acid, but not eicosapentaenoic acid, improves septic shock-induced arterial dysfunction in rats.

Boivin A, Burban M, Clere-Jehl R, Le Borgne P, Merdji H, Auger C, Schini-Kerth V, Meziani F, Helms J

PLoS ONE. 2017 ;12(12):e0189658

The Redox-sensitive Induction of the Local Angiotensin System Promotes Both Premature and Replicative Endothelial Senescence: Preventive Effect of a Standardized Crataegus Extract.

Khemais-Benkhiat S, Idris-Khodja N, Ribeiro TP, Silva GC, Abbas M, Kheloufi M, Lee JO, Toti F, Auger C, Schini-Kerth VB

J. Gerontol. A Biol. Sci. Med. Sci.. 2016 12;71(12):1581-1590

An Intravenous Bolus of Epa: Dha 6: 1 Protects Against Myocardial Ischemia-Reperfusion-Induced Shock.

Burban M, Meyer G, Olland A, Séverac F, Yver B, Toti F, Schini-Kerth V, Meziani F, Boisramé-Helms J

Shock. 2016 Nov;46(5):549-556

Microparticles: A new insight into lung primary graft dysfunction?

Olland A, Reeb J, Leclerq A, Renaud-Picard B, Falcoz PE, Kessler R, Schini-Kerth V, Kessler L, Toti F, Massard G

Hum. Immunol.. 2016 Nov;77(11):1101-1107

Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells.

Constantinescu AA, Abbas M, Kassem M, Gleizes C, Kreutter G, Schini-Kerth V, Mitrea IL, Toti F, Kessler L

Mol. Cell. Biochem.. 2016 Jul;418(1-2):91-102

Endothelium-independent vasorelaxant effect of a Berberis orthobotrys root extract via inhibition of phosphodiesterases in the porcine coronary artery.

Alamgeer, Chabert P, Akhtar MS, Jabeen Q, Delecolle J, Heintz D, Garo E, Hamburger M, Auger C, Lugnier C, Kim HJ, Oak MH, Schini-Kerth VB

Phytomedicine. 2016 Jul;23(8):793-9

Potential of Food and Natural Products to Promote Endothelial and Vascular Health.

Auger C, Said A, Nguyen PN, Chabert P, Idris-Khodja N, Schini-Kerth VB

J. Cardiovasc. Pharmacol.. 2016 Jul;68(1):11-8

The effect of urapidil, an alpha-1 adrenoceptor antagonist and a 5-HT1A agonist, on the vascular tone of the porcine coronary and pulmonary arteries, the rat aorta and the human pulmonary artery.

Bopp C, Auger C, Diemunsch P, Schini-Kerth V

Eur. J. Pharmacol.. 2016 May;779:53-8

Beneficial effects of a red wine polyphenol extract on high-fat diet-induced metabolic syndrome in rats.

Auberval N, Dal S, Maillard E, Bietiger W, Peronet C, Pinget M, Schini-Kerth V, Sigrist S

Eur J Nutr. 2016 Feb;:

The Effect of Quercus salicina Leaf Extracts on Vascular Endothelial Function: Role of Nitric Oxide.

Park SH, Kim HJ, Yoon JS, Lee HW, Park GC, Yi E, Yoon G, Schini-Kerth VB, Oak MH

J Nanosci Nanotechnol. 2016 Feb;16(2):2069-71

"Immunonutrition" Has Failed to Improve Peritonitis-Induced Septic Shock in Rodents.

Boisramé-Helms J, Meyer G, Degirmenci SE, Burban M, Schini-Kerth V, Cynober L, De Bandt JP, Hasselmann M, Meziani F

PLoS ONE. 2016 ;11(1):e0147644

Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy.

Leon-Gonzalez AJ, Auger C, Schini-Kerth VB

Biochem Pharmacol. 2015 Jul 20. pii: S0006-2952(15)00387-1

Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway.

Alhosin M, León-González AJ, Dandache I, Lelay A, Rashid SK, Kevers C, Pincemail J, Fornecker LM, Mauvieux L, Herbrecht R, Schini-Kerth VB

Sci Rep. 2015 Mar;5:8996

Effect of the estrogen receptor antagonist fulvestrant on the cirrhotic rat lung.

Oswald-Mammosser M, Rashid S, Boehm N, Agin A, Geny B, Kerth VS, Charloux A

Fundam Clin Pharmacol. 2015 Mar 7

Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells.

Ali Azouaou S, Emhemmed F, Idris-Khodja N, Lobstein A, Schini-Kerth V, Muller CD, Fuhrmann G

Invest New Drugs. 2015 Feb;33(1):64-74

Betanin--a food colorant with biological activity.

Esatbeyoglu T, Wagner AE, Schini-Kerth VB, Rimbach G

Mol Nutr Food Res. 2015 Jan;59(1):36-47

CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene p16INK4A in glioblastoma cells.

Boukhari A, Alhosin M, Bronner C, Sagini K, Truchot C, Sick E, Schini-Kerth VB, Andre P, Mely Y, Mousli M, Gies JP

Anticancer Res. 2015 Jan;35(1):149-57.

Great heterogeneity of commercial fruit juices to induce endothelium-dependent relaxations in isolated porcine coronary arteries: role of the phenolic content and composition.

Auger C, Pollet B, Arnold C, Marx C, Schini-Kerth VB

J Med Food. 2015 Jan;18(1):128-36

Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells.

Auberval N, Dal S, Bietiger W, Seyfritz E, Peluso J, Muller C, Zhao M, Marchioni E, Pinget M, Jeandidier N, Maillard E, Schini-Kerth V, Sigrist S

Evid Based Complement Alternat Med. 2015;2015:859048

Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related stroke.

Wolff V, Schlagowski AI, Rouyer O, Charles AL, Singh F, Auger C, Schini-Kerth V, Marescaux C, Raul JS, Zoll J, Geny B

Biomed Res Int. 2015 ;2015:323706

Medium-chain triglyceride supplementation exacerbates peritonitis-induced septic shock in rats: role on cell membrane remodeling.

Boisramé-Helms J, Said A, Burban M, Delabranche X, Stiel L, Zobairi F, Hasselmann M, Schini-Kerth V, Toti F, Meziani F

Shock. 2014 Dec;42(6):548-53

A Chinese 2-herb formula (NF3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats.

Tam JC, Ko CH, Lau KM, To MH, Kwok HF, Chan YW, Siu WS, Etienne-Selloum N, Lau CP, Chan WY, Leung PC, Fung KP, Schini-Kerth VB, Lau CB

J Diabetes Complications. 2014 Jul-Aug;28(4):436-47

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.

Emhemmed F, Ali Azouaou S, Thuaud F, Schini-Kerth V, Desaubry L, Muller CD, Fuhrmann G

Biochem Pharmacol. 2014 May 15;89(2):185-96

Probiotics (VSL#3) prevent endothelial dysfunction in rats with portal hypertension: role of the angiotensin system.

Rashid SK, Khodja NI, Auger C, Alhosin M, Boehm N, Oswald-Mammosser M, Schini-Kerth VB

PLoS One. 2014 May 15;9(5):e97458

Redox-sensitive induction of Src/PI3-kinase/Akt and MAPKs pathways activate eNOS in response to EPA:DHA 6:1.

Zgheel F, Alhosin M, Rashid S, Burban M, Auger C, Schini-Kerth VB

PLoS One. 2014 Aug 18;9(8):e105102

Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase.

Kim JH, Auger C, Kurita I, Anselm E, Rivoarilala LO, Lee HJ, Lee KW, Schini-Kerth VB

Nitric Oxide. 2013 Nov 30;35:54-64

Role of endothelial cell membrane transport in red wine polyphenols-induced coronary vasorelaxation: involvement of bilitranslocase.

Ziberna L, Kim JH, Auger C, Passamonti S, Schini-Kerth V

Food Funct. 2013 Oct;4(10):1452-6

Do iodinated nano-emulsions designed for preclinical vascular imaging alter the vascular reactivity in rat aorta?

Anton N, Atzenhoffer M, Daubeuf F, Li X, Schini-Kerth VB, Delmotte B, Vandamme TF, Chataigneau T

Int J Pharm. 2013 Sep 15;454(1):143-8

Hydroxylation of (-)-epigallocatechin-3-O-gallate at 3'', but not 4'', is essential for the PI3-kinase/Akt-dependent phosphorylation of endothelial NO synthase in endothelial cells and relaxation of coronary artery rings.

Kurita I, Kim JH, Auger C, Kinoshita Y, Miyase T, Ito T, Schini-Kerth VB

Food Funct. 2013 Feb;4(2):249-57

Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.

Charles AL, Meyer A, Dal-Ros S, Auger C, Keller N, Ramamoorthy TG, Zoll J, Metzger D, Schini-Kerth V, Geny B

Exp Physiol. 2013 Feb;98(2):536-45

'ENDOTHELIUM-INDEPENDENT AND ENDOTHELIUM-DEPENDENT VASORELAXATION BY A DICHLOROMETHANE FRACTION FROM ANOGEISSUS LEIOCARPUS (DC) GUILL. ET PERR. (COMBRETACEAE): POSSIBLE INVOLVEMENT OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITION.

Belemnaba L, Ouedraogo S, Auger C, Chataigneau T, Traore A, Guissou IP, Lugnier C, Schini-Kerth VB, Bucher B

Afr J Tradit Complement Alt M. 2013;10(2):173-9.

An ethanolic extract of Lindera obtusiloba stems, YJP-14, improves endothelial dysfunction, metabolic parameters and physical performance in diabetic db/db mice.

Lee JO, Auger C, Park DH, Kang M, Oak MH, Kim KR, Schini-Kerth VB

PLoS One. 2013 Jun 3;8(6):e65227

Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from Anogeissus Leiocarpus (DC) Guill. Et Perr. (Combretaceae): possible involvement of cyclic nucleotide phosphodiesterase inhibition.

Belemnaba L, Ouedraogo S, Auger C, Chataigneau T, Traore A, Guissou IP, Lugnier C, Schini-Kerth VB, Bucher B

Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):173-9. eCollection 2013.

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.

Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner C

Biochem Biophys Res Commun. 2013 Jan 4;430(1):208-12

Molecular mechanisms of the cardiovascular protective effects of polyphenols.

Andriantsitohaina R, Auger C, Chataigneau T, Étienne-Selloum N, Li H, Martínez MC, Schini-Kerth VB, Laher I

Br. J. Nutr.. 2012 Nov 14;108(9):1532-49

Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts.

Alhosin M, Ibrahim A, Boukhari A, Sharif T, Gies JP, Auger C, Schini-Kerth VB

Invest New Drugs. 2012 Oct;30(5):1813-9

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.

Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner C

Biochem Biophys Res Commun. 2012 Jul 3.

Crataegus special extract WS((R))1442 prevents aging-related endothelial dysfunction.

Idris-Khodja N, Auger C, Koch E, Schini-Kerth VB

Phytomedicine. 2012 Jun 15;19(8-9):699-706

Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress.

Dal-Ros S, Bronner C, Auger C, Schini-Kerth VB

Biochem Biophys Res Commun. 2012 Mar 9;419(2):381-7

Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.

Sharif T, Alhosin M, Auger C, Minker C, Kim JH, Etienne-Selloum N, Bories P, Gronemeyer H, Lobstein A, Bronner C, Fuhrmann G, Schini-Kerth VB

PLoS One. 2012;7(3):e32526

Grape-derived polyphenols improve aging-related endothelial dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system.

Idris Khodja N, Chataigneau T, Auger C, Schini-Kerth VB

PLoS One. 2012;7(2):e32039

Natural product extract of Dicksonia sellowiana induces endothelium-dependent relaxations by a redox-sensitive Src- and Akt-dependent activation of eNOS in porcine coronary arteries.

Rattmann YD, Anselm E, Kim JH, Dal-Ros S, Auger C, Miguel OG, Santos AR, Chataigneau T, Schini-Kerth VB

J Vasc Res. 2012;49(4):284-98

Vascular protection by natural product-derived polyphenols: in vitro and in vivo evidence.

Schini-Kerth VB, Etienne-Selloum N, Chataigneau T, Auger C

Planta Med. 2011 Jul;77(11):1161-7

An ethanolic extract of Lindera obtusiloba stems causes NO-mediated endothelium-dependent relaxations in rat aortic rings and prevents angiotensin II-induced hypertension and endothelial dysfunction in rats.

Lee JO, Oak MH, Jung SH, Park DH, Auger C, Kim KR, Lee SW, Schini-Kerth VB

Naunyn Schmiedebergs Arch Pharmacol. 2011 Jun;383(6):635-45

Fruit juice-induced endothelium-dependent relaxations in isolated porcine coronary arteries: evaluation of different fruit juices and purees and optimization of a red fruit juice blend.

Auger C, Kim JH, Trinh S, Chataigneau T, Popken AM, Schini-Kerth VB

Food Funct. 2011 May;2(5):245-50

Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell.

Sharif T, Auger C, Bronner C, Alhosin M, Klein T, Etienne-Selloum N, Schini-Kerth VB, Fuhrmann G

Invest New Drugs. 2011 Apr;29(2):239-47

Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase.

Dal-Ros S, Zoll J, Lang AL, Auger C, Keller N, Bronner C, Geny B, Schini-Kerth VB

Biochem Biophys Res Commun. 2011 Jan 14;404(2):743-9

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties.

Alhosin M, Sharif T, Mousli M, Etienne-Selloum N, Fuhrmann G, Schini-Kerth VB, Bronner C

J Exp Clin Cancer Res. 2011 Apr 15;30:41.

Procyanidin-rich fractions from Parkia biglobosa (Mimosaceae) leaves cause redox-sensitive endothelium-dependent relaxation involving NO and EDHF in porcine coronary artery.

Tokoudagba JM, Auger C, Breant L, N'Gom S, Chabert P, Idris-Khodja N, Gbaguidi F, Gbenou J, Moudachirou M, Lobstein A, Schini-Kerth VB

J Ethnopharmacol. 2010 Oct 28;132(1):246-50

Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis.

Walter A, Etienne-Selloum N, Brasse D, Khallouf H, Bronner C, Rio MC, Beretz A, Schini-Kerth VB

FASEB J. 2010 Sep;24(9):3360-9

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.

Alhosin M, Abusnina A, Achour M, Sharif T, Muller C, Peluso J, Chataigneau T, Lugnier C, Schini-Kerth VB, Bronner C, Fuhrmann G

Biochem Pharmacol. 2010 May 1;79(9):1251-60

Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF.

Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T

Pflugers Arch. 2010 May;459(6):853-62

Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols.

Kane MO, Etienne-Selloum N, Madeira SV, Sarr M, Walter A, Dal-Ros S, Schott C, Chataigneau T, Schini-Kerth VB

Pflugers Arch. 2010 Apr;459(5):671-9

Losartan prevents portal hypertension-induced, redox-mediated endothelial dysfunction in the mesenteric artery in rats.

Dal-Ros S, Oswald-Mammosser M, Pestrikova T, Schott C, Boehm N, Bronner C, Chataigneau T, Geny B, Schini-Kerth VB

Gastroenterology. 2010 Apr;138(4):1574-84

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1.

Sharif T, Auger C, Alhosin M, Ebel C, Achour M, Etienne-Selloum N, Fuhrmann G, Bronner C, Schini-Kerth VB

Eur J Cancer. 2010 Mar;46(5):983-94

The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties.

Auger C, Kim JH, Chabert P, Chaabi M, Anselm E, Lanciaux X, Lobstein A, Schini-Kerth VB

Biochem Biophys Res Commun. 2010 Feb 26;393(1):162-7

Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II.

Mokni W, Keravis T, Etienne-Selloum N, Walter A, Kane MO, Schini-Kerth VB, Lugnier C

PLoS One. 2010 Dec 3;5(12):e14227.

MECHANISMS UNDERLYING THE ENDOTHELIUM-DEPENDENT VASODILATORY EFFECT OF AN AQUEOUS EXTRACT OF ELAEIS GUINEENSIS JACQ. (ARECACEAE) IN PORCINE CORONARY ARTERY RINGS

Ndiaye M, Anselm E, Sene M, Diatta W, Dieye AM, Faye B, Schini-Kerth VB

Afr J Tradit Complement Alt M. 2010;7(2):118-24

Mechanisms underlying the endothelium-dependent vasodilatory effect of an aqueous extract of Elaeis Guineensis Jacq. (Arecaceae) in porcine coronary artery rings.

Ndiaye M, Anselm E, Sene M, Diatta W, Dieye AM, Faye B, Schini-Kerth VB

Afr J Tradit Complement Altern Med. 2009 Dec 30;7(2):118-24.

Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF.

Schini-Kerth VB, Auger C, Etienne-Selloum N, Chataigneau T

Adv Pharmacol. 2010;60:133-75.

UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity.

Achour M, Fuhrmann G, Alhosin M, Ronde P, Chataigneau T, Mousli M, Schini-Kerth VB, Bronner C

Biochem Biophys Res Commun. 2009 Dec 18;390(3):523-8

Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression.

Ihm SH, Lee JO, Kim SJ, Seung KB, Schini-Kerth VB, Chang K, Oak MH

Atherosclerosis. 2009 Sep;206(1):47-53

Role of gender and estrogen receptors in the rat aorta endothelium-dependent relaxation to red wine polyphenols.

Kane MO, Anselm E, Rattmann YD, Auger C, Schini-Kerth VB

Vascul Pharmacol. 2009 Aug-Sep;51(2-3):140-6

Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb.

Walter A, Etienne-Selloum N, Brasse D, Schleiffer R, Bekaert V, Vanhoutte PM, Beretz A, Schini-Kerth VB

J Pharmacol Exp Ther. 2009 May;329(2):699-707

Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells.

Zerr-Fouineau M, Jourdain M, Boesch C, Hecker M, Bronner C, Schini-Kerth VB

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):586-93

Crataegus special extract WS 1442 causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of endothelial NO synthase but not via activation of estrogen receptors.

Anselm E, Socorro VF, Dal-Ros S, Schott C, Bronner C, Schini-Kerth VB

J Cardiovasc Pharmacol. 2009 Mar;53(3):253-60.

Angiotensin II-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery.

Dal-Ros S, Bronner C, Schott C, Kane MO, Chataigneau M, Schini-Kerth VB, Chataigneau T

J Pharmacol Exp Ther. 2009 Feb;328(2):478-86

Vascular protection by grape-derived polyphenols

Auger C, Chataigneau T, Schini-Kerth VB

Agro Food Ind Hi-tech. 2009 Jan-feb;20(1):38-40

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression.

Achour M, Jacq X, Ronde P, Alhosin M, Charlot C, Chataigneau T, Jeanblanc M, Macaluso M, Giordano A, Hughes AD, Schini-Kerth VB, Bronner C

Oncogene. 2008 Apr 3;27(15):2187-97

Angiotensin II induces the vascular expression of VEGF and MMP-2 in vivo: preventive effect of red wine polyphenols.

Walter A, Etienne-Selloum N, Sarr M, Kane MO, Beretz A, Schini-Kerth VB

J Vasc Res. 2008;45(5):386-94

The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?

Bronner C, Achour M, Arima Y, Chataigneau T, Saya H, Schini-Kerth VB

Pharmacol Ther. 2007 Sep;115(3):419-34

Targeted and persistent effects of NO mediated by S-nitrosation of tissue thiols in arteries with endothelial dysfunction.

Sarr M, Chataigneau M, Etienne-Selloum N, Diallo AS, Schott C, Geffard M, Stoclet JC, Schini-Kerth VB, Muller B

Nitric Oxide. 2007 Aug;17(1):1-9

Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Acai) extracts in mesenteric vascular bed of the rat.

Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, Schini-Kerth VB, Resende AC, Soares de Moura R

Vascul Pharmacol. 2007 Feb;46(2):97-104

Progestins overcome inhibition of platelet aggregation by endothelial cells by down-regulating endothelial NO synthase via glucocorticoid receptors.

Zerr-Fouineau M, Chataigneau M, Blot C, Schini-Kerth VB

FASEB J. 2007 Jan;21(1):265-73

The "epigenetic, code replication machinery", ECREM: A promising drugable target of the epigenetic cell memory

Bronner C, Chataigneau T, Schini-Kerth VB, Landry Y

Curr Med Chem. 2007;14(25):2629-41.

[Culture and characterization of porcine coronary endothelial cells]

Ndiaye M, Chataigneau T, Dieye AM, Chataigneau M, Ndiaye A, Ndiaye A, Kane MO, Faye B, Schini-Kerth VB

Dakar Med. 2007;52(1):27-30.

Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK.

Oak MH, Bedoui JE, Madeira SV, Chalupsky K, Schini-Kerth VB

Br J Pharmacol. 2006 Oct;149(3):283-90

Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase.

Sarr M, Chataigneau M, Martins S, Schott C, El Bedoui J, Oak MH, Muller B, Chataigneau T, Schini-Kerth VB

Cardiovasc Res. 2006 Sep 1;71(4):794-802

Formation of releasable NO stores by S-nitrosoglutathione in arteries exhibiting tolerance to glyceryl-trinitrate.

Sarr M, Lobysheva I, Diallo AS, Stoclet JC, Schini-Kerth VB, Muller B

Eur J Pharmacol. 2005 Apr 18;513(1-2):119-23

Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery.

Ndiaye M, Chataigneau M, Lobysheva I, Chataigneau T, Schini-Kerth VB

FASEB J. 2005 Mar;19(3):455-7

Red wine polyphenols induce EDHF-mediated relaxations in porcine coronary arteries through the redox-sensitive activation of the PI3-kinase/Akt pathway.

Ndiaye M, Chataigneau T, Chataigneau M, Schini-Kerth VB

Br J Pharmacol. 2004 Aug;142(7):1131-6

Chronic treatment with progesterone but not medroxyprogesterone acetate restores the endothelial control of vascular tone in the mesenteric artery of ovariectomized rats.

Chataigneau T, Zerr M, Chataigneau M, Hudlett F, Hirn C, Pernot F, Schini-Kerth VB

Menopause. 2004 May-Jun;11(3):255-63.

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