Ageing enhances the shedding of splenocyte microvesicles with endothelial pro-senescent effect that is prevented by a short-term intake of omega-3 PUFA EPA:DHA 6:1.
Fiche publication
Date publication
décembre 2019
Journal
Biochemical pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie, Dr AUGER Cyril
Tous les auteurs :
Qureshi AW, Altamimy R, El Habhab A, El Itawi H, Farooq MA, Zobairi F, Hasan H, Amoura L, Auger C, Schini-Kerth V, Toti F
Lien Pubmed
Résumé
Ageing is associated with progressive endothelial senescence and dysfunction, and cardiovascular risk. Circulating endothelial microvesicles (MVs) are pro-senescent and pro-inflammatory endothelial effectors in acute coronary syndrome. Omega 3 PUFAs intake was claimed beneficial in cardiovascular prevention.
Mots clés
Microparticles, angiotensin system, endothelial senescence, omega-3 polyunsaturated fatty acids, oxidative stress, spleen leukocyte
Référence
Biochem. Pharmacol.. 2019 Dec 4;:113734