An aqueous extract of the Anogeissus leiocarpus bark (AEAL) induces the endothelium-dependent relaxation of porcine coronary artery rings involving predominantly nitric oxide.
Fiche publication
Date publication
novembre 2018
Journal
Journal of basic and clinical physiology and pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie, Dr AUGER Cyril
Tous les auteurs :
Belemnaba L, Ouédraogo S, Nitiéma M, Chataigneau T, Guissou IP, Schini-Kerth VB, Bucher B, Auger C
Lien Pubmed
Résumé
Anogeissus leiocarpus is a Sahel tree traditionally used by the residents of Burkina Faso for its antihypertensive properties. In this study, experiments were conducted to evaluate whether an aqueous extract of the Anogeissus leiocarpus (AEAL) trunk bark induces a vasorelaxant effect on porcine coronary artery rings and to investigate the underlying mechanism.
Mots clés
Anogeissus leiocarpus, endothelial NO synthase, endothelium-dependent relaxation, nitric oxide
Référence
J Basic Clin Physiol Pharmacol. 2018 Nov 27;29(6):599-608