A Chinese 2-herb formula (NF3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats.
Fiche publication
Date publication
juillet 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ETIENNE-SELLOUM Nelly, Pr SCHINI-KERTH Valérie
Tous les auteurs :
Tam JC, Ko CH, Lau KM, To MH, Kwok HF, Chan YW, Siu WS, Etienne-Selloum N, Lau CP, Chan WY, Leung PC, Fung KP, Schini-Kerth VB, Lau CB
Lien Pubmed
Résumé
Diabetic foot ulcer is closely associated with peripheral vascular disease. Enhancement of tissue oxidative stress, reduction of nitric oxide (NO) and angiogenic growth factors, and abnormal matrix metalloproteinase (MMP) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing. Our previous study demonstrated that the Chinese 2-herb formula, NF3, showed significant wound healing effects on diabetic foot ulcer rats. A novel rat diabetic foot ulcer with hindlimb ischemia model was established in order to strengthen our claims on the diabetic wound healing and post-ischemic neovascularization effects of NF3. Our results demonstrate that NF3 can significantly reduce the wound area of the diabetic foot ulcer rat with hindlimb ischemia by 21.6% (p
Référence
J Diabetes Complications. 2014 Jul-Aug;28(4):436-47