Docosahexaenoic acid, but not eicosapentaenoic acid, improves septic shock-induced arterial dysfunction in rats.
Fiche publication
Date publication
janvier 2017
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie, Dr AUGER Cyril
Tous les auteurs :
Boivin A, Burban M, Clere-Jehl R, Le Borgne P, Merdji H, Auger C, Schini-Kerth V, Meziani F, Helms J
Lien Pubmed
Résumé
Long chain n-3 fatty acid supplementation may modulate septic shock-induced host response to pathogen-induced sepsis. The composition of lipid emulsions for parenteral nutrition however remains a real challenge in intensive care, depending on their fatty acid content. Because they have not been assessed yet, we aimed at determining the respective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) during septic shock-induced vascular dysfunction.
Mots clés
Animals, Arteries, pathology, Docosahexaenoic Acids, therapeutic use, Eicosapentaenoic Acid, therapeutic use, Epoprostenol, biosynthesis, Male, Nitric Oxide, biosynthesis, Norepinephrine, administration & dosage, Oxidative Stress, Rats, Rats, Wistar, Shock, Septic, complications, Vascular Diseases, drug therapy
Référence
PLoS ONE. 2017 ;12(12):e0189658