Tambulin is a major active compound of a methanolic extract of fruits of Zanthoxylum armatum DC causing endothelium-independent relaxations in porcine coronary artery rings via the cyclic AMP and cyclic GMP relaxing pathways.
Fiche publication
Date publication
février 2019
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie, Dr AUGER Cyril
Tous les auteurs :
Mushtaq MN, Ghimire S, Alamgeer, Akhtar MS, Adhikari A, Auger C, Schini-Kerth VB
Lien Pubmed
Résumé
Zanthoxylum armatum DC (Z. armatum), belonging to Rutaceae family, has been traditionally used for the treatment of various diseases such as hypertension, abdominal pain, headache, fever, high altitude sickness, diarrhea, dysentery, and as a tonic, condiment, and an anthelmintic treatment.
Mots clés
Endothelium, Tambulin, Vasorelaxation, Zanthoxylum armatum
Référence
Phytomedicine. 2019 Feb;53:163-170