Red Wine Extract Disrupts Th17 Lymphocyte Differentiation in a Colorectal Cancer Context.

Fiche publication


Date publication

avril 2020

Journal

Molecular nutrition & food research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DELMAS Dominique, Pr GHIRINGHELLI François, Pr SCHINI-KERTH Valérie, Dr AUGER Cyril, Dr CHALMIN Fanny, Dr AIRES Virginie, Dr LIMAGNE Emeric


Tous les auteurs :
Chalons P, Courtaut F, Limagne E, Chalmin F, Cantos-Villar E, Richard T, Auger C, Chabert P, Schini-Kerth V, Ghiringhelli F, Aires V, Delmas D

Résumé

It is well established that immune response and inflammation promote tumoral progression. Immune cells communicate through direct contact or through cytokine secretion, and it is the expression of these mediators and of the pro-inflammatory status that will tip the balance toward tumor progression or anti-tumor immunity. We have demonstrated that a red wine extract (RWE) was able to decrease inflammation through its action on the inflammasome complex. In this study, we sought to determine whether an RWE could impact other key actors of inflammation, in particular T helper 17 (Th17) immune cells.

Mots clés

Interleukins, Polyphenols, Red wine extract, Th17 lymphocytes

Référence

Mol Nutr Food Res. 2020 Apr 18;:e1901286