Medium-chain triglyceride supplementation exacerbates peritonitis-induced septic shock in rats: role on cell membrane remodeling.
Fiche publication
Date publication
décembre 2014
Journal
Shock (Augusta, Ga.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie
Tous les auteurs :
Boisramé-Helms J, Said A, Burban M, Delabranche X, Stiel L, Zobairi F, Hasselmann M, Schini-Kerth V, Toti F, Meziani F
Lien Pubmed
Résumé
Lipid emulsions for parenteral nutrition interfere with immunity and may alter the cell plasma membrane and microparticle release, thus modulating their biological effects. Our aim was to evaluate the effect of two lipid emulsions for parenteral nutrition containing either a mixture of long- and medium-chain triglycerides (LCTs and MCTs) or LCTs only, to assess their role on microparticle release and acute inflammation during septic shock in rats.
Mots clés
Animals, Aorta, metabolism, Cell Membrane, metabolism, Coagulants, chemistry, Electron Spin Resonance Spectroscopy, Emulsions, chemistry, Glucose, chemistry, Hemodynamics, Inflammation, Lipids, chemistry, Male, Microspheres, Myocardium, metabolism, Nitric Oxide, chemistry, Parenteral Nutrition Solutions, chemistry, Peritonitis, physiopathology, Phosphorylation, Rats, Rats, Wistar, Shock, Septic, chemically induced, Superoxides, chemistry, Time Factors, Triglycerides, adverse effects
Référence
Shock. 2014 Dec;42(6):548-53