Endothelium-independent vasorelaxant effect of Asphodelus tenuifolius Cav. via inhibition of myosin light chain kinase activity in the porcine coronary artery.
Fiche publication
Date publication
décembre 2020
Journal
Journal of ethnopharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie
Tous les auteurs :
Younis W, Alamgeer, Schini-Kerth VB, Junior AG, Nocchi SR, Silva DB, Roberts RE
Lien Pubmed
Résumé
Asphodelus tenuifolius Cav. (Asphodelaceae), a wild, terrestrial, annual stemless herb, is widely used in traditional medicine for the treatment of hypertension, diabetes, atherosclerosis and circulatory problems. A previous research study from our laboratory revealed that A. tenuifolius has beneficial effects in reducing blood pressure and improves aortic endothelial dysfunction in chronically glucose fed rats. Despite the fact that A. tenuifolius reduces blood pressure and improves endothelial function in vivo, there are no detailed studies about its possible mechanism of action.
Mots clés
Alpha,beta-MeATP (PubChem CID: 91557), Asphodelus tenuifolius, Bayk8644 (PubChem CID: 2303), Bradykinin (PubChem CID: 439201), Dicloromethane (PubChem CID: 6344), Ethyl acetate (PubChem CID: 8857), Forskolin (PubChem CID: 47936), Ionomycin (PubChem CID: 6912226), Methanol (PubChem CID: 887), Myosin light chain kinase, Nifedipine (PubChem CID: 4485), ODQ (PubChem CID: 1456), Tetraethylammonium (PubChem CID: 5413), U46619 (PubChem CID: 5311493), Y27632 (PubChem CID: 448042), calcium influx, coronary artery, n-Butanol (PubChem CID: 263), n-Hexane (PubChem CID: 8058), vascular smooth muscle, vasodilatation
Référence
J Ethnopharmacol. 2020 Dec 13;:113693