The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins.
Fiche publication
Date publication
mars 2018
Journal
BMC complementary and alternative medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie, Dr AUGER Cyril
Tous les auteurs :
Yao AN, Kamagaté M, Amonkan AK, Chabert P, Kpahé F, Koffi C, Kouamé MN, Auger C, Kati-Coulibaly S, Schini-Kerth V, Die-Kakou H
Lien Pubmed
Résumé
Phyllanthus amarus (Schum & Thonn), a plant belonging to the family of Euphorbiaceae is used in Ivorian traditional medicine to treat cardiovascular disorders such as hypertension. However, although this plant has been described as a diuretic agent, the underlying mechanism remains unclear. Therefore, the aim of the present study was to investigate the mechanism action of diuretic effects of an ethanolic fraction of Phyllanthus amarus (EFPA) in rats.
Mots clés
Animals, Chlorides, urine, Diuretics, administration & dosage, Humans, Hypertension, drug therapy, Male, Phyllanthus, chemistry, Plant Extracts, administration & dosage, Prostaglandins, metabolism, Rats, Rats, Wistar, Sodium, urine
Référence
BMC Complement Altern Med. 2018 Mar 15;18(1):94