Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium.
Fiche publication
Date publication
juillet 2018
Journal
Free radical biology & medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie, Dr AUGER Cyril
Tous les auteurs :
Oak MH, Auger C, Belcastro E, Park SH, Lee HH, Schini-Kerth VB
Lien Pubmed
Résumé
Epidemiological studies have indicated that regular intake of polyphenol-rich diets such as red wine and tea, are associated with a reduced risk of cardiovascular diseases. The beneficial effect of polyphenol-rich products has been attributable, at least in part, to their direct action on the endothelial function. Indeed, polyphenols from tea, grapes, cacao, berries, and plants have been shown to activate endothelial cells to increase the formation of potent vasoprotective factors including nitric oxide (NO) and to delay endothelial ageing. Moreover, intake of such polyphenol-rich products has been associated with the prevention and/or the improvement of an established endothelial dysfunction in several experimental models of cardiovascular diseases and in Humans with cardiovascular diseases. This review will discuss both experimental and clinical evidences indicating that polyphenols are able to promote endothelial and vascular health, as well as the underlying mechanisms.
Mots clés
Cardiovascular risk factors, Endothelium, Nitric oxide, Polyphenols
Référence
Free Radic. Biol. Med.. 2018 07;122:161-170