Pr GUEANT Jean-Louis

Clinical Exome Sequencing in Unexplained Hyperferritinemia Reveals Digenic and Oligogenic Inheritance Beyond Iron Homeostasis.

Morel P, Silva Rodriguez M, Benmouffek C, Goksen B, Chéry C, Haghnejad V, Bensenane M, Feillet F, Guéant JL, Namour F, Bronowicki JP, Oussalah A

Liver Int. 2026 05;46(5):e70646

Acylcarnitines Are Associated with Metabolic Syndrome and Hypertension in Two Contrasted Obese Populations.

Chabi N, Nominé-Criqui C, Heinken A, Quilliot D, Brunaud L, Li Z, Jeannesson-Thivisol E, Sanni A, Ziegler O, Gueant JL, Guéant-Rodriguez RM

Nutrients. 2026 04 1;18(7):

IFNγ-associated immune-metabolic remodeling is linked to serotonin-kynurenine imbalance and cortical vulnerability in lupus-prone mice.

Matmat K, Guéant-Rodriguez RM, Darcq E, Baspinar O, Alberto JM, Guéant JL, Mensah-Nyagan AG, Jeltsch-David H

Front Immunol. 2026 03 5;17:1740039

SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism.

Matmat K, Hassan Z, Pourié G, Atlasi Y, Seal SV, Jeandel M, Arnold C, Luharia S, Umoret R, Safar R, Heinken A, Alberto JM, Baspinar O, Paoli J, Hergalant S, Rouyer P, Camadro JM, Lignières L, Coelho D, Guéant JL, Guéant-Rodriguez RM

Cell Rep Med. 2026 02 25;:102643

IgG-Related Neutrophil Activation Is a Novel Mechanism That Defines a New Type of Immediate Hypersensitivity Reactions (IHR) to Beta-Lactam.

Guéant JL, Gallizzi AA, Guéant-Rodriguez RM, Romano A, Laguna JJ

Clin Exp Allergy. 2026 02 23;:

Multi-omics analysis of a prebiotic intervention with pectin in lipid transfer proteins (LTPs) allergic patients.

Gómez F, Pérez-Sánchez N, Macías-Camero A, Núñez R, Contreras N, Cañas JA, Jiménez-Sánchez IM, Díez-Echave P, Barbas C, Guéant JL, Barber D, Vieths S, Scheurer S, Villaseñor A, Rodríguez-Nogales A, Mayorga C, Torres MJ

Carbohydr Polym. 2025 12 1;369:124236

A smoothing method for DNA methylome analysis to enhance epigenomic signature detection in epigenome-wide association studies.

Oussalah A, Mousel L, Trégouët DA, Guéant JL

Methods. 2025 11 20;:

Reconsidering the urea-to-creatinine ratio as a signal of muscle catabolism in patients with cirrhosis.

Oussalah A, Haghnejad V, Audouy A, Silva Rodriguez M, Guéant JL, Namour F, Bronowicki JP

Crit Care. 2025 10 8;29(1):428

Ammonia-to-Urea Ratio: A Noninvasive First-Line Tool for Detecting Clinically Significant Portal Hypertension.

Ouahbi H, Haghnejad V, Audouy A, Silva Rodriguez M, Barbé F, Guéant JL, Bronowicki JP, Oussalah A

JGH Open. 2025 09;9(9):e70273

Personalized Genome-Scale Modeling Reveals Metabolic Perturbations in Fibroblasts of Methylmalonic Aciduria Patients.

Heinken A, Awada H, Zanotelli VRT, Froese DS, Guéant-Rodriguez RM, Guéant JL

J Inherit Metab Dis. 2025 09;48(5):e70077

Exome-based genotype-first reverse phenotyping using structured electronic health record data identifies novel SERPINA1 variants associated with liver markers and demonstrates a dominant effect for specific variants on liver phenotype.

Silva Rodriguez M, Mulot M, Chéry C, Bensenane M, Guéant-Rodriguez RM, Jaussaud R, Cobat A, Feillet F, Bronowicki JP, Namour F, Guéant JL, Oussalah A

Hepatol Res. 2025 05 13;:

Assessment of Patients With Beta-Lactams Positive Provocation Tests by Biomarkers of IgG-Related Neutrophil Activation.

Gallizzi AA, Guéant-Rodriguez RM, Boteanu C, Alberto JM, Lakomy C, Louis H, Chery C, Renard P, Regnault V, Safar R, Heinken A, Romano A, Laguna JJ, Guéant JL

Clin Exp Allergy. 2025 04 23;:

Legends of Allergy and Immunology: Antonino Romano.

Torres MJ, Bonadonna P, Guéant JL

Allergy. 2025 03 12;:

Mid-regional pro-adrenomedullin: A rapid sepsis biomarker for diagnosing spontaneous bacterial peritonitis in cirrhosis.

Oussalah A, Haghnejad V, Silva Rodriguez M, Lagneaux AS, Alix T, Filhine-Tresarrieu P, Ferrand J, Jung J, Broseus J, Salignac S, Luc A, Baumann C, Schuetz P, Lozniewski A, Peoc'h K, Puy H, Guéant JL, Bronowicki JP

Eur J Clin Invest. 2025 03 7;:e70021

A systematic review/meta-analysis of xenobiotics in apple products highlights lack of compliance with European Food Safety Authority Regulation.

Noel A, Guéant-Rodriguez RM, Cachard O, Kouche SE, Graindorge PH, Wanny NE, Alpers DH, Grova N, Guéant JL

Compr Rev Food Sci Food Saf. 2025 03;24(2):e70153

Population-level impact of COVID-19 on thyroid function tests: Results from a repeated cross-sectional study.

Berkebile G, Barbé F, Malaplate C, Le Collen L, Guéant JL, Klein M, Oussalah A

J Infect Public Health. 2025 01 22;18(3):102681

Personalized modeling of gut microbiome metabolism throughout the first year of life.

Shaaban R, Busi SB, Wilmes P, Guéant JL, Heinken A

Commun Med (Lond). 2024 12 30;4(1):281

Heterozygous Mutations in Both the and Genes: Double Haploinsufficiency as an Unusual Cause of Vitamin B Deficiency-A Case Report.

Iversen PO, Gueant JL, Oussalah A, Refsum H, Nexo E, Tjønnfjord GE, Qvigstad C

Clin Case Rep. 2024 11;12(11):e9600

The EKFC equation outperforms the CKD-EPI and CKiD equations for GFR estimation in adolescent and young adult kidney transplant patients.

Grosyeux C, Alla A, Barbé F, Dubourg LD, Chardon L, Guéant JL, Frimat L, Oussalah A, Vrillon I

Nephrology (Carlton). 2024 05 27;:

Multiparametric renal function assessment in cirrhotic patients shows high prevalence of medically actionable changes in multiple modules.

Belmonte R, Silva-Rodriguez M, Barbé F, Bensenane M, Haghenejad V, Vrillon I, Alla A, Flahault A, Kormann R, Corbel A, Aitdjafer Z, Quilliot D, Derain-Dubourg L, Namour F, Guéant JL, Bronowicki JP, Oussalah A

Hepatol Res. 2024 04 25;:

Long-term follow-up of neutrophil activation after severe-to-critical SARS-CoV-2 infection: A longitudinal study.

Valentin S, Regnault V, Gueant JL, Ribeiro Baptista B, Abel T, Lacolley P, Schlemmer F, Chaouat A, Chabot F, Gueant-Rodriguez RM

Allergy. 2024 04 12;:

Multiomic analysis in fibroblasts of patients with inborn errors of cobalmin metabolism reveals concordance with clinical and metabolic variability.

Wiedemann A, Oussalah A, Guéant Rodriguez RM, Jeannesson E, Mertens M, Rotaru I, Alberto JM, Baspinar O, Rashka C, Hassan Z, Siblini Y, Matmat K, Jeandel M, Chery C, Robert A, Chevreux G, Lignières L, Camadro JM, Feillet F, Coelho D, Guéant JL

EBioMedicine. 2024 01 1;99:104911

Towards personalized genome-scale modeling of inborn errors of metabolism for systems medicine applications.

Heinken A, El Kouche S, Rodriguez-Guéant RM, Guéant JL

Metabolism. 2023 11 17;:155738

A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism.

Matmat K, Conart JB, Graindorge PH, El Kouche S, Hassan Z, Siblini Y, Umoret R, Safar R, Baspinar O, Robert A, Alberto JM, Oussalah A, Coelho D, Guéant JL, Guéant-Rodriguez RM

Clin Epigenetics. 2023 10 5;15(1):158

Cross-Talk between miRNAs from the Dlk1-Dio3 Locus and Histone Methylation to Protect Male Cerebellum from Methyl Donor Deficiency.

Willekens J, Mosca P, Burt-Oberecken N, Laugeais E, Kaoma T, Bernardin F, Vallar L, Dimofski P, Renaud M, Lambert L, Leheup B, Guéant JL, Leininger-Muller B, Dreumont N

Mol Nutr Food Res. 2023 09 6;:e2300040

MicroRNAs miR-16 and miR-519 control meningioma cell proliferation overlapping transcriptomic programs shared with the RNA-binding protein HuR.

Hergalant S, Casse JM, Oussalah A, Houlgatte R, Helle D, Rech F, Vallar L, Guéant JL, Vignaud JM, Battaglia-Hsu SF, Gauchotte G

Front Oncol. 2023 08 2;13:1158773

Folate and Cobalamin Deficiencies during Pregnancy Disrupt the Glucocorticoid Response in Hypothalamus through -Homocysteinilation of the Glucocorticoid Receptor.

Michel A, Kokten T, Saber-Cherif L, Umoret R, Alberto JM, Helle D, Julien A, Daval JL, Guéant JL, Bossenmeyer-Pourié C, Pourié G

Int J Mol Sci. 2023 06 7;24(12):

Cognitive Impairment Is Associated with AMPAR Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine Synthase Deficiency.

Hassan Z, Coelho D, Bossenmeyer-Pourié C, Matmat K, Arnold C, Savladori A, Alberto JM, Umoret R, Guéant JL, Pourié G

Cells. 2023 04 27;12(9):

Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study.

Mertes PM, Petitpain N, Tacquard C, Delpuech M, Baumann C, Malinovsky JM, Longrois D, Gouel-Cheron A, Le Quang D, Demoly P, Guéant JL, Gillet P,

Br J Anaesth. 2023 03 24;:

Epigenome alterations in food allergy: A systematic review of candidate gene and epigenome-wide association studies.

Safar R, Oussalah A, Mayorga L, Vieths S, Barber D, Torres MJ, Guéant JL

Clin Exp Allergy. 2023 02 9;:

Predictors of the utility of clinical exome sequencing as a first-tier genetic test in patients with Mendelian phenotypes: results from a referral center study on 603 consecutive cases.

Alix T, Chéry C, Josse T, Bronowicki JP, Feillet F, Guéant-Rodriguez RM, Namour F, Guéant JL, Oussalah A

Hum Genomics. 2023 02 5;17(1):5

Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis.

Broséus J, Hergalant S, Vogt J, Tausch E, Kreuz M, Mottok A, Schneider C, Dartigeas C, Roos-Weil D, Quinquenel A, Moulin C, Ott G, Blanchet O, Tomowiak C, Lazarian G, Rouyer P, Chteinberg E, Bernhart SH, Tournilhac O, Gauchotte G, Lomazzi S, Chapiro E, Nguyen-Khac F, Chery C, Davi F, Hunault M, Houlgatte R, Rosenwald A, Delmer A, Meyre D, Béné MC, Thieblemont C, Lichter P, Ammerpohl O, Guéant JL, ,Guièze R, Martin-Subero JI, Cymbalista F, Feugier P, Siebert R, Stilgenbauer S

Nat Commun. 2023 01 19;14(1):309

Usefulness of procalcitonin at admission as a risk-stratifying biomarker for 50-day in-hospital mortality among patients with community-acquired bloodstream infection: an observational cohort study.

Oussalah A, Callet J, Manteaux AE, Thilly N, Jay N, Guéant JL, Lozniewski A

Biomark Res. 2023 01 17;11(1):4

The importance of vitamin B for individuals choosing plant-based diets.

Niklewicz A, Smith AD, Smith A, Holzer A, Klein A, McCaddon A, Molloy AM, Wolffenbuttel BHR, Nexo E, McNulty H, Refsum H, Gueant JL, Dib MJ, Ward M, Murphy M, Green R, Ahmadi KR, Hannibal L, Warren MJ, Owen PJ,

Eur J Nutr. 2022 12 5;:

Stemness of Normal and Cancer Cells: The Influence of Methionine Needs and SIRT1/PGC-1α/PPAR-α Players.

Siblini Y, Namour F, Oussalah A, Guéant JL, Chéry C

Cells. 2022 11 15;11(22):

[Medical biology in France: evolution and issues].

Bonnefont-Rousselot D, Delpech M, Chatron P, Gueant JL, Le Bouc Y, Maquart FX, Massoubre B, Rives N, Vigneron C

Ann Biol Clin (Paris). 2022 11 1;80(6):551-564

Hyperhomocysteinemia in cardiovascular diseases: revisiting observational studies and clinical trials.

Gueant JL, Gueant-Rodriguez RM, Oussalah A, Zuily S, Rosenberg I

Thromb Haemost. 2022 09 28;:

Inherited metabolic disorders beyond the new generation sequencing era: the need for in-depth cellular and molecular phenotyping.

Guéant JL, Feillet F

Hum Genet. 2022 06 27;:

Clinical, phenotypic and genetic landscape of case reports with genetically proven inherited disorders of vitamin B metabolism: A meta-analysis.

Wiedemann A, Oussalah A, Lamireau N, Théron M, Julien M, Mergnac JP, Augay B, Deniaud P, Alix T, Frayssinoux M, Feillet F, Guéant JL

Cell Rep Med. 2022 06 21;:100670

Knockout in U251 Glioblastoma Cells Reduces Tumor Sphere Formation by Increasing Oxidative Stress and Suppressing Methionine Dependency.

Quéré M, Alberto JM, Broly F, Hergalant S, Christov C, Gauchotte G, Guéant JL, Namour F, Battaglia-Hsu SF

Nutrients. 2022 04 30;14(9):

Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B.

Oussalah A, Siblini Y, Hergalant S, Chéry C, Rouyer P, Cavicchi C, Guerrini R, Morange PE, Trégouët D, Pupavac M, Watkins D, Pastinen T, Chung WK, Ficicioglu C, Feillet F, Froese DS, Baumgartner MR, Benoist JF, Majewski J, Morrone A, Rosenblatt DS, Guéant JL

Clin Epigenetics. 2022 Apr 19;14(1):52

Epimutation in inherited metabolic disorders: the influence of aberrant transcription in adjacent genes.

Guéant JL, Siblini Y, Chéry C, Schmitt G, Guéant-Rodriguez RM, Coelho D, Watkins D, Rosenblatt DS, Oussalah A

Hum Genet. 2022 Feb 21;:

Behavioral profile of vitamin B deficiency: A reflection of impaired brain development, neuronal stress and altered neuroplasticity.

Pourié G, Guéant JL, Quadros EV

Vitam Horm. 2022 ;119:377-404

Vitamin B12 absorption and malabsorption.

Guéant JL, Guéant-Rodriguez RM, Alpers DH

Vitam Horm. 2022 ;119:241-274

[A long non-coding RNA regulates the activity of phenylalanine hydroxylase, the key enzyme of phenylketonuria].

Wiedemann A, Lin C, Oussalah A, Namour B, Jeannesson É, Guéant JL, Feillet F

Med Sci (Paris). 2022 Jan;38(1):12-14

Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study.

Trépo E, Caruso S, Yang J, Imbeaud S, Couchy G, Bayard Q, Letouzé E, Ganne-Carrié N, Moreno C, Oussalah A, Féray C, Blanc JF, Clément B, Hillon P, Boursier J, Paradis V, Calderaro J, Gnemmi V, Nault JC, Guéant JL, Devière J, Archambeaud I, Vitellius C, Turlin B, Bronowicki JP, Gustot T, Sutton A, ,Ziol M, Nahon P, Zucman-Rossi J

Lancet Oncol. 2021 Dec 10;:

Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency.

Siblini Y, Chéry C, Rouyer P, Raso J, Julien A, Hergalant S, François A, Bezdetnaya L, Vogin G, Guéant JL, Oussalah A

Clin Epigenetics. 2021 Dec 1;13(1):212

Low-frequency coding variants associated with body-mass-index impact the success of bariatric surgery.

Antoine D, Guéant-Rodriguez RM, Chèvre JC, Hergalant S, Sharma T, Li Z, Rouyer P, Chery C, Halvick S, Bui C, Oussalah A, Ziegler O, Quilliot D, Brunaud L, Guéant JL, Meyre D

J Clin Endocrinol Metab. 2021 Oct 26;:

Next-Generation Sequencing and Genotype Association Studies Reveal the Association of HLA-DRB3*02:02 With Delayed Hypersensitivity to Penicillins.

Romano A, Oussalah A, Chery C, Guéant-Rodriguez RM, Gaeta F, Cornejo-Garcia JA, Rouyer P, Josse T, Mayorga C, Torres MJ, Guéant JL

Allergy. 2021 Oct 23;:

Ocular manifestations in patients with inborn errors of intracellular cobalamin metabolism: a systematic review.

Matmat K, Guéant-Rodriguez RM, Oussalah A, Wiedemann-Fodé A, Dionisi-Vici C, Coelho D, Guéant JL, Conart JB

Hum Genet. 2021 Oct 15;:

Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B metabolism.

Guéant JL, Guéant-Rodriguez RM, Kosgei VJ, Coelho D

Crit Rev Biochem Mol Biol. 2021 Oct 5;:1-23

A bi-allelic loss-of-function SARS1 variant in children with neurodevelopmental delay, deafness, cardiomyopathy, and decompensation during fever.

Ravel JM, Dreumont N, Mosca P, Smith DEC, Mendes MI, Wiedemann A, Coelho D, Schmitt E, Rivière JB, Mau-Them FT, Thevenon J, Kuentz P, Polivka M, Fuchs SA, Kok G, Thauvin-Robinet C, Guéant JL, Salomons GS, Faivre L, Feillet F

Hum Mutat. 2021 Sep 27;:

Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers.

Gallet P, Oussalah A, Pouget C, Dittmar G, Chery C, Gauchotte G, Jankowski R, Gueant JL, Houlgatte R

Clin Epigenetics. 2021 Sep 25;13(1):179

Accuracy of procalcitonin for diagnosing peripheral blood culture contamination among patients with positive blood culture for potential contaminants.

Berthezène C, Aissa N, Manteaux AE, Guéant JL, Oussalah A, Lozniewski A

Infection. 2021 Sep 15;:

Diagnostic yield of clinical exome sequencing as a first-tier genetic test for the diagnosis of genetic disorders in pediatric patients: results from a referral center study.

Mergnac JP, Wiedemann A, Chery C, Ravel JM, Namour F, Guéant JL, Feillet F, Oussalah A

Hum Genet. 2021 Sep 8;:

A noncoding RNA modulator potentiates phenylalanine metabolism in mice.

Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Guéant JL, Muntau AC, Blau N, Sutton VR, Schiff M, Feillet F, Zhang S, Lin C, Yang L

Science. 2021 Aug 6;373(6555):662-673

Vitamin B Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.

Mosca P, Robert A, Alberto JM, Meyer M, Kundu U, Hergalant S, Umoret R, Coelho D, Guéant JL, Leheup B, Dreumont N

Mol Nutr Food Res. 2021 Jul 22;:e2100206

Ovarian Telomerase and Female Fertility.

Toupance S, Fattet AJ, Thornton SN, Benetos A, Guéant JL, Koscinski I

Biomedicines. 2021 Jul 20;9(7):

PRDX1 gene-related epi-cblC disease is a common type of inborn error of cobalamin metabolism with mono- or bi-allelic MMACHC epimutations.

Cavicchi C, Oussalah A, Falliano S, Ferri L, Gozzini A, Gasperini S, Motta S, Rigoldi M, Parenti G, Tummolo A, Meli C, Menni F, Furlan F, Daniotti M, Malvagia S, la Marca G, Chery C, Morange PE, Tregouet D, Donati MA, Guerrini R, Guéant JL, Morrone A

Clin Epigenetics. 2021 Jul 2;13(1):137

Hypozincemia in the early stage of COVID-19 is associated with an increased risk of severe COVID-19.

Fromonot J, Gette M, Ben Lassoued A, Guéant JL, Guéant-Rodriguez RM, Guieu R

Clin Nutr. 2021 May 4;:

[Newborn screening of phenylketonuria in France].

Wiedemann A, Jeannesson É, Oussalah A, Guéant JL, Guéant-Rodriguez RM, Feillet F

Med Sci (Paris). 2021 May;37(5):468-473

Fetal Programming by Methyl Donor Deficiency Produces Pathological Remodeling of the Ascending Aorta.

Balint B, Hergalan S, Camadro JM, Blaise S, Vanalderwiert L, Lignières L, Guéant-Rodriguez RM, Guéant JL

Arterioscler Thromb Vasc Biol. 2021 Apr 8;:ATVBAHA120315587

Positioning digital tracing applications in France's COVID-19 pandemic management.

Albouy-Llaty M, Martin C, Benamousig D, Bothorel E, Munier G, Simonin C, Guéant JL, Rusch E

J Med Internet Res. 2021 Mar 31;:

Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients.

Levy J, Rodriguez-Guéant RM, Oussalah A, Jeannesson E, Wahl D, Ziuly S, Guéant JL

Am J Clin Nutr. 2021 Mar 10;:

Elastase and Exacerbation of Neutrophil Innate Immunity are Involved in Multi-Visceral Manifestations of COVID-19.

Guéant JL, Guéant-Rodriguez RM, Fromonot J, Oussalah A, Louis H, Chery C, Gette M, Gleye S, Callet J, Raso J, Blanchecotte F, Lacolley P, Guieu R, Regnault V

Allergy. 2021 Jan 23;:

Expanding the clinical spectrum of STIP1 homology and U-box containing protein 1-associated ataxia.

Ravel JM, Benkirane M, Calmels N, Marelli C, Ory-Magne F, Ewenczyk C, Halleb Y, Tison F, Lecocq C, Pische G, Casenave P, Chaussenot A, Frismand S, Tyvaert L, Larrieu L, Pointaux M, Drouot N, Bossenmeyer-Pourié C, Oussalah A, Guéant JL, Leheup B, Bonnet C, Anheim M, Tranchant C, Lambert L, Chelly J, Koenig M, Renaud M

J Neurol. 2021 Jan 8;:

Beneficial and deleterious effects of sitagliptin on a methionine/choline-deficient diet-induced steatohepatitis in rats.

Sámano-Hernández L, Fierro R, Marchal A, Guéant JL, González-Márquez H, Guéant-Rodríguez RM

Biochimie. 2020 Dec 14;181:240-248

The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9-12 Vitamins.

Pourié G, Martin N, Daval JL, Alberto JM, Umoret R, Guéant JL, Bossenmeyer-Pourié C

Int J Mol Sci. 2020 Oct 28;21(21):

Glucocorticoid Receptor Activation Restores Learning Memory by Modulating Hippocampal Plasticity in a Mouse Model of Brain Vitamin B Deficiency.

Dreumont N, Mimoun K, Pourié C, Quadros EV, Alberto JM, Umoret R, Helle D, Robert A, Daval JL, Guéant JL, Pourié G

Mol Neurobiol. 2020 Oct 20;:

Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop.

Maruvada P, Stover PJ, Mason JB, Bailey RL, Davis CD, Field MS, Finnell RH, Garza C, Green R, Gueant JL, Jacques PF, Klurfeld DM, Lamers Y, MacFarlane AJ, Miller JW, Molloy AM, O'Connor DL, Pfeiffer CM, Potischman NA, Rodricks JV, Rosenberg IH, Ross SA, Shane B, Selhub J, Stabler SP, Trasler J, Yamini S, Zappalà G

Am J Clin Nutr. 2020 Oct 6;:

The Fate of Transplanted Olfactory Progenitors Is Conditioned by the Cell Phenotypes of the Receiver Brain Tissue in Cocultures.

Pourié G, Akchiche N, Millot JL, Guéant JL, Daval JL, Bossenmeyer-Pourié C

Int J Mol Sci. 2020 09 30;21(19):

The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study.

Oussalah A, Gleye S, Urmes IC, Laugel E, Barbé F, Orlowski S, Malaplate C, Aimone-Gastin I, Caillierez BM, Merten M, Jeannesson E, Kormann R, Olivier JL, Rodriguez-Guéant RM, Namour F, Bevilacqua S, Thilly N, Losser MR, Kimmoun A, Frimat L, Levy B, Gibot S, Schvoerer E, Guéant JL

. 2020 Sep 20;:100554

Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature.

Fattet AJ, Toupance S, Thornton SN, Monnin N, Guéant JL, Benetos A, Koscinski I

J Ovarian Res. 2020 Aug 21;13(1):96

Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism.

Kosgei VJ, Coelho D, Guéant-Rodriguez RM, Guéant JL

Cells. 2020 Aug 11;9(8):

Blood Myeloperoxidase-DNA, a biomarker of early response to SARS-CoV-2 infection?

Guéant JL, Fromonot J, Guéant-Rodriguez RM, Lacolley P, Guieu R, Regnault V

Allergy. 2020 Aug 2;:

Long-Term ACE Inhibitor/ARB Use Is Associated with Severe Renal Dysfunction and Acute Kidney Injury in Patients with severe COVID-19: Results from a Referral Center Cohort in the North East of France.

Oussalah A, Gleye S, Clerc Urmes I, Laugel E, Callet J, Barbé F, Orlowski S, Malaplate C, Aimone-Gastin I, Caillierez BM, Merten M, Jeannesson E, Kormann R, Olivier JL, Rodriguez-Guéant RM, Namour F, Bevilacqua S, Losser MR, Levy B, Kimmoun A, Gibot S, Thilly N, Frimat L, Schvoerer E, Guéant JL

Clin. Infect. Dis.. 2020 Jul 5;:

Coronavirus disease 2019: acute Fanconi syndrome precedes acute kidney injury.

Kormann R, Jacquot A, Alla A, Corbel A, Koszutski M, Voirin P, Garcia Parrilla M, Bevilacqua S, Schvoerer E, Gueant JL, Namour F, Levy B, Frimat L, Oussalah A

Clin Kidney J. 2020 Jun;13(3):362-370

The deficit in folate and vitamin B12 triggers liver macrovesicular steatosis and inflammation in rats with dextran sodium sulfate-induced colitis.

Harb Z, Deckert V, Bressenot AM, Christov C, Guéant-Rodriguez RM, Raso J, Alberto JM, de Barros JP, Umoret R, Biroulet LP, Lagrost L, Bronowicki JP, Guéant JL

J. Nutr. Biochem.. 2020 May 20;84:108415

Prolonged 25-OH Vitamin D Deficiency Does Not Impair Bone Mineral Density in Adult Patients With Vitamin D 25-Hydroxylase Deficiency (CYP2R1).

Wiedemann A, Renard E, Molin A, Weryha G, Oussalah A, Guéant JL, Feillet F

Calcif. Tissue Int.. 2020 May 19;:

Folinic acid improves the score of Autism in the EFFET placebo-controlled randomized trial.

Renard E, Leheup B, Guéant-Rodriguez RM, Oussalah A, Quadros EV, Guéant JL

Biochimie. 2020 May 6;:

Biochemical analysis of patients with mutations in MTHFD1 and a diagnosis of methylenetetrahydrofolate dehydrogenase 1 deficiency.

Bidla G, Watkins D, Chéry C, Froese DS, Ells C, Kerachian M, Saskin A, Christensen KE, Gilfix BM, Guéant JL, Rosenblatt DS

Mol. Genet. Metab.. 2020 May 5;:

Medium term post-bariatric surgery deficit of vitamin B12 is predicted by deficit at time of surgery.

Antoine D, Li Z, Quilliot D, Sirveaux MA, Meyre D, Mangeon A, Brunaud L, Guéant JL, Guéant-Rodriguez RM

Clin Nutr. 2020 Apr 25;:

B vitamins and one carbon metabolism micronutrients in health and disease.

Murphy MM, Guéant JL

Biochimie. 2020 Apr 22;:

Comparative accuracy of ferritin, transferrin saturation and soluble transferrin receptor for the diagnosis of iron deficiency in inflammatory bowel disease.

Daude S, Remen T, Chateau T, Danese S, Gastin I, Baumann C, Gueant JL, Peyrin-Biroulet L

Aliment. Pharmacol. Ther.. 2020 Apr 22;:

Genetic, epigenetic and genomic mechanisms of methionine dependency of cancer and tumor-initiating cells: What could we learn from folate and methionine cycles.

Guéant JL, Oussalah A, Zgheib R, Siblini Y, Hsu SB, Namour B

Biochimie. 2020 Apr 11;:

Effects of e-health educational interventions with patients as active participants on HbA level in type 1 diabetes on intensive insulin therapy: A systematic review and meta-analysis of randomized controlled trials.

Feigerlová E, Oussalah A, Zuily S, Sordet S, Braun M, Guéant JL, Guerci B

Diabetes Metab. Res. Rev.. 2020 Mar 25;:

Health outcomes associated with vegetarian diets: An umbrella review of systematic reviews and meta-analyses.

Oussalah A, Levy J, Berthezène C, Alpers DH, Guéant JL

Clin Nutr. 2020 Mar 11;:

Mechanisms of homocysteine-induced damage to the endothelial, medial and adventitial layers of the arterial wall.

Balint B, Jepchumba VK, Guéant JL, Guéant-Rodriguez RM

Biochimie. 2020 Feb 24;:

Analysis of fibroblasts from patients with cblC and cblG genetic defects of cobalamin metabolism reveals global dysregulation of alternative splicing.

Rashka C, Hergalant S, Dreumont N, Oussalah A, Camadro JM, Marchand V, Hassan Z, Baumgartner MR, Rosenblatt DS, Feillet F, Guéant JL, Coelho D

Hum. Mol. Genet.. 2020 Feb 18;:

Population and evolutionary genetics of the PAH locus to uncover overdominance and adaptive mechanisms in phenylketonuria: Results from a multiethnic study.

Oussalah A, Jeannesson-Thivisol E, Chéry C, Perrin P, Rouyer P, Josse T, Cano A, Barth M, Fouilhoux A, Mention K, Labarthe F, Arnoux JB, Maillot F, Lenaerts C, Dumesnil C, Wagner K, Terral D, Broué P, De Parscau L, Gay C, Kuster A, Bédu A, Besson G, Lamireau D, Odent S, Masurel A, Rodriguez-Guéant RM, Feillet F, Guéant JL, Namour F

EBioMedicine. 2020 Jan 7;51:102623

Genetic Variants Associated with T-Cell Mediated Cutaneous Adverse Drug Reactions: A Prisma-Compliant Systematic Review - an EAACI Position Paper.

Oussalah A, Yip V, Mayorga C, Blanca M, Barbaud A, Nakonechna A, Cernadas J, Gotua M, Brockow K, Caubet JC, Bircher A, Atanaskovic-Markovic M, Demoly P, Kase-Tanno L, Terreehorst I, Laguna JJ, Romano A, Guéant JL, Munir P,

Allergy. 2020 Jan 3;:

Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats.

Hassan Z, Coelho D, Kokten T, Alberto JM, Umoret R, Daval JL, Guéant JL, Bossenmeyer-Pourié C, Pourié G

Int J Mol Sci. 2019 Nov 14;20(22):

GNAI2 variants predict non-steroidal anti-inflammatory drug hypersensitivity in a genome-wide study.

Blanca M, Oussalah A, Cornejo-García JA, Blanca-López N, Guéant-Rodriguez RM, Doña I, Mayorga C, Chery C, Rouyer P, Carmona FD, Bossini Castillo L, Canto G, Martin J, Torres MJ, Guéant JL

Allergy. 2019 Nov 8;:

SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders.

Ghemrawi R, Arnold C, Battaglia-Hsu SF, Pourié G, Trinh I, Bassila C, Charif R, Wiedemann A, Flayac J, Robert A, Dreumont N, Feillet F, Guéant JL, Coelho D

Metab. Clin. Exp.. 2019 Oct 28;:153992

Mutations in MTHFR and POLG impaired activity of the mitochondrial respiratory chain in 46-year-old twins with spastic paraparesis.

Wiedemann A, Chery C, Coelho D, Flayac J, Gueguen N, Desquiret-Dumas V, Feillet F, Lavigne C, Neau JP, Fowler B, Baumgartner MR, Reynier P, Guéant JL, Oussalah A

J. Hum. Genet.. 2019 Oct 23;:

Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus.

Saber Cherif L, Pourié G, Geoffroy A, Julien A, Helle D, Robert A, Umoret R, Guéant JL, Bossenmeyer-Pourié C, Daval JL

Int J Mol Sci. 2019 Oct 14;20(20):

IgE-mediated anaphylactic reaction against free synthetic folic acid and methyl folate.

Gaeta F, Romano A, Guéant-Rodriguez RM, Guéant JL

J Allergy Clin Immunol Pract. 2019 Aug 28;:

Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency.

Zgheib R, Battaglia-Hsu SF, Hergalant S, Quéré M, Alberto JM, Chéry C, Rouyer P, Gauchotte G, Guéant JL, Namour F

Cell Death Dis. 2019 Aug 8;10(8):596

Thyroid hormone and folinic acid in young children with Down syndrome: the phase 3 ACTHYF trial.

Mircher C, Sacco S, Bouis C, Gallard J, Pichot A, Le Galloudec E, Cieuta C, Marey I, Greiner-Mahler O, Dorison N, Gambarini A, Stora S, Durand S, Polak M, Baruchel A, Schlumberger E, Dewailly J, Azar-Kolakez A, Guéant-Rodriguez RM, Guéant JL, Borderie D, Bonnefont-Rousselot D, Blondiaux E, Ravel A, Sturtz FG

Genet. Med.. 2019 Jul 8;:

Efficacy of low dose nitisinone in the management of alkaptonuria.

Sloboda N, Wiedemann A, Merten M, Alqhatani A, Jeannesson E, Blum A, Henn-Ménétré S, Guéant JL, Renard E, Feillet F

Mol. Genet. Metab.. 2019 Jun 19;:

Exome sequencing of cases with neural tube defects identifies candidate genes involved in one-carbon/vitamin B12 metabolisms and Sonic Hedgehog pathway.

Renard E, Chéry C, Oussalah A, Josse T, Perrin P, Tramoy D, Voirin J, Klein O, Leheup B, Feillet F, Guéant-Rodriguez RM, Guéant JL

Hum. Genet.. 2019 May 28;:

Global Burden Related to Nitrous Oxide Exposure in Medical and Recreational Settings: A Systematic Review and Individual Patient Data Meta-Analysis.

Oussalah A, Julien M, Levy J, Hajjar O, Franczak C, Stephan C, Laugel E, Wandzel M, Filhine-Tresarrieu P, Green R, Guéant JL

J Clin Med. 2019 Apr 23;8(4):

Vitamin B-12 and liver activity and expression of methionine synthase are decreased in fetuses with neural tube defects.

Fofou-Caillierez MB, Guéant-Rodriguez RM, Alberto JM, Chéry C, Josse T, Gérard P, Forges T, Foliguet B, Feillet F, Guéant JL

Am. J. Clin. Nutr.. 2019 Mar 6;:

Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid.

Geoffroy A, Saber-Cherif L, Pourié G, Helle D, Umoret R, Guéant JL, Bossenmeyer-Pourié C, Daval JL

Int J Mol Sci. 2019 Feb 23;20(4):

N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia.

Bossenmeyer-Pourié C, Smith AD, Lehmann S, Deramecourt V, Sablonnière B, Camadro JM, Pourié G, Kerek R, Helle D, Umoret R, Guéant-Rodriguez RM, Rigau V, Gabelle A, Sequeira JM, Quadros EV, Daval JL, Guéant JL

J. Pathol.. 2019 Feb 8;:

Biallelic pathogenic variants in the lanosterol synthase gene LSS involved in the cholesterol biosynthesis cause alopecia with intellectual disability, a rare recessive neuroectodermal syndrome.

Besnard T, Sloboda N, Goldenberg A, Küry S, Cogné B, Breheret F, Trochu E, Conrad S, Vincent M, Deb W, Balguerie X, Barbarot S, Baujat G, Ben-Omran T, Bursztejn AC, Carmignac V, Datta AN, Delignières A, Faivre L, Gardie B, Guéant JL, Kuentz P, Lenglet M, Nassogne MC, Ramaekers V, Schnur RE, Si Y, Torti E, Thevenon J, Vabres P, Van Maldergem L, Wand D, Wiedemann A, Cariou B, Redon R, Lamazière A, Bézieau S, Feillet F, Isidor B

Genet. Med.. 2019 Feb 6;:

Adenosine plasma level in patients with paroxysmal or persistent atrial fibrillation and normal heart during ablation procedure and/or cardioversion.

Maille B, Marlinge M, Vairo D, Mottola G, Koutbi L, Deharo P, Gastaldi M, Gaudry M, Guiol C, Bottone S, Mace P, Gueant R, Chefrour M, Martinez E, Michelet P, Gueant JL, Boussuges A, Ruf J, Fenouillet E, Deharo JC, Guieu R, Franceschi F

Purinergic Signal.. 2018 Dec 7;:

Medical biology in the face of the evolution of health care needs.

Dreux C, Maquart FX, Bonnefont-Rousselot D, Delpech M, Gueant JL, Le Bouc Y, Massoubre B, Porquet D, Rives N, Vigneron C

Ann. Biol. Clin. (Paris). 2018 Aug 29;:

Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR.

Battaglia-Hsu SF, Ghemrawi R, Coelho D, Dreumont N, Mosca P, Hergalant S, Gauchotte G, Sequeira JM, Ndiongue M, Houlgatte R, Alberto JM, Umoret R, Robert A, Paoli J, Jung M, Quadros EV, Guéant JL

Nucleic Acids Res.. 2018 Jul 17;:

Wnt Signaling Pathways Are Dysregulated in Rat Female Cerebellum Following Early Methyl Donor Deficiency.

Willekens J, Hergalant S, Pourié G, Marin F, Alberto JM, Georges L, Paoli J, Nemos C, Daval JL, Guéant JL, Leininger-Muller B, Dreumont N

Mol. Neurobiol.. 2018 May 26;:

Production of Elastin-Derived Peptides Contribute to the Development of Non-Alcoholic Steatohepatitis.

Romier B, Ivaldi C, Sartelet H, Heinz A, Schmelzer CEH, Garnotel R, Guillot A, Jonquet J, Bertin E, Guéant JL, Alberto JM, Bronowicki JP, Amoyel J, Hocine T, Duca L, Maurice P, Bennasroune A, Martiny L, Debelle L, Durlach V, Blaise S

Diabetes. 2018 May 25;:

[Culture conditions for gametes and embryos: Which culture medium? Which impact on newborn?]

Koscinski I, Merten M, Kazdar N, Guéant JL

Gynecol Obstet Fertil Senol. 2018 May;46(5):474-480

2009-2017 report on the attractiveness of laboratory medicine among young doctors.

Cassinari K, Grunewald O, Snanoudj-Verber S, Moulis M, Rollier P, Barrand L, Porquet D, Gueant JL

Ann. Biol. Clin. (Paris). 2018 Apr 1;76(2):125-130

Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma.

Hotton J, Agopiantz M, Leroux A, Charra-Brunaud C, Marie B, Busby-Venner H, Morel O, Guéant JL, Vignaud JM, Battaglia-Hsu SF, Gauchotte G

Virchows Arch.. 2018 Apr;472(4):623-633

Plasma mSEPT9: A Novel Circulating Cell-free DNA-Based Epigenetic Biomarker to Diagnose Hepatocellular Carcinoma.

Oussalah A, Rischer S, Bensenane M, Conroy G, Filhine-Tresarrieu P, Debard R, Forest-Tramoy D, Josse T, Reinicke D, Garcia M, Luc A, Baumann C, Ayav A, Laurent V, Hollenbach M, Ripoll C, Guéant-Rodriguez RM, Namour F, Zipprich A, Fleischhacker M, Bronowicki JP, Guéant JL

EBioMedicine. 2018 Apr;30:138-147

APRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients.

Guéant JL, Chéry C, Oussalah A, Nadaf J, Coelho D, Josse T, Flayac J, Robert A, Koscinski I, Gastin I, Filhine-Tresarrieu P, Pupavac M, Brebner A, Watkins D, Pastinen T, Montpetit A, Hariri F, Tregouët D, Raby BA, Chung WK, Morange PE, Froese DS, Baumgartner MR, Benoist JF, Ficicioglu C, Marchand V, Motorin Y, Bonnemains C, Feillet F, Majewski J, Rosenblatt DS

Nat Commun. 2018 01 4;9(1):67

MTHFR 677C → T genotype modulates the effect of a 5-year supplementation with B-vitamins on homocysteine concentration: The SU.FOL.OM3 randomized controlled trial.

Fezeu LK, Ducros V, Guéant JL, Guilland JC, Andreeva VA, Hercberg S, Galan P

PLoS ONE. 2018 ;13(5):e0193352

BRIP1 coding variants are associated with a high risk of hepatocellular carcinoma occurrence in patients with HCV- or HBV-related liver disease.

Oussalah A, Avogbe PH, Guyot E, Chery C, Guéant-Rodriguez RM, Ganne-Carrié N, Cobat A, Moradpour D, Nalpas B, Negro F, Poynard T, Pol S, Bochud PY, Abel L, Jeulin H, Schvoerer E, Chabi N, Amouzou E, Sanni A, Barraud H, Rouyer P, Josse T, Goffinet L, Jouve JL, Minello A, Bonithon-Kopp C, Thiefin G, Di Martino V, Doffoël M, Richou C, Raab JJ, Hillon P, Bronowicki JP, Guéant JL,

Oncotarget. 2017 Sep;8(38):62842-62857

TREM-1 inhibition restores impaired autophagy activity and reduces colitis in mice.

Kökten T, Gibot S, Lepage P, D'Alessio S, Hablot J, Ndiaye NC, Busby-Venner H, Monot C, Garnier B, Moulin D, Jouzeau JY, Hansmannel F, Danese S, Guéant JL, Muller S, Peyrin-Biroulet L

J Crohns Colitis. 2017 Sep;:

Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.

Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL

Am. J. Clin. Nutr.. 2017 Aug;:

Compliance with the faecal calprotectin test in patients with inflammatory bowel disease.

Maréchal C, Aimone-Gastin I, Baumann C, Dirrenberger B, Guéant JL, Peyrin-Biroulet L

United European Gastroenterol J. 2017 Aug;5(5):702-707

Expression of neurotensin receptor 1 in endometrial adenocarcinoma is correlated with histological grade and clinical outcome.

Agopiantz M, Forgez P, Casse JM, Lacomme S, Charra-Brunaud C, Clerc-Urmès I, Morel O, Bonnet C, Guéant JL, Vignaud JM, Gompel A, Gauchotte G

Virchows Arch.. 2017 Aug;:

Extracellular vesicles as immune mediators in response to kidney injury.

Feigerlova E, Battaglia-Hsu SF, Hauet T, Guéant JL

Am. J. Physiol. Renal Physiol.. 2017 Aug;:ajprenal.00336.2017

Association of combined GIF290T>C heterozygous mutation/FUT2 secretor variant with neural tube defects.

Guéant-Rodriguez RM, Chery C, Fofou-Caillierez BM, Voirin J, Foliguet B, Josse T, Tramoy D, François F, Guéant JL

Clin. Genet.. 2017 Jul;:

Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity.

Li Z, Gueant-Rodriguez RM, Quilliot D, Sirveaux MA, Meyre D, Gueant JL, Brunaud L

Clin Nutr. 2017 Jul;:

Vitamin B12 deficiency.

Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, Molloy AM, Nexo E, Stabler S, Toh BH, Ueland PM, Yajnik C

Nat Rev Dis Primers. 2017 Jun;3:17040

Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia.

Gauchotte G, Hergalant S, Vigouroux C, Casse JM, Houlgatte R, Kaoma T, Helle D, Brochin L, Rech F, Peyre M, Labrousse F, Vallar L, Gueant JL, Vignaud JM, Battaglia-Hsu SF

J. Pathol.. 2017 May;:

Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC.

Bassila C, Ghemrawi R, Flayac J, Froese DS, Baumgartner MR, Guéant JL, Coelho D

Biochim. Biophys. Acta. 2017 Jan;1863(1):103-112

Cystathionine β-synthase genetic variant rs2124459 is associated with a reduced risk of cleft palate in French and Belgian populations.

Goffinet L, Oussalah A, Guéant-Rodriguez RM, Chery C, Basha M, Avogbe PH, Josse T, Jeannesson E, Rouyer P, Flayac J, Gerard P, Le Touze A, Bonin-Goga B, Goga D, Simon E, Feillet F, Vikkula M, Guéant JL

J. Med. Genet.. 2016 Dec;53(12):828-834

Relapsed diffuse large B-cell lymphoma present different genomic profiles between early and late relapses.

Broséus J, Chen G, Hergalant S, Ramstein G, Mounier N, Guéant JL, Feugier P, Gisselbrecht C, Thieblemont C, Houlgatte R

Oncotarget. 2016 Dec;7(51):83987-84002

Foetal programming by methyl donor deficiency produces steato-hepatitis in rats exposed to high fat diet.

Bison A, Marchal-Bressenot A, Li Z, Elamouri I, Feigerlova E, Peng L, Houlgatte R, Beck B, Pourié G, Alberto JM, Umoret R, Conroy G, Bronowicki JP, Guéant JL, Guéant-Rodriguez RM

Sci Rep. 2016 Nov;6:37207

Methyl donor deficiency impairs bone development via peroxisome proliferator-activated receptor-γ coactivator-1α-dependent vitamin D receptor pathway.

Feigerlova E, Demarquet L, Melhem H, Ghemrawi R, Battaglia-Hsu SF, Ewu E, Alberto JM, Helle D, Weryha G, Guéant JL

FASEB J.. 2016 Oct;30(10):3598-3612

The importance of gene-environment interactions in human obesity.

Reddon H, Guéant JL, Meyre D

Clin. Sci.. 2016 Sep;130(18):1571-97

BRIP1 coding variants are associated with a high risk of hepatocellular carcinoma occurrence in patients with HCV- or HBV-related liver disease.

Oussalah A, Avogbe PH, Guyot E, Chery C, Guéant-Rodriguez RM, Ganne-Carrié N, Cobat A, Moradpour D, Nalpas B, Negro F, Poynard T, Pol S, Bochud PY, Abel L, Jeulin H, Schvoerer E, Chabi N, Amouzou E, Sanni A, Barraud H, Rouyer P, Josse T, Goffinet L, Jouve JL, Minello A, Bonithon-Kopp C, Thiefin G, Di Martino V, Doffoël M, Richou C, Raab JJ, Hillon P, Bronowicki JP, Guéant JL, Study Group FT

Oncotarget. 2016 Aug;:

In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper.

Mayorga C, Celik G, Rouzaire P, Whitaker P, Bonadonna P, Rodrigues-Cernadas J, Vultaggio A, Brockow K, Caubet JC, Makowska J, Nakonechna A, Romano A, Montañez MI, Laguna JJ, Zanoni G, Gueant JL, Oude Elberink H, Fernandez J, Viel S, Demoly P, Torres MJ,

Allergy. 2016 Aug;71(8):1103-34

Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways.

Geoffroy A, Kerek R, Pourié G, Helle D, Guéant JL, Daval JL, Bossenmeyer-Pourié C

Mol. Neurobiol.. 2016 Aug;:

Genetic animal models to decipher the pathogenic effects of vitamin B12 and folate deficiency.

Peng L, Dreumont N, Coelho D, Guéant JL, Arnold C

Biochimie. 2016 Jul;126:43-51

NOD2 gene variant is a risk factor for postoperative complications in patients with Crohn's disease: A genetic association study.

Germain A, Guéant RM, Chamaillard M, Allen PB, Bresler L, Guéant JL, Peyrin-Biroulet L

Surgery. 2016 Jul;160(1):74-80

One carbon metabolism and bone homeostasis and remodeling: A review of experimental research and population studies.

Feigerlova E, Demarquet L, Guéant JL

Biochimie. 2016 Jul;126:115-23

One carbon metabolism, a complex metabolic network involved in pathomechanisms of inherited disorders, birth defects and age-related pathologies.

Guéant JL

Biochimie. 2016 Jul;126:1-2

Mutation Update and Review of Severe Methylenetetrahydrofolate Reductase Deficiency.

Froese DS, Huemer M, Suormala T, Burda P, Coelho D, Guéant JL, Landolt MA, Kožich V, Fowler B, Baumgartner MR

Hum. Mutat.. 2016 May;37(5):427-38

Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.

Oussalah A, Mayorga C, Blanca M, Barbaud A, Nakonechna A, Cernadas J, Gotua M, Brockow K, Caubet JC, Bircher A, Atanaskovic M, Demoly P, K Tanno L, Terreehorst I, Laguna JJ, Romano A, Guéant JL,

Allergy. 2016 Apr;71(4):443-62

Predictors of High Motivation Score for Performing Research Initiation Fellowship, Master 1, Research Master 2, and PhD Curricula During Medical Studies: A Strobe-Compliant Article.

Feigerlova E, Oussalah A, Fournier JP, Antonelli A, Hadjadj S, Marechaud R, Guéant JL, Roblot P, Braun M

Medicine (Baltimore). 2016 Feb;95(5):e2633

Genetic Predictors of Drug Hypersensitivity.

Cornejo-Garcia JA, Oussalah A, Blanca M, Gueant-Rodriguez RM, Mayorga C, Waton J, Barbaud A, Gaeta F, Romano A, Gueant JL

Curr. Pharm. Des.. 2016 ;22(45):6725-6733

Genotype-phenotype associations in French patients with phenylketonuria and importance of genotype for full assessment of tetrahydrobiopterin responsiveness.

Jeannesson-Thivisol E, Feillet F, Chéry C, Perrin P, Battaglia-Hsu SF, Herbeth B, Cano A, Barth M, Fouilhoux A, Mention K, Labarthe F, Arnoux JB, Maillot F, Lenaerts C, Dumesnil C, Wagner K, Terral D, Broué P, de Parscau L, Gay C, Kuster A, Bédu A, Besson G, Lamireau D, Odent S, Masurel A, Guéant JL, Namour F

Orphanet J Rare Dis. 2015 Dec;10:158

Diagnostic Accuracy of Procalcitonin for Predicting Blood Culture Results in Patients With Suspected Bloodstream Infection: An Observational Study of 35,343 Consecutive Patients (A STROBE-Compliant Article).

Oussalah A, Ferrand J, Filhine-Tresarrieu P, Aissa N, Aimone-Gastin I, Namour F, Garcia M, Lozniewski A, Gueant JL

Medicine (Baltimore). 2015 Nov;94(44):e1774

Folate- and vitamin B12-deficient diet during gestation and lactation alters cerebellar synapsin expression via impaired influence of estrogen nuclear receptor alpha.

Pourie G, Martin N, Bossenmeyer-Pourie C, Akchiche N, Gueant-Rodriguez RM, Geoffroy A, Jeannesson E, El Hajj Chehadeh S, Mimoun K, Brachet P, Koziel V, Alberto JM, Helle D, Debard R, Leininger B, Daval JL, Gueant JL

FASEB J. 2015 Sep;29(9):3713-25

Impact of immunosuppressive therapy on hepatitis B vaccination in inflammatory bowel diseases.

Belle A, Baumann C, Bigard MA, Zallot C, Gizard E, Gueant JL, Bronowicki JP, Peyrin-Biroulet L

Eur J Gastroenterol Hepatol. 2015 Aug;27(8):877-81

CARD8 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.

Germain A, Gueant RM, Chamaillard M, Bresler L, Gueant JL, Peyrin-Biroulet L

Dig Liver Dis. 2015 Jul 29. pii: S1590-8658(15)00419-3

IgE antibodies and skin tests in immediate hypersensitivity reactions to infliximab in inflammatory bowel disease: impact on infliximab retreatment.

Freling E, Peyrin-Biroulet L, Poreaux C, Morali A, Waton J, Schmutz JL, Gueant JL, Barbaud A

Eur J Gastroenterol Hepatol. 2015 Jul 15.

Exome-Wide Association Study Identifies New Low-Frequency and Rare UGT1A1 Coding Variants and UGT1A6 Coding Variants Influencing Serum Bilirubin in Elderly Subjects: A Strobe Compliant Article.

Oussalah A, Bosco P, Anello G, Spada R, Gueant-Rodriguez RM, Chery C, Rouyer P, Josse T, Romano A, Elia M, Bronowicki JP, Gueant JL

Medicine (Baltimore). 2015 Jun;94(22):e925

Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma.

Vigouroux C, Casse JM, Battaglia-Hsu SF, Brochin L, Luc A, Paris C, Lacomme S, Gueant JL, Vignaud JM, Gauchotte G

Lung Cancer. 2015 May 16. pii: S0169-5002(15)00244-5

A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics.

Cornejo-Garcia JA, Romano A, Gueant-Rodriguez RM, Oussalah A, Blanca-Lopez N, Gaeta F, Tramoy D, Josse T, Dona I, Torres MJ, Canto G, Blanca M, Gueant JL

Pharmacogenomics J. 2015 Apr 14

Identification of master genes involved in liver key functions through transcriptomics and epigenomics of methyl donor deficiency in rat: relevance to nonalcoholic liver disease.

Chen G, Broseus J, Hergalant S, Donnart A, Chevalier C, Bolanos-Jimenez F, Gueant JL, Houlgatte R

Mol Nutr Food Res. 2015 Feb;59(2):293-302

Information-seeking behavior during residency is associated with quality of theoretical learning, academic career achievements, and evidence-based medical practice: a strobe-compliant article.

Oussalah A, Fournier JP, Gueant JL, Braun M

Medicine (Baltimore). 2015 Feb;94(6):e535

HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping.

Gueant JL, Romano A, Cornejo-Garcia JA, Oussalah A, Chery C, Blanca-Lopez N, Gueant-Rodriguez RM, Gaeta F, Rouyer P, Josse T, Canto G, Carmona FD, Bossini-Castillo L, Martin J, Laguna JJ, Fernandez J, Feo F, Ostrov DA, Plasencia PC, Mayorga C, Torres MJ, Blanca M

J Allergy Clin Immunol. 2015 Jan;135(1):253-9

Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress.

Melhem H, Hansmannel F, Bressenot A, Battaglia-Hsu SF, Billioud V, Alberto JM, Gueant JL, Peyrin-Biroulet L

Gut. 2015 Jan 20. pii: gutjnl-2014-307030

WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation.

Mignot C, Lambert L, Pasquier L, Bienvenu T, Delahaye-Duriez A, Keren B, Lefranc J, Saunier A, Allou L, Roth V, Valduga M, Moustaine A, Auvin S, Barrey C, Chantot-Bastaraud S, Lebrun N, Moutard ML, Nougues MC, Vermersch AI, Heron B, Pipiras E, Heron D, Olivier-Faivre L, Gueant JL, Jonveaux P, Philippe C

J Med Genet. 2015 Jan;52(1):61-70

Early methyl donor deficiency alters cAMP signaling pathway and neurosteroidogenesis in the cerebellum of female rat pups.

El Hajj Chehadeh S, Dreumont N, Willekens J, Canabady-Rochelle L, Jeannesson E, Alberto JM, Daval JL, Gueant JL, Leininger-Muller B

Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E1009-19

Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart.

Gueant JL, Elakoum R, Ziegler O, Coelho D, Feigerlova E, Daval JL, Gueant-Rodriguez RM

Pflugers Arch. 2014 May;466(5):833-50

Comparison of cytokine gene polymorphism in drug-induced maculopapular eruption, urticaria and drug reaction with eosinophilia and systemic symptoms (DRESS).

Barbaud A, Waton J, Herbeth B, Bursztejn AC, Bollaert M, Schmutz JL, Gueant-Rodriguez RM, Namour F, Gueant JL, Aimone-Gastin I

J Eur Acad Dermatol Venereol. 2014 Apr;28(4):491-9

Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis.

Rondon C, Campo P, Zambonino MA, Blanca-Lopez N, Torres MJ, Melendez L, Herrera R, Gueant-Rodriguez RM, Gueant JL, Canto G, Blanca M

J Allergy Clin Immunol. 2014 Apr;133(4):1026-31

IgE to penicillins with different specificities can be identified by a multiepitope macromolecule: Bihaptenic penicillin structures and IgE specificities.

Ariza A, Barrionuevo E, Mayorga C, Montanez MI, Perez-Inestrosa E, Ruiz-Sanchez A, Rodriguez-Gueant RM, Fernandez TD, Gueant JL, Torres MJ, Blanca M

J Immunol Methods. 2014 Apr;406:43-50

Gestational methyl donor deficiency alters key proteins involved in neurosteroidogenesis in the olfactory bulbs of newborn female rats and is associated with impaired olfactory performance.

El Hajj Chehadeh S, Pourie G, Martin N, Alberto JM, Daval JL, Gueant JL, Leininger-Muller B

Br J Nutr. 2014 Mar 28;111(6):1021-31

CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features.

Elakoum R, Gauchotte G, Oussalah A, Wissler MP, Clement-Duchene C, Vignaud JM, Gueant JL, Namour F

Biochimie. 2014 Feb;97:210-8

Contributions of pharmacogenetics and transcriptomics to the understanding of the hypersensitivity drug reactions.

Fernandez TD, Mayorga C, Gueant JL, Blanca M, Cornejo-Garcia JA

Allergy. 2014 Feb;69(2):150-8

Variants of CEP68 gene are associated with acute urticaria/angioedema induced by multiple non-steroidal anti-inflammatory drugs.

Cornejo-Garcia JA, Flores C, Plaza-Seron MC, Acosta-Herrera M, Blanca-Lopez N, Dona I, Torres MJ, Mayorga C, Gueant-Rodriguez RM, Ayuso P, Fernandez J, Laguna JJ, Agundez JA, Garcia-Martin E, Gueant JL, Canto G, Blanca M

PLoS One. 2014 Mar 11;9(3):e90966

Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.

Cornejo-Garcia JA, Liou LB, Blanca-Lopez N, Dona I, Chen CH, Chou YC, Chuang HP, Wu JY, Chen YT, Plaza-Seron Mdel C, Mayorga C, Gueant-Rodriguez RM, Lin SC, Torres MJ, Campo P, Rondon C, Laguna JJ, Fernandez J, Gueant JL, Canto G, Blanca M, Lee MT

Pharmacogenomics. 2013 Nov;14(15):1857-69

Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia.

Fofou-Caillierez MB, Mrabet NT, Chery C, Dreumont N, Flayac J, Pupavac M, Paoli J, Alberto JM, Coelho D, Camadro JM, Feillet F, Watkins D, Fowler B, Rosenblatt DS, Gueant JL

Hum Mol Genet. 2013 Nov 15;22(22):4591-601

Advanced phenotyping in hypersensitivity drug reactions to NSAIDs.

Ayuso P, Blanca-Lopez N, Dona I, Torres MJ, Gueant-Rodriguez RM, Canto G, Sanak M, Mayorga C, Gueant JL, Blanca M, Cornejo-Garcia JA

Clin Exp Allergy. 2013 Oct;43(10):1097-109

Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms.

Bursztejn AC, Romano A, Gueant-Rodriguez RM, Cornejo JA, Oussalah A, Chery C, Gastin I, Gaeta F, Barbaud A, Blanca M, Gueant JL

Allergy. 2013 Aug;68(8):1076-80

Homocysteine predicts increased NT-pro-BNP through impaired fatty acid oxidation.

Gueant Rodriguez RM, Spada R, Pooya S, Jeannesson E, Moreno Garcia MA, Anello G, Bosco P, Elia M, Romano A, Alberto JM, Juilliere Y, Gueant JL

Int J Cardiol. 2013 Aug 10;167(3):768-75

Mediator release after nasal aspirin provocation supports different phenotypes in subjects with hypersensitivity reactions to NSAIDs.

Campo P, Ayuso P, Salas M, Plaza MC, Cornejo-Garcia JA, Dona I, Torres MJ, Blanca-Lopez N, Canto G, Gueant JL, Sanak M, Blanca M

Allergy. 2013 Aug;68(8):1001-7

Microscopic features for initial diagnosis and disease activity evaluation in inflammatory bowel disease.

Bressenot A, Geboes K, Vignaud JM, Gueant JL, Peyrin-Biroulet L

Inflamm Bowel Dis. 2013 Jul;19(8):1745-52

Myocardium proteome remodelling after nutritional deprivation of methyl donors.

Martinez E, Gerard N, Garcia MM, Mazur A, Gueant-Rodriguez RM, Comte B, Gueant JL, Brachet P

J Nutr Biochem. 2013 Jul;24(7):1241-50

Submucosal plexitis as a predictor of postoperative surgical recurrence in Crohn's disease.

Bressenot A, Chevaux JB, Williet N, Oussalah A, Germain A, Gauchotte G, Wissler MP, Vignaud JM, Bresler L, Bigard MA, Plenat F, Gueant JL, Peyrin-Biroulet L

Inflamm Bowel Dis. 2013 Jul;19(8):1654-61

Early methyl donor deficiency produces severe gastritis in mothers and offspring through N-homocysteinylation of cytoskeleton proteins, cellular stress, and inflammation.

Bossenmeyer-Pourie C, Pourie G, Koziel V, Helle D, Jeannesson E, Gueant JL, Beck B

FASEB J. 2013 Jun;27(6):2185-97

Folate and fetal programming: a play in epigenomics?

Gueant JL, Namour F, Gueant-Rodriguez RM, Daval JL

Trends Endocrinol Metab. 2013 Jun;24(6):279-89

Genetic predictors of inflammation in the risk of occupational asthma in young apprentices.

Acouetey DS, Zmirou-Navier D, Avogbe P, Tossa P, Remen T, Barbaud A, Cornejo-Garcia JA, Blanca M, Bohadana A, Paris C, Gueant JL, Gueant-Rodriguez RM

Ann Allergy Asthma Immunol. 2013 Jun;110(6):423-428.e5

Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.

Chery C, Hehn A, Mrabet N, Oussalah A, Jeannesson E, Besseau C, Alberto JM, Gross I, Josse T, Gerard P, Gueant-Rodriguez RM, Freund JN, Devignes J, Bourgaud F, Peyrin-Biroulet L, Feillet F, Gueant JL

Biochimie. 2013 May;95(5):995-1001

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase.

Gueant JL, Caillerez-Fofou M, Battaglia-Hsu S, Alberto JM, Freund JN, Dulluc I, Adjalla C, Maury F, Merle C, Nicolas JP, Namour F, Daval JL

Biochimie. 2013 May;95(5):1033-40

Vitamin B12, a fascinating micronutrient, which influences human health in the very early and later stages of life.

Gueant JL, Alpers DH

Biochimie. 2013 May;95(5):967-9

Ocular symptoms are not predictive of ophthalmologic inflammation in inflammatory bowel disease.

Cloche V, Buisson A, Trechot F, Batta B, Locatelli A, Favel C, Premy S, Collet-Fenetrier B, Freling E, Lopez A, Massoure MP, Humbert AL, Hansmannel F, Gueant JL, Bigard MA, Peyrin-Biroulet L, Angioi K

Dig Liver Dis. 2013 Mar;45(3):195-9

Methyl donor deficiency affects small-intestinal differentiation and barrier function in rats.

Bressenot A, Pooya S, Bossenmeyer-Pourie C, Gauchotte G, Germain A, Chevaux JB, Coste F, Vignaud JM, Gueant JL, Peyrin-Biroulet L

Br J Nutr. 2013 Feb 28;109(4):667-77

Phospholipase D activation mediates cobalamin-induced downregulation of Multidrug Resistance-1 gene and increase in sensitivity to vinblastine in HepG2 cells.

Marguerite V, Gkikopoulou E, Alberto JM, Gueant JL, Merten M

Int J Biochem Cell Biol. 2013 Feb;45(2):213-20

Biological determinants of postural disorders in elderly women.

Lion A, Spada RS, Bosser G, Gauchard GC, Anello G, Bosco P, Calabrese S, Iero A, Stella G, Elia M, Perrin PP

Int J Neurosci. 2013 Jan;123(1):24-30

Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1.

Ghemrawi R, Pooya S, Lorentz S, Gauchotte G, Arnold C, Gueant JL, Battaglia-Hsu SF

Cell Death Dis. 2013 Mar 21;4:e553

Dietary beliefs and behavior among inflammatory bowel disease patients.

Zallot C, Quilliot D, Chevaux JB, Peyrin-Biroulet C, Gueant-Rodriguez RM, Freling E, Collet-Fenetrier B, Williet N, Ziegler O, Bigard MA, Gueant JL, Peyrin-Biroulet L

Inflamm Bowel Dis. 2013 Jan;19(1):66-72

Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124.

Kerek R, Geoffroy A, Bison A, Martin N, Akchiche N, Pourie G, Helle D, Gueant JL, Bossenmeyer-Pourie C, Daval JL

Cell Death Dis. 2013 Aug 8;4:e755

Colorectal cancer in inflammatory bowel diseases: a population-based study (1976-2008).

Peyrin-Biroulet L, Lepage C, Jooste V, Gueant JL, Faivre J, Bouvier AM

Inflamm Bowel Dis. 2012 Dec;18(12):2247-51

Genetic variants of the arachidonic acid pathway in non-steroidal anti-inflammatory drug-induced acute urticaria.

Cornejo-Garcia JA, Jagemann LR, Blanca-Lopez N, Dona I, Flores C, Gueant-Rodriguez RM, Torres MJ, Fernandez J, Laguna JJ, Rosado A, Agundez JA, Garcia-Martin E, Canto G, Gueant JL, Blanca M

Clin Exp Allergy. 2012 Dec;42(12):1772-81

[Folates and fetal programming: role of epigenetics and epigenomics].

Gueant JL, Daval JL, Vert P, Nicolas JP

Bull Acad Natl Med. 2012 Dec;196(9):1829-42.

Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells.

Akchiche N, Bossenmeyer-Pourie C, Kerek R, Martin N, Pourie G, Koziel V, Helle D, Alberto JM, Ortiou S, Camadro JM, Leger T, Gueant JL, Daval JL

FASEB J. 2012 Oct;26(10):3980-92

Incidence of and impact of medications on colectomy in newly diagnosed ulcerative colitis in the era of biologics.

Williet N, Pillot C, Oussalah A, Billioud V, Chevaux JB, Bresler L, Bigard MA, Gueant JL, Peyrin-Biroulet L

Inflamm Bowel Dis. 2012 Sep;18(9):1641-6

Increased homocysteinemia is associated with beneficial effects on body weight after long-term high-protein, low-fat diet in rats.

Beck B, Bossenmeyer-Pourie C, Jeannesson E, Richy S, Gueant JL

Nutrition. 2012 Sep;28(9):932-6

Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver.

Pooya S, Blaise S, Moreno Garcia M, Giudicelli J, Alberto JM, Guéant-Rodriguez RM, Jeannesson E, Gueguen N, Bressenot A, Nicolas B, Malthiery Y, Daval JL, Peyrin-Biroulet L, Bronowicki JP, Guéant JL

J. Hepatol.. 2012 Aug;57(2):344-51

Fumonisin FB1 treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3- and H4-histone methylation patterns in fetuses.

Pellanda H, Forges T, Bressenot A, Chango A, Bronowicki JP, Gueant JL, Namour F

Mol Nutr Food Res. 2012 Jun;56(6):976-85

Methotrexate for psoriasiform lesions associated with anti-tumour necrosis factor therapy in inflammatory bowel disease.

Buisson A, Cuny JF, Barbaud A, Schmutz JL, Bigard MA, Gueant JL, Peyrin-Biroulet L

Aliment Pharmacol Ther. 2012 May;35(10):1175-80

Urinary tract infections in hospitalized inflammatory bowel disease patients: a 10-year experience.

Peyrin-Biroulet L, Pillot C, Oussalah A, Billioud V, Aissa N, Balde M, Williet N, Germain A, Lozniewski A, Bresler L, Gueant JL, Bigard MA

Inflamm Bowel Dis. 2012 Apr;18(4):697-702

A splicing variant leads to complete loss of function of betaine-homocysteine methyltransferase (BHMT) gene in hepatocellular carcinoma.

Pellanda H, Namour F, Fofou-Caillierez M, Bressenot A, Alberto JM, Chery C, Ayav A, Bronowicki JP, Gueant JL, Forges T

Int J Biochem Cell Biol. 2012 Feb;44(2):385-92

Genetic diversity and genotype multiplicity of Plasmodium falciparum infections in symptomatic individuals in the maritime region of Togo.

Awaga KL, Missihoun TD, Karou SD, Djadou KE, Chabi NW, Akati A, Lawson-Hukportie A, Amevo K, Djegno K, Gueant JL, Sanni A, Amouzou SK

Trop Med Int Health. 2012 Feb;17(2):153-60

Helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (FUT2 461 G->A) and vitamin B-12 in Europe and West Africa.

Oussalah A, Besseau C, Chery C, Jeannesson E, Gueant-Rodriguez RM, Anello G, Bosco P, Elia M, Romano A, Bronowicki JP, Gerard P, Paoli J, Avogbe PH, Chabi N, Sanni A, Amouzou E, Peyrin-Biroulet L, Gueant JL

Am J Clin Nutr. 2012 Feb;95(2):514-21

Non-injurious neonatal hypoxia confers resistance to brain senescence in aged male rats.

Martin N, Bossenmeyer-Pourie C, Koziel V, Jazi R, Audonnet S, Vert P, Gueant JL, Daval JL, Pourie G

PLoS One. 2012;7(11):e48828

Luminal expression of cubilin is impaired in Imerslund-Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7.

Namour F, Dobrovoljski G, Chery C, Audonnet S, Feillet F, Sperl W, Gueant JL

Haematologica. 2011 Nov;96(11):1715-9

Meta-analysis: hyperhomocysteinaemia in inflammatory bowel diseases.

Oussalah A, Gueant JL, Peyrin-Biroulet L

Aliment Pharmacol Ther. 2011 Nov;34(10):1173-84

Methyl deficient diet aggravates experimental colitis in rats.

Chen M, Peyrin-Biroulet L, George A, Coste F, Bressenot A, Bossenmeyer-Pourie C, Alberto JM, Xia B, Namour B, Gueant JL

J Cell Mol Med. 2011 Nov;15(11):2486-97

Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1alpha by PRMT1 and SIRT1.

Garcia MM, Gueant-Rodriguez RM, Pooya S, Brachet P, Alberto JM, Jeannesson E, Maskali F, Gueguen N, Marie PY, Lacolley P, Herrmann M, Juilliere Y, Malthiery Y, Gueant JL

J Pathol. 2011 Nov;225(3):324-35

Association of IL1B polymorphism with left ventricular systolic dysfunction: a relation with the release of interleukin-1beta in stress condition.

Gueant-Rodriguez RM, Juilliere Y, Battaglia-Hsu SF, Debard R, Gerard P, Reyes P, Danchin N, Gueant JL

Pharmacogenet Genomics. 2011 Sep;21(9):579-86.

Using logic programming for modeling the one-carbon metabolism network to study the impact of folate deficiency on methylation processes.

Gnimpieba EZ, Eveillard D, Gueant JL, Chango A

Mol Biosyst. 2011 Aug;7(8):2508-21

Recognition of iodixanol by dendritic cells increases the cellular response in delayed allergic reactions to contrast media.

Antunez C, Barbaud A, Gomez E, Audonnet S, Lopez S, Gueant-Rodriguez RM, Aimone-Gastin I, Gomez F, Blanca M, Gueant JL

Clin Exp Allergy. 2011 May;41(5):657-64

Carotenoid deficiency in chronic pancreatitis: the effect of an increase in tomato consumption.

Quilliot D, Forbes A, Dubois F, Gueant JL, Ziegler O

Eur J Clin Nutr. 2011 Feb;65(2):262-8

Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an ambulatory elderly population.

Gueant-Rodriguez RM, Spada R, Moreno-Garcia M, Anello G, Bosco P, Lagrost L, Romano A, Elia M, Gueant JL

Atherosclerosis. 2011 Feb;214(2):480-5

Evaluation of a new routine diagnostic test for immunoglobulin e sensitization to neuromuscular blocking agents.

Laroche D, Chollet-Martin S, Leturgie P, Malzac L, Vergnaud MC, Neukirch C, Venemalm L, Gueant JL, Roland PN

Anesthesiology. 2011 Jan;114(1):91-7.

Ovarian tissue cryopreservation and subsequent spontaneous pregnancies in a patient with classic galactosemia.

Forges T, Monnier P, Leheup B, Cheillan D, Brivet M, Barbarino A, Gueant JL, Feillet F

Fertil Steril. 2011 Jan;95(1):290.e1-3.

Additional benefit of procalcitonin to C-reactive protein to assess disease activity and severity in Crohn's disease.

Oussalah A, Laurent V, Bruot O, Gueant JL, Regent D, Bigard MA, Peyrin-Biroulet L

Aliment Pharmacol Ther. 2010 Nov;32(9):1135-44

Differentiation and neural integration of hippocampal neuronal progenitors: signaling pathways sequentially involved.

Akchiche N, Bossenmeyer-Pourie C, Pourie G, Koziel V, Nedelec E, Gueant JL, Daval JL

Hippocampus. 2010 Aug;20(8):949-61.

Life-threatening methylenetetrahydrofolate reductase (MTHFR) deficiency with extremely early onset: characterization of two novel mutations in compound heterozygous patients.

Forges T, Chery C, Audonnet S, Feillet F, Gueant JL

Mol Genet Metab. 2010 Jun;100(2):143-8

Prevalence of hepatitis B and C and risk factors for nonvaccination in inflammatory bowel disease patients in Northeast France.

Chevaux JB, Nani A, Oussalah A, Venard V, Bensenane M, Belle A, Gueant JL, Bigard MA, Bronowicki JP, Peyrin-Biroulet L

Inflamm Bowel Dis. 2010 Jun;16(6):916-24.

Controversy: Sensitization against quaternary ammonium compounds is involved in allergic reactions to neuromuscular blocking agents

Mertes PM, Regnier MA, Hasdenteufel F, Gueant-Rodriguez RM, Mouton-Faivre C, Malinovsky JM, Gueant JL, Kanny G

Rev Fr Allergol. 2010 Apr;50(3):174-8

Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study.

Remen T, Coevoet V, Acouetey DS, Gueant JL, Gueant-Rodriguez RM, Paris C, Zmirou-Navier D

BMC Public Health. 2010 Apr 26;10:206.

Methyl donor deficiency affects fetal programming of gastric ghrelin cell organization and function in the rat.

Bossenmeyer-Pourie C, Blaise S, Pourie G, Tomasetto C, Audonnet S, Ortiou S, Koziel V, Rio MC, Daval JL, Gueant JL, Beck B

Am J Pathol. 2010 Jan;176(1):270-7

Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE.

Battaglia-Hsu SF, Akchiche N, Noel N, Alberto JM, Jeannesson E, Orozco-Barrios CE, Martinez-Fong D, Daval JL, Gueant JL

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21930-5

What investigations should be undertaken when faced with worsening perioperative anaphylaxis?

Mertes PM, Lambert M, Regnier MA, Gueant-Rodriguez RM, Aimone-Gastin I, Mouton-Faivre C, Moneret-Vautrin DA, Malinovsky JM, Gueant JL, Demoly P

Rev Fr Allergol. 2009 Sep;49(5):437-42

Perioperative Anaphylaxis

Mertes PM, Lambert M, Gueant-Rodriguez RM, Aimone-Gastin I, Mouton-Faivre C, Moneret-Vautrin DA, Gueant JL, Malinovsky JM, Demoly P

Immunol Allergy Clin North Am. 2009 Aug;29(3):429-51.

Prevalence of dementia in mountainous village of Sicily.

Spada RS, Stella G, Calabrese S, Bosco P, Anello G, Gueant-Rodriguez RM, Romano A, Benamghar L, Gueant JL

J Neurol Sci. 2009 Aug 15;283(1-2):62-5

Head-up tilt induced syncope and adenosine A2A receptor gene polymorphism.

Saadjian AY, Gerolami V, Giorgi R, Mercier L, Berge-Lefranc JL, Paganelli F, Ibrahim Z, By Y, Gueant JL, Levy S, Guieu RP

Eur Heart J. 2009 Jun;30(12):1510-5

Time course gene expression in the one-carbon metabolism network using HepG2 cell line grown in folate-deficient medium.

Chango A, Nour AA, Bousserouel S, Eveillard D, Anton PM, Gueant JL

J Nutr Biochem. 2009 Apr;20(4):312-20

Short hypoxia could attenuate the adverse effects of hyperhomocysteinemia on the developing rat brain by inducing neurogenesis.

Blaise SA, Nedelec E, Alberto JM, Schroeder H, Audonnet S, Bossenmeyer-Pourie C, Gueant JL, Daval JL

Exp Neurol. 2009 Mar;216(1):231-8

Gene variants of IL13, IL4, and IL4RA are predictors of beta-lactam allergy.

Gueant JL, Gueant-Rodriguez RM, Cornejo-Garcia JA, Viola M, Blanca M, Romano A

J Allergy Clin Immunol. 2009 Feb;123(2):509; author reply 509-10

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project.

Bousquet PJ, Demoly P, Romano A, Aberer W, Bircher A, Blanca M, Brockow K, Pichler W, Torres MJ, Terreehorst I, Arnoux B, Atanaskovic-Markovic M, Barbaud A, Bijl A, Bonadonna P, Burney PG, Caimmi S, Canonica GW, Cernadas J, Dahlen B, Daures JP, Fernandez J, Gomes E, Gueant JL, Kowalski ML, Kvedariene V, Mertes PM, Martins P, Nizankowska-Mogilnicka E, Papadopoulos N, Ponvert C, Pirmohamed M, Ring J, Salapatas M, Sanz ML, Szczeklik A, Van Ganse E, De Weck AL, Zuberbier T, Merk HF, Sachs B, Sidoroff A

Allergy. 2009 Feb;64(2):194-203.

Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin.

Pons L, Battaglia-Hsu SF, Orozco-Barrios CE, Ortiou S, Chery C, Alberto JM, Arango-Rodriguez ML, Dumas D, Martinez-Fong D, Freund JN, Gueant JL

PLoS One. 2009 Jul 22;4(7):e6325.

Vitamin B deficiency causes neural cell loss and cognitive impairment in the developing rat.

Daval JL, Blaise S, Gueant JL

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):E1; author reply E2

Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra.

Orozco-Barrios CE, Battaglia-Hsu SF, Arango-Rodriguez ML, Ayala-Davila J, Chery C, Alberto JM, Schroeder H, Daval JL, Martinez-Fong D, Gueant JL

PLoS One. 2009 Dec 21;4(12):e8268.

Acute decompensation of isovaleric acidemia induced by Graves' disease.

Kimmoun A, Abboud G, Strazeck J, Merten M, Gueant JL, Feillet F

Intensive Care Med. 2008 Dec;34(12):2315-6

Interaction of ribavirin with azathioprine metabolism potentially induces myelosuppression.

Peyrin-Biroulet L, Cadranel JF, Nousbaum JB, Oussalah A, Seddik M, Canva V, Cortot A, Sogni P, Gueant JL, Bigard MA, Roblin X, Bronowicki JP

Aliment Pharmacol Ther. 2008 Oct 15;28(8):984-93

[Do folates have an impact on fertility?]

Forges T, Pellanda H, Diligent C, Monnier P, Gueant JL

Gynecol Obstet Fertil. 2008 Sep;36(9):930-9

Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors.

Lu X, Freund JN, Muller M, Ravey J, Nicolas JP, Gueant JL, Namour F

Biochimie. 2008 May;90(5):697-704

Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study.

Candito M, Rivet R, Herbeth B, Boisson C, Rudigoz RC, Luton D, Journel H, Oury JF, Roux F, Saura R, Vernhet I, Gaucherand P, Muller F, Guidicelli B, Heckenroth H, Poulain P, Blayau M, Francannet C, Roszyk L, Brustie C, Staccini P, Gerard P, Fillion-Emery N, Gueant-Rodriguez RM, Van Obberghen E, Gueant JL

Am J Med Genet A. 2008 May 1;146A(9):1128-33.

Association of tumor necrosis factor-alpha -308G>A polymorphism with IgE-mediated allergy to betalactams in an Italian population.

Gueant-Rodriguez RM, Gueant JL, Viola M, Tramoy D, Gaeta F, Romano A

Pharmacogenomics J. 2008 Apr;8(2):162-8

Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa

Bronowicki JP, Abdelmouttalebl D, Peyrin-Biroulet L, Venard V, Khiri H, Chabi N, Amouzou EK, Barraud H, Halfon P, Sanni A, Bigard MA, Le Faou A, Gueant JL

J Hepatol. 2008 Apr;48(4):532-9

Evidence of cataplerosis in a patient with neonatal classical galactosemia presenting as citrin deficiency.

Feillet F, Merten M, Battaglia-Hsu SF, Rabier D, Kobayashi K, Straczek J, Brivet M, Favre E, Gueant JL

J Hepatol. 2008 Mar;48(3):517-22

Association of MTRR 66A>G polymorphism with superoxide dismutase and disease activity in patients with Crohn's disease.

Peyrin-Biroulet L, Guéant-Rodriguez RM, Chen M, Bronowicki JP, Bigard MA, Guéant JL

Am. J. Gastroenterol.. 2008 Feb;103(2):399-406

Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice.

Lalonde R, Barraud H, Ravey J, Gueant JL, Bronowicki JP, Strazielle C

Brain Res. 2008 Jan 10;1188:122-31

Hypersensitivity reactions to neuromuscular blocking agents.

Mertes PM, Aimone-Gastin I, Gueant-Rodriguez RM, Mouton-Faivre C, Audibert G, O'Brien J, Frendt D, Brezeanu M, Bouaziz H, Gueant JL

Curr Pharm Des. 2008;14(27):2809-25.

Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China.

Chen M, Peyrin-Biroulet L, Xia B, Gueant-Rodriguez RM, Bronowicki JP, Bigard MA, Gueant JL

BMC Med Genet. 2008 Aug 13;9:78.

Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity.

Gueant JL, Gueant-Rodriguez RM, Gastin IA, Cornejo-Garcia JA, Viola M, Barbaud A, Mertes PM, Blanca M, Romano A

Curr Pharm Des. 2008;14(27):2770-7.

Influence of preconditioning-like hypoxia on the liver of developing methyl-deficient rats.

Blaise SA, Alberto JM, Audonnet-Blaise S, Gueant JL, Daval JL

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1492-502

Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency.

Abdel Nour AM, Ringot D, Gueant JL, Chango A

Carcinogenesis. 2007 Nov;28(11):2291-7

Does hyperhomocysteinaemia contribute to gastric carcinogenesis in Helicobacter pylori infected patients?

Peyrin-Biroulet L, Gueant JL

Gut. 2007 Oct;56(10):1480; author reply 1480-1.

Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway.

Alberto JM, Hamelet J, Noll C, Blaise S, Bronowicki JP, Gueant JL, Delabar JM, Janel N

Mol Genet Metab. 2007 Aug;91(4):396-8

Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).

Gueant JL, Chabi NW, Gueant-Rodriguez RM, Mutchinick OM, Debard R, Payet C, Lu X, Villaume C, Bronowicki JP, Quadros EV, Sanni A, Amouzou E, Xia B, Chen M, Anello G, Bosco P, Romano C, Arrieta HR, Sanchez BE, Romano A, Herbeth B, Anwar W, Namour F

J Med Genet. 2007 Jun;44(6):363-7

Left ventricular systolic dysfunction is an independent predictor of homocysteine in angiographically documented patients with or without coronary artery lesions.

Gueant-Rodriguez RM, Juilliere Y, Nippert M, Abdelmouttaleb I, Herbeth B, Aliot E, Danchin N, Gueant JL

J Thromb Haemost. 2007 Jun;5(6):1209-16.

Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine.

Peyrin-Biroulet L, Rodriguez-Gueant RM, Chamaillard M, Desreumaux P, Xia B, Bronowicki JP, Bigard MA, Gueant JL

Am J Gastroenterol. 2007 May;102(5):1108-15

Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats.

Blaise SA, Nedelec E, Schroeder H, Alberto JM, Bossenmeyer-Pourie C, Gueant JL, Daval JL

Am J Pathol. 2007 Feb;170(2):667-79.

Association of thyroid dysfunction with vitamin B12, folate and plasma homocysteine levels in the elderly: a population-based study in Sicily.

Stella G, Spada RS, Calabrese S, Bosco P, Anello G, Gueant-Rodriguez RM, Romano A, Benamghar L, Proto C, Castellano A, Fajardo A, Lipari L, Sirna S, Gueant JL

Clin Chem Lab Med. 2007;45(2):143-7.

Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily.

Spada RS, Stella G, Calabrese S, Bosco P, Anello G, Gueant-Rodriguez RM, Romano A, Benamghar L, Fontaine T, Gueant JL

Clin Chem Lab Med. 2007;45(2):136-42.

Associations between folate, vitamin B12, homocysteine and pathologies related to aging: the need to consider complex nutrient-nutrient and gene-nutrient interactions and the functional and socio-economic determinants in population-based studies.

Gueant JL, Elia M, Romano A

Clin Chem Lab Med. 2007;45(2):127-9.

Cobalamin potentiates vinblastine cytotoxicity through Downregulation of mdr-1 gene expression in HepG2 cells

Marguerite V, Beri-Dexheimer M, Ortiou S, Gueant JL, Merten M

Cell Physiol Biochem. 2007;20(6):967-76.

Coffee and diabetes: is homocysteine the missing link?

Peyrin-Biroulet L, Gueant JL, Roblin X

Arch Intern Med. 2007 Jan 22;167(2):204; author reply 205.

Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.

Candito M, Naimi M, Boisson C, Rudigoz JC, Gaucherand P, Gueant JL, Luton D, Van Obberghen E

Birth Defects Res A Clin Mol Teratol. 2007 Jan;79(1):62-4.

[Epigenetic changes and liver carcinogenesis].

Peyrin-Biroulet L, Barraud H, Darfeuil F, Lefebvre M, Bigard MA, Gueant JL, Bronowicki JP

Gastroenterol Clin Biol. 2006 Dec;30(12):1354-9.

Gene-gene interactions of IL13 and IL4RA variants in immediate allergic reactions to betalactam antibiotics.

Gueant-Rodriguez RM, Romano A, Beri-Dexheimer M, Viola M, Gaeta F, Gueant JL

Pharmacogenet Genomics. 2006 Oct;16(10):713-9.

Quantitative methylation-sensitive arbitrarily primed PCR method to determine differential genomic DNA methylation in Down Syndrome.

Chango A, Abdennebi-Najar L, Tessier F, Ferre S, Do S, Gueant JL, Nicolas JP, Willequet F

Biochem Biophys Res Commun. 2006 Oct 20;349(2):492-6

Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily.

Bosco P, Gueant-Rodriguez RM, Anello G, Spada R, Romano A, Fajardo A, Caraci F, Ferri R, Gueant JL

Thromb Haemost. 2006 Aug;96(2):154-9.

Lack of association between microsatellite instability and benign adrenal tumors.

Namour F, Ayav A, Lu X, Klein M, Muresan M, Bresler L, Tramoy D, Gueant JL, Brunaud L

World J Surg. 2006 Jul;30(7):1240-6.

Mild, non-lesioning transient hypoxia in the newborn rat induces delayed brain neurogenesis associated with improved memory scores.

Pourie G, Blaise S, Trabalon M, Nedelec E, Gueant JL, Daval JL

Neuroscience. 2006 Jul 21;140(4):1369-79

Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida.

Rat E, Billaut-Laden I, Allorge D, Lo-Guidice JM, Tellier M, Cauffiez C, Jonckheere N, van Seuningen I, Lhermitte M, Romano A, Gueant JL, Broly F

Birth Defects Res A Clin Mol Teratol. 2006 Jun;76(6):491-8.

Imipenem in patients with immediate hypersensitivity to penicillins.

Romano A, Viola M, Gueant-Rodriguez RM, Gaeta F, Pettinato R, Gueant JL

N Engl J Med. 2006 Jun 29;354(26):2835-7.

Antiepileptic drugs: a case report in a pregnancy with a neural tube defect.

Candito M, Gueant JL, Naimi M, Bongain A, Van Obberghen E

Pediatr Neurol. 2006 Apr;34(4):323-4.

Heterogeneity of association between MTHFR and stroke among European regions: additional population studies are needed in Italy.

Bosco P, Anello G, Ferri R, Gueant-Rodriguez RM, Gueant JL

Stroke. 2006 Mar;37(3):761; author reply 761-2.

Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations.

Gueant-Rodriguez RM, Gueant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, Namour F, Chabi NW, Sanni A, Anello G, Bosco P, Romano C, Amouzou E, Arrieta HR, Sanchez BE, Romano A, Herbeth B, Guilland JC, Mutchinick OM

Am J Clin Nutr. 2006 Mar;83(3):701-7.