IFNγ-associated immune-metabolic remodeling is linked to serotonin-kynurenine imbalance and cortical vulnerability in lupus-prone mice.

Fiche publication

Date publication

mars 2026

Journal

Frontiers in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis , Dr DARCQ Emmanuel

Tous les auteurs :
Matmat K, Guéant-Rodriguez RM, Darcq E, Baspinar O, Alberto JM, Guéant JL, Mensah-Nyagan AG, Jeltsch-David H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41869319

Résumé

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major clinical challenge, characterized by heterogeneous manifestations and the absence of reliable biomarkers. The mechanisms linking systemic autoimmunity to neuronal injury and neuropsychiatric symptoms remain poorly understood.