Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Mapping the tRNA modification landscape of Houston I and Toulouse.

Quaiyum S, Sun J, Marchand V, Sun G, Reed CJ, Motorin Y, Dedon PC, Minnick MF, de Crécy-Lagard V

Front Microbiol. 2024 03 13;15:1369018

Comprehensive map of ribosomal 2'-O-methylation and C/D box snoRNAs in Drosophila melanogaster.

Sklias A, Cruciani S, Marchand V, Spagnuolo M, Lavergne G, Bourguignon V, Brambilla A, Dreos R, Marygold SJ, Novoa EM, Motorin Y, Roignant JY

Nucleic Acids Res. 2024 02 28;:

Depletion of Abolishes ψ of 28S-U4966 and Affects the Ribosome Translational Apparatus.

Chabronova A, van den Akker G, Housmans BAC, Caron MMJ, Cremers A, Surtel DAM, Peffers MJ, van Rhijn LW, Marchand V, Motorin Y, Welting TJM

Int J Mol Sci. 2023 08 8;24(16):

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer.

García-Vílchez R, Añazco-Guenkova AM, Dietmann S, López J, Morón-Calvente V, D'Ambrosi S, Nombela P, Zamacola K, Mendizabal I, García-Longarte S, Zabala-Letona A, Astobiza I, Fernández S, Paniagua A, Miguel-López B, Marchand V, Alonso-López D, Merkel A, García-Tuñón I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Bárcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sánchez-Martín MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S

Mol Cancer. 2023 07 29;22(1):119

nicotianamine synthase activity affects nucleolar iron accumulation and impacts rDNA silencing and RNA methylation in Arabidopsis.

Montacié C, Riondet C, Wei L, Darriere T, Weiss A, Pontvianne F, Escande ML, de Bures A, Jobet E, Barbarossa A, Carpentier MC, Aarts MGM, Attina A, Hirtz C, David A, Marchand V, Motorin Y, Curie C, Mari S, Reichheld JP, Sáez-Vásquez J

J Exp Bot. 2023 05 14;:

Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing.

Lucas MC, Pryszcz LP, Medina R, Milenkovic I, Camacho N, Marchand V, Motorin Y, Ribas de Pouplana L, Novoa EM

Nat Biotechnol. 2023 04 6;:

The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance.

Brazane M, Dimitrova DG, Pigeon J, Paolantoni C, Ye T, Marchand V, Da Silva B, Schaefer E, Angelova MT, Stark Z, Delatycki M, Dudding-Byth T, Gecz J, Plaçais PY, Teysset L, Préat T, Piton A, Hassan BA, Roignant JY, Motorin Y, Carré C

Life Sci Alliance. 2023 04;6(4):

A dual-purpose polymerase engineered for direct sequencing of pseudouridine and queuosine.

Huber LB, Kaur N, Henkel M, Marchand V, Motorin Y, Ehrenhofer-Murray AE, Marx A

Nucleic Acids Res. 2023 03 27;:

FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications.

Gawade K, Plewka P, Häfner SJ, Lund AH, Marchand V, Motorin Y, Szczesniak MW, Raczynska KD

Sci Rep. 2023 02 20;13(1):2974

Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis.

Chabronova A, van den Akker GGH, Housmans BAC, Caron MMJ, Cremers A, Surtel DAM, Wichapong K, Peffers MMJ, van Rhijn LW, Marchand V, Motorin Y, Welting TJM

Osteoarthritis Cartilage. 2023 01 5;:

Data Analysis Pipeline for Detection and Quantification of Pseudouridine (ψ) in RNA by HydraPsiSeq.

Pichot F, Marchand V, Helm M, Motorin Y

Methods Mol Biol. 2023 ;2624:207-223

Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines.

Pichot F, Hogg MC, Marchand V, Bourguignon V, Jirström E, Farrell C, Gibriel HA, Prehn JHM, Motorin Y, Helm M

Comput Struct Biotechnol J. 2022 12 19;21:401-417

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.

Maharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MA

Mol Cell. 2022 09 16;:

Pseudouridylation of Epstein-Barr Virus Noncoding RNA EBER2 Facilitates Lytic Replication.

Henry BA, Marchand V, Schlegel BT, Helm M, Motorin Y, Lee N

RNA. 2022 09 13;:

Synthesis of point-modified mRNA.

Hertler J, Slama K, Schober B, Özrendeci Z, Marchand V, Motorin Y, Helm M

Nucleic Acids Res. 2022 09 5;:

Studies of mutations of assembly factor Hit 1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome.

Dreggors-Walker RE, Cohen LN, Khoshnevis S, Marchand V, Motorin Y, Ghalei H

J Biol Chem. 2022 07 14;:102261

Ribosomal RNA 2'--methylations regulate translation by impacting ribosome dynamics.

Khoshnevis S, Dreggors-Walker RE, Marchand V, Motorin Y, Ghalei H

Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2117334119

Machine learning algorithm for precise prediction of 2'-O-methylation (Nm) sites from experimental RiboMethSeq datasets.

Pichot F, Marchand V, Helm M, Motorin Y

Methods. 2022 Mar 18;:

Systematic mapping of rRNA 2'-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis.

Delhermite J, Tafforeau L, Sharma S, Marchand V, Wacheul L, Lattuca R, Desiderio S, Motorin Y, Bellefroid E, Lafontaine DLJ

PLoS Genet. 2022 Jan 18;18(1):e1010012

Balancing of mitochondrial translation through METTL8-mediated mC modification of mitochondrial tRNAs.

Schöller E, Marks J, Marchand V, Bruckmann A, Powell CA, Reichold M, Mutti CD, Dettmer K, Feederle R, Hüttelmaier S, Helm M, Oefner P, Minczuk M, Motorin Y, Hafner M, Meister G

Mol Cell. 2021 Nov 8;:

Constitutive and variable 2'-O-methylation (Nm) in human ribosomal RNA.

Motorin Y, Quinternet M, Rhalloussi W, Marchand V

RNA Biol. 2021 Sep 10;:1-10

Analysis of pseudouridines and other RNA modifications using hydraPsiSeq protocol.

Marchand V, Bourguignon-Igel V, Helm M, Motorin Y

Methods. 2021 Sep 1;:

Implication of repeat insertion domains in the trans-activity of the long non-coding RNA ANRIL.

Alfeghaly C, Sanchez A, Rouget R, Thuillier Q, Igel-Bourguignon V, Marchand V, Branlant C, Motorin Y, Behm-Ansmant I, Maenner S

Nucleic Acids Res. 2021 Apr 19;:

Detection and functions of viral RNA modifications: perspectives in biology and medicine.

Marchand V, Motorin Y

Virologie (Montrouge). 2021 Apr 1;25(2):5-20

[Detection and functions of viral RNA modifications: perspectives in biology and medicine].

Marchand V, Motorin Y

Virologie (Montrouge). 2021 Apr 1;25(2):93-110

FTO-mediated cytoplasmic mA demethylation adjusts stem-like properties in colorectal cancer cell.

Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, Vialaret J, Attina A, Debart F, Choquet A, Macari F, Marchand V, Motorin Y, Samalin E, Vasseur JJ, Pannequin J, Aguilo F, Lopez-Crapez E, Hirtz C, Rivals E, Bastide A, David A

Nat Commun. 2021 Mar 19;12(1):1716

Instrumental analysis of RNA modifications.

Yoluç Y, Ammann G, Barraud P, Jora M, Limbach PA, Motorin Y, Marchand V, Tisné C, Borland K, Kellner S

Crit Rev Biochem Mol Biol. 2021 Feb 22;:1-27

Mapping rRNA 2'-O-methylations and identification of C/D snoRNAs in Arabidopsis thaliana plants.

Azevedo-Favory J, Gaspin C, Ayadi L, Montacié C, Marchand V, Jobet E, Rompais M, Carapito C, Motorin Y, Sáez-Vásquez J

RNA Biol. 2021 Feb 17;:1-18

Analysis of RNA Modifications by Second- and Third-Generation Deep Sequencing: 2020 Update.

Motorin Y, Marchand V

Genes (Basel). 2021 Feb 16;12(2):

Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo.

Heiss M, Hagelskamp F, Marchand V, Motorin Y, Kellner S

Nat Commun. 2021 Jan 15;12(1):389

Non-Redundant tRNA Reference Sequences for Deep Sequencing Analysis of tRNA Abundance and Epitranscriptomic RNA Modifications.

Pichot F, Marchand V, Helm M, Motorin Y

Genes (Basel). 2021 Jan 10;12(1):

Isolation, Extraction and Deep-Sequencing Analysis of Extracellular RNAs (exRNAs) from Human Plasma.

Marchand V, Galvanin A, Motorin Y

Methods Mol Biol. 2021 ;2300:165-182

Mapping of 7-methylguanosine (mG), 3-methylcytidine (mC), dihydrouridine (D) and 5-hydroxycytidine (hoC) RNA modifications by AlkAniline-Seq.

Marchand V, Bourguignon-Igel V, Helm M, Motorin Y

Methods Enzymol. 2021 ;658:25-47

Quantitative and Qualitative Assessment of Small RNA Preparations.

Marchand V, Ayadi L, Bourguignon-Igel V, Motorin Y

Methods Mol Biol. 2021 ;2300:17-29

NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination.

Werner S, Galliot A, Pichot F, Kemmer T, Marchand V, Sednev MV, Lence T, Roignant JY, König J, Höbartner C, Motorin Y, Hildebrandt A, Helm M

Nucleic Acids Res. 2020 Dec 11;:

Bacterial tRNA 2'-O-methylation is dynamically regulated under stress conditions and modulates innate immune response.

Galvanin A, Vogt LM, Grober A, Freund I, Ayadi L, Bourguignon-Igel V, Bessler L, Jacob D, Eigenbrod T, Marchand V, Dalpke A, Helm M, Motorin Y

Nucleic Acids Res. 2020 Dec 4;:

Ribosomal RNA 2'O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer.

Marcel V, Kielbassa J, Marchand V, Natchiar KS, Paraqindes H, Nguyen Van Long F, Ayadi L, Bourguignon-Igel V, Lo Monaco P, Monchiet D, Scott V, Tonon L, Bray SE, Diot A, Jordan LB, Thompson AM, Bourdon JC, Dubois T, André F, Catez F, Puisieux A, Motorin Y, Klaholz BP, Viari A, Diaz JJ

NAR Cancer. 2020 Dec;2(4):zcaa036

HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA.

Marchand V, Pichot F, Neybecker P, Ayadi L, Bourguignon-Igel V, Wacheul L, Lafontaine DLJ, Pinzano A, Helm M, Motorin Y

Nucleic Acids Res.. 2020 Sep 25;:

Manganese Ions Individually Alter the Reverse Transcription Signature of Modified Ribonucleosides.

Kristen M, Plehn J, Marchand V, Friedland K, Motorin Y, Helm M, Werner S

Genes (Basel). 2020 Aug 18;11(8):

Survey and Validation of tRNA Modifications and Their Corresponding Genes in sp Subtilis Strain 168.

de Crécy-Lagard V, Ross RL, Jaroch M, Marchand V, Eisenhart C, Brégeon D, Motorin Y, Limbach PA

Biomolecules. 2020 Jun 30;10(7):

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations.

Trzaska C, Amand S, Bailly C, Leroy C, Marchand V, Duvernois-Berthet E, Saliou JM, Benhabiles H, Werkmeister E, Chassat T, Guilbert R, Hannebique D, Mouray A, Copin MC, Moreau PA, Adriaenssens E, Kulozik A, Westhof E, Tulasne D, Motorin Y, Rebuffat S, Lejeune F

Nat Commun. 2020 Mar 20;11(1):1509

Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes.

Werner S, Schmidt L, Marchand V, Kemmer T, Falschlunger C, Sednev MV, Bec G, Ennifar E, Höbartner C, Micura R, Motorin Y, Hildebrandt A, Helm M

Nucleic Acids Res.. 2020 Feb 25;:

Analysis of fibroblasts from patients with cblC and cblG genetic defects of cobalamin metabolism reveals global dysregulation of alternative splicing.

Rashka C, Hergalant S, Dreumont N, Oussalah A, Camadro JM, Marchand V, Hassan Z, Baumgartner MR, Rosenblatt DS, Feillet F, Guéant JL, Coelho D

Hum. Mol. Genet.. 2020 Feb 18;:

tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila.

Angelova MT, Dimitrova DG, Da Silva B, Marchand V, Jacquier C, Achour C, Brazane M, Goyenvalle C, Bourguignon-Igel V, Shehzada S, Khouider S, Lence T, Guerineau V, Roignant JY, Antoniewski C, Teysset L, Bregeon D, Motorin Y, Schaefer MR, Carré C

Nucleic Acids Res.. 2020 Jan 16;:

Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2'-O-Methylations in RNA by RiboMethSeq.

Pichot F, Marchand V, Ayadi L, Bourguignon-Igel V, Helm M, Motorin Y

Front Genet. 2020 ;11:38

Diversity and heterogeneity of extracellular RNA in human plasma.

Galvanin A, Dostert G, Ayadi L, Marchand V, Velot É, Motorin Y

Biochimie. 2019 May 17;:

2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.

Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T

RNA. 2019 Apr 24;:

Absolute quantification of noncoding RNA by microscale thermophoresis.

Jacob D, Thüring K, Galliot A, Marchand V, Galvanin A, Ciftci A, Scharmann K, Stock M, Roignant JY, Leidel SA, Motorin Y, Schaffrath R, Klassen R, Helm M

Angew. Chem. Int. Ed. Engl.. 2019 Mar 20;:

Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.

Wei J, Kishton RJ, Angel M, Conn CS, Dalla-Venezia N, Marcel V, Vincent A, Catez F, Ferré S, Ayadi L, Marchand V, Dersh D, Gibbs JS, Ivanov IP, Fridlyand N, Couté Y, Diaz JJ, Qian SB, Staudt LM, Restifo NP, Yewdell JW

Mol. Cell. 2019 Jan 24;:

FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.

Ringeard M, Marchand V, Decroly E, Motorin Y, Bennasser Y

Nature. 2019 Jan 9;:

Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures.

Schmidt L, Werner S, Kemmer T, Niebler S, Kristen M, Ayadi L, Johe P, Marchand V, Schirmeister T, Motorin Y, Hildebrandt A, Schmidt B, Helm M

Front Genet. 2019 ;10:876

Mapping and Quantification of tRNA 2'-O-Methylation by RiboMethSeq.

Galvanin A, Ayadi L, Helm M, Motorin Y, Marchand V

Methods Mol. Biol.. 2019 ;1870:273-295

Detection and Analysis of RNA Ribose 2'-O-Methylations: Challenges and Solutions.

Motorin Y, Marchand V

Genes (Basel). 2018 Dec 18;9(12):

RNA ribose methylation (2'-O-methylation): Occurrence, biosynthesis and biological functions.

Ayadi L, Galvanin A, Pichot F, Marchand V, Motorin Y

Biochim Biophys Acta Gene Regul Mech. 2018 Dec 17;:

AlkAniline-Seq: profiling of m7G and m3C RNA modifications at single nucleotide resolution.

Marchand V, Ayadi L, Ernst FGM, Hertler J, Bourguignon-Igel V, Galvanin A, Kotter A, Helm M, Lafontaine DLJ, Motorin Y

Angew. Chem. Int. Ed. Engl.. 2018 Oct 29;:

Double methylation of tRNA-U54 to 2'-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7.

Keller P, Freund I, Marchand V, Bec G, Huang R, Motorin Y, Eigenbrod T, Dalpke A, Helm M

Nucleic Acids Res.. 2018 Aug 8;:

A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure.

Dal Magro C, Keller P, Kotter A, Werner S, Duarte V, Marchand V, Ignarski M, Freiwald A, Müller RU, Dieterich C, Motorin Y, Butter F, Atta M, Helm M

Angew. Chem. Int. Ed. Engl.. 2018 Apr 6;:

Engineering of a DNA Polymerase for Direct m A Sequencing.

Aschenbrenner J, Werner S, Marchand V, Adam M, Motorin Y, Helm M, Marx A

Angew. Chem. Int. Ed. Engl.. 2018 Jan 8;57(2):417-421

APRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients.

Guéant JL, Chéry C, Oussalah A, Nadaf J, Coelho D, Josse T, Flayac J, Robert A, Koscinski I, Gastin I, Filhine-Tresarrieu P, Pupavac M, Brebner A, Watkins D, Pastinen T, Montpetit A, Hariri F, Tregouët D, Raby BA, Chung WK, Morange PE, Froese DS, Baumgartner MR, Benoist JF, Ficicioglu C, Marchand V, Motorin Y, Bonnemains C, Feillet F, Majewski J, Rosenblatt DS

Nat Commun. 2018 01 4;9(1):67

Structural and functional analysis of the Rous Sarcoma virus negative regulator of splicing and demonstration of its activation by the 9G8 SR protein.

Bar A, Marchand V, Khoury G, Dreumont N, Mougin A, Robas N, Stevenin J, Visvikis A, Branlant C

Nucleic Acids Res. 2011 Apr;39(8):3388-403

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