RNA ribose methylation (2'-O-methylation): Occurrence, biosynthesis and biological functions.
Fiche publication
Date publication
décembre 2018
Journal
Biochimica et biophysica acta. Gene regulatory mechanisms
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MOTORINE Iouri, Dr MARCHAND Virginie
Tous les auteurs :
Ayadi L, Galvanin A, Pichot F, Marchand V, Motorin Y
Lien Pubmed
Résumé
Methylation of riboses at 2'-OH group is one of the most common RNA modifications found in number of cellular RNAs from almost any species which belong to all three life domains. This modification was extensively studied for decades in rRNAs and tRNAs, but recent data revealed the presence of 2'-O-methyl groups also in low abundant RNAs, like mRNAs. Ribose methylation is formed in RNA by two alternative enzymatic mechanisms: either by stand-alone protein enzymes or by complex assembly of proteins associated with snoRNA guides (sno(s)RNPs). In that case one catalytic subunit acts at various RNA sites, the specificity is provided by base pairing of the sno(s)RNA guide with the target RNA. In this review we compile available information on 2'-OH ribose methylation in different RNAs, enzymatic machineries involved in their biosynthesis and dynamics, as well as on the physiological functions of these modified residues.
Mots clés
Epitranscriptome, RNA modification, Ribose methylation, Sn/snoRNA, mRNA, rRNA, tRNA
Référence
Biochim Biophys Acta Gene Regul Mech. 2018 Dec 17;: