Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis.
Fiche publication
Date publication
janvier 2023
Journal
Osteoarthritis and cartilage
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MOTORINE Iouri, Dr MARCHAND Virginie
Tous les auteurs :
Chabronova A, van den Akker GGH, Housmans BAC, Caron MMJ, Cremers A, Surtel DAM, Wichapong K, Peffers MMJ, van Rhijn LW, Marchand V, Motorin Y, Welting TJM
Lien Pubmed
Résumé
Osteoarthritis-related cartilage extracellular matrix remodelling is dependent on changes in chondrocyte protein expression. Yet, the role of ribosomes in chondrocyte translation regulation is unknown. In this exploratory study, we investigated ribosomal RNA (rRNA) epitranscriptomic-based ribosome heterogeneity in human articular chondrocytes and its relevance for osteoarthritis.
Mots clés
5.8S rRNA, chondrocytes, collagen type I, preferential translation, rRNA epitranscriptomic regulation, ribosome
Référence
Osteoarthritis Cartilage. 2023 01 5;: