Walther L, Mittelheisser V, Claudepierre MC, Bochler L, Rompais M, Deforges J, Silvestre N, Larnicol A, Carapito C, Quémeneur E, Goetz JG, Rittner K, Hyenne V

J Extracell Vesicles. 2026 06;15(6):e70307

[When organelle positioning drives tumor progression].

Jerabkova-Roda K, Hyenne V, Goetz JG

Med Sci (Paris). 2026 03;42(3):258-262

Using 3D Invasion properties of RCC Cell Lines In Vitro to predict their Metastatic Potential In Vivo.

Cesana B, Nemoz-Billet L, Azemard V, Pillet C, Guyon L, Bigot E, Chaumontel N, Descotes JL, Osmani N, Goetz JG, Cochet C, Filhol O

Cell Death Discov. 2026 02 27;:

Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells.

Gensbittel V, Yesilata Z, Bochler L, Follain G, Nemoz-Billet L, Lefebvre O, Uhlmann K, Larnicol A, Ammirati GEM, Harlepp S, Goswami R, Girardo S, Paulen L, Hyenne V, Mittelheisser V, Stemmelen T, Molitor A, Carapito R, Belthier G, Pannequin J, Kräter M, Müller DJ, Balzani D, Guck J, Osmani N, Goetz JG

Nat Mater. 2026 01 19;:

Serum albumin-coated stellate mesoporous silica nanocomposites inhibit metastatic outgrowth in zebrafish embryos.

Asokan N, Mittelheisser V, Jablonski A, Adam A, Bizeau J, Harlepp S, Hyenne V, Lefebvre O, Goetz JG, Tasso M, Mertz D

Nanoscale. 2025 11 27;:

Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche.

Masson C, Scandola C, Rinckel JY, Proamer F, Janus-Bell E, Batool F, Osmani N, Goetz JG, Mallo L, Brouard N, Leon C, Bornert A, Poincloux R, Destaing O, Mansson A, Qian H, Lehmann M, Eckly A

Elife. 2025 10 8;14:

Functionalization of lipid nanoemulsions with humanized antibodies using plug-and-play cholesterol anchor for targeting cancer cells.

Boide-Trujillo VJ, Mittelheisser V, Liu F, Lefebvre O, Andreiuk B, Anton N, Goetz JG, Klymchenko AS

Nanoscale Adv. 2025 09 23;:

Depletion of all platelet integrins impacts hemostasis, thrombosis, and tumor metastasis.

Janus-Bell E, Liboni C, Yakusheva A, Mittelheisser V, Mouriaux C, Bourdon C, Bochler L, Hyenne V, Garcia-Leon M, Lefebvre O, Goetz JG, Mangin PH

iScience. 2025 09 19;28(9):113250

Tks5 interactome reveals endoplasmic-reticulum-associated translation machinery in invadosomes.

Normand L, Bonnard B, Sala M, Di Tommaso S, Dourthe C, Raymond AA, Dupuy JW, Mercier L, Goetz JG, Moreau V, Henriet E, Saltel F

FEBS J. 2025 07 24;:

Platelets: tailoring metastasis treatment.

Mittelheisser V, Liboni C, Trivigno SMG, Lefebvre O, Mangin PH, Goetz JG

Trends Cancer. 2025 07 17;:

Nanomaterials Trigger Functional Anti-Tumoral Responses in Primary Human Immune Cells.

Mittelheisser V, Lefebvre O, Banerjee M, Ghosh S, Dupas A, Diringer MC, Blumberger J, Bochler L, Harlepp S, Larnicol A, Pichot A, Stemmelen T, Molitor A, Moritz C, Carapito C, Carapito R, Charbonnière LJ, Lux F, Tillement O, Goetz JG, Detappe A

Adv Sci (Weinh). 2025 07 12;:e05729

Reinforced Polymer-Nanoparticle Hydrogels for Subcutaneous and Sustained Delivery of Trastuzumab.

Bovone G, Bernhard S, Jacquot G, Mittelheisser V, Mirjolet C, Guzzi EA, Paganella LG, Liebi L, Draussin J, Lopez Navarro P, Barbé E, Lefebvre O, Goetz JG, Charbonnière LJ, Pivot X, Harlepp S, Tibbitt MW, Detappe A

Adv Healthc Mater. 2025 06 9;:e2404660

Peripheral positioning of lysosomes supports melanoma aggressiveness.

Jerabkova-Roda K, Peralta M, Huang KJ, Mousson A, Bourgeat Maudru C, Bochler L, Busnelli I, Karali R, Justiniano H, Lisii LM, Carl P, Mittelheisser V, Asokan N, Larnicol A, Lefebvre O, Lachuer H, Pichot A, Stemmelen T, Molitor A, Scheid L, Frenger Q, Gros F, Hirschler A, Delalande F, Sick E, Carapito R, Carapito C, Lipsker D, Schauer K, Rondé P, Hyenne V, Goetz JG

Nat Commun. 2025 04 9;16(1):3375

Endothelial calcium firing mediates the extravasation of metastatic tumor cells.

Peralta M, Dupas A, Larnicol A, Lefebvre O, Goswami R, Stemmelen T, Molitor A, Carapito R, Girardo S, Osmani N, Goetz JG

iScience. 2025 02 21;28(2):111690

Deciphering circulating tumor cells binding in a microfluidic system thanks to a parameterized mathematical model.

Ciavolella G, Granet J, Goetz JG, Osmani N, Etchegaray C, Collin A

J Theor Biol. 2024 12 16;:112029

Extravasation of immune and tumor cells from an endothelial perspective.

Dupas A, Goetz JG, Osmani N

J Cell Sci. 2024 11 1;137(21):

A pleiotropic recurrent dominant variant causes a complex multisystemic disease.

Molitor A, Lederle A, Radosavljevic M, Sapuru V, Zavorka Thomas ME, Yang J, Shirin M, Collin-Bund V, Jerabkova-Roda K, Miao Z, Bernard A, Rolli V, Grenot P, Castro CN, Rosenzwajg M, Lewis EG, Person R, Esperón-Moldes US, Kaare M, Nokelainen PT, Batzir NA, Hoffer GZ, Paul N, Stemmelen T, Naegely L, Hanauer A, Bibi-Triki S, Grün S, Jung S, Busnelli I, Tripolszki K, Al-Ali R, Ordonez N, Bauer P, Song E, Zajo K, Partida-Sanchez S, Robledo-Avila F, Kumanovics A, Louzoun Y, Hirschler A, Pichot A, Toker O, Mejía CAM, Parvaneh N, Knapp E, Hersh JH, Kenney H, Delmonte OM, Notarangelo LD, Goetz JG, Kahwash SB, Carapito C, Bajwa RPS, Thomas C, Ehl S, Isidor B, Carapito R, Abraham RS, Hite RK, Marcus N, Bertoli-Avella A, Bahram S

Sci Adv. 2024 09 13;10(37):eado5545

Targeting monocytic Occludin impairs transendothelial migration and HIV neuroinvasion.

Brychka D, Ayala-Nunez NV, Dupas A, Bare Y, Partiot E, Mittelheisser V, Lucansky V, Goetz JG, Osmani N, Gaudin R

EMBO Rep. 2024 07 22;:

Platelets favor the outgrowth of established metastases.

Garcia-Leon MJ, Liboni C, Mittelheisser V, Bochler L, Follain G, Mouriaux C, Busnelli I, Larnicol A, Colin F, Peralta M, Osmani N, Gensbittel V, Bourdon C, Samaniego R, Pichot A, Paul N, Molitor A, Carapito R, Jandrot-Perrus M, Lefebvre O, Mangin PH, Goetz JG

Nat Commun. 2024 05 13;15(1):3297

Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases.

Mittelheisser V, Gensbittel V, Bonati L, Li W, Tang L, Goetz JG

Nat Nanotechnol. 2024 01 29;:

Organelle morphology and positioning orchestrate physiological and disease-associated processes.

Jerabkova-Roda K, Marwaha R, Das T, Goetz JG

Curr Opin Cell Biol. 2023 12 13;86:102293

Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis.

Mary B, Asokan N, Jerabkova-Roda K, Larnicol A, Busnelli I, Stemmelen T, Pichot A, Molitor A, Carapito R, Lefebvre O, Goetz JG, Hyenne V

EMBO Rep. 2023 11 16;:e57042

Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization.

Karreman MA, Bauer AT, Solecki G, Berghoff AS, Mayer CD, Frey K, Hebach N, Feinauer MJ, Schieber NL, Tehranian C, Mercier L, Singhal M, Venkataramani V, Schubert MC, Hinze D, Hölzel M, Helfrich I, Schadendorf D, Schneider SW, Westphal D, Augustin HG, Goetz JG, Schwab Y, Wick W, Winkler F

Cancer Res. 2023 01 19;:

Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma.

André-Grégoire G, Maghe C, Douanne T, Rosińska S, Spinelli F, Thys A, Trillet K, Jacobs KA, Ballu C, Dupont A, Lyne AM, Cavalli FMG, Busnelli I, Hyenne V, Goetz JG, Bidère N, Gavard J

iScience. 2022 10 21;25(10):105118

Circulating extracellular vesicles and tumor cells: sticky partners in metastasis.

Jerabkova-Roda K, Dupas A, Osmani N, Hyenne V, Goetz JG

Trends Cancer. 2022 05 26;:

Circulating tumor cells: Towards mechanical phenotyping of metastasis.

Peralta M, Osmani N, Goetz JG

iScience. 2022 Mar 18;25(3):103969

Optimal Physicochemical Properties of Antibody-Nanoparticle Conjugates for Improved Tumor Targeting.

Mittelheisser V, Coliat P, Moeglin E, Goepp L, Goetz JG, Charbonnière LJ, Pivot X, Detappe A

Adv Mater. 2022 Mar 15;:e2110305

Core-shell iron oxide@stellate mesoporous silica for combined nearinfrared photothermia and drug delivery: influence of pH and surface chemistry

Adam A, Harlepp S, Ghilini F, Cotin G, Freis B, Goetz J, Begin-Colin S, Tasso M, Mertz D

Colloids Surf. A: Physicochem. Eng. Asp.. 2022 ;640:128407

Liquid Biopsies: Flowing Biomarkers.

Hyenne V, Goetz JG, Osmani N

Adv Exp Med Biol. 2022 ;1379:341-368

[Ral-dependent tumor extracellular vesicles induce premetastatic niches in secondary organs].

Mary B, Ghoroghi S, Goetz JG, Hyenne V

Med Sci (Paris). 2021 Dec;37(12):1116-1118

Biomechanics: a driving force behind metastatic progression.

Colin F, Gensbittel V, Goetz JG

C R Biol. 2021 11 15;344(3):249-262

Tumor extracellular vesicles drive metastasis (it's a long way from home).

Ghoroghi S, Mary B, Asokan N, Goetz JG, Hyenne V

FASEB Bioadv. 2021 Nov;3(11):930-943

Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status.

Murphy KJ, Reed DA, Vennin C, Conway JRW, Nobis M, Yin JX, Chambers CR, Pereira BA, Lee V, Filipe EC, Trpceski M, Ritchie S, Lucas MC, Warren SC, Skhinas JN, Magenau A, Metcalf XL, Stoehr J, Major G, Parkin A, Bidanel R, Lyons RJ, Zaratzian A, Tayao M, Da Silva A, Abdulkhalek L, ,,Gill AJ, Johns AL, Biankin AV, Samra J, Grimmond SM, Chou A, Goetz JG, Samuel MS, Lyons JG, Burgess A, Caldon CE, Horvath LG, Daly RJ, Gadegaard N, Wang Y, Sansom OJ, Morton JP, Cox TR, Pajic M, Herrmann D, Timpson P

Sci Adv. 2021 Oct;7(40):eabh0363

The power of imaging to understand extracellular vesicle biology in vivo.

Verweij FJ, Balaj L, Boulanger CM, Carter DRF, Compeer EB, D'Angelo G, El Andaloussi S, Goetz JG, Gross JC, Hyenne V, Krämer-Albers EM, Lai CP, Loyer X, Marki A, Momma S, Nolte-'t Hoen ENM, Pegtel DM, Peinado H, Raposo G, Rilla K, Tahara H, Théry C, van Royen ME, Vandenbroucke RE, Wehman AM, Witwer K, Wu Z, Wubbolts R, van Niel G

Nat Methods. 2021 Aug 26;:

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells.

Follain G, Osmani N, Gensbittel V, Asokan N, Larnicol A, Mercier L, Garcia-Leon MJ, Busnelli I, Pichot A, Paul N, Carapito R, Bahram S, Lefebvre O, Goetz JG

Sci Rep. 2021 Jun 23;11(1):13144

Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells.

Belcastro E, Rehman AU, Remila L, Park SH, Gong DS, Anton N, Auger C, Lefebvre O, Goetz JG, Collot M, Klymchenko AS, Vandamme TF, Schini-Kerth VB

Nanomedicine. 2021 Mar 10;:102379

The NANOTUMOR consortium - towards the Tumor Cell Atlas.

Colin F, Schauer K, Hamiche A, Martineau P, Borg JP, Bednar J, Bertolin G, Camoin L, Collette Y, Dimitrov S, Fournier I, Hyenne V, Mendoza-Parra MA, Morelli X, Rondé P, Sumara I, Tramier M, Schultz P, Goetz JG

Biol Cell. 2021 Feb 7;:

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes.

Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, Gros F, Fouillen L, Haeberle AM, Royer C, Spiegelhalter C, André-Grégoire G, Mittelheisser V, Detappe A, Murphy K, Timpson P, Carapito R, Blot-Chabaud M, Gavard J, Carapito C, Vitale N, Lefebvre O, Goetz JG, Hyenne V

Elife. 2021 Jan 6;10:

Probing Intravascular Adhesion and Extravasation of Tumor Cells with Microfluidics.

Osmani N, Follain G, Gensbittel V, García-León MJ, Harlepp S, Goetz JG

Methods Mol Biol. 2021 ;2294:111-132

Visualizing Cancer.

Krummel M, Hu K, de Vries EGE, Goetz JG, Passaro D, Subramaniam S, Misteli T, Skala M, Bravo-Cordero JJ, Sutcliffe JL

Cancer Cell. 2020 Dec 14;38(6):753-756

Nanoluminal Signaling Shapes Collective Metastasis.

Gensbittel V, Busnelli I, Osmani N, Goetz JG

Trends Cancer. 2020 Nov 28;:

Mechanical Adaptability of Tumor Cells in Metastasis.

Gensbittel V, Kräter M, Harlepp S, Busnelli I, Guck J, Goetz JG

Dev Cell. 2020 Nov 3;:

Tracking Mechanisms of Viral Dissemination In Vivo.

Gaudin R, Goetz JG

Trends Cell Biol. 2020 Oct 3;:

[Influence of fluid mechanics on metastasis formation].

Follain G, Gensbittel V, Mary B, Lefebvre O, Harlepp S, Hyenne V, Goetz JG

Med Sci (Paris). 2020 Oct;36(10):872-878

Live tracking of extracellular vesicles in larval zebrafish.

Mary B, Ghoroghi S, Hyenne V, Goetz JG

Methods Enzymol. 2020 ;645:243-275

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

Mertz D, Harlepp S, Goetz JG, Bégin D, Schlatter G, Bégin‐Colin S, Hébraud A

. 2020 ;3(2):1900143

Near Infra-Red Light Responsive Carbon Nanotubes@Mesoporous Silica for Photothermia and Drug Delivery to Cancer Cells

Li B, Harlepp S, Gensbittel V, Wells CJR, Bringel O, Goetz JG, Begin-Colin S, Tasso M, Begin D, Mertz D

. 2020 ;17:100308

Multiscale Imaging of Metastasis in Zebrafish.

Osmani N, Goetz JG

Trends Cancer. 2019 Dec;5(12):766-778

Fluids and their mechanics in tumour transit: shaping metastasis.

Follain G, Herrmann D, Harlepp S, Hyenne V, Osmani N, Warren SC, Timpson P, Goetz JG

Nat. Rev. Cancer. 2019 Nov 28;:

The Complexities of Metastasis.

San Juan BP, Garcia-Leon MJ, Rangel L, Goetz JG, Chaffer CL

Cancers (Basel). 2019 Oct 16;11(10):

Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.

Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C, Swift J, Campo AD, Starborg T, Zech T, Goetz JG, Paluch EK, Schwartz JM, Caswell PT

Dev. Cell. 2019 Oct 9;:

Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells.

Ayala-Nunez NV, Follain G, Delalande F, Hirschler A, Partiot E, Hale GL, Bollweg BC, Roels J, Chazal M, Bakoa F, Carocci M, Bourdoulous S, Faklaris O, Zaki SR, Eckly A, Uring-Lambert B, Doussau F, Cianferani S, Carapito C, Jacobs FMJ, Jouvenet N, Goetz JG, Gaudin R

Nat Commun. 2019 Sep 27;10(1):4430

Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces during Intravascular Arrest.

Osmani N, Follain G, García León MJ, Lefebvre O, Busnelli I, Larnicol A, Harlepp S, Goetz JG

Cell Rep. 2019 Sep 3;28(10):2491-2500.e5

Extracellular Vesicles: Catching the Light in Zebrafish.

Verweij FJ, Hyenne V, Van Niel G, Goetz JG

Trends Cell Biol.. 2019 Aug 7;:

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo.

Verweij FJ, Revenu C, Arras G, Dingli F, Loew D, Pegtel MD, Follain G, Allio G, Goetz JG, Zimmermann P, Herbomel P, Del Bene F, Raposo G, van Niel G

Dev. Cell. 2019 Feb 5;:

Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo.

Hyenne V, Ghoroghi S, Collot M, Bons J, Follain G, Harlepp S, Mary B, Bauer J, Mercier L, Busnelli I, Lefebvre O, Fekonja N, Garcia-Leon MJ, Machado P, Delalande F, López AA, Silva SG, Verweij FJ, van Niel G, Djouad F, Peinado H, Carapito C, Klymchenko AS, Goetz JG

Dev. Cell. 2019 Feb 4;:

Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo.

Perton F, Harlepp S, Follain G, Parkhomenko K, Goetz JG, Bégin-Colin S, Mertz D

J Colloid Interface Sci. 2019 Jan 23;542:469-482

CD44 Orchestrates Metastatic Teamwork.

Chaffer CL, Goetz JG

Dev. Cell. 2018 Dec 17;47(6):691-693

Metastases go with the flow.

Goetz JG

Science. 2018 Nov 30;362(6418):999-1000

The Small GTPase Ral orchestrates MVB biogenesis and exosome secretion.

Hyenne V, Labouesse M, Goetz JG

Small GTPases. 2018 11 2;9(6):445-451

Synergistic Mechano-Chemical Sensing by Vascular Cilia.

Follain G, Goetz JG

Trends Cell Biol.. 2018 Jul;28(7):507-508

Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma.

Mammadova-Bach E, Rupp T, Spenlé C, Jivkov I, Shankaranarayanan P, Klein A, Pisarsky L, Méchine-Neuville A, Cremel G, Kedinger M, De Wever O, Ambartsumian N, Robine S, Pencreach E, Guenot D, Simon-Assmann P, Goetz JG, Orend G, Lefebvre O

Biol. Cell. 2018 Jun 15;:

Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation.

Ezzoukhry Z, Henriet E, Cordelières FP, Dupuy JW, Maître M, Gay N, Di-Tommaso S, Mercier L, Goetz JG, Peter M, Bard F, Moreau V, Raymond AA, Saltel F

Nat Commun. 2018 May 23;9(1):2031

An Arf6- and caveolae-dependent pathway links hemidesmosome remodeling and mechanoresponse.

Osmani N, Pontabry J, Comelles J, Fekonja N, Goetz JG, Riveline D, Georges-Labouesse E, Labouesse M

Mol. Biol. Cell. 2018 Feb 15;29(4):435-451

Using the Zebrafish Embryo to Dissect the Early Steps of the Metastasis Cascade.

Follain G, Osmani N, Fuchs C, Allio G, Harlepp S, Goetz JG

Methods Mol. Biol.. 2018 ;1749:195-211

Hemodynamic forces can be accurately measured in vivo with optical tweezers.

Harlepp S, Thalmann F, Follain G, Goetz JG

Mol. Biol. Cell. 2017 Nov 7;28(23):3252-3260

Fluorescent Polymer Nanoparticles for Cell Barcoding In Vitro and In Vivo.

Andreiuk B, Reisch A, Lindecker M, Follain G, Peyriéras N, Goetz JG, Klymchenko AS

Small. 2017 Oct;13(38):

Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features.

Carapito R, Konantz M, Paillard C, Miao Z, Pichot A, Leduc MS, Yang Y, Bergstrom KL, Mahoney DH, Shardy DL, Alsaleh G, Naegely L, Kolmer A, Paul N, Hanauer A, Rolli V, Müller JS, Alghisi E, Sauteur L, Macquin C, Morlon A, Sancho CS, Amati-Bonneau P, Procaccio V, Mosca-Boidron AL, Marle N, Osmani N, Lefebvre O, Goetz JG, Unal S, Akarsu NA, Radosavljevic M, Chenard MP, Rialland F, Grain A, Béné MC, Eveillard M, Vincent M, Guy J, Faivre L, Thauvin-Robinet C, Thevenon J, Myers K, Fleming MD, Shimamura A, Bottollier-Lemallaz E, Westhof E, Lengerke C, Isidor B, Bahram S

J. Clin. Invest.. 2017 Oct;:

Extracellular vesicles on the wire.

Hyenne V, Goetz JG

Cell Adh Migr. 2017 Mar 4;11(2):121-123

Going live with tumor exosomes and microvesicles.

Hyenne V, Lefebvre O, Goetz JG

Cell Adh Migr. 2017 Mar;11(2):173-186

Find your way with X-Ray: Using microCT to correlate in vivo imaging with 3D electron microscopy.

Karreman MA, Ruthensteiner B, Mercier L, Schieber NL, Solecki G, Winkler F, Goetz JG, Schwab Y

Methods Cell Biol.. 2017 ;140:277-301

Seeing is believing - multi-scale spatio-temporal imaging towards in vivo cell biology.

Follain G, Mercier L, Osmani N, Harlepp S, Goetz JG

J. Cell. Sci.. 2017 01 1;130(1):23-38

Intravital Correlative Microscopy: Imaging Life at the Nanoscale.

Karreman MA, Hyenne V, Schwab Y, Goetz JG

Trends Cell Biol.. 2016 11;26(11):848-863

Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide.

Jacob L, Sawma P, Garnier N, Meyer LA, Fritz J, Hussenet T, Spenlé C, Goetz J, Vermot J, Fernandez A, Baumlin N, Aci-Sèche S, Orend G, Roussel G, Crémel G, Genest M, Hubert P, Bagnard D

Oncotarget. 2016 09;7(36):57851-57865