Fiche publication
Date publication
mars 2026
Journal
Medecine sciences : M/S
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Jacky
,
Dr HYENNE Vincent
Tous les auteurs :
Jerabkova-Roda K, Hyenne V, Goetz JG
Lien Pubmed
Résumé
Long considered mere degradative compartments, lysosomes are now recognized as key regulators of metabolism, signaling, and tumor invasion. Here, we discuss how their intracellular localization controls their function, signaling, and secretion. In melanoma, the peripheral distribution of lysosomes promotes aggressiveness and metastasis. Similar changes exist in other types of cancer, highlighting the role of lysosomal trafficking as a factor in malignancy and as a promising biomarker for diagnosis and treatment.
Mots clés
Humans, Disease Progression, Lysosomes, physiology, Neoplasms, pathology, Organelles, physiology, Animals, Signal Transduction, physiology, Melanoma, pathology, Neoplasm Invasiveness
Référence
Med Sci (Paris). 2026 03;42(3):258-262
