Reinforced Polymer-Nanoparticle Hydrogels for Subcutaneous and Sustained Delivery of Trastuzumab.

Fiche publication

Date publication

juin 2025

Journal

Advanced healthcare materials

Auteurs

Membres identifiés du Cancéropôle Est :
Dr CHARBONNIERE Loïc , Dr GOETZ Jacky , Dr LEFEBVRE Olivier , Dr MIRJOLET Céline , Pr PIVOT Xavier , Dr HARLEPP Sébastien , Dr DETAPPE Alexandre

Tous les auteurs :
Bovone G, Bernhard S, Jacquot G, Mittelheisser V, Mirjolet C, Guzzi EA, Paganella LG, Liebi L, Draussin J, Lopez Navarro P, Barbé E, Lefebvre O, Goetz JG, Charbonnière LJ, Pivot X, Harlepp S, Tibbitt MW, Detappe A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40489148

Résumé

In oncology, the advent of monoclonal antibody (mAb) therapeutics represents a breakthrough in various cancer diseases. However, these therapies often necessitate iterative hospital visits for intravenous infusion that alter patient quality of life and contribute to the chronic saturation of hospitals. Subcutaneous formulations of mAbs offer a promising alternative facilitating faster administration compared with traditional intravenous methods, while still maintaining the same dosing schedule and providing time-saving advantages. Here, an injectable mAb delivery platform using α-cyclodextrin (αCD)-reinforced polymer-nanoparticle hydrogels to perform subcutaneous mAb depots and delay their release is developed. By leveraging mAb-polymer electrostatic complexation, hyaluronic acid- and alginate-based injectable drug depots are formulated by simply mixing components that are generally regarded as safe. Trastuzumab is included as a clinically relevant therapeutic antibody. These formulations delayed mAb release both in vitro and in vivo mice models, with a similar pharmacokinetic performance to the clinically approved Herceptin SC (Roche) formulation composed of trastuzumab with recombinant human hyaluronidase (rHuPH20).