Fiche publication
Date publication
juin 2026
Journal
Trends in cancer
Lien Pubmed
Résumé
Heart cancer or metastasis is very rare, yet the heart is highly vascularized and mechanically pumps blood flow through our body. Recent findings from Ciucci et al. show that mechanical load in the beating heart suppresses cancer growth via Nesprin-2-dependent mechanotransduction, which changes histone methylation and chromatin compaction to keep proliferation genes less active in cardiac tumor cells.
Mots clés
cancer, heart, mechanical loading
Référence
Trends Cancer. 2026 06 19;:
