Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Combination of Irinotecan and Melatonin with the Natural Compounds Wogonin and Celastrol for Colon Cancer Treatment.

Radajewska A, Moreira H, Bęben D, Siwiela O, Szyjka A, Gębczak K, Nowak P, Frąszczak J, Emhemmed F, Muller CD, Barg E

Int J Mol Sci. 2023 05 31;24(11):

Cytotoxic and Pro-Apoptotic Effects of Leaves Extract of Engler ().

Thiam K, Zhao M, Marchioni E, Muller CD, Diop YM, Julien-David D, Emhemmed F

Molecules. 2022 11 9;27(22):

A New Triterpenoid Saponin from Albizia zygia Induced Apoptosis by Reduction of Mitochondrial Potential Status in Malignant Melanoma Cells.

Simo LM, Messi LM, Mbing JN, Muller CD, Boyom FF, Begoudé AB, Pegnyemb DE, Haddad M, Noté OP

Planta Med. 2022 07 22;:

Celastrol and Resveratrol Modulate Genes Expression and Exert Anticancer Activity in Colon Cancer Cells and Cancer Stem-like Cells.

Moreira H, Szyjka A, Grzesik J, Pelc K, Żuk M, Kulma A, Emhemmed F, Muller CD, Gąsiorowski K, Barg E

Cancers (Basel). 2022 Mar 8;14(6):

Extract Induces Apoptosis in Human Pancreatic 3D Cancer Models: Importance of Major Antioxidant Molecules Present Therein.

Emhemmed F, Zhao M, Yorulmaz S, Steyer D, Leitao C, Alignan M, Cerny M, Paillard A, Delacourt FM, Julien-David D, Muller CD

Molecules. 2022 Feb 11;27(4):

Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of .

Ashraf W, Ahmad T, Almalki NAR, Krifa M, Zaayter L, Pizzi A, Muller CD, Hamiche A, Mély Y, Bronner C, Mousli M

Food Funct. 2021 Dec 13;:

TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex.

Ahmad T, Ashraf W, Ibrahim A, Zaayter L, Muller CD, Hamiche A, Mély Y, Bronner C, Mousli M

Int J Oncol. 2021 Nov;59(5):

Three dimensional in vitro culture systems in anticancer drug discovery targeted on cancer stem cells.

Radajewska A, Przybyszewski O, Emhemmed F, Muller CD, Barg E, Moreira H

Am J Cancer Res. 2021 ;11(10):4931-4946

Biofunctionalization of 3D-printed silicone implants with immunomodulatory hydrogels for controlling the innate immune response: An in vivo model of tracheal defect repair.

Barthes J, Lagarrigue P, Riabov V, Lutzweiler G, Kirsch J, Muller C, Courtial EJ, Marquette C, Projetti F, Kzhyskowska J, Lavalle P, Vrana NE, Dupret-Bories A

Biomaterials. 2020 Nov 24;268:120549

Anti-Proliferative and Apoptosis-Inducing Activity of Acacia Modesta and Opuntia Monocantha Extracts on HeLa Cells.

Abid F, Saleem M, Muller CD, Asim MH, Arshad S, Maqbool T, Hadi F

Asian Pac J Cancer Prev. 2020 Oct 1;21(10):3125-3131

Biological Activities of Aqueous Extracts from Carob Plant ( L.) by Antioxidant, Analgesic and Proapoptotic Properties Evaluation.

Ben Ayache S, Behija Saafi E, Emhemmed F, Flamini G, Achour L, Muller CD

Molecules. 2020 Jul 8;25(14):

Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification.

Bjelogrlić SK, Todorović TR, Kojić M, Senćanski M, Nikolić M, Višnjevac A, Araškov J, Miljković M, Muller CD, Filipović NR

J. Inorg. Biochem.. 2019 Jun 26;199:110758

The synthetic flavagline FL3 spares normal human skin cells from its cytotoxic effect via an activation of Bad.

Emhemmed F, Azouaou SA, Hassan S, Lefevbre R, Désaubry L, Muller CD, Fuhrmann G

Toxicol In Vitro. 2019 Apr 24;:

Characterization of sulfated polysaccharide from Laurencia obtusa and its apoptotic, gastroprotective and antioxidant activities.

Lajili S, Ammar HH, Mzoughi Z, Amor HBH, Muller CD, Majdoub H, Bouraoui A

Int. J. Biol. Macromol.. 2018 Dec 10;:

A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells.

Bjelogrlić S, Todorović TR, Cvijetić I, Rodić MV, Vujčić M, Marković S, Araškov J, Janović B, Emhemmed F, Muller CD, Filipović NR

J. Inorg. Biochem.. 2018 Oct 14;190:45-66

Marine Microalgae: Promising Source for New Bioactive Compounds.

de Vera CR, Díaz Crespín G, Hernández Daranas A, Montalvão Looga S, Lillsunde KE, Tammela P, Perälä M, Hongisto V, Virtanen J, Rischer H, Muller CD, Norte M, Fernández JJ, Souto ML

Mar Drugs. 2018 Sep 6;16(9):

Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies.

Dovgan I, Erb S, Hessmann S, Ursuegui S, Michel C, Muller C, Chaubet G, Cianférani S, Wagner A

Org. Biomol. Chem.. 2018 Feb 21;16(8):1305-1311

New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera C.A. Smith.

Simo LM, Noté OP, Mbing JN, Aouazou SA, Guillaume D, Muller CD, Pegnyemb DE, Lobstein A

Chem. Biodivers.. 2017 Sep;:

Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates.

Kolodych S, Michel C, Delacroix S, Koniev O, Ehkirch A, Eberova J, Cianférani S, Renoux B, Krezel W, Poinot P, Muller CD, Papot S, Wagner A

Eur J Med Chem. 2017 Aug;:

Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae).

Auberon F, Olatunji OJ, Raminoson D, Muller CD, Soengas B, Bonté F, Lobstein A

Fitoterapia. 2017 Jan;116:99-105

Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells.

Emhemmed F, Ali Azouaou S, Zhao Q, Appert-Collin A, Bennasroune A, Schini-Kerth VB, Muller CD, Désaubry L, Fuhrmann G

Cell Biol. Toxicol.. 2016 Dec;:

In vitro immunomodulatory activity and in vivo anti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red alga Laurencia obtusa.

Lajili S, Deghrigue M, Bel Haj Amor H, Muller CD, Bouraoui A

Pharm Biol. 2016 Nov;54(11):2486-2495

Pregnane Glycosides from Cynanchum marnierianum Stimulate GLP-1 Secretion in STC-1 Cells.

Tsoukalas M, Muller CD, Lobstein A, Urbain A

Planta Med.. 2016 Jul;82(11-12):992-9

From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release.

Jacques SA, Leriche G, Mosser M, Nothisen M, Muller CD, Remy JS, Wagner A

Org. Biomol. Chem.. 2016 Jun;14(21):4794-803

Additional Insights into the Obtusallene Family: Components of Laurencia marilzae.

Gutiérrez-Cepeda A, Fernández JJ, Norte M, López-Rodríguez M, Brito I, Muller CD, Souto ML

J. Nat. Prod.. 2016 Apr 22;79(4):1184-8

Phenotype-specific apoptosis induced by three new triterpenoid saponins from Albizia glaberrima (Schumach. & Thonn.) Benth.

Noté OP, Azouaou SA, Simo L, Antheaume C, Guillaume D, Pegnyemb DE, Muller CD, Lobstein A

Fitoterapia. 2016 Mar;109:80-6

Spiro Di-orthoester (SpiDo), a Human Plasma Stable Acid-Sensitive Cleavable Linker for Lysosomal Release.

Leriche G, Nothisen M, Baumlin N, Muller CD, Bagnard D, Remy JS, Jacques SA, Wagner A

Bioconjug Chem. 2015 Jul 1.

Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells.

Ali Azouaou S, Emhemmed F, Idris-Khodja N, Lobstein A, Schini-Kerth V, Muller CD, Fuhrmann G

Invest New Drugs. 2015 Feb;33(1):64-74

Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer.

Minker C, Duban L, Karas D, Järvinen P, Lobstein A, Muller CD

Oxid Med Cell Longev. 2015 ;2015:154164

Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells.

Auberval N, Dal S, Bietiger W, Seyfritz E, Peluso J, Muller C, Zhao M, Marchioni E, Pinget M, Jeandidier N, Maillard E, Schini-Kerth V, Sigrist S

Evid Based Complement Alternat Med. 2015;2015:859048

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.

Emhemmed F, Ali Azouaou S, Thuaud F, Schini-Kerth V, Desaubry L, Muller CD, Fuhrmann G

Biochem Pharmacol. 2014 May 15;89(2):185-96

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway.

Khelfaoui M, Gambino F, Houbaert X, Ragazzon B, Muller C, Carta M, Lanore F, Srikumar BN, Gastrein P, Lepleux M, Zhang CL, Kneib M, Poulain B, Reibel-Foisset S, Vitale N, Chelly J, Billuart P, Luthi A, Humeau Y

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130160

Major bioactivities and mechanism of action of essential oils and their components.

Saad NY, Muller CD, Lobstein A

Flavour Frag J. 2013 Sep;28(5):269-79.

Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry.

Saab L, Peluso J, Muller CD, Ubeaud-Sequier G

Cytometry A. 2013 Apr;83(4):403-8

Oligobenzylethylenimine enriches linear polyethylenimine with a pH-sensitive membrane-disruptive property and leads to enhanced gene delivery activity.

Chandrashekhar C, Pons B, Muller CD, Tounsi N, Mulherkar R, Zuber G

Acta Biomater. 2013 Feb;9(2):4985-93

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.

Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner C

Biochem Biophys Res Commun. 2013 Jan 4;430(1):208-12

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.

Krifa M, Alhosin M, Muller CD, Gies JP, Chekir-Ghedira L, Ghedira K, Mely Y, Bronner C, Mousli M

J Exp Clin Cancer Res. 2013 May 20;32:30

A nice refreshing technological breeze was blowing this June at the CYTO 2012 ISAC meeting in Leipzig (Germany).

Muller CD

Cytometry A. 2012 Oct;81(10):929

Pemetrexed-induced skin sclerosis.

Merklen-Djafri C, Imbert E, Courouge-Dorcier D, Schott R, Meraud JP, Muller C, Tebacher M, Springinsfeld G, Cribier B, Lipsker D

Clin Oncol (R Coll Radiol). 2012 Aug;24(6):452-3

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.

Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner C

Biochem Biophys Res Commun. 2012 Jul 3.

Labdane-type diterpenes and flavones from Dodonaea viscosa.

Wabo HK, Chabert P, Tane P, Note O, Tala MF, Peluso J, Muller C, Kikuchi H, Oshima Y, Lobstein A

Fitoterapia. 2012 Jul;83(5):859-63

Unlike for human monocytes after LPS activation, release of TNF-alpha by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.

Moreira-Tabaka H, Peluso J, Vonesch JL, Hentsch D, Kessler P, Reimund JM, Dumont S, Muller CD

PLoS One. 2012;7(3):e34184

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.

Abusnina A, Alhosin M, Keravis T, Muller CD, Fuhrmann G, Bronner C, Lugnier C

Cell Signal. 2011 Jan;23(1):152-60

Synthesis of exotic polycycles such as cyclooctatrienes and fenestrenes with differential pro-apoptotic activities on human TRAIL-resistant metastatic cell lines.

Hulot C, Peluso J, Blond G, Muller CD, Suffert J

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6836-9

Advances in flow cytometry for drug screening.

Peluso J, Muller CD

Expert Opin Drug Discov. 2010 Sep;5(9):827-33.

Advances in flow cytometry for drug screening.

Peluso J, Muller CD

Expert Opin Drug Discov. 2010 Sep;5(9):827-33

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.

Alhosin M, Abusnina A, Achour M, Sharif T, Muller C, Peluso J, Chataigneau T, Lugnier C, Schini-Kerth VB, Bronner C, Fuhrmann G

Biochem Pharmacol. 2010 May 1;79(9):1251-60

Distribution, ecology and impact of a small invasive shellfish, Hemimysis anomala in Alsatian water

Dumont S, Muller CD

Biol Invasions. 2010 Mar;12(3):495-500

Differential between protein and mRNA expression of CCR7 and SSTR5 receptors in Crohn's disease patients.

Taquet N, Dumont S, Vonesch JL, Hentsch D, Reimund JM, Muller CD

Mediators Inflamm. 2009;2009:285812

Cyclic nucleotide phosphodiesterase type 4 inhibitors: evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere.

Raboisson P, Schultz D, Muller C, Reimund JM, Pinna G, Mathieu R, Bernard P, Do QT, Desjarlais RL, Justiano H, Lugnier C, Bourguignon JJ

Eur J Med Chem. 2008 Apr;43(4):816-29

Can flow cytometry play a part in cell based high-content screening?

Peluso J, Tabaka-Moreira H, Taquet N, Dumont S, Muller CD

Cytometry A. 2007 Nov;71(11):901-4.

Upregulation of proinflammatory proteins through NF-kappaB pathway by shed membrane microparticles results in vascular hyporeactivity.

Tesse A, Martinez MC, Hugel B, Chalupsky K, Muller CD, Meziani F, Mitolo-Chieppa D, Freyssinet JM, Andriantsitohaina R

Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2522-7

The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle.

Jeanblanc M, Mousli M, Hopfner R, Bathami K, Martinet N, Abbady AQ, Siffert JC, Mathieu E, Muller CD, Bronner C

Oncogene. 2005 Nov 10;24(49):7337-45.

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