New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera C.A. Smith.
Fiche publication
Date publication
septembre 2017
Journal
Chemistry & biodiversity
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUILLAUME Dominique, Dr MULLER Christian
Tous les auteurs :
Simo LM, Noté OP, Mbing JN, Aouazou SA, Guillaume D, Muller CD, Pegnyemb DE, Lobstein A
Lien Pubmed
Résumé
As part of our search of new bioactive saponins from Cameroonian medicinal plants, two new oleanane-type saponins, named gummiferaosides D-E (1-2), along with one known saponin, julibroside J8 (3), were isolated from the roots of Albizia gummifera. Their structures were established on the basis of extensive 1D and 2D NMR ((1) H-, (13) C-NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC-TOCSY and HMBC) and HRESIMS studies, and by chemical evidence. The apoptotic effect of saponins 1-3 was evaluated on the A431 human epidermoid cancer cell. Flow cytometric analyses showed that saponins 1-3 induced apoptosis of human epidermoid cancer cell (A431) in a dose-dependent manner. This article is protected by copyright. All rights reserved.
Mots clés
Albizia gummifera , Apoptosis of human epidermoid cancer cell A431, Gummiferaosides D and E, Mimosaceae, Triterpenoid saponins
Référence
Chem. Biodivers.. 2017 Sep;: