Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae).
Fiche publication
Date publication
janvier 2017
Journal
Fitoterapia
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MULLER Christian
Tous les auteurs :
Auberon F, Olatunji OJ, Raminoson D, Muller CD, Soengas B, Bonté F, Lobstein A
Lien Pubmed
Résumé
Four new stilbenoids, named cyrtopodinone (1), cyrtopodinol (2), and coeludols A and B (3-4) were isolated from the roots of Cyrtopodium paniculatum, together with 21 known stilbenoids derivatives (5-25). Their structures were elucidated by comprehensive spectroscopic analysis including extensive 1D and 2D-NMR techniques. The cytotoxic activities of the isolated compounds were tested on human glioblastoma U-87MG cell line with fluorescence-based image cytometry. Only four compounds (18, 19, 22 and 25) displayed moderate cytotoxicity with IC values of 45.2, 39.9, 58.2 and 48.0μM, respectively.
Mots clés
Antineoplastic Agents, Phytogenic, chemistry, Cell Line, Tumor, Humans, Magnetic Resonance Spectroscopy, Molecular Structure, Orchidaceae, chemistry, Plant Extracts, chemistry, Plant Roots, chemistry, Stilbenes, chemistry
Référence
Fitoterapia. 2017 Jan;116:99-105