Labdane-type diterpenes and flavones from Dodonaea viscosa.
Fiche publication
Date publication
juillet 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MULLER Christian
Tous les auteurs :
Wabo HK, Chabert P, Tane P, Note O, Tala MF, Peluso J, Muller C, Kikuchi H, Oshima Y, Lobstein A
Lien Pubmed
Résumé
A new labdane diterpenoid, 2,18-dihydroxylabda-7,13(E)-dien-15-oic acid (1), together with two known labdane diterpenes (3, 4), a new flavone, 5,7-dihydroxy-3,6,4'-trimethoxy-3'-(4-hydroxy-3-methyl-but-2-enyl)flavone (2) with three known flavones (5-7) were isolated from the aerial parts of Dodonaea viscosa. Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, MS) and by comparison with literature data. The anti-inflammatory activity of five compounds (1-5) was evaluated with a flow cytometry TNF-alpha secretion assay on human THP-1 cell line.
Référence
Fitoterapia. 2012 Jul;83(5):859-63