Fiche personne
Coordonnées
Plateforme de séquençage à haut-débit (NGS)
UMS2008 IBSLor
Bâtiment BioPôle
Campus Brabois-Santé
9 avenue de la Forêt de Haye
BP 20199
54505 VANDOEUVRE-LES-NANCY
03 72 74 66 69
Territoire
Lorraine
Statut
Ingénieur/Technicien
Affiliation
Équipes/plateformes
Recherche
Mots clés : Next Generation Sequencing, RNA-seq, small RNA-seq, Exome (capture), RiboMethSeq, Ribosome profiling
Publications
A Zur-dependent regulatory RNA involved in maintaining zinc homeostasis in Staphylococcus aureus.
Charbonnier M, Racine H, Probst-Lotze S, Radin JN, Rios-Delgado G, Lyu L, Laster HM, Kohl MP, Mazgaj R, Blum M, Marchand V, Chicher J, Romby P, Marzi S, Caldelari I, Tree JJ, Waldron KJ, Boyd JM, Dutheil JY, Kehl-Fie TE, Lalaouna D
Nucleic Acids Res. 2026 09 7;54(17):
Chemistry and biology of oxidatively damaged RNA nucleotides.
Raorane K, Weber M, Marchand V, Helm M, Motorin Y
RSC Chem Biol. 2026 09 1;:
SNHG family lncRNAs promote Ewing sarcoma cell fitness through intronic snoRNA-guided rRNA modifications.
Briones-Martin-Del-Campo M, Lee AG, Dinh T, Marchand V, Motorin Y, Román M, Bi Q, Leung SG, Horlbeck MA, Sayles LC, Seong BKA, Gilbert L, Stegmaier K, Sweet-Cordero EA
NAR Cancer. 2026 09;8(3):zcag019
Comprehensive post-transcriptional modification profiles in individual Staphylococcus aureus tRNA species.
Jaramillo-Ponce JR, Wolff P, Marchand V, Motorin Y, Kohl M, Chane-Woon-Ming B, Kanazawa H, Ruiz-Paterson A, Paulus C, Chicher J, Lenon M, Krämer M, Gribling-Burrer AS, Stathopoulos C, Smyth R, Helm M, Romby P, Marzi S
Nucleic Acids Res. 2026 07 17;54(14):
Human RNA ligase 1 as a novel regulator of ribosome function and translation under oxidative stress.
Stumpf FM, Glauner M, Jansen J, Marchand V, Motorin Y, Stengel F, Marx A
Nucleic Acids Res. 2026 06 8;54(11):
ModiCal: A Targeted Calibration Workflow for Site-Specific mC Validation by Nanopore Direct RNA Sequencing.
Özrendeci Z, Mündnich S, Pastore S, Wu CC, Marchand V, Motorin Y, Ruggieri A, Gerber S, Helm M
ACS Chem Biol. 2026 05 19;:
tRNA modification landscapes in streptococci: shared losses and clade-specific adaptations.
Tsui HT, Chan CK, Yuan Y, Elias R, Sun J, Marchand V, Jaroch M, Sun G, Manzoor I, Kutchuashvili A, Leszczynska G, Seaton K, Motorin Y, Rice K, Swairjo M, Dedon PC, Winkler ME, de Crécy-Lagard V
Open Biol. 2026 04 15;16(4):
2'-O-Methylation maintains ribosome structural and translation integrity.
Zhao Y, Rai J, Cohen LN, Shu Y, Xu C, Goswami H, Chen X, Jin H, Marchand V, Motorin Y, Ghalei H, Li H
Mol Cell. 2026 04 1;:
Trub1-mediated pseudouridylation is dispensable for immune cell development and homeostasis.
Malviya V, Pham CT, Michiels L, Seldeslachts L, Marchand V, Vella G, Rangan L, Motorin Y, Vande Velde G, Lemaitre P, Schlenner SM
Genes Immun. 2026 03 24;:
Complementary DNA oligonucleotide direct in-gel quantification (cDINGQ) for precise tRNA fragment analysis.
Joerg M, Kristen M, Walz L, Lietz C, Mueller M, Nathal S, Marchand V, Motorin Y, Winz ML, Helm M, Friedland K
RNA. 2026 01 29;:
The two-step purification method ViREn identifies a single NSUN6-mediated 5-methylcytosine modification promoting dengue virus RNA genome turnover.
Wu CC, Naarmann-de Vries IS, Hartmann J, Nidoieva Z, Kopietz K, Marchand V, Özrendeci Z, Lindner D, Schelchshorn S, Flad S, Frye M, Papavasiliou FN, Schirmeister T, Stoecklin G, Schott J, Motorin Y, Tuorto F, Dieterich C, Helm M, Ruggieri A
Nucleic Acids Res. 2026 01 14;54(2):
Beyond RNA modification: a novel role for tRNA modifying enzyme in oxidative stress response and metabolism.
Fruchard L, Sudol C, Rouard C, Treffkorn-Maurau A, Hardy L, Bos J, Duchateau M, Giai Gianetto Q, Matondo M, Bonhomme F, Thuillier Q, Marchand V, Motorin Y, Bregeon D, Mazel D, Hamdane D, Baharoglu Z
Nucleic Acids Res. 2025 11 26;53(22):
Probing the function of J1074 gene for SPOUT family ribose methyltransferase.
Tseduliak V-M, Koshla O, Mulartschyk SN, Marchand V, Motorin Y, Helm M, Ostash B
Microbiol Spectr. 2025 11 26;:e0219225
Pseudouridine increases ribosome stability in a thermophilic eukaryote.
Wild K, Klein M, Burkard A, Marchand V, Kellner N, Paez A, Pastore S, Butto T, Motorin Y, Helm M, Sinning I
Nucleic Acids Res. 2025 11 26;53(22):
Mapping of HOCl-oxidized RNA identifies abasic sites as major damage and oxidation product of oxoG.
Weber M, Raorane K, Grampp CJ, Bourguignon V, Kilz LM, Glänzer D, Marchand V, Kreutz C, Motorin Y, Helm M
Nat Commun. 2025 11 21;16(1):10251
Fibrillarin-dependent 2'-O-methylation modulates RPS28 ribosome incorporation and oncogenic translation.
Groza P, Kumari K, Esteva-Socias M, Schott J, Bhattarai DP, Sajkowska JJ, Dasgupta R, Peula C, Destefanis E, Williams C, Marchand V, Wikström P, Wiberg R, Campos AB, Gilthorpe JD, Pop B, Mateus A, Motorin Y, Dassi E, Petzold K, Tuorto F, Aguilo F
Cancer Lett. 2025 11 17;:218124
Dynamic rRNA Methylation Regulates Translation in the Hematopoietic System and is Essential for Stem Cell Fitness.
Rabany O, Ben Dror S, Arafat M, Aharoni Levitanus H, Halperin Y, Marchand V, Romanovski N, Ussishkin N, Livneh Golany M, Reches A, Wexler J, Mayorek N, Monderer-Rothkoff G, Shifman S, Mâmmer Bouhou W, VanInsberghe M, Pauli C, Müller-Tidow C, Karmi O, Livneh Y, van Oudenaarden A, Motorin Y, Nachmani D
Blood. 2025 11 5;:
Ribosomal protein L5 (RPL5/uL18) I60V mutation is associated to increased translation and modulates drug sensitivity in T-cell acute lymphoblastic leukemia cells.
Bacci L, Pollutri D, Ripa IJ, D'Andrea M, Marchand V, Motorin Y, Hesse AM, Couté Y, Filipek K, Penzo M
Biochem Pharmacol. 2025 10 31;:117497
The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae.
Hardy L, Marchand V, Bourguignon V, Thuillier Q, Dias C, Krin E, Fruchard L, Yaacov DB, Mazel D, Motorin Y, Baharoglu Z
PLoS Genet. 2025 10 31;21(10):e1011937
Specificity and mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system.
Belukhina S, Saudemont B, Depardieu F, Lorthios T, P Maviza T, Livenskyi A, Serebryakova M, Aleksandrova M, Ukholkina E, Burmistrova N, Sergiev P, Libiad M, Dubrac S, Barras F, Motorin Y, Marchand V, Hagelueken G, Isaev A, Bikard D, Rouillon C
Philos Trans R Soc Lond B Biol Sci. 2025 09 4;380(1934):20240074
Engineering of novel DNA polymerase variants for single enzyme quantitative multiplex reverse transcription-PCR.
Huber LB, Marchand V, Somtürk M, Müller S, Marx A
Sci Rep. 2025 07 18;15(1):26147
Copy Number Determination of Sperm-Borne Small RNAs Implied in the Intergenerational Inheritance of Metabolic Syndromes.
Koenig L, Guggenberger V, Eleftheriou K, Pinter Z, Marotto A, Kreutz CR, Wossidlo M, Marchand V, Motorin Y, Schaefer MR
RNA. 2025 05 28;:
A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors.
Leroy E, Challal D, Pelletier S, Goncalves C, Menant A, Marchand V, Jaszczyszyn Y, van Dijk E, Naquin D, Andreani J, Motorin Y, Palancade B, Rougemaille M
Nat Commun. 2025 04 5;16(1):3250
Specific modulation of 28S_Um2402 rRNA 2'--ribose methylation as a novel epitranscriptomic marker of ZEB1-induced epithelial-mesenchymal transition in different mammary cell contexts.
Morin C, Paraqindes H, Van Long FN, Isaac C, Thomas E, Pedri D, Pulido-Vicuna CA, Morel AP, Marchand V, Motorin Y, Carrere M, Auclair J, Attignon V, Pommier RM, Ruiz E, Bourdelais F, Catez F, Durand S, Ferrari A, Viari A, Marine JC, Puisieux A, Diaz JJ, Moyret-Lalle C, Marcel V
NAR Cancer. 2025 03;7(1):zcaf001
TGT Damages its Substrate tRNAs by the Formation of Abasic Sites in the Anticodon Loop.
Kopietz K, Raorane K, Guo W, Flegler F, Bourguignon V, Thuillier Q, Kilz LM, Weber M, Marchand V, Reuter K, Tuorto F, Helm M, Motorin Y
J Mol Biol. 2025 02 25;:169000
Aminoglycoside tolerance in engages translational reprogramming associated with queuosine tRNA modification.
Fruchard L, Babosan A, Carvalho A, Lang M, Li B, Duchateau M, Giai Gianetto Q, Matondo M, Bonhomme F, Hatin I, Arbes H, Fabret C, Corler E, Sanchez G, Marchand V, Motorin Y, Namy O, de Crécy-Lagard V, Mazel D, Baharoglu Z
Elife. 2025 01 6;13:
The dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction.
Dominique C, Maiga NK, Méndez-Godoy A, Pillet B, Hamze H, Léger-Silvestre I, Henry Y, Marchand V, Gomes Neto V, Dez C, Motorin Y, Kressler D, Gadal O, Henras AK, Albert B
Nat Commun. 2024 10 31;15(1):9415
Differential redox sensitivity of tRNA dihydrouridylation.
Kilz LM, Zimmermann S, Marchand V, Bourguignon V, Sudol C, Brégeon D, Hamdane D, Motorin Y, Helm M
Nucleic Acids Res. 2024 10 26;:
A DNA Polymerase Variant Senses the Epigenetic Marker 5-Methylcytosine by Increased Misincorporation.
Henkel M, Fillbrunn A, Marchand V, Raghunathan G, Berthold MR, Motorin Y, Marx A
Angew Chem Int Ed Engl. 2024 10 24;:e202413304
Selective RNA pseudouridinylation in situ by circular gRNAs in designer organelles.
Schartel L, Jann C, Wierczeiko A, Butto T, Mündnich S, Marchand V, Motorin Y, Helm M, Gerber S, Lemke EA
Nat Commun. 2024 10 24;15(1):9177
DORQ-seq: high-throughput quantification of femtomol tRNA pools by combination of cDNA hybridization and Deep sequencing.
Kristen M, Lander M, Kilz LM, Gleue L, Jörg M, Bregeon D, Hamdane D, Marchand V, Motorin Y, Friedland K, Helm M
Nucleic Acids Res. 2024 10 14;52(18):e89
Exploring a unique class of flavoenzymes: Identification and biochemical characterization of ribosomal RNA dihydrouridine synthase.
Toubdji S, Thullier Q, Kilz LM, Marchand V, Yuan Y, Sudol C, Goyenvalle C, Jean-Jean O, Rose S, Douthwaite S, Hardy L, Baharoglu Z, de Crécy-Lagard V, Helm M, Motorin Y, Hamdane D, Brégeon D
Proc Natl Acad Sci U S A. 2024 08 6;121(32):e2401981121
TGF-β2 Induces Ribosome Activity, Alters Ribosome Composition and Inhibits IRES-Mediated Translation in Chondrocytes.
van den Akker GGH, Chabronova A, Housmans BAC, van der Vloet L, Surtel DAM, Cremers A, Marchand V, Motorin Y, Caron MMJ, Peffers MJ, Welting TJM
Int J Mol Sci. 2024 05 5;25(9):
Functional redundancy in tRNA dihydrouridylation.
Sudol C, Kilz LM, Marchand V, Thullier Q, Guérineau V, Goyenvalle C, Faivre B, Toubdji S, Lombard M, Jean-Jean O, de Crécy-Lagard V, Helm M, Motorin Y, Brégeon D, Hamdane D
Nucleic Acids Res. 2024 04 29;:
Mapping the tRNA modification landscape of Houston I and Toulouse.
Quaiyum S, Sun J, Marchand V, Sun G, Reed CJ, Motorin Y, Dedon PC, Minnick MF, de Crécy-Lagard V
Front Microbiol. 2024 03 13;15:1369018
Comprehensive map of ribosomal 2'-O-methylation and C/D box snoRNAs in Drosophila melanogaster.
Sklias A, Cruciani S, Marchand V, Spagnuolo M, Lavergne G, Bourguignon V, Brambilla A, Dreos R, Marygold SJ, Novoa EM, Motorin Y, Roignant JY
Nucleic Acids Res. 2024 02 28;:
Depletion of Abolishes ψ of 28S-U4966 and Affects the Ribosome Translational Apparatus.
Chabronova A, van den Akker G, Housmans BAC, Caron MMJ, Cremers A, Surtel DAM, Peffers MJ, van Rhijn LW, Marchand V, Motorin Y, Welting TJM
Int J Mol Sci. 2023 08 8;24(16):
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer.
García-Vílchez R, Añazco-Guenkova AM, Dietmann S, López J, Morón-Calvente V, D'Ambrosi S, Nombela P, Zamacola K, Mendizabal I, García-Longarte S, Zabala-Letona A, Astobiza I, Fernández S, Paniagua A, Miguel-López B, Marchand V, Alonso-López D, Merkel A, García-Tuñón I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Bárcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sánchez-Martín MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S
Mol Cancer. 2023 07 29;22(1):119
nicotianamine synthase activity affects nucleolar iron accumulation and impacts rDNA silencing and RNA methylation in Arabidopsis.
Montacié C, Riondet C, Wei L, Darriere T, Weiss A, Pontvianne F, Escande ML, de Bures A, Jobet E, Barbarossa A, Carpentier MC, Aarts MGM, Attina A, Hirtz C, David A, Marchand V, Motorin Y, Curie C, Mari S, Reichheld JP, Sáez-Vásquez J
J Exp Bot. 2023 05 14;:
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing.
Lucas MC, Pryszcz LP, Medina R, Milenkovic I, Camacho N, Marchand V, Motorin Y, Ribas de Pouplana L, Novoa EM
Nat Biotechnol. 2023 04 6;:
The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance.
Brazane M, Dimitrova DG, Pigeon J, Paolantoni C, Ye T, Marchand V, Da Silva B, Schaefer E, Angelova MT, Stark Z, Delatycki M, Dudding-Byth T, Gecz J, Plaçais PY, Teysset L, Préat T, Piton A, Hassan BA, Roignant JY, Motorin Y, Carré C
Life Sci Alliance. 2023 04;6(4):
A dual-purpose polymerase engineered for direct sequencing of pseudouridine and queuosine.
Huber LB, Kaur N, Henkel M, Marchand V, Motorin Y, Ehrenhofer-Murray AE, Marx A
Nucleic Acids Res. 2023 03 27;:
FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications.
Gawade K, Plewka P, Häfner SJ, Lund AH, Marchand V, Motorin Y, Szczesniak MW, Raczynska KD
Sci Rep. 2023 02 20;13(1):2974
Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis.
Chabronova A, van den Akker GGH, Housmans BAC, Caron MMJ, Cremers A, Surtel DAM, Wichapong K, Peffers MMJ, van Rhijn LW, Marchand V, Motorin Y, Welting TJM
Osteoarthritis Cartilage. 2023 01 5;:
Data Analysis Pipeline for Detection and Quantification of Pseudouridine (ψ) in RNA by HydraPsiSeq.
Pichot F, Marchand V, Helm M, Motorin Y
Methods Mol Biol. 2023 ;2624:207-223
Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines.
Pichot F, Hogg MC, Marchand V, Bourguignon V, Jirström E, Farrell C, Gibriel HA, Prehn JHM, Motorin Y, Helm M
Comput Struct Biotechnol J. 2022 12 19;21:401-417
SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.
Maharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MA
Mol Cell. 2022 09 16;:
Pseudouridylation of Epstein-Barr Virus Noncoding RNA EBER2 Facilitates Lytic Replication.
Henry BA, Marchand V, Schlegel BT, Helm M, Motorin Y, Lee N
RNA. 2022 09 13;:
Synthesis of point-modified mRNA.
Hertler J, Slama K, Schober B, Özrendeci Z, Marchand V, Motorin Y, Helm M
Nucleic Acids Res. 2022 09 5;:
Studies of mutations of assembly factor Hit 1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome.
Dreggors-Walker RE, Cohen LN, Khoshnevis S, Marchand V, Motorin Y, Ghalei H
J Biol Chem. 2022 07 14;:102261
Ribosomal RNA 2'--methylations regulate translation by impacting ribosome dynamics.
Khoshnevis S, Dreggors-Walker RE, Marchand V, Motorin Y, Ghalei H
Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2117334119
Machine learning algorithm for precise prediction of 2'-O-methylation (Nm) sites from experimental RiboMethSeq datasets.
Pichot F, Marchand V, Helm M, Motorin Y
Methods. 2022 Mar 18;:
Systematic mapping of rRNA 2'-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis.
Delhermite J, Tafforeau L, Sharma S, Marchand V, Wacheul L, Lattuca R, Desiderio S, Motorin Y, Bellefroid E, Lafontaine DLJ
PLoS Genet. 2022 Jan 18;18(1):e1010012
Balancing of mitochondrial translation through METTL8-mediated mC modification of mitochondrial tRNAs.
Schöller E, Marks J, Marchand V, Bruckmann A, Powell CA, Reichold M, Mutti CD, Dettmer K, Feederle R, Hüttelmaier S, Helm M, Oefner P, Minczuk M, Motorin Y, Hafner M, Meister G
Mol Cell. 2021 Nov 8;:
Constitutive and variable 2'-O-methylation (Nm) in human ribosomal RNA.
Motorin Y, Quinternet M, Rhalloussi W, Marchand V
RNA Biol. 2021 Sep 10;:1-10
Analysis of pseudouridines and other RNA modifications using hydraPsiSeq protocol.
Marchand V, Bourguignon-Igel V, Helm M, Motorin Y
Methods. 2021 Sep 1;:
Implication of repeat insertion domains in the trans-activity of the long non-coding RNA ANRIL.
Alfeghaly C, Sanchez A, Rouget R, Thuillier Q, Igel-Bourguignon V, Marchand V, Branlant C, Motorin Y, Behm-Ansmant I, Maenner S
Nucleic Acids Res. 2021 Apr 19;:
Detection and functions of viral RNA modifications: perspectives in biology and medicine.
Marchand V, Motorin Y
Virologie (Montrouge). 2021 Apr 1;25(2):5-20
[Detection and functions of viral RNA modifications: perspectives in biology and medicine].
Marchand V, Motorin Y
Virologie (Montrouge). 2021 Apr 1;25(2):93-110
FTO-mediated cytoplasmic mA demethylation adjusts stem-like properties in colorectal cancer cell.
Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, Vialaret J, Attina A, Debart F, Choquet A, Macari F, Marchand V, Motorin Y, Samalin E, Vasseur JJ, Pannequin J, Aguilo F, Lopez-Crapez E, Hirtz C, Rivals E, Bastide A, David A
Nat Commun. 2021 Mar 19;12(1):1716
Instrumental analysis of RNA modifications.
Yoluç Y, Ammann G, Barraud P, Jora M, Limbach PA, Motorin Y, Marchand V, Tisné C, Borland K, Kellner S
Crit Rev Biochem Mol Biol. 2021 Feb 22;:1-27
Mapping rRNA 2'-O-methylations and identification of C/D snoRNAs in Arabidopsis thaliana plants.
Azevedo-Favory J, Gaspin C, Ayadi L, Montacié C, Marchand V, Jobet E, Rompais M, Carapito C, Motorin Y, Sáez-Vásquez J
RNA Biol. 2021 Feb 17;:1-18
Analysis of RNA Modifications by Second- and Third-Generation Deep Sequencing: 2020 Update.
Motorin Y, Marchand V
Genes (Basel). 2021 Feb 16;12(2):
Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo.
Heiss M, Hagelskamp F, Marchand V, Motorin Y, Kellner S
Nat Commun. 2021 Jan 15;12(1):389
Non-Redundant tRNA Reference Sequences for Deep Sequencing Analysis of tRNA Abundance and Epitranscriptomic RNA Modifications.
Pichot F, Marchand V, Helm M, Motorin Y
Genes (Basel). 2021 Jan 10;12(1):
Isolation, Extraction and Deep-Sequencing Analysis of Extracellular RNAs (exRNAs) from Human Plasma.
Marchand V, Galvanin A, Motorin Y
Methods Mol Biol. 2021 ;2300:165-182
Mapping of 7-methylguanosine (mG), 3-methylcytidine (mC), dihydrouridine (D) and 5-hydroxycytidine (hoC) RNA modifications by AlkAniline-Seq.
Marchand V, Bourguignon-Igel V, Helm M, Motorin Y
Methods Enzymol. 2021 ;658:25-47
Quantitative and Qualitative Assessment of Small RNA Preparations.
Marchand V, Ayadi L, Bourguignon-Igel V, Motorin Y
Methods Mol Biol. 2021 ;2300:17-29
NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination.
Werner S, Galliot A, Pichot F, Kemmer T, Marchand V, Sednev MV, Lence T, Roignant JY, König J, Höbartner C, Motorin Y, Hildebrandt A, Helm M
Nucleic Acids Res. 2020 Dec 11;:
Bacterial tRNA 2'-O-methylation is dynamically regulated under stress conditions and modulates innate immune response.
Galvanin A, Vogt LM, Grober A, Freund I, Ayadi L, Bourguignon-Igel V, Bessler L, Jacob D, Eigenbrod T, Marchand V, Dalpke A, Helm M, Motorin Y
Nucleic Acids Res. 2020 Dec 4;:
Ribosomal RNA 2'O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer.
Marcel V, Kielbassa J, Marchand V, Natchiar KS, Paraqindes H, Nguyen Van Long F, Ayadi L, Bourguignon-Igel V, Lo Monaco P, Monchiet D, Scott V, Tonon L, Bray SE, Diot A, Jordan LB, Thompson AM, Bourdon JC, Dubois T, André F, Catez F, Puisieux A, Motorin Y, Klaholz BP, Viari A, Diaz JJ
NAR Cancer. 2020 Dec;2(4):zcaa036
HydraPsiSeq: a method for systematic and quantitative mapping of pseudouridines in RNA.
Marchand V, Pichot F, Neybecker P, Ayadi L, Bourguignon-Igel V, Wacheul L, Lafontaine DLJ, Pinzano A, Helm M, Motorin Y
Nucleic Acids Res.. 2020 Sep 25;:
Manganese Ions Individually Alter the Reverse Transcription Signature of Modified Ribonucleosides.
Kristen M, Plehn J, Marchand V, Friedland K, Motorin Y, Helm M, Werner S
Genes (Basel). 2020 Aug 18;11(8):
Survey and Validation of tRNA Modifications and Their Corresponding Genes in sp Subtilis Strain 168.
de Crécy-Lagard V, Ross RL, Jaroch M, Marchand V, Eisenhart C, Brégeon D, Motorin Y, Limbach PA
Biomolecules. 2020 Jun 30;10(7):
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations.
Trzaska C, Amand S, Bailly C, Leroy C, Marchand V, Duvernois-Berthet E, Saliou JM, Benhabiles H, Werkmeister E, Chassat T, Guilbert R, Hannebique D, Mouray A, Copin MC, Moreau PA, Adriaenssens E, Kulozik A, Westhof E, Tulasne D, Motorin Y, Rebuffat S, Lejeune F
Nat Commun. 2020 Mar 20;11(1):1509
Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes.
Werner S, Schmidt L, Marchand V, Kemmer T, Falschlunger C, Sednev MV, Bec G, Ennifar E, Höbartner C, Micura R, Motorin Y, Hildebrandt A, Helm M
Nucleic Acids Res.. 2020 Feb 25;:
Analysis of fibroblasts from patients with cblC and cblG genetic defects of cobalamin metabolism reveals global dysregulation of alternative splicing.
Rashka C, Hergalant S, Dreumont N, Oussalah A, Camadro JM, Marchand V, Hassan Z, Baumgartner MR, Rosenblatt DS, Feillet F, Guéant JL, Coelho D
Hum. Mol. Genet.. 2020 Feb 18;:
tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila.
Angelova MT, Dimitrova DG, Da Silva B, Marchand V, Jacquier C, Achour C, Brazane M, Goyenvalle C, Bourguignon-Igel V, Shehzada S, Khouider S, Lence T, Guerineau V, Roignant JY, Antoniewski C, Teysset L, Bregeon D, Motorin Y, Schaefer MR, Carré C
Nucleic Acids Res.. 2020 Jan 16;:
Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2'-O-Methylations in RNA by RiboMethSeq.
Pichot F, Marchand V, Ayadi L, Bourguignon-Igel V, Helm M, Motorin Y
Front Genet. 2020 ;11:38
Diversity and heterogeneity of extracellular RNA in human plasma.
Galvanin A, Dostert G, Ayadi L, Marchand V, Velot É, Motorin Y
Biochimie. 2019 May 17;:
2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.
Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T
RNA. 2019 Apr 24;:
Absolute quantification of noncoding RNA by microscale thermophoresis.
Jacob D, Thüring K, Galliot A, Marchand V, Galvanin A, Ciftci A, Scharmann K, Stock M, Roignant JY, Leidel SA, Motorin Y, Schaffrath R, Klassen R, Helm M
Angew. Chem. Int. Ed. Engl.. 2019 Mar 20;:
Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.
Wei J, Kishton RJ, Angel M, Conn CS, Dalla-Venezia N, Marcel V, Vincent A, Catez F, Ferré S, Ayadi L, Marchand V, Dersh D, Gibbs JS, Ivanov IP, Fridlyand N, Couté Y, Diaz JJ, Qian SB, Staudt LM, Restifo NP, Yewdell JW
Mol. Cell. 2019 Jan 24;:
FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.
Ringeard M, Marchand V, Decroly E, Motorin Y, Bennasser Y
Nature. 2019 Jan 9;:
Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures.
Schmidt L, Werner S, Kemmer T, Niebler S, Kristen M, Ayadi L, Johe P, Marchand V, Schirmeister T, Motorin Y, Hildebrandt A, Schmidt B, Helm M
Front Genet. 2019 ;10:876
Mapping and Quantification of tRNA 2'-O-Methylation by RiboMethSeq.
Galvanin A, Ayadi L, Helm M, Motorin Y, Marchand V
Methods Mol. Biol.. 2019 ;1870:273-295
Detection and Analysis of RNA Ribose 2'-O-Methylations: Challenges and Solutions.
Motorin Y, Marchand V
Genes (Basel). 2018 Dec 18;9(12):
RNA ribose methylation (2'-O-methylation): Occurrence, biosynthesis and biological functions.
Ayadi L, Galvanin A, Pichot F, Marchand V, Motorin Y
Biochim Biophys Acta Gene Regul Mech. 2018 Dec 17;:
AlkAniline-Seq: profiling of m7G and m3C RNA modifications at single nucleotide resolution.
Marchand V, Ayadi L, Ernst FGM, Hertler J, Bourguignon-Igel V, Galvanin A, Kotter A, Helm M, Lafontaine DLJ, Motorin Y
Angew. Chem. Int. Ed. Engl.. 2018 Oct 29;:
Double methylation of tRNA-U54 to 2'-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7.
Keller P, Freund I, Marchand V, Bec G, Huang R, Motorin Y, Eigenbrod T, Dalpke A, Helm M
Nucleic Acids Res.. 2018 Aug 8;:
A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure.
Dal Magro C, Keller P, Kotter A, Werner S, Duarte V, Marchand V, Ignarski M, Freiwald A, Müller RU, Dieterich C, Motorin Y, Butter F, Atta M, Helm M
Angew. Chem. Int. Ed. Engl.. 2018 Apr 6;:
Engineering of a DNA Polymerase for Direct m A Sequencing.
Aschenbrenner J, Werner S, Marchand V, Adam M, Motorin Y, Helm M, Marx A
Angew. Chem. Int. Ed. Engl.. 2018 Jan 8;57(2):417-421
APRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients.
Guéant JL, Chéry C, Oussalah A, Nadaf J, Coelho D, Josse T, Flayac J, Robert A, Koscinski I, Gastin I, Filhine-Tresarrieu P, Pupavac M, Brebner A, Watkins D, Pastinen T, Montpetit A, Hariri F, Tregouët D, Raby BA, Chung WK, Morange PE, Froese DS, Baumgartner MR, Benoist JF, Ficicioglu C, Marchand V, Motorin Y, Bonnemains C, Feillet F, Majewski J, Rosenblatt DS
Nat Commun. 2018 01 4;9(1):67
Quantification of 2'-O-Me Residues in RNA Using Next-Generation Sequencing (Illumina RiboMethSeq Protocol).
Ayadi L, Motorin Y, Marchand V
Methods Mol. Biol.. 2018 ;1649:29-48
Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes.
Erales J, Marchand V, Panthu B, Gillot S, Belin S, Ghayad SE, Garcia M, Laforêts F, Marcel V, Baudin-Baillieu A, Bertin P, Couté Y, Adrait A, Meyer M, Therizols G, Yusupov M, Namy O, Ohlmann T, Motorin Y, Catez F, Diaz JJ
Proc. Natl. Acad. Sci. U.S.A.. 2017 Dec 5;114(49):12934-12939
Identification of sites of 2'-O-methylation vulnerability in human ribosomal RNAs by systematic mapping.
Sharma S, Marchand V, Motorin Y, Lafontaine DLJ
Sci Rep. 2017 Sep;7(1):11490
Next-Generation Sequencing-Based RiboMethSeq Protocol for Analysis of tRNA 2'-O-Methylation.
Marchand V, Pichot F, Thüring K, Ayadi L, Freund I, Dalpke A, Helm M, Motorin Y
Biomolecules. 2017 Feb;7(1):
High-Throughput Mapping of 2'-O-Me Residues in RNA Using Next-Generation Sequencing (Illumina RiboMethSeq Protocol).
Marchand V, Ayadi L, El Hajj A, Blanloeil-Oillo F, Helm M, Motorin Y
Methods Mol. Biol.. 2017 ;1562:171-187
High-throughput sequencing for 1-methyladenosine (m(1)A) mapping in RNA.
Tserovski L, Marchand V, Hauenschild R, Blanloeil-Oillo F, Helm M, Motorin Y
Methods. 2016 Sep;107:110-21
Illumina-based RiboMethSeq approach for mapping of 2'-O-Me residues in RNA.
Marchand V, Blanloeil-Oillo F, Helm M, Motorin Y
Nucleic Acids Res.. 2016 Sep;44(16):e135
Structural and functional analysis of the Rous Sarcoma virus negative regulator of splicing and demonstration of its activation by the 9G8 SR protein.
Bar A, Marchand V, Khoury G, Dreumont N, Mougin A, Robas N, Stevenin J, Visvikis A, Branlant C
Nucleic Acids Res. 2011 Apr;39(8):3388-403
