Triplet-Triplet Annihilation Upconversion Based Photolysis: Applications in Photopharmacology.
Fiche publication
Date publication
avril 2024
Journal
Advanced healthcare materials
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FRISCH Benoit, Dr HEURTAULT Béatrice, Dr KICHLER Antoine, Dr SPECHT Alexandre
Tous les auteurs :
Klimezak M, Chaud J, Brion A, Bolze F, Frisch B, Heurtault B, Kichler A, Specht A
Lien Pubmed
Résumé
The emerging field of photopharmacology is a promising chemobiological methodology for optical control of drug activities that could ultimately solve the off-target toxicity outside the disease location of many drugs for the treatment of a given pathology. The use of photolytic reactions looks very attractive for a light activated drug release but requires to develop photolytic reactions sensitive to red or NIR light excitation for better tissue penetration. In this review, we will present the concepts of triplet-triplet annihilation upconversion (TTA-UC) based photolysis and their recent in vivo applications for light induced drug delivery using photoactivatable nanoparticles (NPs). This article is protected by copyright. All rights reserved.
Mots clés
drug delivery, nanomedicine, photopharmacology, triplet‐triplet annihilation upconversion, uncaging
Référence
Adv Healthc Mater. 2024 04 13;:e2400354