Design of a new cell penetrating peptide for DNA, siRNA and mRNA delivery.
Fiche publication
Date publication
décembre 2021
Journal
The journal of gene medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FRISCH Benoit, Dr KICHLER Antoine
Tous les auteurs :
Ali S, Dussouillez C, Padilla B, Frisch B, Mason AJ, Kichler A
Lien Pubmed
Résumé
Delivery systems, including peptide-based ones, that destabilize endosomes in a pH-dependent manner are increasingly used to deliver cargoes of therapeutic interest such as nucleic acids and proteins into mammalian cells.
Mots clés
DNA transfection, cationic peptide, cell penetrating peptide, histidine residues, mRNA vectorization, siRNA delivery
Référence
J Gene Med. 2021 Dec 2;:e3401