Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress.

Sandoz J, Cigrang M, Zachayus A, Catez P, Donnio LM, Elly C, Nieminuszczy J, Berico P, Braun C, Alekseev S, Egly JM, Niedzwiedz W, Giglia-Mari G, Compe E, Coin F

Nat Commun. 2023 01 20;14(1):341

XPF activates break-induced telomere synthesis.

Guh CY, Shen HJ, Chen LW, Chiu PC, Liao IH, Lo CC, Chen Y, Hsieh YH, Chang TC, Yen CP, Chen YY, Chen TW, Chen LY, Wu CS, Egly JM, Chu HC

Nat Commun. 2022 10 2;13(1):5781

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary.

Schmauck-Medina T, Molière A, Lautrup S, Zhang J, Chlopicki S, Madsen HB, Cao S, Soendenbroe C, Mansell E, Vestergaard MB, Li Z, Shiloh Y, Opresko PL, Egly JM, Kirkwood T, Verdin E, Bohr VA, Cox LS, Stevnsner T, Rasmussen LJ, Fang EF

Aging (Albany NY). 2022 08 29;14(undefined):

Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions.

Compe E, Pangou E, Le May N, Elly C, Braun C, Hwang JH, Coin F, Sumara I, Choi KW, Egly JM

Sci Adv. 2022 08 19;8(33):eabp9457

Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cells.

Costanzo F, Martínez Diez M, Santamaría Nuñez G, Díaz-Hernandéz JI, Genes Robles CM, Díez Pérez J, Compe E, Ricci R, Li TK, Coin F, Martínez Leal JF, Garrido-Martin EM, Egly JM

EMBO Mol Med. 2022 Mar 9;:e14841

CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma.

Berico P, Cigrang M, Davidson G, Braun C, Sandoz J, Legras S, Vokshi BH, Slovic N, Peyresaubes F, Gene Robles CM, Egly JM, Compe E, Davidson I, Coin F

EMBO Rep. 2021 Jul 23;:e51683

The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes.

Compe E, Egly JM

Annu Rev Biochem. 2021 Jun 20;90:193-219

The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division.

Paccosi E, Costanzo F, Costantino M, Balzerano A, Monteonofrio L, Soddu S, Prantera G, Brancorsini S, Egly JM, Proietti-De-Santis L

Proc Natl Acad Sci U S A. 2020 Nov 16;:

In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair.

Peissert S, Sauer F, Grabarczyk DB, Braun C, Sander G, Poterszman A, Egly JM, Kuper J, Kisker C

Nat Commun. 2020 Apr 3;11(1):1667

Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome.

Epanchintsev A, Rauschendorf MA, Costanzo F, Calmels N, Obringer C, Sarasin A, Coin F, Laugel V, Egly JM

Sci Rep. 2020 Jan 24;10(1):1105

Dysregulation of LXR responsive genes contribute to ichthyosis in trichothiodystrophy.

Hashimoto S, Takanari H, Compe E, Egly JM

J. Dermatol. Sci.. 2020 Jan 24;:

DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.

Semer M, Bidon B, Larnicol A, Caliskan G, Catez P, Egly JM, Coin F, Le May N

Nat. Chem. Biol.. 2019 Sep 16;:

Variants in MED12L, encoding a subunit of the mediator kinase module, are responsible for intellectual disability associated with transcriptional defect.

Nizon M, Laugel V, Flanigan KM, Pastore M, Waldrop MA, Rosenfeld JA, Marom R, Xiao R, Gerard A, Pichon O, Le Caignec C, Gérard M, Dieterich K, Truitt Cho M, McWalter K, Hiatt S, Thompson ML, Bézieau S, Wadley A, Wierenga KJ, Egly JM, Isidor B

Genet. Med.. 2019 Jun 3;:

TFIIE orchestrates the recruitment of the TFIIH kinase module at promoter before release during transcription.

Compe E, Genes CM, Braun C, Coin F, Egly JM

Nat Commun. 2019 May 7;10(1):2084

Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.

Sandoz J, Nagy Z, Catez P, Caliskan G, Geny S, Renaud JB, Concordet JP, Poterszman A, Tora L, Egly JM, Le May N, Coin F

Nat Commun. 2019 Mar 20;10(1):1288

C1D is not directly involved in the repair of UV-damaged DNA but protects cells from oxidative stress by regulating gene expressions in human cell lines.

Tomita T, Ieguchi K, Takita M, Tsukahara F, Yamada M, Egly JM, Maru Y

J. Biochem.. 2018 Aug 27;:

XPC is an RNA polymerase II cofactor recruiting ATAC to promoters by interacting with E2F1.

Bidon B, Iltis I, Semer M, Nagy Z, Larnicol A, Cribier A, Benkirane M, Coin F, Egly JM, Le May N

Nat Commun. 2018 Jul 4;9(1):2610

Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation.

Epanchintsev A, Costanzo F, Rauschendorf MA, Caputo M, Ye T, Donnio LM, Proietti-de-Santis L, Coin F, Laugel V, Egly JM

Mol. Cell. 2017 Dec 21;68(6):1054-1066.e6

Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro.

Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schröter F, Royer-Pokora B, Hildebrandt B, Schmuck M, Epanchintsev A, Theiss S, Adjaye J, Egly JM, Krutmann J, Fritsche E

Stem Cell Res. 2017 Dec;25:72-82

The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.

Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt DR, Kuper J, Cianférani S, Egly JM, Poterszman A, Kisker C

Nucleic Acids Res.. 2017 Aug;:

MED12-related XLID disorders are dose-dependent of immediate early genes (IEGs) expression.

Donnio LM, Bidon B, Hashimoto S, May M, Epantchintsev A, Ryan C, Allen W, Hackett A, Gecz J, Skinner C, Stevenson RE, de Brouwer AP, Coutton C, Francannet C, Jouk PS, Schwartz CE, Egly JM

Hum. Mol. Genet.. 2017 Mar;:

Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression.

Alekseev S, Nagy Z, Sandoz J, Weiss A, Egly JM, Le May N, Coin F

Mol. Cell. 2017 Feb;65(3):504-514.e4

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

Anastasina M, Le May N, Bugai A, Fu Y, Söderholm S, Gaelings L, Ohman T, Tynell J, Kyttänen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE

Biochim. Biophys. Acta. 2016 Nov;1859(11):1440-1448

Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.

Santamaría Nuñez G, Robles CM, Giraudon C, Martínez-Leal JF, Compe E, Coin F, Aviles P, Galmarini CM, Egly JM

Mol. Cancer Ther.. 2016 Oct;15(10):2399-2412

Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond.

Compe E, Egly JM

Annu. Rev. Biochem.. 2016 Jun;85:265-90

Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor.

Coin F, Egly JM

Mol Cell. 2015 Aug 20;59(4):513-4

Crystal structure of the Rad3/XPD regulatory domain of Ssl1/p44.

Kim JS, Saint-Andre C, Lim HS, Hwang CS, Egly JM, Cho Y

J Biol Chem. 2015 Mar 27;290(13):8321-30

TFIIH subunit alterations causing xeroderma pigmentosum and trichothiodystrophy specifically disturb several steps during transcription.

Singh A, Compe E, Le May N, Egly JM

Am J Hum Genet. 2015 Feb 5;96(2):194-207

TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin.

Arseni L, Lanzafame M, Compe E, Fortugno P, Afonso-Barroso A, Peverali FA, Lehmann AR, Zambruno G, Egly JM, Stefanini M, Orioli D

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1499-504

Dynamic partnership between TFIIH, PGC-1alpha and SIRT1 is impaired in trichothiodystrophy.

Traboulsi H, Davoli S, Catez P, Egly JM, Compe E

PLoS Genet. 2014 Oct 23;10(10):e1004732

In TFIIH, XPD helicase is exclusively devoted to DNA repair.

Kuper J, Braun C, Elias A, Michels G, Sauer F, Schmitt DR, Poterszman A, Egly JM, Kisker C

PLoS Biol. 2014 Sep 30;12(9):e1001954

Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin.

Ziani S, Nagy Z, Alekseev S, Soutoglou E, Egly JM, Coin F

J Cell Biol. 2014 Sep 1;206(5):589-98

Response to Emanuele.

Gueranger Q, Li F, Peacock M, Larnicol-Fery A, Brem R, Macpherson P, Egly JM, Karran P

J Invest Dermatol. 2014 Jul;134(7):2053-5

Protein oxidation and DNA repair inhibition by 6-thioguanine and UVA radiation.

Gueranger Q, Li F, Peacock M, Larnicol-Fery A, Brem R, Macpherson P, Egly JM, Karran P

J Invest Dermatol. 2014 May;134(5):1408-17

A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of TFIIH and the chemosensitization of tumor cells to platinum.

Alekseev S, Ayadi M, Brino L, Egly JM, Larsen AK, Coin F

Chem Biol. 2014 Mar 20;21(3):398-407

Design and development of a robotized system coupled to microCT imaging for intratumoral drug evaluation in a HCC mouse model.

Bour G, Martel F, Goffin L, Bayle B, Gangloff J, Aprahamian M, Marescaux J, Egly JM

PLoS One. 2014 Sep 9;9(9):e106675

Abnormal XPD-induced nuclear receptor transactivation in DNA repair disorders: trichothiodystrophy and xeroderma pigmentosum.

Zhou X, Khan SG, Tamura D, Ueda T, Boyle J, Compe E, Egly JM, DiGiovanna JJ, Kraemer KH

Eur J Hum Genet. 2013 Aug;21(8):831-7

Design and in vivo evaluation of a robotized needle insertion system for small animals.

Goffin L, Bour G, Martel F, Nicolau S, Gangloff J, Egly JM, Bayle B

IEEE Trans Biomed Eng. 2013 Aug;60(8):2193-204

Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress.

Kristensen U, Epanchintsev A, Rauschendorf MA, Laugel V, Stevnsner T, Bohr VA, Coin F, Egly JM

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2261-70

Cockayne syndrome group B (CSB) protein: at the crossroads of transcriptional networks.

Velez-Cruz R, Egly JM

Mech Ageing Dev. 2013 May-Jun;134(5-6):234-42

XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression.

Orioli D, Compe E, Nardo T, Mura M, Giraudon C, Botta E, Arrigoni L, Peverali FA, Egly JM, Stefanini M

Hum Mol Genet. 2013 Mar 15;22(6):1061-73

Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells.

Velez-Cruz R, Zadorin AS, Coin F, Egly JM

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E212-20

Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.

Le May N, Iltis I, Ame JC, Zhovmer A, Biard D, Egly JM, Schreiber V, Coin F

Mol Cell. 2012 Dec 14;48(5):785-98

XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes.

Le May N, Fradin D, Iltis I, Bougneres P, Egly JM

Mol Cell. 2012 Aug 24;47(4):622-32

TFIIH: when transcription met DNA repair.

Compe E, Egly JM

Nat Rev Mol Cell Biol. 2012 May 10;13(6):343-54

[Early gene expression dysregulation and intellectual disability].

Boissel S, Hashimoto S, Rio M, Zarhrate M, Munnich A, Colleaux L, Egly JM

Med Sci (Paris). 2012 Feb;28(2):128-9

Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations.

Bueren-Calabuig JA, Giraudon C, Galmarini CM, Egly JM, Gago F

Nucleic Acids Res. 2011 Oct;39(18):8248-57

[DNA repair mechanisms: from basic biology to genetic pathology].

Egly JM

Bull Acad Natl Med. 2011 Oct;195(7):1689-90.

MED23 mutation links intellectual disability to dysregulation of immediate early gene expression.

Hashimoto S, Boissel S, Zarhrate M, Rio M, Munnich A, Egly JM, Colleaux L

Science. 2011 Aug 26;333(6046):1161-3.

XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids.

Feuerhahn S, Giraudon C, Martinez-Diez M, Bueren-Calabuig JA, Galmarini CM, Gago F, Egly JM

Chem Biol. 2011 Aug 26;18(8):988-99.

A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.

Egly JM, Coin F

DNA Repair (Amst). 2011 Jul 15;10(7):714-21

Myo-InositolTrisPyroPhosphate treatment leads to HIF-1alpha suppression and eradication of early hepatoma tumors in rats.

Aprahamian M, Bour G, Akladios CY, Fylaktakidou K, Greferath R, Soler L, Marescaux J, Egly JM, Lehn JM, Nicolau C

Chembiochem. 2011 Mar 21;12(5):777-83

The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process.

Chymkowitch P, Le May N, Charneau P, Compe E, Egly JM

EMBO J. 2011 Feb 2;30(3):468-79

Mechanics of the IL2RA gene activation revealed by modeling and atomic force microscopy.

Milani P, Marilley M, Sanchez-Sevilla A, Imbert J, Vaillant C, Argoul F, Egly JM, Rocca-Serra J, Arneodo A

PLoS One. 2011 Apr 13;6(4):e18811.

A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.

Anindya R, Mari PO, Kristensen U, Kool H, Giglia-Mari G, Mullenders LH, Fousteri M, Vermeulen W, Egly JM, Svejstrup JQ

Mol Cell. 2010 Jun 11;38(5):637-48.

NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack.

Le May N, Mota-Fernandes D, Velez-Cruz R, Iltis I, Biard D, Egly JM

Mol Cell. 2010 Apr 9;38(1):54-66.

Mutation Update for the CSB/ERCC6 and CSA/ERCC8 Genes Involved in Cockayne Syndrome

Laugel V, Dalloz C, Durand M, Sauvanaud F, Kristensen U, Vincent MC, Pasquier L, Odent S, Cormier-Daire V, Gener B, Tobias ES, Tolmie JL, Martin-Coignard D, Drouin-Garraud V, Heron D, Journel H, Raffo E, Vigneron J, Lyonnet S, Murday V, Gubser-Mercati D, Funalot B, Brueton L, del Pozo JS, Munoz E, Gennery AR, Salih M, Noruzinia M, Prescott K, Ramos L, Stark Z, Fieggen K, Chabrol B, Sarda P, Edery P, Bloch-Zupan A, Fawcett H, Pham D, Egly JM, Lehmann AR, Sarasin A, Dollfus H

Hum Mutat. 2010 Feb;31(2):113-26.