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UMR 7365 IMoPA - Equipe "Enzymologie Moléculaire & Structurale (EMS)

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Territoire

Lorraine

Coordonnées

UMR 7365 CNRS-UL IMoPA
Biopôle de l’Université de Lorraine
Campus Biologie Santé
9 Avenue de la Forêt de Haye
CS 50184

54505 VANDOEUVRE-LES-NANCY

Recherche

Thématique de recherche :

The EMS team is interested in establishing structure/function relationships for enzymes and multienzymatic complexes using a diverse range of expertise (molecular biology, protein production/purification, protein biochemistry, pre- and steady state kinetics, structural biology, biophysical analysis, synthetic biology, etc.), addressing issues of catalytic mechanism, as well as the molecular basis for substrate specificity and interactions with partner proteins. Targets studied can be classified into two main areas: cysteine- containing enzymes involved in redox cellular regulation and cellular metabolism and modular megaenzymes called polyketide synthases (PKSs), which participate in the biosynthesis in bacteria of secondary metabolites of high clinical value.


Mots clés : Rétinal déshydrogénase, Sulfiredoxine, Sextrine, Peroxyrédoxine, Méthionine sulfoydes réductases, Stress oxydant
Cysteine redox enzymology, modular polyketide synthases (PKSs), molecular mechanism, catalysis, specificity, structure-function relationships, kinetics, synthetic biology