Dr METZGER Daniel

KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer.

Peñarando J, Willmann D, Sum M, Jia Y, Berlin C, Braun LM, Chen Z, Urban S, Jung M, Duteil D, Metzger D, Gratzke C, Zeiser R, Greschik H, Schüle R, Metzger E

Mol Cancer. 2026 09 17;25(1):

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair.

Souali-Crespo S, Rizk JG, Calvano E, Sahu R, Colovic E, Chabba I, Gilbart V, Grandgirard E, Morlet B, Cai Q, Metzger D, Duteil D

Adv Sci (Weinh). 2026 09 13;:e77653

Androgen receptor imprints satellite cell stemness and preserves their reservoir for lifelong regeneration and optimal repair.

Rizk JG, Ghaibour KC, Souali-Crespo S, Calvano E, Bilger A, Jacobs H, Messaddeq N, Cai Q, Grangirard E, Sahu R, Ferry A, Fourcade V, Zoll J, Zanardelli G, Molina N, Fontaine C, Arnal JF, Metzger D, Duteil D

Sci Adv. 2026 09 11;12(37):eaec8073

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Metzger D

Proc Natl Acad Sci U S A. 2026 07 7;123(27):e2618999123

Impaired vitamin D signaling reveals neutrophils as key drivers of prostate cancer dissemination.

Len-Tayon K, Gantzer J, Dariane C, Fogel O, Friedrich V, Rovito D, Lindner V, Gilbart V, Yanushko D, Henri S, Metzger D, Laverny G

EMBO Mol Med. 2026 04 10;:

HIF1 inhibition targets tumoral and myeloid cells, and is a promising therapy for metastatic castration-resistant prostate cancer.

Yanushko D, Pichot A, Vincent A, Keime C, Laverny G, Metzger D

Cell Death Dis. 2026 03 27;:

Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy.

Baurès M, Vieira Aleixo AS, Pacreau E, Koshy A, Friedrich V, Diedisheim M, Raigel M, Hua Y, Dariane C, Boutillon F, Kenner L, Marine JC, Laverny G, Metzger D, Rambow F, Guidotti JE, Goffin V

EMBO Mol Med. 2026 02 2;:

Characterization of the immune landscape in healthy mouse prostate and during prostate cancer progression.

Pervizou D, De Chiara J, Spinelli L, Nestor-Martin M, Chasson L, Len-Tayon K, Yanushko D, Fiore F, Bajénoff M, Malissen B, Metzger D, Laverny G, Henri S

Oncoimmunology. 2025 12;14(1):2562220

Enhanced proteasome activity in perifascicular myofibres is a hallmark of dermatomyositis and its inhibition is efficient in preclinical models.

Debrut L, Giannini M, Quiring G, Perniola S, Rovito D, Keime C, Lannes B, Nadaj-Pakleza A, Chanson JB, Charles AL, Geny B, Metzger D, Laverny G, Meyer A

Ann Rheum Dis. 2025 10 6;:

Experimental myositis: an optimised version of C-protein-induced myositis.

Giannini M, Rovito D, Oulad-Abdelghani M, Messaddeq N, Debrut L, Quiring G, Kessler P, Charles AL, Geny B, Metzger D, Laverny G, Meyer A

RMD Open. 2025 03 5;11(1):

[New insights of vitamin D-based therapy for prostate cancer].

Len-Tayon K, Metzger D, Laverny G

Med Sci (Paris). 2025 02;41(2):154-159

p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment.

Yanushko D, German Falcon B, El Bizri R, Pervizou D, Dolgos R, Keime C, Ye T, Thibault-Carpentier C, Le Magnen C, Henri S, Laverny G, Metzger D

Cell Death Dis. 2025 01 26;16(1):46

A vitamin D-based strategy overcomes chemoresistance in prostate cancer.

Len-Tayon K, Beraud C, Fauveau C, Belorusova AY, Chebaro Y, Mouriño A, Massfelder T, Chauchereau A, Metzger D, Rochel N, Laverny G

Br J Pharmacol. 2024 07 9;:

LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice.

Cai Q, Sahu R, Ueberschlag-Pitiot V, Souali-Crespo S, Charvet C, Silem I, Cottard F, Ye T, Taleb F, Metzger E, Schuele R, Billas IML, Laverny G, Metzger D, Duteil D

Nat Commun. 2024 04 26;15(1):3563

[Hope for a new treatment for castration-resistant prostate cancer].

Terzic J, Metzger D

Med Sci (Paris). 2023 10;39(10):709-711

An Efficient Protocol for CUT&RUN Analysis of FACS-Isolated Mouse Satellite Cells.

Ghaibour K, Rizk J, Ebel C, Ye T, Philipps M, Schreiber V, Metzger D, Duteil D

J Vis Exp. 2023 07 7;(197):

Androgen receptor coordinates muscle metabolic and contractile functions.

Ghaibour K, Schuh M, Souali-Crespo S, Chambon C, Charlot A, Rizk J, Rovito D, Rerra AI, Cai Q, Messaddeq N, Zoll J, Duteil D, Metzger D

J Cachexia Sarcopenia Muscle. 2023 05 20;:

Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors.

Terzic J, Abu El Maaty MA, Lutzing R, Vincent A, El Bizri R, Jung M, Keime C, Metzger D

EMBO Mol Med. 2023 04 18;:e17209

Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants.

Belorusova AY, Rovito D, Chebaro Y, Doms S, Verlinden L, Verstuyf A, Metzger D, Rochel N, Laverny G

Int J Mol Sci. 2022 07 30;23(15):

Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.

Abu El Maaty MA, Terzic J, Keime C, Rovito D, Lutzing R, Yanushko D, Parisotto M, Grelet E, Namer IJ, Lindner V, Laverny G, Metzger D

Sci Adv. 2022 07 22;8(29):eabo2295

TRPC3 shapes the ER-mitochondria Ca transfer characterizing tumour-promoting senescence.

Farfariello V, Gordienko DV, Mesilmany L, Touil Y, Germain E, Fliniaux I, Desruelles E, Gkika D, Roudbaraki M, Shapovalov G, Noyer L, Lebas M, Allart L, Zienthal-Gelus N, Iamshanova O, Bonardi F, Figeac M, Laine W, Kluza J, Marchetti P, Quesnel B, Metzger D, Bernard D, Parys JB, Lemonnier L, Prevarskaya N

Nat Commun. 2022 Feb 17;13(1):956

Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions.

Abu El Maaty MA, Grelet E, Keime C, Rerra AI, Gantzer J, Emprou C, Terzic J, Lutzing R, Bornert JM, Laverny G, Metzger D

Sci Adv. 2021 Jul;7(31):

Myod1 and GR coordinate myofiber-specific transcriptional enhancers.

Rovito D, Rerra AI, Ueberschlag-Pitiot V, Joshi S, Karasu N, Dacleu-Siewe V, Rayana KB, Ghaibour K, Parisotto M, Ferry A, Jelinsky SA, Laverny G, Klaholz BP, Sexton T, Billas IML, Duteil D, Metzger D

Nucleic Acids Res. 2021 Apr 9;:

Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways.

Miyajima K, Kawamoto C, Hara S, Mori-Kojima M, Ohye T, Sumi-Ichinose C, Saito N, Sasaoka T, Metzger D, Ichinose H

J Biol Chem. 2021 Mar 15;:100544

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia.

Rovito D, Belorusova AY, Chalhoub S, Rerra AI, Guiot E, Molin A, Linglart A, Rochel N, Laverny G, Metzger D

Nat Commun. 2020 12 7;11(1):6249

In vivo RyR1 reduction in muscle triggers a core-like myopathy.

Pelletier L, Petiot A, Brocard J, Giannesini B, Giovannini D, Sanchez C, Travard L, Chivet M, Beaufils M, Kutchukian C, Bendahan D, Metzger D, Franzini Armstrong C, Romero NB, Rendu J, Jacquemond V, Fauré J, Marty I

Acta Neuropathol Commun. 2020 Nov 11;8(1):192

La Société de Biologie de Strasbourg : 100 ans au service de la science et de la société

Antony P, Fournel S, Zoll J, Mantz JM, Befort K, Massotte D, Giégé P, Céraline J, Metzger D, Becker H, Drouard L, Florentz C, Martin R, Nébigil C, Potier S, Schaefer A, Schaeffer E, Schuster C, Bresson A, Quéméneur E, Choulier L, Matt N, Monassier L, Lugnier C, Freysz L, Hoffmann J, Dreyfus H, Romier C

Biol Aujourdhui. 2020 ;214(3-4):137-148

Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle.

Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B

Antioxidants (Basel). 2019 Jun 8;8(6):

Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis.

Bone DBJ, Meister J, Knudsen JR, Dattaroy D, Cohen A, Lee R, Lu H, Metzger D, Jensen TE, Wess J

Diabetes. 2019 Apr 1;:

Senescence controls prostatic neoplasia driven by Pten loss.

Parisotto M, Grelet E, El Bizri R, Metzger D

Mol Cell Oncol. 2019 ;6(1):1511205

PGC-1β modulates statin-associated myotoxicity in mice.

Singh F, Zoll J, Duthaler U, Charles AL, Panajatovic MV, Laverny G, McWilliams TG, Metzger D, Geny B, Krähenbühl S, Bouitbir J

Arch. Toxicol.. 2018 Dec 3;:

[How to limit the progression of PTEN-deficient prostatic tumors?]

Grelet É, Parisotto M, Metzger D

Med Sci (Paris). 2018 Nov;34(11):904-906

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver.

Della Torre S, Mitro N, Meda C, Lolli F, Pedretti S, Barcella M, Ottobrini L, Metzger D, Caruso D, Maggi A

Cell Metab.. 2018 Jun 6;:

deletion in luminal cells of mature prostate induces replication stress and senescence in vivo.

Parisotto M, Grelet E, El Bizri R, Dai Y, Terzic J, Eckert D, Gargowitsch L, Bornert JM, Metzger D

J. Exp. Med.. 2018 May 9;:

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB

Cell Metab.. 2018 Apr 3;27(4):816-827.e4

Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways?

Pottecher J, Adamopoulos C, Lejay A, Bouitbir J, Charles AL, Meyer A, Singer M, Wolff V, Diemunsch P, Laverny G, Metzger D, Geny B

Front Physiol. 2018 ;9:579

The histone code reader Spin1 controls skeletal muscle development.

Greschik H, Duteil D, Messaddeq N, Willmann D, Arrigoni L, Sum M, Jung M, Metzger D, Manke T, Günther T, Schüle R

Cell Death Dis. 2017 Nov 23;8(11):e3173

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle.

Joshi S, Ueberschlag-Pitiot V, Metzger D, Davidson I

J Vis Exp. 2017 11 6;(129):

Peroxisome proliferator-activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut.

Fumery M, Speca S, Langlois A, Davila AM, Dubuquoy C, Grauso M, Martin Mena A, Figeac M, Metzger D, Rousseaux C, Colombel JF, Dubuquoy L, Desreumaux P, Bertin B

EMBO Mol Med. 2017 Sep;:

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease.

Vieira JM, Howard S, Villa Del Campo C, Bollini S, Dubé KN, Masters M, Barnette DN, Rohling M, Sun X, Hankins LE, Gavriouchkina D, Williams R, Metzger D, Chambon P, Sauka-Spengler T, Davies B, Riley PR

Nat Commun. 2017 Jul;8:16034

Conditional expression of Ki-Ras(G12V) in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma.

Andò S, Malivindi R, Catalano S, Rizza P, Barone I, Panza S, Rovito D, Emprou C, Bornert JM, Laverny G, Metzger D

Oncogene. 2017 Jul;:

IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis.

Meyer A, Laverny G, Allenbach Y, Grelet E, Ueberschlag V, Echaniz-Laguna A, Lannes B, Alsaleh G, Charles AL, Singh F, Zoll J, Lonsdorfer E, Maurier F, Boyer O, Gottenberg JE, Nicot AS, Laporte J, Benveniste O, Metzger D, Sibilia J, Geny B

Acta Neuropathol.. 2017 Jun;:

Androgen signaling negatively controls group 2 innate lymphoid cells.

Laffont S, Blanquart E, Savignac M, Cénac C, Laverny G, Metzger D, Girard JP, Belz GT, Pelletier L, Seillet C, Guéry JC

J. Exp. Med.. 2017 May;:

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation.

Rothe T, Ipseiz N, Faas M, Lang S, Perez-Branguli F, Metzger D, Ichinose H, Winner B, Schett G, Krönke G

J. Immunol.. 2017 Apr;:

Gonad-related factors promote muscle performance gain during postnatal development in male and female mice.

Ueberschlag-Pitiot V, Stantzou A, Messéant J, Lemaitre M, Owens DJ, Noirez P, Roy P, Agbulut O, Metzger D, Ferry A

Am. J. Physiol. Endocrinol. Metab.. 2017 Mar;:ajpendo.00446.2016

Regeneration of fat cells from myofibroblasts during wound healing.

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G

Science. 2017 Feb;355(6326):748-752

Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia.

Lejay A, Laverny G, Paradis S, Schlagowski AI, Charles AL, Singh F, Zoll J, Thaveau F, Lonsdorfer E, Dufour S, Favret F, Wolff V, Metzger D, Chakfe N, Geny B

Front Physiol. 2017 ;8:523

Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice.

Cortez-Toledo O, Schnair C, Sangngern P, Metzger D, Chao LC

PLoS ONE. 2017 ;12(2):e0171268

Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance.

Vavrova E, Lenoir V, Alves-Guerra MC, Denis RG, Castel J, Esnous C, Dyck JR, Luquet S, Metzger D, Bouillaud F, Prip-Buus C

Am. J. Physiol. Endocrinol. Metab.. 2016 Sep;311(3):E649-60

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.

Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW

J. Clin. Invest.. 2016 Sep;126(9):3626

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.

Xie T, Liang J, Liu N, Huan C, Zhang Y, Liu W, Kumar M, Xiao R, D'Armiento J, Metzger D, Chambon P, Papaioannou VE, Stripp BR, Jiang D, Noble PW

J. Clin. Invest.. 2016 Aug;126(8):3063-79

SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation.

Bilir B, Osunkoya AO, Wiles WG, Sannigrahi S, Lefebvre V, Metzger D, Spyropoulos DD, Martin WD, Moreno CS

Cancer Res.. 2016 Mar;76(5):1112-21

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles.

Gali Ramamoorthy T, Laverny G, Schlagowski AI, Zoll J, Messaddeq N, Bornert JM, Panza S, Ferry A, Geny B, Metzger D

Nat Commun. 2015 Dec;6:10210

Patrolling monocytes control tumor metastasis to the lung.

Hanna RN, Cekic C, Sag D, Tacke R, Thomas GD, Nowyhed H, Herrley E, Rasquinha N, McArdle S, Wu R, Peluso E, Metzger D, Ichinose H, Shaked I, Chodaczek G, Biswas SK, Hedrick CC

Science. 2015 Nov 20;350(6263):985-90

VDR and gemini ligands.

Laverny G, Metzger D

Oncotarget. 2015 Sep 1.

The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.

Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, Conneely O, Metzger D, Chao LC

Mol Cell Biol. 2015 Apr;35(7):1125-38

A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology.

Lejay A, Choquet P, Thaveau F, Singh F, Schlagowski A, Charles AL, Laverny G, Metzger D, Zoll J, Chakfe N, Geny B

Eur J Vasc Endovasc Surg. 2015 Feb;49(2):205-12

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.

Palumbo-Zerr K, Zerr P, Distler A, Fliehr J, Mancuso R, Huang J, Mielenz D, Tomcik M, Fürnrohr BG, Scholtysek C, Dees C, Beyer C, Krönke G, Metzger D, Distler O, Schett G, Distler JH

Nat. Med.. 2015 Feb;21(2):150-8

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.

Menendez-Gutierrez MP, Roszer T, Fuentes L, Nunez V, Escolano A, Redondo JM, De Clerck N, Metzger D, Valledor AF, Ricote M

J Clin Invest. 2015 Feb;125(2):809-23

A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects.

Huet T, Laverny G, Ciesielski F, Molnar F, Ramamoorthy TG, Belorusova AY, Antony P, Potier N, Metzger D, Moras D, Rochel N

Cell Rep. 2015 Jan 21. pii: S2211-1247(14)01098-5

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation.

Vitaliano-Prunier A, Halftermeyer J, Ablain J, de Reynies A, Peres L, Le Bras M, Metzger D, de The H

Blood. 2014 Dec 11;124(25):3772-80

Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type.

Rahmani W, Abbasi S, Hagner A, Raharjo E, Kumar R, Hotta A, Magness S, Metzger D, Biernaskie J

Dev. Cell. 2014 Dec;31(5):543-58

Myofiber androgen receptor promotes maximal mechanical overload-induced muscle hypertrophy and fiber type transition in male mice.

Ferry A, Schuh M, Parlakian A, Mgrditchian T, Valnaud N, Joanne P, Butler-Browne G, Agbulut O, Metzger D

Endocrinology. 2014 Dec;155(12):4739-48

Mammary stem cells have myoepithelial cell properties.

Prater MD, Petit V, Alasdair Russell I, Giraddi RR, Shehata M, Menon S, Schulte R, Kalajzic I, Rath N, Olson MF, Metzger D, Faraldo MM, Deugnier MA, Glukhova MA, Stingl J

Nat Cell Biol. 2014 Oct;16(10):942-50, 1-7

Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles.

Fraysse B, Vignaud A, Fane B, Schuh M, Butler-Browne G, Metzger D, Ferry A

Steroids. 2014 Sep;87:6-11

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine.

Holik AZ, Young M, Krzystyniak J, Williams GT, Metzger D, Shorning BY, Clarke AR

PLoS Genet. 2014 Jul 10;10(7):e1004453

Skeletal myofiber VEGF is essential for the exercise training response in adult mice.

Delavar H, Nogueira L, Wagner PD, Hogan MC, Metzger D, Breen EC

Am J Physiol Regul Integr Comp Physiol. 2014 Apr 15;306(8):R586-95

Retraction for Endoh et al., Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.

Mol Cell Biol. 2014 Mar;34(5):915

LSD1 promotes oxidative metabolism of white adipose tissue.

Duteil D, Metzger E, Willmann D, Karagianni P, Friedrichs N, Greschik H, Gunther T, Buettner R, Talianidis I, Metzger D, Schule R

Nat Commun. 2014 Jun 10;5:4093

Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.

Zhu D, Holz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Gunther T, Arnold SJ, Schule R

Nat Commun. 2014;5:3174

Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons.

Tokuoka H, Hatanaka T, Metzger D, Ichinose H

Neurosci Lett. 2014 Jan 24;559:50-5

The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network.

Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Gotz M

Cell Stem Cell. 2013 Oct 3;13(4):403-18

Retinoid signaling in progenitors controls specification and regeneration of the urothelium.

Gandhi D, Molotkov A, Batourina E, Schneider K, Dan H, Reiley M, Laufer E, Metzger D, Liang F, Liao Y, Sun TT, Aronow B, Rosen R, Mauney J, Adam R, Rosselot C, Van Batavia J, McMahon A, McMahon J, Guo JJ, Mendelsohn C

Dev Cell. 2013 Sep 16;26(5):469-82

Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure.

Raison D, Coquard C, Hochane M, Steger J, Massfelder T, Moulin B, Karaplis AC, Metzger D, Chambon P, Helwig JJ, Barthelmebs M

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F333-42

Smoothened is a master regulator of adult liver repair.

Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Kruger L, Premont R, Yang L, Syn WK, Metzger D, Diehl AM

J Clin Invest. 2013 Jun 3;123(6):2380-94.

The role of p38 in mitochondrial respiration in male and female mice.

Ju X, Wen Y, Metzger D, Jung M

Neurosci Lett. 2013 Jun 7;544:152-6

Genetically engineered mouse models of prostate cancer.

Parisotto M, Metzger D

Mol Oncol. 2013 Apr;7(2):190-205

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.

Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A

Nat Immunol. 2013 Mar;14(3):230-7

Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.

Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara K, Nakamichi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y

Endocrinology. 2013 Mar;154(3):1008-20

Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.

Charles AL, Meyer A, Dal-Ros S, Auger C, Keller N, Ramamoorthy TG, Zoll J, Metzger D, Schini-Kerth V, Geny B

Exp Physiol. 2013 Feb;98(2):536-45

Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity.

Szatkowski C, Vallet J, Dormishian M, Messaddeq N, Valet P, Boulberdaa M, Metzger D, Chambon P, Nebigil CG

PLoS One. 2013 Dec 4;8(12):e81175

Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension.

Enache I, Charles AL, Bouitbir J, Favret F, Zoll J, Metzger D, Oswald-Mammosser M, Geny B, Charloux A

Mol Cell Biochem. 2013 Jan;373(1-2):161-70

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.

Nadra K, Medard JJ, Mul JD, Han GS, Gres S, Pende M, Metzger D, Chambon P, Cuppen E, Saulnier-Blache JS, Carman GM, Desvergne B, Chrast R

Mol Cell Biol. 2012 Dec;32(23):4794-810

PPARbeta/delta affects pancreatic beta cell mass and insulin secretion in mice.

Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, Pradevand S, McDonald A, Bonal C, Reimann F, Gribble F, Debril MB, Metzger D, Chambon P, Herrera P, Rutter GA, Prentki M, Thorens B, Wahli W

J Clin Invest. 2012 Nov 1;122(11):4105-17

Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium.

Mori M, Gargowitsch L, Bornert JM, Garnier JM, Mark M, Chambon P, Metzger D

Genesis. 2012 Nov;50(11):828-32

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors.

McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ

Nat Med. 2012 Sep;18(9):1429-33.

Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination.

Weider M, Kuspert M, Bischof M, Vogl MR, Hornig J, Loy K, Kosian T, Muller J, Hillgartner S, Tamm ER, Metzger D, Wegner M

Dev Cell. 2012 Jul 17;23(1):193-201.

Biofilm formed by a hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae does not enhance serum resistance or survival in an in vivo abscess model.

Kong Q, Beanan JM, Olson R, Macdonald U, Shon AS, Metzger DJ, Pomakov AO, Russo TA

Virulence. 2012 May 1;3(3):309-18

Relevance of exocytotic glutamate release from retinal glia.

Slezak M, Grosche A, Niemiec A, Tanimoto N, Pannicke T, Munch TA, Crocker B, Isope P, Hartig W, Beck SC, Huber G, Ferracci G, Perraut M, Reber M, Miehe M, Demais V, Leveque C, Metzger D, Szklarczyk K, Przewlocki R, Seeliger MW, Sage-Ciocca D, Hirrlinger J, Reichenbach A, Reibel S, Pfrieger FW

Neuron. 2012 May 10;74(3):504-16.

Transdermal estradiol in castrate and chemotherapy resistant prostate cancer.

Stein M, Goodin S, Doyle-Lindrud S, Silberberg J, Kane M, Metzger D, Eddy S, Shih W, DiPaola RS

Med. Sci. Monit.. 2012 Apr;18(4):CR260-4

The nuclear hormone receptor PPARgamma counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells.

Woldt E, Terrand J, Mlih M, Matz RL, Bruban V, Coudane F, Foppolo S, El Asmar Z, Chollet ME, Ninio E, Bednarczyk A, Thierse D, Schaeffer C, Van Dorsselaer A, Boudier C, Wahli W, Chambon P, Metzger D, Herz J, Boucher P

Nat Commun. 2012;3:1077

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection.

Tokuoka H, Muramatsu S, Sumi-Ichinose C, Sakane H, Kojima M, Aso Y, Nomura T, Metzger D, Ichinose H

J Biol Chem. 2011 Dec 16;286(50):43549-58

Aggravated TSLP-induced atopic dermatitis in mice lacking Dicer in adult skin keratinocytes.

Hener P, Friedmann L, Metzger D, Chambon P, Li M

J Invest Dermatol. 2011 Nov;131(11):2324-7

Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate.

Liu J, Pascal LE, Isharwal S, Metzger D, Ramos Garcia R, Pilch J, Kasper S, Williams K, Basse PH, Nelson JB, Chambon P, Wang Z

Mol. Endocrinol.. 2011 Nov;25(11):1849-57

Hypoxia-inducible transcription factor 2alpha promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis.

Qu A, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, Shah YM

Hepatology. 2011 Aug;54(2):472-83

SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.

Zhang M, Chen M, Kim JR, Zhou J, Jones RE, Tune JD, Kassab GS, Metzger D, Ahlfeld S, Conway SJ, Herring BP

Mol Cell Biol. 2011 Jul;31(13):2618-31

Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor.

Surjit M, Ganti KP, Mukherji A, Ye T, Hua G, Metzger D, Li M, Chambon P

Cell. 2011 Apr 15;145(2):224-41.

Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer.

Takahashi S, Watanabe T, Okada M, Inoue K, Ueda T, Takada I, Watabe T, Yamamoto Y, Fukuda T, Nakamura T, Akimoto C, Fujimura T, Hoshino M, Imai Y, Metzger D, Miyazono K, Minami Y, Chambon P, Kitamura T, Matsumoto T, Kato S

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4938-43

Chromatin remodelling complex dosage modulates transcription factor function in heart development.

Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguin P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau BG

Nat Commun. 2011 Feb 8;2:187

Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse.

Metzger D, Chambon P

Curr Protoc Mouse Biol. 2011 Mar 1;1(1):55-70

Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells.

Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann J, Schirmbeck R, Hauser H, Wirth D

Nucleic Acids Res. 2011 Jan 1;39(1):e1

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.

Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A

Nat Commun. 2011;2:269.

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.

Duteil D, Chambon C, Ali F, Malivindi R, Zoll J, Kato S, Geny B, Chambon P, Metzger D

Cell Metab. 2010 Nov 3;12(5):496-508.

Myocytic androgen receptor controls the strength but not the mass of limb muscles.

Chambon C, Duteil D, Vignaud A, Ferry A, Messaddeq N, Malivindi R, Kato S, Chambon P, Metzger D

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14327-32

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.

Rocher-Ros V, Marco S, Mao JH, Gines S, Metzger D, Chambon P, Balmain A, Saura CA

Oncogene. 2010 May 20;29(20):2950-61

Epidermal gammadelta T cells sense precancerous cellular dysregulation and initiate immune responses.

Shimura E, Hozumi N, Kanagawa O, Metzger D, Chambon P, Radtke F, Hirose S, Nakano N

Int Immunol. 2010 Apr;22(4):329-40

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

Cheng L, Guo J, Sun L, Fu J, Barnes PF, Metzger D, Chambon P, Oshima RG, Amagai T, Su DM

J Biol Chem. 2010 Feb 19;285(8):5836-47

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation.

He S, Pirity MK, Wang WL, Wolf L, Chauhan BK, Cveklova K, Tamm ER, Ashery-Padan R, Metzger D, Nakai A, Chambon P, Zavadil J, Cvekl A

Epigenetics Chromatin. 2010 Nov 30;3(1):21.

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice.

Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K

PLoS One. 2010 Jun 23;5(6):e11275.

Autophagy is required to maintain muscle mass.

Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M, Metzger D, Reggiani C, Schiaffino S, Sandri M

Cell Metab. 2009 Dec;10(6):507-15.

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.

Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Bjorklund A, Ichinose H, Perlmann T

J Neurosci. 2009 Dec 16;29(50):15923-32.

Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.

Wang X, Sansam CG, Thom CS, Metzger D, Evans JA, Nguyen PT, Roberts CW

Cancer Res. 2009 Oct 15;69(20):8094-101

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction.

Leclerc EA, Huchenq A, Mattiuzzo NR, Metzger D, Chambon P, Ghyselinck NB, Serre G, Jonca N, Guerrin M

J Cell Sci. 2009 Aug 1;122(Pt 15):2699-709

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

Bourgo RJ, Siddiqui H, Fox S, Solomon D, Sansam CG, Yaniv M, Muchardt C, Metzger D, Chambon P, Roberts CW, Knudsen ES

Mol Biol Cell. 2009 Jul;20(14):3192-9

Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation.

Golonzhka O, Liang X, Messaddeq N, Bornert JM, Campbell AL, Metzger D, Chambon P, Ganguli-Indra G, Leid M, Indra AK

J Invest Dermatol. 2009 Jun;129(6):1459-70

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis.

Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4278-83

Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin.

Li M, Hener P, Zhang Z, Ganti KP, Metzger D, Chambon P

J Invest Dermatol. 2009 Feb;129(2):498-502

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.

Zhang Z, Hener P, Frossard N, Kato S, Metzger D, Li M, Chambon P

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1536-41

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse.

Wendling O, Bornert JM, Chambon P, Metzger D

Genesis. 2009 Jan;47(1):14-8.

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.

Terrand J, Bruban V, Zhou L, Gong W, El Asmar Z, May P, Zurhove K, Haffner P, Philippe C, Woldt E, Matz RL, Gracia C, Metzger D, Auwerx J, Herz J, Boucher P

J Biol Chem. 2009 Jan 2;284(1):381-8

Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice.

Diaz MB, Krones-Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, Muller-Decker K, Herzig S

Hepatology. 2008 Sep;48(3):782-91.

Abrogation of mitochondrial transcription in smooth muscle cells impairs smooth muscle contractility and vascular tone.

Jawien J, Bian Z, Sheikine Y, Oloffson PS, Pang Y, Edholm T, Dou Y, Metzger D, Hellstrom PM, Feil R, Hansson GK

J Physiol Pharmacol. 2008 Jun;59(2):239-52.

Targeted knockout of BRG1 potentiates lung cancer development.

Glaros S, Cirrincione GM, Palanca A, Metzger D, Reisman D

Cancer Res. 2008 May 15;68(10):3689-96.

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.

Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, Chambon P, Huber M, Hohl D, Cano A, Birchmeier W, Huelsken J

Nature. 2008 Apr 3;452(7187):650-3.

Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy.

Orengo JP, Chambon P, Metzger D, Mosier DR, Snipes GJ, Cooper TA

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2646-51

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.

Ratnacaram CK, Teletin M, Jiang M, Meng X, Chambon P, Metzger D

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2521-6

Premature aging in skeletal muscle lacking serum response factor.

Lahoute C, Sotiropoulos A, Favier M, Guillet-Deniau I, Charvet C, Ferry A, Butler-Browne G, Metzger D, Tuil D, Daegelen D

PLoS ONE. 2008;3(12):e3910

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

Mataki C, Magnier BC, Houten SM, Annicotte JS, Argmann C, Thomas C, Overmars H, Kulik W, Metzger D, Auwerx J, Schoonjans K

Mol Cell Biol. 2007 Dec;27(23):8330-9

Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha.

Khetchoumian K, Teletin M, Tisserand J, Mark M, Herquel B, Ignat M, Zucman-Rossi J, Cammas F, Lerouge T, Thibault C, Metzger D, Chambon P, Losson R

Nat. Genet.. 2007 Dec;39(12):1500-6

TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation.

Klopcic B, Maass T, Meyer E, Lehr HA, Metzger D, Chambon P, Mann A, Blessing M

Eur J Cell Biol. 2007 Dec;86(11-12):781-99

Transgenic mice for conditional gene manipulation in astroglial cells.

Slezak M, Goritz C, Niemiec A, Frisen J, Chambon P, Metzger D, Pfrieger FW

Glia. 2007 Nov 15;55(15):1565-76.

Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice.

MacLean G, Li H, Metzger D, Chambon P, Petkovich M

Endocrinology. 2007 Oct;148(10):4560-7

Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.

Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S

Cell. 2007 Sep;130(5):811-23

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.

Coste A, Dubuquoy L, Barnouin R, Annicotte JS, Magnier B, Notti M, Corazza N, Antal MC, Metzger D, Desreumaux P, Brunner T, Auwerx J, Schoonjans K

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13098-103

The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.

Fadloun A, Kobi D, Pointud JC, Indra AK, Teletin M, Bole-Feysot C, Testoni B, Mantovani R, Metzger D, Mengus G, Davidson I

Development. 2007 Aug;134(16):2947-58

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.

Dali-Youcef N, Mataki C, Coste A, Messaddeq N, Giroud S, Blanc S, Koehl C, Champy MF, Chambon P, Fajas L, Metzger D, Schoonjans K, Auwerx J

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10703-8

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

Berry A, Balard P, Coste A, Olagnier D, Lagane C, Authier H, Benoit-Vical F, Lepert JC, Seguela JP, Magnaval JF, Chambon P, Metzger D, Desvergne B, Wahli W, Auwerx J, Pipy B

Eur J Immunol. 2007 Jun;37(6):1642-52.

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.

Indra AK, Castaneda E, Antal MC, Jiang M, Messaddeq N, Meng X, Loehr CV, Gariglio P, Kato S, Wahli W, Desvergne B, Metzger D, Chambon P

J Invest Dermatol. 2007 May;127(5):1250-60

Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.

Metzger D, Chambon P

Handb Exp Pharmacol. 2007;(178):511-24.

Inducible Cre/loxP recombination in the mouse proximal tubule.

Dworniczak B, Skryabin B, Tchinda J, Heuck S, Seesing FJ, Metzger D, Chambon P, Horst J, Pennekamp P

Nephron Exp Nephrol. 2007;106(1):e11-20

PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes.

Schuler M, Ali F, Chambon C, Duteil D, Bornert JM, Tardivel A, Desvergne B, Wahli W, Chambon P, Metzger D

Cell Metab. 2006 Nov;4(5):407-14.

LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways.

Tang X, Metzger D, Leeman S, Amar S

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13777-82

Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.

Oskarsson T, Essers MA, Dubois N, Offner S, Dubey C, Roger C, Metzger D, Chambon P, Hummler E, Beard P, Trumpp A

Genes Dev.. 2006 Aug;20(15):2024-9

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.

Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes.

Calleja C, Messaddeq N, Chapellier B, Yang H, Krezel W, Li M, Metzger D, Mascrez B, Ohta K, Kagechika H, Endo Y, Mark M, Ghyselinck NB, Chambon P

Genes Dev. 2006 Jun 1;20(11):1525-38.

Temporal regulation of Cre recombinase activity in neural stem cells.

Imayoshi I, Ohtsuka T, Metzger D, Chambon P, Kageyama R

Genesis. 2006 May;44(5):233-8.

Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis.

Stratis A, Pasparakis M, Markur D, Knaup R, Pofahl R, Metzger D, Chambon P, Krieg T, Haase I

J Invest Dermatol. 2006 Mar;126(3):614-20.

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.

Nenci A, Huth M, Funteh A, Schmidt-Supprian M, Bloch W, Metzger D, Chambon P, Rajewsky K, Krieg T, Haase I, Pasparakis M

Hum Mol Genet. 2006 Feb 15;15(4):531-42

Brg1 is required for murine neural stem cell maintenance and gliogenesis.

Matsumoto S, Banine F, Struve J, Xing R, Adams C, Liu Y, Metzger D, Chambon P, Rao MS, Sherman LS

Dev Biol. 2006 Jan 15;289(2):372-83

Premature ovarian failure in androgen receptor-deficient mice.

Shiina H, Matsumoto T, Sato T, Igarashi K, Miyamoto J, Takemasa S, Sakari M, Takada I, Nakamura T, Metzger D, Chambon P, Kanno J, Yoshikawa H, Kato S

Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):224-9

Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease.

Li XG, Okada T, Kodera M, Nara Y, Takino N, Muramatsu C, Ikeguchi K, Urano F, Ichinose H, Metzger D, Chambon P, Nakano I, Ozawa K, Muramatsu S

Mol. Ther.. 2006 Jan;13(1):160-6

Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency.

Herrmann T, Grone HJ, Langbein L, Kaiser I, Gosch I, Bennemann U, Metzger D, Chambon P, Stewart AF, Stremmel W

J Invest Dermatol. 2005 Dec;125(6):1228-35.

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

Li M, Messaddeq N, Teletin M, Pasquali JL, Metzger D, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 2005 Oct;102(41):14795-800

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation.

Indra AK, Dupe V, Bornert JM, Messaddeq N, Yaniv M, Mark M, Chambon P, Metzger D

Development. 2005 Oct;132(20):4533-44.

TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis.

Indra AK, Mohan WS 2nd, Frontini M, Scheer E, Messaddeq N, Metzger D, Tora L

Dev Biol. 2005 Sep 1;285(1):28-37.

Functional role of RXRs and PPARgamma in mature adipocytes.

Metzger D, Imai T, Jiang M, Takukawa R, Desvergne B, Wahli W, Chambon P

Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):51-8.

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.

Rousseaux C, Lefebvre B, Dubuquoy L, Lefebvre P, Romano O, Auwerx J, Metzger D, Wahli W, Desvergne B, Naccari GC, Chavatte P, Farce A, Bulois P, Cortot A, Colombel JF, Desreumaux P

J Exp Med. 2005 Apr 18;201(8):1205-15

Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse.

Schuler M, Ali F, Metzger E, Chambon P, Metzger D

Genesis. 2005 Apr;41(4):165-70.

Targeted somatic mutagenesis in the mouse epidermis.

Metzger D, Li M, Chambon P

Methods Mol Biol. 2005;289:329-40.

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SG, Frame MC

Genes Dev.. 2004 Dec;18(24):2998-3003

Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action.

Rieusset J, Seydoux J, Anghel SI, Escher P, Michalik L, Soon Tan N, Metzger D, Chambon P, Wahli W, Desvergne B

Mol. Endocrinol.. 2004 Oct;18(10):2363-77

Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation.

Mao-Qiang M, Fowler AJ, Schmuth M, Lau P, Chang S, Brown BE, Moser AH, Michalik L, Desvergne B, Wahli W, Li M, Metzger D, Chambon PH, Elias PM, Feingold KR

J. Invest. Dermatol.. 2004 Aug;123(2):305-12

Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse.

Schuler M, Dierich A, Chambon P, Metzger D

Genesis. 2004 Jul;39(3):167-72

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium.

el Marjou F, Janssen KP, Chang BH, Li M, Hindie V, Chan L, Louvard D, Chambon P, Metzger D, Robine S

Genesis. 2004 Jul;39(3):186-93

Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.

Andl T, Ahn K, Kairo A, Chu EY, Wine-Lee L, Reddy ST, Croft NJ, Cebra-Thomas JA, Metzger D, Chambon P, Lyons KM, Mishina Y, Seykora JT, Crenshaw EB, Millar SE

Development. 2004 May;131(10):2257-68

In vivo activation of PPAR target genes by RXR homodimers.

IJpenberg A, Tan NS, Gelman L, Kersten S, Seydoux J, Xu J, Metzger D, Canaple L, Chambon P, Wahli W, Desvergne B

EMBO J.. 2004 May;23(10):2083-91

Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.

Imai T, Takakuwa R, Marchand S, Dentz E, Bornert JM, Messaddeq N, Wendling O, Mark M, Desvergne B, Wahli W, Chambon P, Metzger D

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4543-7

Brain masculinization requires androgen receptor function.

Sato T, Matsumoto T, Kawano H, Watanabe T, Uematsu Y, Sekine K, Fukuda T, Aihara K, Krust A, Yamada T, Nakamichi Y, Yamamoto Y, Nakamura T, Yoshimura K, Yoshizawa T, Metzger D, Chambon P, Kato S

Proc. Natl. Acad. Sci. U.S.A.. 2004 Feb;101(6):1673-8

Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia.

Simon D, Seznec H, Gansmuller A, Carelle N, Weber P, Metzger D, Rustin P, Koenig M, Puccio H

J. Neurosci.. 2004 Feb;24(8):1987-95

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.

Mori M, Metzger D, Picaud S, Hindelang C, Simonutti M, Sahel J, Chambon P, Mark M

Am. J. Pathol.. 2004 Feb;164(2):701-10

Hedgehog signaling regulates sebaceous gland development.

Allen M, Grachtchouk M, Sheng H, Grachtchouk V, Wang A, Wei L, Liu J, Ramirez A, Metzger D, Chambon P, Jorcano J, Dlugosz AA

Am. J. Pathol.. 2003 Dec;163(6):2173-8

Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development.

Chi TH, Wan M, Lee PP, Akashi K, Metzger D, Chambon P, Wilson CB, Crabtree GR

Immunity. 2003 Aug;19(2):169-82

Suppressive function of androgen receptor in bone resorption.

Kawano H, Sato T, Yamada T, Matsumoto T, Sekine K, Watanabe T, Nakamura T, Fukuda T, Yoshimura K, Yoshizawa T, Aihara K, Yamamoto Y, Nakamichi Y, Metzger D, Chambon P, Nakamura K, Kawaguchi H, Kato S

Proc. Natl. Acad. Sci. U.S.A.. 2003 Aug;100(16):9416-21

TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.

Mohan WS, Scheer E, Wendling O, Metzger D, Tora L

Mol. Cell. Biol.. 2003 Jun;23(12):4307-18

Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1.

Abu-Abed S, Dollé P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M

Development. 2003 Apr;130(7):1449-59

Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells.

Leone DP, Genoud S, Atanasoski S, Grausenburger R, Berger P, Metzger D, Macklin WB, Chambon P, Suter U

Mol. Cell. Neurosci.. 2003 Apr;22(4):430-40

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis.

Weber P, Schuler M, Gérard C, Mark M, Metzger D, Chambon P

Biol. Reprod.. 2003 Feb;68(2):553-9

Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes.

Metzger D, Indra AK, Li M, Chapellier B, Calleja C, Ghyselinck NB, Chambon P

Methods Enzymol. 2003;364:379-408.

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.

Chapellier B, Mark M, Messaddeq N, Calléja C, Warot X, Brocard J, Gérard C, Li M, Metzger D, Ghyselinck NB, Chambon P

EMBO J.. 2002 Jul;21(13):3402-13

Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse.

Weber P, Cammas F, Gerard C, Metzger D, Chambon P, Losson R, Mark M

Development. 2002 May;129(10):2329-37

Site-specific somatic mutagenesis in the retinal pigment epithelium.

Mori M, Metzger D, Garnier JM, Chambon P, Mark M

Invest. Ophthalmol. Vis. Sci.. 2002 May;43(5):1384-8

[Genetic dissection of retinoic acid function in epidermis physiology].

Ghyselinck NB, Chapellier B, Calléja C, Kumar Indra A, Li M, Messaddeq N, Mark M, Metzger D, Chambon P

Ann Dermatol Venereol. 2002 May;129(5 Pt 2):793-9

Temporally controlled targeted somatic mutagenesis in the mouse brain.

Weber P, Metzger D, Chambon P

Eur. J. Neurosci.. 2001 Dec;14(11):1777-83

Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice.

Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, Peters JM, Kaya G, Gonzalez FJ, Zakany J, Metzger D, Chambon P, Duboule D, Wahli W

J. Cell Biol.. 2001 Aug;154(4):799-814

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.

Rangarajan A, Talora C, Okuyama R, Nicolas M, Mammucari C, Oh H, Aster JC, Krishna S, Metzger D, Chambon P, Miele L, Aguet M, Radtke F, Dotto GP

EMBO J.. 2001 Jul;20(13):3427-36

Site- and time-specific gene targeting in the mouse.

Metzger D, Chambon P

Methods. 2001 May;24(1):71-80

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity.

Imai T, Jiang M, Kastner P, Chambon P, Metzger D

Proc. Natl. Acad. Sci. U.S.A.. 2001 Apr;98(8):4581-6

RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.

Li M, Chiba H, Warot X, Messaddeq N, Gérard C, Chambon P, Metzger D

Development. 2001 Mar;128(5):675-88

An efficient system for conditional gene expression in embryonic stem cells and in their in vitro and in vivo differentiated derivatives.

Vallier L, Mancip J, Markossian S, Lukaszewicz A, Dehay C, Metzger D, Chambon P, Samarut J, Savatier P

Proc. Natl. Acad. Sci. U.S.A.. 2001 Feb;98(5):2467-72

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.

Imai T, Jiang M, Chambon P, Metzger D

Proc. Natl. Acad. Sci. U.S.A.. 2001 Jan;98(1):224-8

The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures.

Abu-Abed S, Dollé P, Metzger D, Beckett B, Chambon P, Petkovich M

Genes Dev.. 2001 Jan;15(2):226-40

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, Gilliam A, Randazzo F, Metzger D, Chambon P, Crabtree G, Magnuson T

Mol. Cell. 2000 Dec;6(6):1287-95

F9 embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression.

Chiba H, Chambon P, Metzger D

Exp. Cell Res.. 2000 Nov;260(2):334-9

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis.

Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P

Nature. 2000 Oct;407(6804):633-6

Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene.

Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, Gonzalez FJ, Desvergne B, Wahli W

J. Biol. Chem.. 2000 Sep;275(37):28488-93

Temporally controlled somatic mutagenesis in smooth muscle.

Kühbandner S, Brummer S, Metzger D, Chambon P, Hofmann F, Feil R

Genesis. 2000 Sep;28(1):15-22

p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains.

Kobayashi Y, Kitamoto T, Masuhiro Y, Watanabe M, Kase T, Metzger D, Yanagisawa J, Kato S

J. Biol. Chem.. 2000 May;275(21):15645-51

Inducible site-specific somatic mutagenesis in mouse hepatocytes.

Imai T, Chambon P, Metzger D

Genesis. 2000 Feb;26(2):147-8

Targeted somatic mutagenesis in mouse epidermis.

Indra AK, Li M, Brocard J, Warot X, Bornert JM, Gérard C, Messaddeq N, Chambon P, Metzger D

Horm. Res.. 2000 ;54(5-6):296-300

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.

Indra AK, Warot X, Brocard J, Bornert JM, Xiao JH, Chambon P, Metzger D

Nucleic Acids Res.. 1999 Nov;27(22):4324-7

Engineering the mouse genome by site-specific recombination.

Metzger D, Feil R

Curr. Opin. Biotechnol.. 1999 Oct;10(5):470-6

Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes.

Metzger D, Scheer E, Soldatov A, Tora L

EMBO J.. 1999 Sep 1;18(17):4823-34

Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.

Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J, Metzger D, Hashimoto S, Kato S

Mol. Cell. Biol.. 1999 Aug;19(8):5363-72

A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor.

Brocard J, Feil R, Chambon P, Metzger D

Nucleic Acids Res.. 1998 Sep;26(17):4086-90

Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.

Abu-Abed SS, Beckett BR, Chiba H, Chithalen JV, Jones G, Metzger D, Chambon P, Petkovich M

J. Biol. Chem.. 1998 Jan;273(4):2409-15

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

Brocard J, Warot X, Wendling O, Messaddeq N, Vonesch JL, Chambon P, Metzger D

Proc. Natl. Acad. Sci. U.S.A.. 1997 Dec;94(26):14559-63

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.

Chiba H, Clifford J, Metzger D, Chambon P

J. Cell Biol.. 1997 Nov;139(3):735-47

SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells.

Sumi-Ichinose C, Ichinose H, Metzger D, Chambon P

Mol. Cell. Biol.. 1997 Oct;17(10):5976-86

Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains.

Feil R, Wagner J, Metzger D, Chambon P

Biochem. Biophys. Res. Commun.. 1997 Aug;237(3):752-7

Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells.

Chiba H, Clifford J, Metzger D, Chambon P

Mol. Cell. Biol.. 1997 Jun;17(6):3013-20

Ligand-activated site-specific recombination in mice.

Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P

Proc. Natl. Acad. Sci. U.S.A.. 1996 Oct;93(20):10887-90

RXRalpha-null F9 embryonal carcinoma cells are resistant to the differentiation, anti-proliferative and apoptotic effects of retinoids.

Clifford J, Chiba H, Sobieszczuk D, Metzger D, Chambon P

EMBO J.. 1996 Aug;15(16):4142-55

Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells.

Metzger D, Ali S, Bornert JM, Chambon P

J. Biol. Chem.. 1995 Apr;270(16):9535-42

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

Berry M, Metzger D, Chambon P

EMBO J.. 1990 Sep;9(9):2811-8

The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation present in the DNA binding domain of the protein.

de Verneuil H, Metzger D

Nucleic Acids Res.. 1990 Aug;18(15):4489-97

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