Fiche publication
Date publication
décembre 2025
Journal
Oncoimmunology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr METZGER Daniel
,
Dr LAVERNY Gilles
Tous les auteurs :
Pervizou D, De Chiara J, Spinelli L, Nestor-Martin M, Chasson L, Len-Tayon K, Yanushko D, Fiore F, Bajénoff M, Malissen B, Metzger D, Laverny G, Henri S
Lien Pubmed
Résumé
The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis, we comprehensively characterized immune cells in wild-type and PTEN mouse prostates, a model that closely recapitulates human PCa. PCa in PTEN is marked by the recruitment of tumor-associated neutrophils (TANs), which represent the dominant immune cell population and resolved into eight distinct states, Trem2 tumor-associated-macrophages (TAMs), and exhausted CD8 T cells. Trem2 TAMs differ from the three main resident macrophage populations in the healthy prostate, exhibiting a strong metabolic and immunosuppressive signature, likely driven by the MIF/HIF1A-signaling axis. This study provides the first detailed characterization of immune cells in the healthy mouse prostate and reveals changes in the immune landscape associated with prostate cancer progression.
Mots clés
PTEN(i)pe−/− prostate cancer murine model, Prostate, Trem2+ tumor-associated-macrophages (TAM), exhausted CD8+ T cells, multiparametric flow cytometry, resident macrophage subsets, scRNA-seq, tumor-associated-neutrophils (TAN)
Référence
Oncoimmunology. 2025 12;14(1):2562220
