Fiche publication
Date publication
septembre 2026
Journal
Science advances
Auteurs
Membres identifiés du Cancéropôle Est :
Dr METZGER Daniel
,
Mme MESSADDEQ Nadia
,
Dr MOLINA Nacho
,
Dr DUTEIL Delphine
,
Dr ZOLL Joffrey
Tous les auteurs :
Rizk JG, Ghaibour KC, Souali-Crespo S, Calvano E, Bilger A, Jacobs H, Messaddeq N, Cai Q, Grangirard E, Sahu R, Ferry A, Fourcade V, Zoll J, Zanardelli G, Molina N, Fontaine C, Arnal JF, Metzger D, Duteil D
Lien Pubmed
Résumé
Skeletal muscle stem cells (MuSC) are the guardians of muscle regeneration, sustaining tissue integrity through a delicate balance of quiescence, activation, and lineage commitment. While numerous molecular cues have been implicated in regulating these processes, the influence of androgen receptor (AR) signaling, an essential hormonal pathway for male muscle physiology, has remained largely unexplored. Here, we show that AR expression defines quiescent MuSC and acts as a safeguard of their dormancy. Integrated multiomic analyses reveal a redistribution of AR binding from quiescence-maintenance loci to regulatory elements driving activation and metabolic reprogramming during repair. Loss of AR in young adult mice disrupts this balance, precipitating premature cell-cycle entry, skewed division modalities, depletion of the stem cell reservoir, and destabilization of the niche. These defects converge with hallmarks of aging-associated androgen decline, while androgen supplementation restores regenerative competence. Together, our findings establish AR signaling as a pivotal determinant of MuSC fate and a cornerstone of skeletal muscle homeostasis.
Mots clés
Animals, Receptors, Androgen, metabolism, Regeneration, genetics, Satellite Cells, Skeletal Muscle, metabolism, Mice, Male, Signal Transduction, Muscle, Skeletal, metabolism, Cell Differentiation, Androgens
Référence
Sci Adv. 2026 09 11;12(37):eaec8073
