Pr MERLIN Jean-Louis

Emergence of KRAS mosaicism with multiple variants during treatment with alectinib in ALK-positive metastatic non-small cell lung cancer: A case report.

Simon A, Treffel G, Pax G, Gauchotte G, Husson M, Hanriot I, Leroux A, Merlin JL, Harlé A, Gilson P

Oncol Lett. 2026 10;32(4):448

Cerebrospinal fluid cell-free DNA sequencing in pediatric CNS tumors: towards liquid molecular neuropathology.

Gehin W, Merlin MS, Harle A, Merlin JL

Acta Neuropathol. 2026 08 10;152(1):

Evaluation of the Idylla IDH1-2 Mutation Assay for the Detection of IDH Variants in Solid Tumors and Hematological Malignancies

Gilson P, Muller M, Gauchotte G, Fadil S, Husson M, Hanriot I, Witz A, Dardare J, Betz M, Merlin JL, Harlé A

Int J Mol Sci. 2026 01 20;27(2):

Sensitive cell-free DNA assay for accurate detection of RAS and BRAF mutations in liquid biopsies of patients with metastatic colorectal cancer: Final results of the multicentric ColoBEAM study.

Harlé A, Gavoille C, Bouché O, Abdelghani MB, Plaza J, Spaeth D, Boudrant A, Ghiringhelli F, Villing AL, Borg C, Rouyer M, Husson M, Gilson P, Salleron J, Lambert A, Merlin JL

Oncol Lett. 2026 01;31(1):13

Radiotherapy in the management of PDAC, from past to present.

Dardare J, Martz N, Witz A, Betz M, Michel C, Gilson P, Merlin JL, Lambert A, Harle A

Transl Oncol. 2025 12 8;63:102632

Improving Radiation Therapy in Pancreatic Cancer Through Radiosensitization Strategies.

Dardare J, Martz N, Witz A, Betz M, Michel C, Gilson P, Merlin JL, Lambert A, Harle A

Int J Radiat Oncol Biol Phys. 2025 09 16;:

A novel ddPCR assay for BRCA1 and RAD51C methylation: Advancing HRD Detection in Ovarian Cancer.

Michel C, Simon A, Witz A, Hanriot I, Dardare J, Betz M, Brun M, Gilson P, Merlin JL, Harlé A

J Mol Diagn. 2025 08 7;:

Fluorescence Imaging-Assessed Surgical Margin Detection in Head and Neck Oncology by Passive and Active Targeting.

Dirheimer L, Cortese S, Dolivet G, Merlin JL, Marchal F, Mastronicola R, Bezdetnaya L

Mol Diagn Ther. 2025 05 8;:

Study of the survival of patients with head and neck cancer in relation to Circulating Tumor Cells (CTCs).

Mastronicola R, Kayser E, Le Roux P, Barrat A, Aubertin A, Casse A, Nominé L, Villard H, Cortese S, Beulque E, Merlin JL, Dolivet G

PLoS One. 2025 04 1;20(4):e0320485

Homologous recombination deficiency (HRD) testing landscape: clinical applications and technical validation for routine diagnostics.

Witz A, Dardare J, Betz M, Michel C, Husson M, Gilson P, Merlin JL, Harlé A

Biomark Res. 2025 02 21;13(1):31

Decoding mutational signatures in breast cancer: Insights from a multi-cohort study.

Betz M, Witz A, Dardare J, Michel C, Massard V, Boidot R, Gilson P, Merlin JL, Harlé A

Transl Oncol. 2025 02 4;53:102315

DDB2 expression lights the way for precision radiotherapy response in PDAC cells, with or without olaparib.

Dardare J, Witz A, Betz M, François A, Lamy L, Husson M, Demange J, Rouyer M, Lambert A, Merlin JL, Gilson P, Harlé A

Cell Death Discov. 2024 09 27;10(1):411

[Development of an artificial intelligence system to improve cancer clinical trial eligibility screening].

Gédor M, Desandes E, Chesnel M, Merlin JL, Marchal F, Lambert A, Baudin A

Bull Cancer. 2024 03 18;:

Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?

Witz A, Dardare J, Betz M, Gilson P, Merlin JL, Harlé A

Clin Exp Med. 2024 01 17;24(1):2

Integrated Molecular Characterization of HER2-Low Breast Cancer Using Next Generation Sequencing (NGS).

Merlin JL, Husson M, Sahki N, Gilson P, Massard V, Harlé A, Leroux A

Biomedicines. 2023 11 28;11(12):

CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines.

Witz A, Dardare J, Francois A, Husson M, Rouyer M, Demange J, Merlin JL, Gilson P, Harlé A

Sci Rep. 2023 10 31;13(1):18741

Gene Mutations and Liquid Biopsy in ER-Positive Breast Cancers: A Small Step Forward, a Giant Leap for Personalization of Endocrine Therapy?

Betz M, Massard V, Gilson P, Witz A, Dardare J, Harlé A, Merlin JL

Cancers (Basel). 2023 10 27;15(21):

Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pathology laboratories across Europe.

Hofman P, Calabrese F, Kern I, Adam J, Alarcão A, Alborelli I, Anton NT, Arndt A, Avdalyan A, Barberis M, Bégueret H, Bisig B, Blons H, Boström P, Brcic L, Bubanovic G, Buisson A, Caliò A, Cannone M, Carvalho L, Caumont C, Cayre A, Chalabreysse L, Chenard MP, Conde E, Copin MC, Côté JF, D'Haene N, Dai HY, de Leval L, Delongova P, Denčić-Fekete M, Fabre A, Ferenc F, Forest F, de Fraipont F, Garcia-Martos M, Gauchotte G, Geraghty R, Guerin E, Guerrero D, Hernandez S, Hurník P, Jean-Jacques B, Kashofer K, Kazdal D, Lantuejoul S, Leonce C, Lupo A, Malapelle U, Matej R, Merlin JL, Mertz KD, Morel A, Mutka A, Normanno N, Ovidiu P, Panizo A, Papotti MG, Parobkova E, Pasello G, Pauwels P, Pelosi G, Penault-Llorca F, Picot T, Piton N, Pittaro A, Planchard G, Poté N, Radonic T, Rapa I, Rappa A, Roma C, Rot M, Sabourin JC, Salmon I, Prince SS, Scarpa A, Schuuring E, Serre I, Siozopoulou V, Sizaret D, Smojver-Ježek S, Solassol J, Steinestel K, Stojšić J, Syrykh C, Timofeev S, Troncone G, Uguen A, Valmary-Degano S, Vigier A, Volante M, Wahl SGF, Stenzinger A, Ilié M

ESMO Open. 2023 09 13;8(5):101628

Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers.

Gilson P, Pouget C, Belmonte R, Fadil S, Demange J, Rouyer M, Lacour J, Betz M, Dardare J, Witz A, Merlin JL, Harlé A

Sci Rep. 2023 08 9;13(1):12909

Personalized follow-up of circulating DNA in resected stage III/IV melanoma: PERCIMEL multicentric prospective study protocol.

Geoffrois L, Harlé A, Sahki N, Sikanja A, Granel-Brocard F, Hervieu A, Mortier L, Jeudy G, Michel C, Nardin C, Huin-Schohn C, Merlin JL

BMC Cancer. 2023 06 16;23(1):554

[Clinical epidemiology and biostatistic innovations 2023 - Welcome In Nancy].

Guillemin F, Merlin JL

Rev Epidemiol Sante Publique. 2023 05;71 Suppl 2:101846

DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy.

Dardare J, Witz A, Betz M, Francois A, Meras M, Lamy L, Lambert A, Grandemange S, Husson M, Rouyer M, Demange J, Merlin JL, Harlé A, Gilson P

Front Oncol. 2022 12 8;12:1052163

Conversational hypnosis versus standard of care to reduce anxiety in patients undergoing marker placement under radiographic control prior to breast cancer surgery: A randomized, multicenter trial.

Lemoine L, Adam V, Galus X, Siles P, Coulon A, Grenier-Desforges J, Orabona J, Kergastel I, Wagner P, Salleron J, Tosti P, Huin-Schohn C, Merlin JL, Etienne R, Henrot P

Front Psychol. 2022 11 22;13:971232

Deciphering Tumour Heterogeneity: From Tissue to Liquid Biopsy.

Gilson P, Merlin JL, Harlé A

Cancers (Basel). 2022 Mar 8;14(6):

Intraoperative prediction of non-sentinel lymph node metastases in breast cancer using cytokeratin 19 mRNA copy number: A retrospective analysis.

Pina H, Salleron J, Gilson P, Husson M, Rouyer M, Leroux A, Rauch P, Marchal F, Käppeli M, Merlin JL, Harlé A

Mol Clin Oncol. 2022 Mar;16(3):58

A phase II randomised study of preoperative trastuzumab alone or combined with everolimus in patients with early HER2-positive breast cancer and predictive biomarkers (RADHER trial).

Campone M, Bachelot T, Treilleux I, Pistilli B, Salleron J, Seegers V, Arnedos M, Loussouarn D, Wang Q, Vanlemmens L, Jimenez M, Rios M, Diéras V, Leroux A, Paintaud G, Rezai K, André F, Lion M, Merlin JL

Eur J Cancer. 2021 Oct 19;158:169-180

Epithelial to Mesenchymal Transition in Patients with Pancreatic Ductal Adenocarcinoma: State-of-the-Art and Therapeutic Opportunities.

Dardare J, Witz A, Merlin JL, Bochnakian A, Toussaint P, Gilson P, Harlé A

Pharmaceuticals (Basel). 2021 Jul 29;14(8):

A NGS-based Blood Test for the Diagnosis of Invasive HPV-associated Carcinomas with Extensive Viral Genomic Characterization.

Sastre-Garau X, Diop M, Martin F, Dolivet G, Marchal F, Charra-Brunaud C, Peiffert D, Leufflen L, Dembele B, Demange J, Tosti P, Thomas J, Leroux A, Merlin JL, Diop-Ndiaye H, Costa JM, Salleron J, Harle A

Clin Cancer Res. 2021 Jun 9;:

Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers.

Gilson P, Saurel C, Salleron J, Husson M, Demange J, Merlin JL, Harlé A

Sci Rep. 2021 May 18;11(1):10470

Detection of Microsatellite Instability: State of the Art and Future Applications in Circulating Tumour DNA (ctDNA).

Gilson P, Merlin JL, Harlé A

Cancers (Basel). 2021 Mar 24;13(7):

Advanced co-culture 3D breast cancer model for investigation of fibrosis induced by external stimuli: optimization study.

Yakavets I, Francois A, Benoit A, Merlin JL, Bezdetnaya L, Vogin G

Sci Rep. 2020 Dec 4;10(1):21273

Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers.

Gilson P, Levy J, Rouyer M, Demange J, Husson M, Bonnet C, Salleron J, Leroux A, Merlin JL, Harlé A

. 2020 Oct 2;10(1):16386

SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma.

Dardare J, Witz A, Merlin JL, Gilson P, Harlé A

Int J Mol Sci. 2020 May 16;21(10):

Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer.

Franczak C, Witz A, Geoffroy K, Demange J, Rouyer M, Husson M, Massard V, Gavoille C, Lambert A, Gilson P, Gambier N, Scala-Bertola J, Merlin JL, Harlé A

PLoS ONE. 2020 ;15(1):e0227294

Identification of Specific Tumor Markers in Vulvar Carcinoma Through Extensive Human Papillomavirus DNA Characterization Using Next Generation Sequencing Method.

Thomas J, Leufflen L, Chesnais V, Diry S, Demange J, Depardieu C, Bani MA, Marchal F, Charra-Brunaud C, Merlin JL, Leroux A, Sastre-Garau X, Harlé A

J Low Genit Tract Dis. 2020 Jan;24(1):53-60

Rapid fully-automated assay for routine molecular diagnosis of mutations for personalized therapy of low grade gliomas.

Merlin MS, Gilson P, Rouyer M, Chastagner P, Doz F, Varlet P, Leroux A, Gauchotte G, Merlin JL

Pediatr Hematol Oncol. 2019 Oct 23;:1-12

Emerging Roles of DDB2 in Cancer.

Gilson P, Drouot G, Witz A, Merlin JL, Becuwe P, Harlé A

Int J Mol Sci. 2019 Oct 18;20(20):

Somatic substitution signature as an innovative tool in lung cancer diagnosis.

Busca S, Salleron J, Boidot R, Merlin JL, Harlé A

Sci Rep. 2019 Oct 10;9(1):14561

Bone marrow vs Wharton's jelly mesenchymal stem cells in experimental sepsis: a comparative study.

Laroye C, Boufenzer A, Jolly L, Cunat L, Alauzet C, Merlin JL, Yguel C, Bensoussan D, Reppel L, Gibot S

Stem Cell Res Ther. 2019 Jun 27;10(1):192

Dual Epigenetic Regulation of ERα36 Expression in Breast Cancer Cells.

Thiebaut C, Chesnel A, Merlin JL, Chesnel M, Leroux A, Harlé A, Dumond H

Int J Mol Sci. 2019 May 29;20(11):

Uncommon mutational profiles of metastatic colorectal cancer detected during routine genotyping using next generation sequencing.

Franczak C, Kandathil SM, Gilson P, Husson M, Rouyer M, Demange J, Leroux A, Merlin JL, Harlé A

Sci Rep. 2019 May 8;9(1):7083

RILA blood biomarker as a predictor of radiation-induced sarcoma in a matched cohort study.

Mirjolet C, Merlin JL, Truc G, Noël G, Thariat J, Domont J, Sargos P, Renard-Oldrini S, Ray-Coquard I, Liem X, Chevreau C, Lagrange JL, Mahé MA, Collin F, Bonnetain F, Bertaut A, Maingon P

EBioMedicine. 2019 Feb 28;:

Technical considerations for circulating tumor DNA detection in oncology.

Franczak C, Filhine-Tresarrieu P, Gilson P, Merlin JL, Au L, Harlé A

Expert Rev. Mol. Diagn.. 2019 Jan 16;:

Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation.

Gilson P, Franczak C, Dubouis L, Husson M, Rouyer M, Demange J, Perceau M, Leroux A, Merlin JL, Harlé A

PLoS ONE. 2019 ;14(7):e0219204

Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma.

Franczak C, Dubouis L, Gilson P, Husson M, Rouyer M, Demange J, Leroux A, Merlin JL, Harlé A

PLoS ONE. 2019 ;14(2):e0212801

Comparison of Three Real-Time PCR Assays for the Detection of PIK3CA Somatic Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Breast Carcinomas.

Lambert A, Salleron J, Lion M, Rouyer M, Lozano N, Leroux A, Merlin JL, Harlé A

Pathol. Oncol. Res.. 2018 Nov 13;:

Clinical Interests of Circulating Tumor DNA in Oncology.

Franczak C, Filhine-Tressarieu P, Broséus J, Gilson P, Merlin JL, Harlé A

Arch. Med. Res.. 2018 Nov 7;:

Detection of ALK, RET, ROS1, NTRK1 and MET rearrangements and actionable mutations using next generation sequencing in patients with non-small cell lung cancer.

Harlé A, Dietmaier W, Vogl I, Neumann K, Haumaier F, Beggs AD, Pestinger V, Grand D, Tallet A, Merlin JL

Ann. Oncol.. 2018 Sep;29 Suppl 6:vi12

Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation.

Vogin G, Merlin JL, Rousseau A, Peiffert D, Harlé A, Husson M, Hajj LE, Levitchi M, Simon T, Simon JM

Oncotarget. 2018 Aug 24;9(66):32680-32689

Accelerated mutation analysis using a fully automated PCR platform improves the management of patients with metastatic melanoma.

Serre D, Salleron J, Husson M, Leroux A, Gilson P, Merlin JL, Geoffrois L, Harlé A

Oncotarget. 2018 Aug 14;9(63):32232-32237

Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples.

Harlé A, Guillet J, Thomas J, Sastre-Garau X, Rouyer M, Ramacci C, Gilson P, Dubois C, Dolivet G, Leroux A, Salleron J, Merlin JL

Sci Rep. 2018 Jul 27;8(1):11313

RAS mutation testing in patients with metastatic colorectal cancer in French clinical practice: A status report in 2014.

Lièvre A, Merlin JL, Sabourin JC, Artru P, Tong S, Libert L, Audhuy F, Gicquel C, Moureau-Zabotto L, Ossendza RA, Laurent-Puig P, Ducreux M

Dig Liver Dis. 2018 May;50(5):507-512

A transnational collaborative network dedicated to the study and applications of the vascular endothelial growth factor-A in medical practice: the VEGF Consortium.

Stathopoulou MG, Xie T, Ruggiero D, Chatelin J, Rancier M, Weryha G, Kurth MJ, Aldasoro Arguinano AA, Gorenjak V, Petrelis AM, Dagher G, Dedoussis G, Deloukas P, Lamont J, Marc J, Simmaco M, Schaik RHNV, Innocenti F, Merlin JL, Schneider J, Alizadeh BZ, Ciullo M, Seshadri S, Visvikis-Siest S,

Clin. Chem. Lab. Med.. 2018 Mar 28;56(4):83-86

A Model of Chronic Exposure to Unpredictable Mild Socio-Environmental Stressors Replicates Some Spaceflight-Induced Immunological Changes.

Gaignier F, Legrand-Frossi C, Stragier E, Mathiot J, Merlin JL, Cohen-Salmon C, Lanfumey L, Frippiat JP

Front Physiol. 2018 ;9:514

Longitudinal serum metabolomics evaluation of trastuzumab and everolimus combination as pre-operative treatment for HER-2 positive breast cancer patients.

Jobard E, Trédan O, Bachelot T, Vigneron AM, Aït-Oukhatar CM, Arnedos M, Rios M, Bonneterre J, Diéras V, Jimenez M, Merlin JL, Campone M, Elena-Herrmann B

Oncotarget. 2017 Oct 13;8(48):83570-83584

Longitudinal serum metabolomics evaluation of trastuzumab and everolimus combination as pre-operative treatment for HER-2 positive breast cancer patients.

Jobard E, Trédan O, Bachelot T, Vigneron AM, Aït-Oukhatar CM, Arnedos M, Rios M, Bonneterre J, Diéras V, Jimenez M, Merlin JL, Campone M, Elena-Herrmann B

Oncotarget. 2017 Jun;:

Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.

Franczak C, Salleron J, Dubois C, Filhine-Trésarrieu P, Leroux A, Merlin JL, Harlé A

Mol Diagn Ther. 2017 Apr;21(2):209-216

New advances in DPYD genotype and risk of severe toxicity under capecitabine.

Etienne-Grimaldi MC, Boyer JC, Beroud C, Mbatchi L, van Kuilenburg A, Bobin-Dubigeon C, Thomas F, Chatelut E, Merlin JL, Pinguet F, Ferrand C, Meijer J, Evrard A, Llorca L, Romieu G, Follana P, Bachelot T, Chaigneau L, Pivot X, Dieras V, Largillier R, Mousseau M, Goncalves A, Roché H, Bonneterre J, Servent V, Dohollou N, Château Y, Chamorey E, Desvignes JP, Salgado D, Ferrero JM, Milano G

PLoS ONE. 2017 ;12(5):e0175998

Beside P53 and PTEN: Identification of molecular alterations of the RAS/MAPK and PI3K/AKT signaling pathways in high-grade serous ovarian carcinomas to determine potential novel therapeutic targets.

Chen S, Cavazza E, Barlier C, Salleron J, Filhine-Tresarrieu P, Gavoilles C, Merlin JL, Harlé A

Oncol Lett. 2016 Nov;12(5):3264-3272

[Sarcoma developed in irradiated area: Preliminary results of the SARI trial].

Maingon P, Mirjolet C, Diallo I, Veres C, Collin F, Italiano A, Chibon F, Merlin JL, Coindre JM

Cancer Radiother. 2016 Oct;20(6-7):690-3

Limited effectiveness of patent blue dye in addition to isotope scanning for identification of sentinel lymph nodes: Cross-sectional real-life study in 1024 breast cancer patients.

Rauch P, Merlin JL, Leufflen L, Salleron J, Harlé A, Olivier P, Marchal F

Int J Surg. 2016 Sep;33 Pt A:177-81

Trastuzumab as a preoperative monotherapy does not inhibit HER2 downstream signaling in HER2-positive breast cancer.

Lion M, Harlé A, Salleron J, Ramacci C, Campone M, Merlin JL

Oncol Lett. 2016 Sep;12(3):2028-2032

Correlation between radio-induced lymphocyte apoptosis measurements obtained from two French centres.

Mirjolet C, Merlin JL, Dalban C, Maingon P, Azria D

Cancer Radiother. 2016 Jul;20(5):391-4

Rare RAS Mutations in Metastatic Colorectal Cancer Detected During Routine RAS Genotyping Using Next Generation Sequencing.

Harlé A, Filhine-Tresarrieu P, Husson M, Boidot R, Rouyer M, Dubois C, Leroux A, Merlin JL

Target Oncol. 2016 Jun;11(3):363-70

Influence of tumour burden on trastuzumab pharmacokinetics in HER2 positive non-metastatic breast cancer.

Bernadou G, Campone M, Merlin JL, Gouilleux-Gruart V, Bachelot T, Lokiec F, Rezai K, Arnedos M, Diéras V, Jimenez M, Paintaud G, Ternant D

Br J Clin Pharmacol. 2016 May;81(5):941-8

Detection of BRAF Mutations Using a Fully Automated Platform and Comparison with High Resolution Melting, Real-Time Allele Specific Amplification, Immunohistochemistry and Next Generation Sequencing Assays, for Patients with Metastatic Melanoma.

Harlé A, Salleron J, Franczak C, Dubois C, Filhine-Tressarieu P, Leroux A, Merlin JL

PLoS ONE. 2016 ;11(4):e0153576

Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers.

Harle A, Salleron J, Perkins G, Pilati C, Blons H, Laurent-Puig P, Merlin JL

Br J Cancer. 2015 Aug 11;113(4):680-5

Detection of BRAF V600 Mutations in Melanoma: Evaluation of Concordance between the Cobas(R) 4800 BRAF V600 Mutation Test and the Methods Used in French National Cancer Institute (INCa) Platforms in a Real-Life Setting.

Mourah S, Denis MG, Narducci FE, Solassol J, Merlin JL, Sabourin JC, Scoazec JY, Ouafik L, Emile JF, Heller R, Souvignet C, Bergougnoux L, Merlio JP

PLoS One. 2015 Mar 19;10(3):e0120232

Detection of disseminated tumor cells in aspirative drains after neck dissection.

Mastronicola R, Berteau C, Tu Q, Cortese S, Guillet J, Phulpin B, Gangloff P, Bezdetnaya L, Merlin JL, Faure G, Dolivet G

Eur Arch Otorhinolaryngol. 2015 Jan 30.

[Response predictive biomarkers to targeted therapies in oncology].

Harlé A, Merlin JL

Ann. Biol. Clin. (Paris). 2013 Nov;71:89-97

Expression and activation of P38 MAP kinase in invasive ductal breast cancers: correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins.

Merlin JL, Harle A, Lion M, Ramacci C, Leroux A

Oncol Rep. 2013 Oct;30(4):1943-8

[Clinical, diagnostic significance and theranostic interest of PIK3CA gene mutations in breast cancer].

Harle A, Lion M, Lozano N, Merlin JL

Bull Cancer. 2013 Oct;100(10):947-54

Using one-step nucleic acid amplification (OSNA) for intraoperative detection of lymph node metastasis in breast cancer patients avoids second surgery and accelerates initiation of adjuvant therapy.

Klingler S, Marchal F, Rauch P, Kenouchi O, Chretien AS, Genin P, Leroux A, Merlin JL

Ann Oncol. 2013 Sep;24(9):2305-9

[Method validation according to ISO 15189 and SH GTA 04: application for the extraction of DNA and its quantitative evaluation by a spectrophotometric assay].

Harle A, Lion M, Husson M, Dubois C, Merlin JL

Ann Biol Clin (Paris). 2013 Sep-Oct;71(5):608-14

The KRAS mutation detection within the initial management of patients with metastatic colorectal cancer: a status report in France in 2011.

Lièvre A, Artru P, Guiu M, Laurent-Puig P, Merlin JL, Sabourin JC, Viguier J, Bastie A, Seronde A, Ducreux M

Eur. J. Cancer. 2013 Jun;49(9):2126-33

Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: correlation with clinicopathological criteria.

Harle A, Lion M, Lozano N, Husson M, Harter V, Genin P, Merlin JL

Oncol Rep. 2013 Mar;29(3):1043-52

Comparison of COBAS 4800 KRAS, TaqMan PCR and High Resolution Melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas.

Harle A, Busser B, Rouyer M, Harter V, Genin P, Leroux A, Merlin JL

Virchows Arch. 2013 Mar;462(3):329-35

Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer.

Chretien AS, Harle A, Meyer-Lefebvre M, Rouyer M, Husson M, Ramacci C, Harter V, Genin P, Leroux A, Merlin JL

Cancer Med. 2013 Feb;2(1):11-20

Performance and cost efficiency of KRAS mutation testing for metastatic colorectal cancer in routine diagnosis: the MOKAECM study, a nationwide experience.

Blons H, Rouleau E, Charrier N, Chatellier G, Côté JF, Pages JC, de Fraipont F, Boyer JC, Merlio JP, Morel A, Gorisse MC, de Cremoux P, Leroy K, Milano G, Ouafik L, Merlin JL, Le Corre D, Aucouturier P, Sabourin JC, Nowak F, Frebourg T, Emile JF, Durand-Zaleski I, Laurent-Puig P,

PLoS ONE. 2013 ;8(7):e68945

Synergistic antitumor effect between gefitinib and fractionated irradiation in anaplastic oligodendrogliomas cannot be predicted by the Egfr signaling activity.

Pinel S, Mriouah J, Vandamme M, Chateau A, Plenat F, Guerin E, Taillandier L, Bernier-Chastagner V, Merlin JL, Chastagner P

PLoS One. 2013 Jul 18;8(7):e68333

Comparison of COBAS 4800 KRAS, PCR TaqMan, and PCR high-resolution melting assays for the detection of KRAS somatic mutations in formalin-fixed paraffin-embedded colorectal tumors.

Merlin JL

J. Clin. Oncol.. 2012 Oct;30(30_suppl):103

Modulation of endothelial cell network formation in vitro by molecular signaling of head and neck squamous cell carcinoma (HNSCC) exposed to cetuximab.

Jouan-Hureaux V, Boura C, Merlin JL, Faivre B

Microvasc. Res.. 2012 Mar;83(2):131-7

Experimental model of naturally occurring post-radiation sarcoma: interest of positron emission tomography (PET) for early detection.

Phulpin B, Tran N, Leroux A, Poussier S, Marie PY, Pinel S, Huger S, Henrot P, Gallet P, Blaise C, Bravetti P, Graff P, Merlin JL, Dolivet G

J Radiat Res. 2012;53(1):101-9.

Regulation of the high basal expression of the manganese superoxide dismutase gene in aggressive breast cancer cells.

Ennen M, Minig V, Grandemange S, Touche N, Merlin JL, Besancenot V, Brunner E, Domenjoud L, Becuwe P

Free Radic. Biol. Med.. 2011 Jun;50(12):1771-9

Intradermal tacrolimus prevent scar hypertrophy in a rabbit ear model: a clinical, histological and spectroscopical analysis.

Gisquet H, Liu H, Blondel WC, Leroux A, Latarche C, Merlin JL, Chassagne JF, Peiffert D, Guillemin F

Skin Res Technol. 2011 May;17(2):160-6

Feasibility of treating irradiated bone with intramedullary delivered autologous mesenchymal stem cells.

Phulpin B, Dolivet G, Marie PY, Poussier S, Huger S, Bravetti P, Graff P, Merlin JL, Tran N

J. Biomed. Biotechnol.. 2011 ;2011:560257

Long-term alterations of cytokines and growth factors expression in irradiated tissues and relation with histological severity scoring.

Gallet P, Phulpin B, Merlin JL, Leroux A, Bravetti P, Mecellem H, Tran N, Dolivet G

PLoS One. 2011;6(12):e29399

Photochemical internalization for pDNA transfection: evaluation of poly(d,l-lactide-co-glycolide) and poly(ethylenimine) nanoparticles.

Gargouri M, Sapin A, Arica-Yegin B, Merlin JL, Becuwe P, Maincent P

Int J Pharm. 2011 Jan 17;403(1-2):276-84

Cellular response to cetuximab in PTEN-silenced head and neck squamous cell carcinoma cell line.

Mriouah J, Boura C, Pinel S, Chretien AS, Fifre A, Merlin JL, Faivre B

Int. J. Oncol.. 2010 Dec;37(6):1555-63

Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal cancer.

Perkins G, Lievre A, Ramacci C, Meatchi T, de Reynies A, Emile JF, Boige V, Tomasic G, Bachet JB, Bibeau F, Bouche O, Penault-Llorca F, Merlin JL, Laurent-Puig P

Int J Cancer. 2010 Sep 1;127(6):1321-31.

Re-assessment of chronic radio-induced tissue damage in a rat hindlimb model.

Phulpin B, Dolivet G, Marie PY, Poussier S, Gallet P, Leroux A, Graff P, Groubach F, Bravetti P, Merlin JL, Tran N

Exp Ther Med. 2010 Jul;1(4):553-560

Optimization of a New Non-viral Vector for Transfection: Eudragit Nanoparticles for the Delivery of a DNA Plasmid

Gargouri M, Sapin A, Bouali S, Becuwe P, Merlin JL, Maincent P

Technol Cancer Res Treat. 2009 Dec;8(6):433-44.

Validation of a phosphoprotein array assay for characterization of human tyrosine kinase receptor downstream signaling in breast cancer.

Chergui F, Chretien AS, Bouali S, Ramacci C, Rouyer M, Bastogne T, Genin P, Leroux A, Merlin JL

Clin Chem. 2009 Jul;55(7):1327-36

Erythropoietin biosimilars in oncology

Merlin JL, Grivel T

Oncologie. 2009 Jun;11(6):363-8

P53 and PTEN expression contribute to the inhibition of EGFR downstream signaling pathway by cetuximab.

Bouali S, Chretien AS, Ramacci C, Rouyer M, Marchal S, Galenne T, Juin P, Becuwe P, Merlin JL

Cancer Gene Ther. 2009 Jun;16(6):498-507

Rehabilitation of irradiated head and neck tissues by autologous fat transplantation.

Phulpin B, Gangloff P, Tran N, Bravetti P, Merlin JL, Dolivet G

Plast Reconstr Surg. 2009 Apr;123(4):1187-97.

PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-type, hormone refractory prostate cancer cells

Bouali S, Chretien AS, Ramacci C, Rouyer M, Becuwe P, Merlin JL

Oncol Rep. 2009 Mar;21(3):731-5.

Translational research and Cancer Plan

Vassal G, Borella L, Pierre A, Pamphile R, Bourrie B, Meflah K, Amalric F, Pauporte I, Caillot JL, Formstecher P, Demers B, Dumontet C, Gregoire M, Lethiec F, Boue AM, Tonelli D, Pilsudski R, Van Hijfte L, Cailliot C, Vrignaud P, Merlin JL, Oudet P, Arnoux PY, Lassale C

Bull Cancer. 2007 Dec 1;94(12):1107-11.

The photodynamic therapy

Barberi-Heyob M, Frochot C, Bezdetnaya-Bolotine L, Brault D, Dumas D, Guillemin F, Krausz P, Maillard P, Maunit B, Merlin JL, Mordon S, Muller JF, Patrice T, Simonneaux G, Tanielian C

Actual Chim. 2007 May-jun;:26-34

[Molecular diagnosis and response prediction to anti-tyrosine kinase receptors in oncology]

Merlin JL

Ann Pharm Fr. 2007 May;65(3):156-61.

Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization.

Ndoye A, Dolivet G, Hogset A, Leroux A, Fifre A, Erbacher P, Berg K, Behr JP, Guillemin F, Merlin JL

Mol Ther. 2006 Jun;13(6):1156-62

Topotecan can compensate for protracted radiation treatment time effects in high grade glioma xenografts.

Pinel S, Chastagner P, Merlin JL, Marchal C, Taghian A, Barberi-Heyob M

J Neurooncol. 2006 Jan;76(1):31-8.

Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells.

Daouphars M, Koufany M, Benani A, Marchal S, Merlin JL, Netter P, Jouzeau JY

Int J Oncol. 2005 Apr;26(4):1069-77.

Sustained gene transfer and enhanced cell death following glucosylated-PEI-mediated p53 gene transfer with photochemical internalisation in p53-mutated head and neck carcinoma cells.

Ndoye A, Bouali S, Dolivet G, Leroux A, Erbacher P, Behr JP, Berg K, Guillemin F, Merlin JL

Int. J. Oncol.. 2004 Dec;25(6):1575-81

Enhanced cell growth inhibition following PTEN nonviral gene transfer using polyethylenimine and photochemical internalization in endometrial cancer cells.

Maurice-Duelli A, Ndoye A, Bouali S, Leroux A, Merlin JL

Technol Cancer Res Treat. 2004 Oct;3(5):459-65.

Foscan-based photodynamic treatment in vivo: correlation between efficacy and Foscan accumulation in tumor, plasma and leukocytes.

Maugain E, Sasnouski S, Zorin V, Merlin JL, Guillemin F, Bezdetnaya L

Oncol. Rep.. 2004 Sep;12(3):639-45

No topoisomerase I alteration in a neuroblastoma model with in vivo acquired resistance to irinotecan.

Calvet L, Santos A, Valent A, Terrier-Lacombe MJ, Opolon P, Merlin JL, Aubert G, Morizet J, Schellens JH, Bénard J, Vassal G

Br. J. Cancer. 2004 Sep;91(6):1205-12

[Targeting of membrane receptor tyrosine kinases: is there resistance in the HER?].

Monnier L, Milano G, Penault-Llorca F, Merlin JL

Bull Cancer. 2004 Sep;91(9):685-94

Enhanced gene transfer and cell death following p53 gene transfer using photochemical internalisation of glucosylated PEI-DNA complexes.

Ndoye A, Merlin JL, Leroux A, Dolivet G, Erbacher P, Behr JP, Berg K, Guillemin F

J Gene Med. 2004 Aug;6(8):884-94

Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts.

Pinel S, Barberi-Heyob M, Cohen-Jonathan E, Merlin JL, Delmas C, Plenat F, Chastagner P

Int. J. Radiat. Oncol. Biol. Phys.. 2004 May;59(1):250-9

Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis.

Barberi-Heyob M, Vedrine PO, Merlin JL, Millon R, Abecassis J, Poupon MF, Guillemin F

Int J Oncol. 2004 Apr;24(4):951-8.

Ethanol stimulates proliferation, ERalpha and aromatase expression in MCF-7 human breast cancer cells.

Etique N, Chardard D, Chesnel A, Merlin JL, Flament S, Grillier-Vuissoz I

Int J Mol Med. 2004 Jan;13(1):149-55.

Oncoprotein expression of E6 and E7 does not prevent 5-fluorouracil (5FU) mediated G1/S arrest and apoptosis in 5FU resistant carcinoma cell lines.

Didelot C, Mirjolet JF, Barberi-Heyob M, Ramacci C, Teiten MH, Merlin JL

Int. J. Oncol.. 2003 Jul;23(1):81-7

[Role of the combination of trastuzumab and taxanes in the therapeutic management of cancer of the breast: from preclinical data to clinical application].

Campone M, Merlin JL, Fumoleau P

Bull Cancer. 2003 Jul;90(7):614-22

In vivo antitumor activity of S16020, a topoisomerase II inhibitor, and doxorubicin against human brain tumor xenografts.

Vassal G, Merlin JL, Terrier-Lacombe MJ, Grill J, Parker F, Sainte-Rose C, Aubert G, Morizet J, Sévenet N, Poullain MG, Lucas C, Kalifa C

Cancer Chemother. Pharmacol.. 2003 May;51(5):385-94

The multidrug resistance modulator SDZ-PSC 833 potentiates the photodynamic activity of chlorin e6 independently of P-glycoprotein in multidrug resistant human breast adenocarcinoma cells.

Merlin JL, Gautier H, Barberi-Heyob M, Teiten MH, Guillemin F

Int. J. Oncol.. 2003 Apr;22(4):733-9

In vitro comparative evaluation of trastuzumab (Herceptin) combined with paclitaxel (Taxol) or docetaxel (Taxotere) in HER2-expressing human breast cancer cell lines.

Merlin JL, Barberi-Heyob M, Bachmann N

Ann Oncol. 2002 Nov;13(11):1743-8.

Polyethylenimine Derivatives as Potent Nonviral Vectors for Gene Transfer.

Merlin JL, N'Doye A, Bouriez T, Dolivet G

Drug News Perspect.. 2002 Sep;15(7):445-451

In vivo growth inhibitory effect of iterative wild-type p53 gene transfer in human head and neck carcinoma xenografts using glucosylated polyethylenimine nonviral vector.

Dolivet G, Merlin JL, Barberi-Heyob M, Ramacci C, Erbacher P, Parache RM, Behr JP, Guillemin F

Cancer Gene Ther.. 2002 Aug;9(8):708-14

Radiation could induce p53-independent and cell cycle--unrelated apoptosis in 5-fluorouracil radiosensitized head and neck carcinoma cells.

Didelot C, Mirjolet JF, Barberi-Heyob M, Ramacci C, Merlin JL

Can. J. Physiol. Pharmacol.. 2002 Jul;80(7):638-43

Human growth hormone gene transfer into tumor cells may improve cancer chemotherapy.

Cherbonnier C, Déas O, Vassal G, Merlin JL, Haeffner A, Senik A, Charpentier B, Dürrbach A, Bénard J, Hirsch F

Cancer Gene Ther.. 2002 Jun;9(6):497-504

G(1)/S but not G(0)/G(1)cell fraction is related to 5-fluorouracil cytotoxicity.

Mirjolet JF, Didelot C, Barberi-Heyob M, Merlin JL

Cytometry. 2002 May;48(1):6-13

Specific fluorescent tracers. Imaging and applications for photodynamic therapy.

Teiten MH, Even P, Burgos P, Frochot C, Aubert S, Carré MC, Bolotine L, Merlin JL, Guillemin F, Viriot ML

C. R. Biol.. 2002 Apr;325(4):487-93

Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines.

Merlin JL, Marchal S, Ramacci C, Berlion M, Poullain MG

Anticancer Drugs. 2002 Feb;13(2):141-7

Encapsulated cancer cells as a model to study the effect of antitumor therapy on small size tumors.

Markvicheva E, Jourdain C, Barth

International Congress on advances in the use of multicellular spheroids in cancer biology and therapy, Roma, 2002

Robotized automatic amage analysis for the evaluation of the response of human tumor spheroids in cancer biology and therapy

Merlin JL, Barth

International Congress on advances in the use of multicellular spheroids in cancer biology and therapy, Roma, 2002

Constitutive NF-kappaB activity influences basal apoptosis and radiosensitivity of head-and-neck carcinoma cell lines.

Didelot C, Barberi-Heyob M, Bianchi A, Becuwe P, Mirjolet JF, Dauça M, Merlin JL

Int. J. Radiat. Oncol. Biol. Phys.. 2001 Dec;51(5):1354-60

Effect of meta-tetra(hydroxyphenyl)chlorin (mTHPC)-mediated photodynamic therapy on sensitive and multidrug-resistant human breast cancer cells.

Teiten MH, Bezdetnaya L, Merlin JL, Bour-Dill C, Pauly ME, Dicato M, Guillemin F

J. Photochem. Photobiol. B, Biol.. 2001 Sep;62(3):146-52

Pharmacokinetic longitudinal studies of antibiotics administered via a permanent intraosseous device in micropigs.

Chastagner P, Lozniewski A, Lascombes P, Barberi-Heyob M, Merthes PM, Merlin JL

Med. Pediatr. Oncol.. 2001 Jun;36(6):635-40

Improvement of nonviral p53 gene transfer in human carcinoma cells using glucosylated polyethylenimine derivatives.

Merlin JL, Dolivet G, Dubessy C, Festor E, Parache RM, Verneuil L, Erbacher P, Behr JP, Guillemin F

Cancer Gene Ther.. 2001 Mar;8(3):203-10

Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status.

Mirjolet JF, Barberi-Heyob M, Didelot C, Peyrat JP, Abecassis J, Millon R, Merlin JL

Br. J. Cancer. 2000 Nov;83(10):1380-6

Modulation of daunorubicin cellular resistance by combination of P-glycoprotein blockers acting on drug efflux and intracellular drug sequestration in Golgi vesicles.

Merlin JL, Bour-Dill C, Marchal S, Ramacci C, Poullain MG, Giroux B

Cytometry. 2000 Sep;41(1):62-72

In vivo potentiation of radiation response by topotecan in human rhabdomyosarcoma xenografted into nude mice.

Chastagner P, Merlin JL, Marchal C, Hoffstetter S, Barberi-Heyob M, Vassal G, Duprez A

Clin. Cancer Res.. 2000 Aug;6(8):3327-33

Involvement of neutrophilic granulocytes in the uptake of biodegradable non-stealth and stealth nanoparticles in guinea pig.

Zambaux MF, Faivre-Fiorina B, Bonneau F, Marchal S, Merlin JL, Dellacherie E, Labrude P, Vigneron C

Biomaterials. 2000 May;21(10):975-80

Resistance to paclitaxel induces time-delayed multinucleation and DNA fragmentation into large fragments in MCF-7 human breast adenocarcinoma cells.

Merlin JL, Bour-Dill C, Marchal S, Bastien L, Gramain MP

Anticancer Drugs. 2000 Apr;11(4):295-302

Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis.

Bour-Dill C, Gramain MP, Merlin JL, Marchal S, Guillemin F

Cytometry. 2000 Jan;39(1):16-25

Foscan (mTHPC) photosensitized macrophage activation: enhancement of phagocytosis, nitric oxide release and tumour necrosis factor-alpha-mediated cytolytic activity.

Coutier S, Bezdetnaya L, Marchal S, Melnikova V, Belitchenko I, Merlin JL, Guillemin F

Br. J. Cancer. 1999 Sep;81(1):37-42

Meta-tetra(hydroxyphenyl)chlorin-sensitized photodynamic damage of cultured tumor and normal cells in the presence of high concentrations of alpha-tocopherol.

Melnikova V, Bezdetnaya L, Belitchenko I, Potapenko A, Merlin JL, Guillemin F

Cancer Lett.. 1999 May 3;139(1):89-95

Subcellular localization of meta-tetra (hydroxyphenyl) chlorin in human tumor cells subjected to photodynamic treatment.

Melnikova VO, Bezdetnaya LN, Bour C, Festor E, Gramain MP, Merlin JL, Potapenko AYa,Guillemin F

J. Photochem. Photobiol. B, Biol.. 1999 Apr;49(2-3):96-103

Influence of the fluoroquinolone ofloxacin on the intrinsic expression of multidrug resistance phenotype in HCT-8 human colon carcinoma cells.

Marchal S, Merlin JL, Colosetti P, Finance C

Oncol. Res.. 1999 ;11(8):375-81

[Elements of epidemiology and initiation of carcinogenesis in carcinomas of the upper aerodigestive tract. Future therapeutic consequence?].

Dolivet G, Colosetti P, Merlin JL, Depardieu C, Lapeyre M, Wattel E, Sarini J, Ton Van J, Geoffrois L, Lagarde P

Rev Laryngol Otol Rhinol (Bord). 1999 ;120(1):5-12

Intracellular distribution of tamoxifen in resistant human breast adenocarcinoma cells using tamoxifen-eosin association.

Bachmann N, Barberi-Heyob M, Bour C, Parache RM, Guillemin F, Batt AM, Merlin JL

Cell Biol. Toxicol.. 1998 Dec;14(6):429-35

Influence of SDZ-PSC833 on daunorubicin intracellular accumulation in bone marrow specimens from patients with acute myeloid leukaemia.

Merlin JL, Guerci AP, Marchal S, Bour C, Colosetti P, Kataki A, Guerci O

Br. J. Haematol.. 1998 Nov;103(2):480-7

Clinical impact of pharmacokinetically-guided dose adaptation of 5-fluorouracil: results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas.

Fety R, Rolland F, Barberi-Heyob M, Hardouin A, Campion L, Conroy T, Merlin JL, Rivière A, Perrocheau G, Etienne MC, Milano G

Clin. Cancer Res.. 1998 Sep;4(9):2039-45

Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity.

Mirjolet JF, Barberi-Heyob M, Merlin JL, Marchal S, Etienne MC, Milano G, Bey P

Br. J. Cancer. 1998 Jul;78(1):62-8

Characterization of photodegradation of meta-tetra(hydroxyphenyl)chlorin (mTHPC) in solution: biological consequences in human tumor cells.

Belitchenko I, Melnikova V, Bezdetnaya L, Rezzoug H, Merlin JL, Potapenko A, Guillemin F

Photochem. Photobiol.. 1998 May;67(5):584-90

Combined flow cytometry and immunohistochemistry analyses for the assessment of nasopharyngeal carcinoma cell kinetics by in vivo bromodeoxyuridine infusion.

Marchal S, Marchal C, Parache RM, Benjaafar N, Odda M, Leclerc A, Merlin JL, el Gueddarri B, Bey P

Cytometry. 1997 Oct;29(2):165-72

French multicentric evaluation of mdr1 gene expression by RT-PCR in leukemia and solid tumours. Standardization of RT-PCR and preliminary comparisons between RT-PCR and immunohistochemistry in solid tumours. French Network of the Drug Resistance Intergrou

Chevillard S, Vielh P, Validire P, Marie JP, Faussat AM, Barbu V, Bayle C, Bénard J, Bonnal C, Boutonnat J, Calvo F, Charrier J, Clary A, Colosetti P, Danel-Moore L, Decrémoux P, Delvincourt C, Finat-Duclos F, Genne P, Kataki A, Kouyoumdjian JC, Lacave R, Maugard C, Merlin JL, Robert J

Leukemia. 1997 Jul;11(7):1095-106

Evaluation of Taxol in head and neck squamous carcinoma multicellular tumor spheroids.

Griffon-Etienne G, Merlin JL, Marchal C

Anticancer Drugs. 1997 Jan;8(1):48-55

Sensitive isocratic liquid chromatographic assay for the determination of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin in plasma and tissue with electrochemical detection.

Barberi-Heyob M, Rezzoug H, Merlin JL, Guillemin F

J. Chromatogr. B Biomed. Sci. Appl.. 1997 Jan;688(2):331-8

[In vitro comparison of the photodynamic activity of meso-tetra (m-hydroxyphenyl) chlorin and hematoporphyrin derivative].

Rezzoug H, Barberi-Heyob M, Merlin JL, Bolotine L, Lignon D, Guillemin F

Bull Cancer. 1996 Oct;83(10):816-22

Association of docetaxel/paclitaxel with irradiation in ovarian carcinoma cell lines in bidimensional (sulforhodamine B assay) and tridimensional (spheroids) cultures.

Griffon-Etienne G, Merlin JL, Marchal C

Anticancer Drugs. 1996 Aug;7(6):660-70

Spectroscopic and biological testing of photobleaching of porphyrins in solutions.

Bezdetnaya L, Zeghari N, Belitchenko I, Barberi-Heyob M, Merlin JL, Potapenko A, Guillemin F

Photochem. Photobiol.. 1996 Aug;64(2):382-6

Comparative in vitro evaluation of dithiane analogs of tiapamil, Ro 11-2933, Ro 44-5911 and Ro 44-5912 as multidrug resistance modulators.

Abderrabi M, Marchal S, Merlin JL

Anticancer Drugs. 1996 Jun;7(4):430-6

[Predictive value of intracellular accumulation of daunorubicin and P-glycoprotein expression simultaneously determined by flow cytometry in adult acute myeloid leukemias].

Guerci A, Merlin JL, Missoum N, Feldmann L, Marchal S, Guerci O

Ann. Biol. Clin. (Paris). 1996 ;54(1):17-9

[Stability of 5-fluorouracil solutions according to different parameters].

Barberi-Heyob M, Watelet M, Merlin JL, Bleger C, Schroeder B

Bull Cancer. 1995 Dec;82(12):1025-31

Determination of amplification level of the c-erbB-2 proto-oncogene in human breast carcinomas: a comparative study between non-radioactive and radioactive labelling.

Edorh A, Parache RM, N'Sossani B, Bottin MC, Merlin JL, Colosetti P, Guillemin F, Le Faou A, Rihn B

Cell. Mol. Biol. (Noisy-le-grand). 1995 Nov;41(7):967-73

Influence of S9788, a new modulator of multidrug resistance, on the cellular accumulation and subcellular distribution of daunorubicin in P-glycoprotein-expressing MCF7 human breast adenocarcinoma cells.

Merlin JL, Marchal S, Ramacci C, Dieterlen A, Schultz G, Lucas C, Poullain MG, Berlion M

Cytometry. 1995 Aug;20(4):315-23

Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry.

Guerci A, Merlin JL, Missoum N, Feldmann L, Marchal S, Witz F, Rose C, Guerci O

Blood. 1995 Apr;85(8):2147-53

Addition of heparin in 5-fluorouracil solution for portal vein infusion has no influence on its stability under clinically relevant conditions.

Barberi-Heyob M, Merlin JL, Vigneron M, Conroy T

Anticancer Drugs. 1995 Feb;6(1):163-4

Comparison of sulforhodamine B, tetrazolium and clonogenic assays for in vitro radiosensitivity testing in human ovarian cell lines.

Griffon G, Merlin JL, Marchal C

Anticancer Drugs. 1995 Feb;6(1):115-23

Evaluation of plasma 5-fluorouracil nucleoside levels in patients with metastatic breast cancer: relationships with toxicities.

Barberi-Heyob M, Weber B, Merlin JL, Dittrich C, de Bruijn EA, Luporsi E, Guillemin F

Cancer Chemother. Pharmacol.. 1995 ;37(1-2):110-6

Radiosensitivity of multicellular tumour spheroids obtained from human ovarian cancers.

Griffon G, Marchal C, Merlin JL, Marchal S, Parache RM, Bey P

Eur. J. Cancer. 1995 ;31A(1):85-91

[Inflammatory myofibroblastic tumor of the lung with endobronchial, infiltrating, multifocal and recurrent form].

Boman F, Champigneulle J, Boccon-Gibod L, Merlin JL, De Miscault G, Schmitt C, Sommelet D, Floquet J

Ann Pathol. 1995 ;15(3):207-10

[Effect of the modality of exposure on the action of S9788 on the modulation of multidrug resistance of human tumor cell lines].

Merlin JL, Marchal S, Ramacci C, Lucas C, Paraire M, Poullain MG

Bull Cancer. 1994 Oct;81(10):906-9

Comparative evaluation of S9788, verapamil, and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematologic malignancies.

Merlin JL, Guerci A, Marchal S, Missoum N, Ramacci C, Humbert JC, Tsuruo T, Guerci O

Blood. 1994 Jul;84(1):262-9

Antiproliferative activity of thermosensitive liposome-encapsulated doxorubicin combined with 43 degrees C hyperthermia in sensitive and multidrug-resistant MCF-7 cells.

Merlin JL, Marchal S, Ramacci C, Notter D, Vigneron C

Eur. J. Cancer. 1993 ;29A(16):2264-8

[Plasma pharmacokinetics of morphine and morphine-6-glucuronide using high performance liquid chromatography and colorimetric detection].

Barberi-Heyob M, Merlin JL, Krakowski I, Kettani C, Collin E, Poulain P

Bull Cancer. 1991 Nov;78(11):1063-70

In vitro combination of high dose busulfan with radiotherapy on medulloblastoma cells: additive effect without potentiation.

Merlin JL, Chastagner P, Marchal C, Weber B, Bey P

Anticancer Drugs. 1991 Oct;2(5):465-8

Clinical randomized study of 5FU monitoring versus standard dose in patients with head and neck cancer: preliminary results.

Fety R, Rolland F, Barberi-Heyob M, Merlin JL, Conroy T, Hardouin A, Riviere A, Milano G

Anticancer Res.. ;14(6A):2347-52

Concepts of synergism and antagonism.

Merlin JL

Anticancer Res.. ;14(6A):2315-9

Modulation of daunorubicin intracellular accumulation in P-glycoprotein expressing MCF-7 human breast adenocarcinoma cells by thermosensitive-liposome encapsulation and hyperthermia.

Merlin JL, Marchal S, Ramacci C, Notter D, Vigneron C

Int J Hyperthermia. ;11(6):855-65

Sensitivity to taxoid derivatives of a newly established human endometrioid ovarian adenocarcinoma radioresistant cell line.

Griffon G, Merlin JL, Parache RM, Martinet N, Marchal S, Nabet F, Wellman M, Barlier C, Marchal C

Anticancer Res.. ;16(1):177-87

[Method validation according to ISO 15189 and SH GTA 04: application for the detection of KRAS mutations using PCR TaqMan assay].

Harlé A, Dubois C, Rouyer M, Merlin JL

Ann. Biol. Clin. (Paris). ;71(5):603-7

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