Controversy: Sensitization against quaternary ammonium compounds is involved in allergic reactions to neuromuscular blocking agents
Fiche publication
Date publication
avril 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis
Tous les auteurs :
Mertes PM, Regnier MA, Hasdenteufel F, Gueant-Rodriguez RM, Mouton-Faivre C, Malinovsky JM, Gueant JL, Kanny G
Lien Pubmed
Résumé
Allergic reactions to neuromuscular blocking agents (NMBAs) remain a major issue in anaesthesia NMBAs possess two quaternary ammonium ions which are necessary for their biological properties but which are also part of the epitope recognised by specific IgEs Immediate hypersensitivity allergic reactions occurring on induction of anesthesia with first exposure to NMBA has led to the hypothesis of pre-existent cross-reactive sensitisation following exposure to compounds in the environment which have a quaternary ammonium determinant Pholcodine is one of the substances which has been recognised as being potentially responsible for this sensitization However, the most recent epidemiologic studies have suggested that other substances which remained to be identified might equally be involved (C) 2010 Elsevier Masson SAS All rights reserved.
Référence
Rev Fr Allergol. 2010 Apr;50(3):174-8