A crucial role for Lyn in TIMP-1 erythroid cell survival signalling pathway.
Fiche publication
Date publication
mai 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DAUCHEZ Manuel, Dr ETIQUE Nicolas, Pr MARTINY Laurent, Dr THEVENARD-DEVY Jessica
Tous les auteurs :
Bridoux L, Etique N, Lambert E, Thevenard J, Sowa ML, Belloy N, Dauchez M, Martiny L, Charpentier E
Lien Pubmed
Résumé
TIMP-1, a well-known MMP inhibitor, displays other biological activities such as cell survival, proliferation and differentiation in hematopoietic cells. In this report, we investigated the role of the Src-related kinase Lyn in TIMP-1 induced UT-7 erythroleukemic cell survival. We showed that (i) tyrosine 507 of Lyn was dephosphorylated and Lyn kinase activity enhanced by TIMP-1, (ii) Lyn silencing suppressed TIMP-1 anti-apoptotic activity and (iii) Lyn was activated upstream the JAK2/PI 3-kinase/Akt pathway. Our data suggest a novel role for Lyn in erythroid cell survival.
Référence
FEBS Lett. 2013 May 21;587(10):1524-8