Cherenkov Radiation induced photodynamic therapy - repurposing older photosensitizers, and radionuclides.
Fiche publication
Date publication
septembre 2023
Journal
Photodiagnosis and photodynamic therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Dr COLLIN Bertrand, Dr DECREAU Richard, Dr BELLAYE Pierre-Simon
Tous les auteurs :
Lioret V, Bellaye PS, Bernhard Y, Moreau M, Guillemin M, Drouet C, Collin B, Decréau RA
Lien Pubmed
Résumé
Old-generation photosensitizers are minimally used in current photodynamic therapy (PDT) because they absorb in the UV/blue/green region of the spectrum where biological tissues are generally highly absorbing. The UV/blue light of Cherenkov Radiation (CR) from nuclear disintegration of beta-emitter radionuclides shows promise as an internal light source to activate these photosensitizers within tissue. Outline of the study: 1) radionuclide choice and Cherenkov Radiation, 2) Photosensitizer choice, synthesis and radiolabeling, 3) CR-induced fluorescence, 4) Verification of ROS formation, 5) CR-induced PDT with either free eosine and free CR emitter, or with radiolabelled eosin.
Mots clés
Cherenkov Radiation Energy Transfer (CRET), Cherenkov Radiation induced Photodynamic Therapy (CR-PDT), Eosin, Eosin-DOTAGA, Fluorescence, Radiolabeling, Radionuclides, Reactive oxygen species
Référence
Photodiagnosis Photodyn Ther. 2023 09 30;:103816