Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Development of an Immuno-SPECT/Fluorescent Bimodal Tracer Targeting Human or Murine PD-L1 on Preclinical Models.

Privat M, Massot A, Hermetet F, Al Sabea H, Racoeur C, Mabrouk N, Cordonnier M, Moreau M, Collin B, Bettaieb A, Denat F, Bodio E, Bellaye PS, Goze C, Paul C

J Med Chem. 2024 01 25;:

Cherenkov Radiation induced photodynamic therapy - repurposing older photosensitizers, and radionuclides.

Lioret V, Bellaye PS, Bernhard Y, Moreau M, Guillemin M, Drouet C, Collin B, Decréau RA

Photodiagnosis Photodyn Ther. 2023 09 30;:103816

SPECT Imaging of Lysyl Oxidase-like 2 in a Model of Idiopathic Pulmonary Fibrosis.

Vizier R, Garnier AR, Dias A, Moreau M, Claron M, Collin B, Denat F, Bellaye PS, Goncalves V

Mol Pharm. 2023 06 12;:

Oleanolic Acid Glycosides from and : Structural Analysis and Cytotoxicity.

Nazaryan S, Bruguière A, Hovhannisyan N, Miyamoto T, Dias AMM, Bellaye PS, Collin B, Briand L, Mitaine-Offer AC

Molecules. 2023 05 25;28(11):

First Comparison Study of the and Properties of a Randomly and Site-Specifically Conjugated SPECT/NIRF Monomolecular Multimodal Imaging Probe (MOMIP) Based on an aza-BODIPY Fluorophore.

Privat M, Bellaye PS, Chazeau E, Racoeur C, Adumeau P, Vivier D, Bernhard C, Moreau M, Collin B, Bettaieb A, Denat F, Bodio E, Paul C, Goze C

Bioconjug Chem. 2023 03 27;:

HSPB5 Inhibition by NCI-41356 Reduces Experimental Lung Fibrosis by Blocking TGF-β1 Signaling.

Tanguy J, Boutanquoi PM, Burgy O, Dondaine L, Beltramo G, Uyanik B, Garrido C, Bonniaud P, Bellaye PS, Goirand F

Pharmaceuticals (Basel). 2023 01 24;16(2):

IL-1RAP, a Key Therapeutic Target in Cancer.

Frenay J, Bellaye PS, Oudot A, Helbling A, Petitot C, Ferrand C, Collin B, Dias AMM

Int J Mol Sci. 2022 11 29;23(23):

Superparamagnetic Iron Oxide Nanoparticles for Immunotherapy of Cancers through Macrophages and Magnetic Hyperthermia.

Dias AMM, Courteau A, Bellaye PS, Kohli E, Oudot A, Doulain PE, Petitot C, Walker PM, Decréau R, Collin B

Pharmaceutics. 2022 11 5;14(11):

Development of Anti-LRRC15 Small Fragments for Imaging Purposes Using a Phage-Display ScFv Approach.

Baurand PE, Balland J, Reynas C, Ramseyer M, Vivier D, Bellaye PS, Collin B, Paul C, Denat F, Asgarov K, Pallandre JR, Ringenbach L

Int J Mol Sci. 2022 10 21;23(20):

Oleanane-type glycosides isolated from the trunk barks of the central African tree Millettia laurentii.

Pertuit D, Mitaine-Offer AC, Miyamoto T, Tanaka C, Delaude C, Bellaye PS, Collin B, Lacaille-Dubois MA

Fitoterapia. 2022 Apr 12;:105193

Measurement of hypoxia in the lung in idiopathic pulmonary fibrosis: a matter of control.

Bellaye PS, Beltramo G, Burgy O, Collin B, Cochet A, Bonniaud P

Eur Respir J. 2022 Jan 27;:

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells.

Limagne E, Nuttin L, Thibaudin M, Jacquin E, Aucagne R, Bon M, Revy S, Barnestein R, Ballot E, Truntzer C, Derangère V, Fumet JD, Latour C, Rébé C, Bellaye PS, Kaderbhaï CG, Spill A, Collin B, Callanan MB, Lagrange A, Favier L, Coudert B, Arnould L, Ladoire S, Routy B, Joubert P, Ghiringhelli F

Cancer Cell. 2022 Jan 17;:

The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with Tc-Tilmanocept SPECT.

Bouchard A, Sikner H, Baverel V, Garnier AR, Monterrat M, Moreau M, Limagne E, Garrido C, Kohli E, Collin B, Bellaye PS

Cells. 2021 12 2;10(12):

Steroidal glycosides from the Vietnamese cultivar Cordyline fruticosa "Fairchild red".

Nguyen DH, Mitaine-Offer AC, Miyamoto T, Tanaka C, Bellaye PS, Collin B, Chambin O, Lacaille-Dubois MA

Phytochemistry. 2021 Oct 5;192:112966

Extracellular Heat Shock Proteins as Therapeutic Targets and Biomarkers in Fibrosing Interstitial Lung Diseases.

Tanguy J, Pommerolle L, Garrido C, Kolb M, Bonniaud P, Goirand F, Bellaye PS

Int J Mol Sci. 2021 Aug 27;22(17):

GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment.

Bouchard A, Collin B, Garrido C, Bellaye PS, Kohli E

Biology (Basel). 2021 Aug 27;10(9):

Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the aza-BODIPY Fluorophore.

Privat M, Bellaye PS, Lescure R, Massot A, Baffroy O, Moreau M, Racoeur C, Marcion G, Denat F, Bettaieb A, Collin B, Bodio E, Paul C, Goze C

J Med Chem. 2021 Aug 2;:

Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with Ga-Labeled Antagonists: The Chelate Makes the Difference Again.

Renard E, Moreau M, Bellaye PS, Guillemin M, Collin B, Prignon A, Denat F, Goncalves V

J Med Chem. 2021 Jun 9;:

Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties.

Lescure R, Privat M, Pliquett J, Massot A, Baffroy O, Busser B, Bellaye PS, Collin B, Denat F, Bettaïeb A, Sancey L, Paul C, Goze C, Bodio E

Eur J Med Chem. 2021 Apr 19;220:113483

Fibrotic extracellular matrix induces release of extracellular vesicles with pro-fibrotic miRNA from fibrocytes.

Sato S, Chong SG, Upagupta C, Yanagihara T, Saito T, Shimbori C, Bellaye PS, Nishioka Y, Kolb MR

Thorax. 2021 Apr 15;:

HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias.

Mshaik R, Simonet J, Georgievski A, Jamal L, Bechoua S, Ballerini P, Bellaye PS, Mlamla Z, Pais de Barros JP, Geissler A, Francin PJ, Girodon F, Garrido C, Quéré R

Blood Cancer J. 2021 Mar 18;11(3):61

[F]FMISO PET/CT imaging of hypoxia as a non-invasive biomarker of disease progression and therapy efficacy in a preclinical model of pulmonary fibrosis: comparison with the [F]FDG PET/CT approach.

Tanguy J, Goirand F, Bouchard A, Frenay J, Moreau M, Mothes C, Oudot A, Helbling A, Guillemin M, Bonniaud P, Cochet A, Collin B, Bellaye PS

Eur J Nucl Med Mol Imaging. 2021 Feb 13;:

Nanofitins targeting heat shock protein 110: an innovative immunotherapeutic modality in cancer.

Marcion G, Hermetet F, Neiers F, Uyanik B, Dondaine L, Dias AMM, Da Costa L, Moreau M, Bellaye PS, Collin B, Gobbo J, Briand L, Seigneuric R, Kitten O, Cinier M, Garrido C

Int J Cancer. 2021 Jan 27;:

The HSP GRP94 interacts with macrophage intracellular complement C3 and impacts M2 profile during ER stress.

Chaumonnot K, Masson S, Sikner H, Bouchard A, Baverel V, Bellaye PS, Collin B, Garrido C, Kohli E

Cell Death Dis. 2021 Jan 22;12(1):114

HSP47: a potential target for fibrotic diseases and implications for therapy.

Bellaye PS, Burgy O, Bonniaud P, Kolb M

Expert Opin Ther Targets. 2020 Dec 8;:

FK506-binding Protein 13 Expression is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity: A Potentially Protective Role.

Tat V, Ayaub EA, Ayoub A, Vierhout M, Naiel S, Padwal MK, Abed S, Mekhael O, Tandon K, Revill SD, Yousof T, Bellaye PS, Kolb PS, Dvorkin-Gheva A, Naqvi A, Cutz JC, Hambly N, Kato J, Vaughan M, Moss J, Kolb MR, Ask K

Am J Respir Cell Mol Biol. 2020 Nov 30;:

Lipoproteins LDL versus HDL as nanocarriers to target either cancer cells or macrophages.

Hadi T, Ramseyer C, Gautier T, Bellaye PS, Lopez T, Schmitt A, Sarah F, Yesylevskyy S, Minervini T, Douhard R, Dondaine L, Proukhnitzky L, Messaoudi S, Wendremaire M, Moreau M, Neiers F, Collin B, Denat F, Lagrost L, Garrido C, Lirussi F

JCI Insight. 2020 Nov 24;:

Pathogenesis of fibrosis in interstitial lung disease.

Burgy O, Bellaye PS, Beltramo G, Goirand F, Bonniaud P

Curr Opin Pulm Med. 2020 Sep;26(5):429-435

Dual Cherenkov Radiation-induced Near-Infrared Luminescence Imaging and Photodynamic Therapy towards Tumor Resection.

Lioret V, Bellaye PS, Arnould C, Collin B, Decreau RA

J. Med. Chem.. 2020 Jul 24;:

TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signaling.

Boutanquoi PM, Burgy O, Beltramo G, Bellaye PS, Dondaine L, Marcion G, Pommerolle L, Vadel A, Spanjaard M, Demidov O, Mailleux A, Crestani B, Kolb M, Garrido C, Goirand F, Bonniaud P

Eur. Respir. J.. 2020 Mar 17;:

Aza-BODIPY Platform: Toward an Efficient Water-Soluble Bimodal Imaging Probe for MRI and Near-Infrared Fluorescence.

Florès O, Pliquett J, Abad Galan L, Lescure R, Denat F, Maury O, Pallier A, Bellaye PS, Collin B, Même S, Bonnet CS, Bodio E, Goze C

Inorg Chem. 2020 Jan 7;:

Cytotoxic glycosides from the roots of Weigela x "Bristol Ruby".

Nguyen DH, Mitaine-Offer AC, Maroso S, Papini AM, Paululat T, Bellaye PS, Collin B, Chambin O, Lacaille-Dubois MA

Fitoterapia. 2019 Jun 13;:104242

Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis.

Shimbori C, Upagupta C, Bellaye PS, Ayaub EA, Sato S, Yanagihara T, Zhou Q, Ognjanovic A, Ask K, Gauldie J, Forsythe P, Kolb MRJ

Thorax. 2019 May;74(5):455-465

Modular assembly of multimodal imaging agents through an inverse electron demand Diels-Alder reaction.

Canovas C, Moreau M, Vrigneaud JM, Bellaye PS, Collin B, Denat F, Goncalves V

Bioconjug. Chem.. 2019 Feb 11;:

A promising family of fluorescent water-soluble aza-BODIPY dyes for in vivo molecular imaging.

Pliquett J, Dubois A, Racoeur C, Mabrouk N, Amor S, Lescure R, Bettaieb A, Collin B, Bernhard C, Denat F, Bellaye PS, Paul C, Bodio E, Goze C

Bioconjug. Chem.. 2019 Jan 7;:

Cherenkov luminescence imaging is a fast and relevant preclinical tool to assess tumour hypoxia in vivo.

Desvaux E, Courteau A, Bellaye PS, Guillemin M, Drouet C, Walker P, Collin B, Decréau RA

EJNMMI Res. 2018 Dec 20;8(1):111

Site-specific near-infrared fluorescent labelling of proteins on cysteine residues with meso-chloro-substituted heptamethine cyanine dyes.

Canovas C, Bellaye PS, Moreau M, Romieu A, Denat F, Goncalves V

Org. Biomol. Chem.. 2018 Nov 9;:

Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension.

Bellaye PS, Yanagihara T, Granton E, Sato S, Shimbori C, Upagupta C, Imani J, Hambly N, Ask K, Gauldie J, Iglarz M, Kolb M

Eur. Respir. J.. 2018 08;52(2):

Radiolabeled F(ab')-cetuximab for theranostic purposes in colorectal and skin tumor-bearing mice models.

Bellaye PS, Moreau M, Raguin O, Oudot A, Bernhard C, Vrigneaud JM, Dumont L, Vandroux D, Denat F, Cochet A, Brunotte F, Collin B

Clin Transl Oncol. 2018 May 17;:

Optimising experimental research in respiratory diseases: an ERS statement.

Bonniaud P, Fabre A, Frossard N, Guignabert C, Inman M, Kuebler WM, Maes T, Shi W, Stampfli M, Uhlig S, White E, Witzenrath M, Bellaye PS, Crestani B, Eickelberg O, Fehrenbach H, Guenther A, Jenkins G, Joos G, Magnan A, Maitre B, Maus UA, Reinhold P, Vernooy JHJ, Richeldi L, Kolb M

Eur. Respir. J.. 2018 05;51(5):

Lysyl Oxidase-Like 1 Protein Deficiency Protects Mice from Adenoviral Transforming Growth Factor-β1-induced Pulmonary Fibrosis.

Bellaye PS, Shimbori C, Upagupta C, Sato S, Shi W, Gauldie J, Ask K, Kolb M

Am. J. Respir. Cell Mol. Biol.. 2018 04;58(4):461-470

Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis.

Bellaye PS, Shimbori C, Yanagihara T, Carlson DA, Hughes P, Upagupta C, Sato S, Wheildon N, Haystead T, Ask K, Kolb M

Eur. Respir. J.. 2018 02;51(2):

Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model.

Bellaye PS, Oudot A, Vrigneaud JM, Raguin O, Bichat F, Vaslin A, Maby-El Hajjami H, Zanna C, Vuagniaux G, Fumoleau P, Denat F, Brunotte F, Collin B

Contrast Media Mol Imaging. 2018 ;2018:8494031

Heat shock protein: a hot topic in idiopathic pulmonary fibrosis.

Bonniaud P, Bellaye PS, Burgy O, Kolb M

Eur. Respir. J.. 2017 02;49(2):

Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin.

Burgy O, Bellaye PS, Causse S, Beltramo G, Wettstein G, Boutanquoi PM, Goirand F, Garrido C, Bonniaud P

Respir. Res.. 2016 Nov;17(1):162

Fibroblast growth factor-1 attenuates TGF-β1-induced lung fibrosis.

Shimbori C, Bellaye PS, Xia J, Gauldie J, Ask K, Ramos C, Becerril C, Pardo A, Selman M, Kolb M

J. Pathol.. 2016 10;240(2):197-210

GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis.

Ayaub EA, Kolb PS, Mohammed-Ali Z, Tat V, Murphy J, Bellaye PS, Shimbori C, Boivin FJ, Lai R, Lynn EG, Lhoták Š, Bridgewater D, Kolb MR, Inman MD, Dickhout JG, Austin RC, Ask K

J. Pathol.. 2016 08;239(4):411-25

Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis.

Froese AR, Shimbori C, Bellaye PS, Inman M, Obex S, Fatima S, Jenkins G, Gauldie J, Ask K, Kolb M

Am. J. Respir. Crit. Care Med.. 2016 07 1;194(1):84-96

Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity.

Burgy O, Wettstein G, Bellaye PS, Decologne N, Racoeur C, Goirand F, Beltramo G, Hernandez JF, Kenani A, Camus P, Bettaieb A, Garrido C, Bonniaud P

Sci Transl Med. 2016 Feb;8(326):326ra20

Why do patients get idiopathic pulmonary fibrosis? Current concepts in the pathogenesis of pulmonary fibrosis.

Bellaye PS, Kolb M

BMC Med. 2015 Sep 24;13:176

Antifibrotic role of alphaB-crystallin inhibition in pleural and subpleural fibrosis.

Bellaye PS, Burgy O, Colas J, Fabre A, Marchal-Somme J, Crestani B, Kolb M, Camus P, Garrido C, Bonniaud P

Am J Respir Cell Mol Biol. 2015 Feb;52(2):244-52

Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes.

Jego G, Lanneau D, De Thonel A, Berthenet K, Hazoumé A, Droin N, Hamman A, Girodon F, Bellaye PS, Wettstein G, Jacquel A, Duplomb L, Le Mouël A, Papanayotou C, Christians E, Bonniaud P, Lallemand-Mezger V, Solary E, Garrido C

Leukemia. 2014 Aug;28(8):1676-86

Heat shock proteins in fibrosis and wound healing: good or evil?

Bellaye PS, Burgy O, Causse S, Garrido C, Bonniaud P

Pharmacol Ther. 2014 Aug;143(2):119-32

The small heat-shock protein alphaB-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis.

Bellaye PS, Wettstein G, Burgy O, Besnard V, Joannes A, Colas J, Causse S, Marchal-Somme J, Fabre A, Crestani B, Kolb M, Gauldie J, Camus P, Garrido C, Bonniaud P

J Pathol. 2014 Mar;232(4):458-72

Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation.

Wettstein G, Bellaye PS, Kolb M, Hammann A, Crestani B, Soler P, Marchal-Somme J, Hazoume A, Gauldie J, Gunther A, Micheau O, Gleave M, Camus P, Garrido C, Bonniaud P

FASEB J.. 2013 Apr;27(4):1549-60

Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity?

Wettstein G, Bellaye PS, Micheau O, Bonniaud P

Int J Biochem Cell Biol. 2012 Oct;44(10):1680-6

Dr BELLAYE Pierre-Simon

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