ADP receptor P2Y12 is the capstone of the cross-talk between Ca mobilization pathways dependent on Ca ATPases sarcoplasmic/endoplasmic reticulum type 3 and type 2b in platelets.
Fiche publication
Date publication
janvier 2023
Journal
Research and practice in thrombosis and haemostasis
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GACHET Christian
Tous les auteurs :
Feng M, Hechler B, Adam F, Gachet C, Eckly A, Kauskot A, Denis CV, Bryckaert M, Bobe R, Rosa JP
Lien Pubmed
Résumé
Blood platelet Ca stores are regulated by 2 Ca-ATPases (SERCA2b and SERCA3). On thrombin stimulation, nicotinic acid adenosine dinucleotide phosphate mobilizes SERCA3-dependent stores, inducing early adenosine 5'-diphosphate (ADP) secretion, potentiating later SERCA2b-dependent secretion.
Mots clés
ADP, NAADP, P2 purinergic receptor (P2Y12, P2Y1), SERCA3, blood platelets
Référence
Res Pract Thromb Haemost. 2023 01;7(1):100004