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Development of an efficient, ready to use, blood platelet-release device based on two new flow regime parameters: the periodic hydrodynamic loading and the shear stress accumulation.

Pongérard A, Mallo L, Do Sacramento V, Boiron O, Eckly A, Gachet C, Lanza F, Knapp Y, Strassel C

N Biotechnol. 2023 07 11;:

ADP receptor P2Y12 is the capstone of the cross-talk between Ca mobilization pathways dependent on Ca ATPases sarcoplasmic/endoplasmic reticulum type 3 and type 2b in platelets.

Feng M, Hechler B, Adam F, Gachet C, Eckly A, Kauskot A, Denis CV, Bryckaert M, Bobe R, Rosa JP

Res Pract Thromb Haemost. 2023 01;7(1):100004

Marginal zone B cells are responsible for the production of alloantibodies following platelet transfusion in mice.

Couvidou A, Angénieux C, Ruch L, Mangin PH, Gachet C, Maître B

Blood Adv. 2022 12 9;:

Platelet dysfunction and thrombus instability in flow conditions in patients with severe COVID-19.

Tacquard C, Mouriaux C, Delabranche X, Bourdon C, Eckly A, Magnenat S, Sattler L, Gachet C, Mertes PM, Hechler B, Mangin PH

Thromb Res. 2022 11 8;:

Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B-deficient mice.

Mazharian A, Maître B, Bornert A, Hennequin D, Lourenco-Rodrigues M, Geer MJ, Smith CW, Heising S, Walter M, Montel F, Walker LSK, de la Salle H, Watson SP, Gachet C, Senis YA

Blood Adv. 2022 10 21;:

Traumatic vessel injuries initiating hemostasis generate high shear conditions.

Yakusheva AA, Butov KR, Bykov GA, Závodszky G, Eckly AE, Ataullakhanov FI, Gachet C, Panteleev MA, Mangin PH

Blood Adv. 2022 06 21;:

A gain-of-function variant in the Wiskott-Aldrich syndrome gene is associated with a MYH9-related disease-like syndrome.

Marx D, Dupuis A, Eckly AE, Molitor A, Olagne J, Touchard G, Kaaki S, Ory C, Faller AL, Gérard B, Cotter M, Westerberg L, Keszei M, Moulin B, Gachet C, Caillard S, Bahram S, Carapito R

Blood Adv. 2022 Apr 11;:

Rasa3 deficiency minimally impacts thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance.

Lee RH, Ghalloussi D, Harousseau GL, Kenny JP, Kramer PA, Proamer F, Nieswandt B, Flick MJ, Gachet C, Casari C, Eckly A, Bergmeier W

JCI Insight. 2022 Mar 15;:

In Vitro and In Vivo Methods to Explore Megakaryopoiesis.

Lanza F, Gachet C, Eckly A

J Vis Exp. 2021 Nov 17;(177):

Transfusion of fresh washed platelets does not prevent experimental polymicrobial-induced septic shock in mice.

Rabouël Y, Magnenat S, Lefebvre F, Delabranche X, Gachet C, Hechler B

J Thromb Haemost. 2021 Nov 9;:

Mutations in the most divergent α-tubulin isotype, α8-tubulin, cause defective platelet biogenesis.

Kimmerlin Q, Dupuis A, Bodakuntla S, Weber C, Heim V, Henriot V, Moog S, Eckly A, Guéguen P, Ferec C, Gachet C, Janke C, Lanza F

J Thromb Haemost. 2021 Oct 26;:

The Effects of Micro-vessel Curvature Induced Elongational Flows on Platelet Adhesion.

Spieker CJ, Závodszky G, Mouriaux C, van der Kolk M, Gachet C, Mangin PH, Hoekstra AG

Ann Biomed Eng. 2021 Oct 19;:

Characterization of the role of integrin α5β1 in platelet function, hemostasis and experimental thrombosis.

Janus-Bell E, Yakusheva A, Scandola C, Receveur N, Muhammad-Usman A, Mouriaux C, Bourdon C, Loubière C, Eckly A, Senis YA, Panteleev MA, Gachet C, Mangin PH

Thromb Haemost. 2021 Oct 1;:

Platelet FcγRIIA-induced serotonin release exacerbates the severity of Transfusion-Related Acute Lung Injury in mice.

El Mdawar MB, Maître B, Magnenat S, Tupin F, Jonsson F, Gachet C, de la Salle H, Hechler B

Blood Adv. 2021 Sep 14;:

In Situ Exploration of Murine Megakaryopoiesis using Transmission Electron Microscopy.

Scandola C, Lanza F, Gachet C, Eckly A

J Vis Exp. 2021 Sep 8;(175):

Megakaryocyte Culture in 3D Methylcellulose-Based Hydrogel to Improve Cell Maturation and Study the Impact of Stiffness and Confinement.

Boscher J, Gachet C, Lanza F, Léon C

J Vis Exp. 2021 Aug 26;(174):

In Vivo Two-photon Imaging of Megakaryocytes and Proplatelets in the Mouse Skull Bone Marrow.

Bornert A, Pertuy F, Lanza F, Gachet C, Léon C

J Vis Exp. 2021 Jul 28;(173):

Impact of COVID-19 and lockdown regarding blood transfusion.

Delabranche X, Kientz D, Tacquard C, Bertrand F, Roche AC, Tran Ba Loc P, Humbrecht C, Sirlin F, Pivot X, Collange O, Levy F, Oulehri W, Gachet C, Mertes PM

Transfusion. 2021 Jul 13;:

Platelet P2Y Receptor Deletion or Pharmacological Inhibition does not Protect Mice from Sepsis or Septic Shock.

Rabouel Y, Magnenat S, Delabranche X, Gachet C, Hechler B

TH Open. 2021 Jul;5(3):e343-e352

Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3-mediated platelet activation to fibrinogen, thrombus buildup, and stability.

Ahmed MU, Receveur N, Janus-Bell E, Mouriaux C, Gachet C, Jandrot-Perrus M, Hechler B, Gardiner EE, Mangin PH

Res Pract Thromb Haemost. 2021 Jul;5(5):e12551

Isolation of Mouse Megakaryocyte Progenitors.

Kimmerlin Q, Tavian M, Gachet C, Lanza F, Brouard N

J Vis Exp. 2021 May 20;(171):

Leukodepletion Filters-Derived CD34+ Cells As a Cell Source to Study Megakaryocyte Differentiation and Platelet Formation.

Pongerard A, Mallo L, Gachet C, de La Salle H, Lanza F, Strassel C

J Vis Exp. 2021 May 20;(171):

Proplatelet Formation Dynamics of Mouse Fresh Bone Marrow Explants.

Guinard I, Lanza F, Gachet C, Léon C, Eckly A

J Vis Exp. 2021 May 20;(171):

CDX2 regulates ACE expression in blood development and leukemia cells.

El Omar R, Julien E, Biasch K, Guffroy B, Lioure B, Vallat L, Gross I, Domon-Dell C, Lanza F, Gachet C, Negroni M, Freund JN, Tavian M

Blood Adv. 2021 Apr 13;5(7):2012-2016

Atypical focal segmental glomerulosclerosis associated with a new PODXL nonsense variant.

Marx D, Caillard S, Olagne J, Moulin B, Hannedouche T, Touchard G, Dupuis A, Gachet C, Molitor A, Bahram S, Carapito R

Mol Genet Genomic Med. 2021 Mar 29;:e1658

Removal of citrate from PAS-III additive solution improves functional and biochemical characteristics of buffy-coat platelet concentrates stored for 7 days, with or without INTERCEPT pathogen reduction.

Isola H, Ravanat C, Rudwill F, Pongerard A, Haas D, Eckly A, Gachet C, Hechler B

Transfusion. 2021 Feb 1;:

Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells.

Julien E, Biasch K, El Omar R, Freund JN, Gachet C, Lanza F, Tavian M

Stem Cells. 2021 Jan 21;:

Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.

Janus-Bell E, Ahmed MU, Receveur N, Mouriaux C, Nieswandt B, Gardiner EE, Gachet C, Jandrot-Perrus M, Mangin PH

Thromb Haemost. 2020 Oct 29;:

[Cultured platelets].

Strassel C, Lanza F, Gachet C

Bull Acad Natl Med. 2020 Oct 14;:

Pathogenic and likely pathogenic variants in at least five genes account for approximately 3% of mild isolated nonsyndromic thrombocytopenia.

Guéguen P, Dupuis A, Py JY, Desprès A, Masson E, Le Marechal C, Cooper DN, Gachet C, Chen JM, Férec C

Transfusion. 2020 Aug 5;:

Platelet δ-Storage Pool Disease: An Update.

Dupuis A, Bordet JC, Eckly A, Gachet C

J Clin Med. 2020 Aug 4;9(8):

Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids.

Eckly A, Scandola C, Oprescu A, Michel D, Rinckel JY, Proamer F, Hoffmann D, Receveur N, Léon C, Bear JE, Ghalloussi D, Harousseau G, Bergmeier W, Lanza F, Gaits-Iacovoni F, de la Salle H, Gachet C

J. Thromb. Haemost.. 2020 Jul 23;:

Pharmacological Blockade of GPVI Promotes Thrombus Disaggregation in the Absence of Thrombin.

Ahmed MU, Kaneva V, Loyau S, Nechipurenko D, Receveur N, Le Bris M, Janus-Bell E, Didelot M, Rauch A, Susen S, Chakfé N, Lanza F, Gardiner EE, Andrews RK, Panteleev M, Gachet C, Jandrot-Perrus M, Mangin PH

Arterioscler. Thromb. Vasc. Biol.. 2020 Jul 23;:ATVBAHA120314301

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.

Selvadurai MV, Moon MJ, Mountford SJ, Ma X, Zheng Z, Jennings IG, Setiabakti NM, Iman RP, Brazilek RJ, Z Abidin NA, Chicanne G, Severin S, Nicholls AJ, Wong CHY, Rinckel JY, Eckly A, Gachet C, Nesbitt WS, Thompson PE, Hamilton JR

Sci Transl Med. 2020 Jul 22;12(553):

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation.

Bornert A, Boscher J, Pertuy F, Eckly A, Stegner D, Strassel C, Gachet C, Lanza F, Léon C

Haematologica. 2020 Apr 23;:

Update of P2Y Receptor Pharmacology: IUPHAR Review:"27".

Jacobson KA, Delicado EG, Gachet C, Kennedy C, von Kügelgen I, Li B, Miras-Portugal MT, Novak I, Schöneberg T, Perez-Sen R, Thor D, Wu B, Yang Z, Müller CE

Br. J. Pharmacol.. 2020 Feb 9;:

High prevalence of the natural Asn89Asp mutation in the GP1BB gene associated with Bernard-Soulier syndrome in French patients from the genetic isolate of Reunion Island.

Fiore M, De Thoré C, Randrianaivo-Ranjatoelina H, Baas MJ, Jacquemont ML, Dreyfus M, Lavenu-Bombled C, Li R, Gachet C, Dupuis A, Lanza F

Br. J. Haematol.. 2020 Jan 30;:

Functional properties of human platelets derived in vitro from CD34 cells.

Do Sacramento V, Mallo L, Freund M, Eckly A, Hechler B, Mangin P, Lanza F, Gachet C, Strassel C

Sci Rep. 2020 Jan 22;10(1):914

Use of electron microscopy to study megakaryocytes.

Scandola C, Erhardt M, Rinckel JY, Proamer F, Gachet C, Eckly A

Platelets. 2020 Jan 5;:1-10

Does a Useful Test Exist to Properly Evaluate the Pathogenicity of Donor-Specific Antibodies? Lessons from a Comprehensive Analysis in a Well-Studied Single-Center Kidney Transplant Cohort.

Gautier Vargas G, Olagne J, Parissiadis A, Joly M, Cognard N, Perrin P, Froelich N, Guntz P, Gachet C, Moulin B, Caillard S

Transplantation. 2019 Dec 27;:

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner.

Receveur N, Nechipurenko D, Knapp Y, Yakusheva A, Maurer E, Denis CV, Lanza F, Panteleev M, Gachet C, Mangin PH

Haematologica. 2019 Nov 14;:

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner.

Receveur N, Nechipurenko D, Knapp Y, Yakusheva A, Maurer E, Denis CV, Lanza F, Panteleev M, Gachet C, Mangin PH

Haematologica. 2019 Nov 14;105(10):2471-2483

Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y12 deficiencies.

Lunghi B, Lecchi A, Santacroce R, Scavone M, Paniccia R, Artoni A, Gachet C, Castaman G, Margaglione M, Bernardi F, Cattaneo M

Haematologica. 2019 Oct 24;:

Platelet preparation for function testing in the laboratory and clinic: Historical and practical aspects.

Hechler B, Dupuis A, Mangin PH, Gachet C

Res Pract Thromb Haemost. 2019 Oct;3(4):615-625

Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.

Aguilar A, Weber J, Boscher J, Freund M, Ziessel C, Eckly A, Magnenat S, Bourdon C, Hechler B, Mangin PH, Gachet C, Lanza F, Léon C

Blood Adv. 2019 Aug 13;3(15):2368-2380

Cell surface expression of HLA I molecules as a marker of young platelets.

Angénieux C, Dupuis A, Gachet C, de la Salle H, Maître B

J. Thromb. Haemost.. 2019 Jun 17;:

The ATP-gated P2X ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice.

El Mdawar MB, Maître B, Magnenat S, Gachet C, Hechler B, de la Salle H

Sci Rep. 2019 Mar 26;9(1):5159

Hypersensitivity transfusion reactions to platelet concentrate: a retrospective analysis of the French hemovigilance network.

Mertes PM, Tacquard C, Andreu G, Kientz D, Gross S, Malard L, Drouet C, Carlier M, Gachet C, Sandid I, Boudjedir K

Transfusion. 2019 Mar 25;:

An essential role for α4A-tubulin in platelet biogenesis.

Strassel C, Magiera MM, Dupuis A, Batzenschlager M, Hovasse A, Pleines I, Guéguen P, Eckly A, Moog S, Mallo L, Kimmerlin Q, Chappaz S, Strub JM, Kathiresan N, de la Salle H, Van Dorsselaer A, Ferec C, Py JY, Gachet C, Schaeffer-Reiss C, Kile BT, Janke C, Lanza F

Life Sci Alliance. 2019 Feb;2(1):

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface.

Nechipurenko DY, Receveur N, Yakimenko AO, Shepelyuk TO, Yakusheva AA, Kerimov RR, Obydennyy SI, Eckly A, Léon C, Gachet C, Grishchuk EL, Ataullakhanov FI, Mangin PH, Panteleev MA

Arterioscler Thromb Vasc Biol. 2019 01;39(1):37-47

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition.

Selvadurai MV, Brazilek RJ, Moon MJ, Rinckel JY, Eckly A, Gachet C, Meikle PJ, Nandurkar HH, Nesbitt WS, Hamilton JR

FEBS Lett.. 2018 Nov 12;:

Neuroprotective effects of microglial P2Y receptors against ischemic neuronal injury.

Fukumoto Y, Tanaka KF, Parajuli B, Shibata K, Yoshioka H, Kanemaru K, Gachet C, Ikenaka K, Koizumi S, Kinouchi H

J. Cereb. Blood Flow Metab.. 2018 Oct 18;:271678X18805317

Laboratory monitoring of P2Y inhibitors: communication from the SSC of the ISTH.

Frelinger AL, Gachet C, Mumford AD, Noris P, Mezzano D, Harrison P, Gresele P,

J. Thromb. Haemost.. 2018 Sep 4;:

On the way to in vitro platelet production.

Strassel C, Gachet C, Lanza F

Transfus Clin Biol. 2018 Aug 24;:

In vitro quality of amotosalen-UVA pathogen-inactivated mini-pool plasma prepared from whole blood stored overnight.

Ravanat C, Dupuis A, Marpaux N, Naegelen C, Mourey G, Isola H, Laforêt M, Morel P, Gachet C

Vox Sang.. 2018 Aug 6;:

Inherited platelet disorders : Management of the bleeding risk.

Dupuis A, Gachet C

Transfus Clin Biol. 2018 Aug 1;:

[Comparative study on platelet transfusion in Lorraine-Champagne and Alsace in 2015].

Humbrecht C, Somme S, Renaudier P, Gross S, Gachet C, Schlanger S

Transfus Clin Biol. 2018 Jul 31;:

Platelets: A more than a centenary old Odyssey and more to come.

Garraud O, Gachet C

Transfus Clin Biol. 2018 Jul 23;:

Platelet transfusion: Current challenges.

Humbrecht C, Kientz D, Gachet C

Transfus Clin Biol. 2018 Jul 20;:

[Adaptation of platelet concentrates delivery to HAS/ANSM requirements evolution in EFS Grand-Est].

Kientz D, Humbrecht C, Isola H, Gachet C

Transfus Clin Biol. 2018 Jul 16;:

Immobilized fibrinogen activates human platelets through glycoprotein VI.

Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, Mezzano D, Jandrot-Perrus M, Gachet C, Watson SP

Haematologica. 2018 May;103(5):898-907

Retinoic acid receptor-α regulates synthetic events in human platelets: comment.

de la Salle H, Angénieux C, Lanza F, Gachet C

J. Thromb. Haemost.. 2018 May;16(5):1013-1014

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

Beutier H, Hechler B, Godon O, Wang Y, Gillis CM, de Chaisemartin L, Gouel-Chéron A, Magnenat S, Macdonald LE, Murphy AJ, , Chollet-Martin S, Longrois D, Gachet C, Bruhns P, Jönsson F

Sci Immunol. 2018 Apr 13;3(22):

Imaging thrombosis with Tc-labeled RAM.1-antibody in vivo.

Ouadi A, Bekaert V, Receveur N, Thomas L, Lanza F, Marchand P, Gachet C, Mangin PH, Brasse D, Laquerriere P

Nucl. Med. Biol.. 2018 Mar 17;61:21-27

The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.

Leiva O, Leon C, Kah Ng S, Mangin P, Gachet C, Ravid K

Am. J. Hematol.. 2018 Mar;93(3):430-441

High-Resolution 3D Imaging of Megakaryocytes Using Focused Ion Beam-Scanning Electron Microscopy.

Eckly A, Rinckel JY, Proamer F, Gachet C

Methods Mol. Biol.. 2018 ;1812:217-231

On the Way to Platelet Production.

Strassel C, Gachet C, Lanza F

Front Med (Lausanne). 2018 ;5:239

Three-Dimensional Culture in a Methylcellulose-Based Hydrogel to Study the Impact of Stiffness on Megakaryocyte Differentiation.

Aguilar A, Boscher J, Pertuy F, Gachet C, Léon C

Methods Mol. Biol.. 2018 ;1812:139-153

Amotosalen/UVA pathogen inactivation technology reduces platelet activability, induces apoptosis and accelerates clearance.

Hechler B, Ravanat C, Gachet C

Haematologica. 2017 Dec;102(12):e502-e503

Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.

Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt M, Massberg S

Cell. 2017 Nov 30;171(6):1368-1382.e23

Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?

Lavergne M, Janus-Bell E, Schaff M, Gachet C, Mangin PH

Cancers (Basel). 2017 Sep 28;9(10):

A unique microenvironment in the developing liver supports the expansion of megakaryocyte progenitors.

Brouard N, Jost C, Matthias N, Albrecht C, Egard S, Gandhi P, Strassel C, Inoue T, Sugiyama D, Simmons PJ, Gachet C, Lanza F

Blood Adv. 2017 Sep 26;1(21):1854-1866

Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro.

Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin PH, Jandrot-Perrus M

Platelets. 2017 Sep;28(6):529-539

Serotonergic 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors.

Ayme-Dietrich E, Lawson R, Côté F, de Tapia C, Da Silva S, Ebel C, Hechler B, Gachet C, Guyonnet J, Rouillard H, Stoltz J, Quentin E, Banas S, Daubeuf F, Frossard N, Gasser B, Mazzucotelli JP, Hermine O, Maroteaux L, Monassier L

Br. J. Pharmacol.. 2017 Aug;:

Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation.

Alberio L, Ravanat C, Hechler B, Mangin PH, Lanza F, Gachet C

Thromb. Haemost.. 2017 Jun 2;117(6):1101-1114

Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

Saultier P, Vidal L, Canault M, Bernot D, Falaise C, Pouymayou C, Bordet JC, Saut N, Rostan A, Baccini V, Peiretti F, Favier M, Lucca P, Deleuze JF, Olaso R, Boland A, Morange PE, Gachet C, Malergue F, Fauré S, Eckly A, Trégouët DA, Poggi M, Alessi MC

Haematologica. 2017 06;102(6):1006-1016

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y Receptor Downregulation.

Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S

Cell Rep. 2017 05 9;19(6):1151-1164

Dual role of IL-21 in megakaryopoiesis and platelet homeostasis.

Benbarche S, Strassel C, Angénieux C, Mallo L, Freund M, Gachet C, Lanza F, de la Salle H

Haematologica. 2017 04;102(4):637-646

Pre-existing donor-specific antibodies are detrimental to kidney allograft only when persistent after transplantation.

Caillard S, Becmeur C, Gautier-Vargas G, Olagne J, Muller C, Cognard N, Perrin P, Braun L, Heibel F, Lefebre F, Renner V, Gachet C, Moulin B, Parissiadis A

Transpl. Int.. 2017 Jan;30(1):29-40

A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease.

Lavenu-Bombled C, Guitton C, Dupuis A, Baas MJ, Desconclois C, Dreyfus M, Li R, Caron C, Gachet C, Fressinaud E, Lanza F

Thromb. Haemost.. 2016 Nov 30;116(6):1070-1078

Respective contributions of single and compound granule fusion to secretion by activated platelets.

Eckly A, Rinckel JY, Proamer F, Ulas N, Joshi S, Whiteheart SW, Gachet C

Blood. 2016 11 24;128(21):2538-2549

Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.

Lecchi A, Femia EA, Paoletta S, Dupuis A, Ohlmann P, Gachet C, Jacobson KA, Machura K, Podda GM, Zieger B, Cattaneo M

Hamostaseologie. 2016 Nov;36(4):279-283

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

Aguilar A, Pertuy F, Eckly A, Strassel C, Collin D, Gachet C, Lanza F, Léon C

Blood. 2016 10 20;128(16):2022-2032

Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting.

Podoplelova NA, Sveshnikova AN, Kotova YN, Eckly A, Receveur N, Nechipurenko DY, Obydennyi SI, Kireev II, Gachet C, Ataullakhanov FI, Mangin PH, Panteleev MA

Blood. 2016 09 29;128(13):1745-55

Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.

Ohlmann P, Hechler B, Chafey P, Ravanat C, Isola H, Wiesel ML, Cazenave JP, Gachet C

Transfusion. 2016 Sep;56(9):2239-47

Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9.

Mammadova-Bach E, Zigrino P, Brucker C, Bourdon C, Freund M, De Arcangelis A, Abrams SI, Orend G, Gachet C, Mangin PH

JCI Insight. 2016 Sep;1(14):e88245

The contribution of mouse models to the understanding of constitutional thrombocytopenia.

Léon C, Dupuis A, Gachet C, Lanza F

Haematologica. 2016 08;101(8):896-908

Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ibβ function.

Strassel C, Bull A, Moog S, Receveur N, Mallo L, Mangin P, Eckly A, Freund M, Dubart-Kupperschmitt A, Gachet C, Lanza F

J. Thromb. Haemost.. 2016 07;14(7):1470-9

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.

Antkowiak A, Viaud J, Severin S, Zanoun M, Ceccato L, Chicanne G, Strassel C, Eckly A, Leon C, Gachet C, Payrastre B, Gaits-Iacovoni F

J. Thromb. Haemost.. 2016 06;14(6):1268-84

Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets.

Strassel C, Brouard N, Mallo L, Receveur N, Mangin P, Eckly A, Bieche I, Tarte K, Gachet C, Lanza F

Blood. 2016 05 5;127(18):2231-40

Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury.

Tang C, Wang Y, Lei D, Huang L, Wang G, Chi Q, Zheng Y, Gachet C, Mangin PH, Zhu L

Thromb. Res.. 2016 May;141:49-57

Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity.

Angénieux C, Maître B, Eckly A, Lanza F, Gachet C, de la Salle H

PLoS ONE. 2016 ;11(1):e0148064

In Vitro Binding of [³H]PSB-0413 to P2Y₁₂ Receptors.

Dupuis A, Heim V, Ohlmann P, Gachet C

Curr Protoc Pharmacol. 2015 Dec;71:1.35.1-19

Purinergic Receptors in Thrombosis and Inflammation.

Hechler B, Gachet C

Arterioscler. Thromb. Vasc. Biol.. 2015 Nov;35(11):2307-15

Dehydration of blood platelets by zeodration: in vitro characterization and hemostatic properties in vivo.

Donnet T, Ravanat C, Eckly A, Maurer E, Alame G, Ziessel C, Mangin PH, Freund M, Cazenave JP, Gachet C, Rendu F

Transfusion. 2015 Sep;55(9):2207-18

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.

Ciciliano JC, Sakurai Y, Myers DR, Fay ME, Hechler B, Meeks S, Li R, Dixon JB, Lyon LA, Gachet C, Lam WA

Blood. 2015 Aug 6;126(6):817-24

Dr GACHET Christian

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