Trajectory Interference for Unraveling Dynamic Biological Processes from Raman Spectral Data.
Fiche publication
Date publication
février 2023
Journal
Analytical chemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BUACHE Emilie, Dr GOBINET Cyril, Pr MORJANI Hamid, Pr PIOT Olivier
Tous les auteurs :
Goffin N, Buache E, Charpentier C, Lehrter V, Morjani H, Gobinet C, Piot O
Lien Pubmed
Résumé
Cell heterogeneity is a crucial parameter for understanding the complexity of numerous biomedical issues. Trajectory inference-based approaches are recent tools developed for single-cell transcriptomics (scRNA-seq) data analysis. They aim to reconstruct evolving pathways from the variety of cell states that coexist simultaneously in a cell population. We propose to expand this concept to Raman spectroscopy, a label-free modality that probes the global molecular nature of a sample, by investigating the dynamics of adipocyte differentiation.
Référence
Anal Chem. 2023 02 14;: