Pr MORJANI Hamid

Fiche personne

Coordonnées

BioSpecT EA 7506
Université de Reims Champagne-Ardenne
Campus Santé, UFR de Médecine/Pharmacie
51 rue Cognacq-Jay
51096 REIMS Cedex

03 26 91 35 65

Territoire

Champagne-Ardenne

Statut

Enseignant-Chercheur

Affiliation

Université de Reims Champagne-Ardenne (URCA)

Équipes/plateformes

EA 7506 - Equipe "BioSpectroscopie Translationnelle (BioSpecT)"

Projets

Identification des acteurs impliqués dans l’invasion tumorale différentielle au cours du vieillissement dans un modèle matriciel de collagène de type I

2017 - Porteur du projet : Pr MORJANI Hamid

Impact des modifications de l'organisation structurale du collagène de type I au cours du vieillissement chronologique sur la migration cellulaire et l'invasion tumorale

2015 - Porteur du projet : Pr MORJANI Hamid

Contribution du microenvironnement à la prolifération et à la résistance à la chimiothérapie des cellules de carcinome mammaire humain : Rôle du collagène de type I glyqué

2011 - Porteur du projet : Pr MORJANI Hamid

Publications

Age-associated changes in type I collagen promote the invasion of BRAF mutated melanoma cells and their resistance to targeted therapies within three-dimensional matrix models.

Florent L, Saby C, Courageot MP, Terryn C, Van Gulick L, Vanmansart J, Slimano F, Morjani H

Biomed Pharmacother. 2025 07 19;190:118351

Raman imaging for monitoring deuterated squalene-gemcitabine nanomedicines in single living breast cancer cells.

Al Assaad A, Alaouta C, Desmaele D, Buache E, Fossier E, Van Gulick L, Slimano F, Dukic S, Mura S, Morjani H, Beljebbar A

Int J Pharm. 2024 10 26;:124870

Novel Bis-1,2,3-triazole-thiazolidinone hybrid as anticancer agents that induce apoptosis and molecular modeling study.

Bimoussa A, Oubella A, Alossaimi MA, Aziz M, Attaullah HM, Ejaz SA, Morjani H, Auhmani A, Robert A, Riahi A, Riadi Y, Ait Itto MY

Future Med Chem. 2024 10 10;:1-18

Semicarbazone, thiosemicarbazone tailed isoxazoline-pyrazole: synthesis, DFT, biological and computational assessment.

Bimoussa A, Hachim ME, Khatabi KE, Laamari Y, Oubella A, AlAjmi MF, Auhmani A, Ajana MA, Morjani H, Ait Itto MY

Future Med Chem. 2024 09 18;:1-14

Thiazolidinone-linked-1,2,3-triazoles with (R)-Carvone as new potential anticancer agents.

Oubella A, Alossaimi MA, Riadi Y, Bhat MA, Bakheit AH, Taha ML, Auhmani A, Morjani H, Geesi MH, Ait Itto MY

Future Med Chem. 2024 05 30;16(14):1449-1464

Biochemical and morpho-mechanical properties, and structural organization of rat tail tendon collagen in diet-induced obesity model.

Van Gulick L, Saby C, Mayer C, Fossier E, Jaisson S, Okwieka A, Gillery P, Chenais B, Mimouni V, Morjani H, Beljebbar A

Int J Biol Macromol. 2023 11 6;:127936

New (S)-verbenone-isoxazoline-1,3,4-thiadiazole hybrids: synthesis, anticancer activity and apoptosis-inducing effect.

Fawzi M, Bimoussa A, Laamari Y, Oussidi AN, Oubella A, Ketatni EM, Saadi M, Ammari LE, Morjani H, Ait Itto MY, Auhmani A

Future Med Chem. 2023 09 29;:

Discovery of a new Bcl-2 inhibitor through synthesis, anticancer activity, docking and MD simulations.

Byadi S, Abdoullah B, Fawzi M, Irrou E, Ait Elmachkouri Y, Oubella A, Auhmani A, Morjani H, Labd Taha M, Robert A, Aboulmouhajir A, Ait Itto MY

J Biomol Struct Dyn. 2023 05 31;:1-10

BRAF V600-Mutated Metastatic Melanoma and Targeted Therapy Resistance: An Update of the Current Knowledge.

Florent L, Saby C, Slimano F, Morjani H

Cancers (Basel). 2023 05 4;15(9):

Molecular Links between Cancer and Metabolic Diseases: New Perspectives and Therapeutic Strategies for Cancer Prevention and Treatment by Targeting Nutritional Patterns and Metabolic Alterations.

Zaiou M, Morjani H

Cancers (Basel). 2023 02 20;15(4):

Trajectory Interference for Unraveling Dynamic Biological Processes from Raman Spectral Data.

Goffin N, Buache E, Charpentier C, Lehrter V, Morjani H, Gobinet C, Piot O

Anal Chem. 2023 02 14;:

Hybrids of thiazolidinone with 1,2,3-triazole derivatives: design, synthesis, biological evaluation, studies, molecular docking, molecular dynamics simulations, and ADMET profiling.

Bimoussa A, Fawzi M, Oubella A, Ejaz SA, Sajjad Bilal M, Labd Taha M, Auhmani A, Morjani H, Robert A, Riahi A, Ait Itto MY

J Biomol Struct Dyn. 2023 01 9;:1-13

Neuraminidase-1: A Sialidase Involved in the Development of Cancers and Metabolic Diseases.

Toussaint K, Appert-Collin A, Morjani H, Albrecht C, Sartelet H, Romier-Crouzet B, Maurice P, Duca L, Blaise S, Bennasroune A

Cancers (Basel). 2022 10 5;14(19):

Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives.

El Mansouri AE, Lachhab S, Oubella A, Ahmad M, Neyts J, Jochmans D, Chiu W, Vangeel L, De Jonghe S, Morjani H, Ali MA, Zahouily M, Sanghvi YS, Lazrek HB

J Mol Struct. 2022 09 9;:134135

Design, synthesis, evaluation of new 3-acetylisoxazolines and their hybrid analogous as anticancer agents: In vitro and in silico analysis.

Fawzi M, Oubella A, Bimoussa A, Bamou FZ, Khdar ZA, Auhmani A, Riahi A, Robert A, Morjani H, Itto MYA

Comput Biol Chem. 2022 Mar 24;98:107666

Chemical profiling, cytotoxic activities through apoptosis induction in human fibrosarcoma and carcinoma cells, and molecular docking of some 1,2,3-triazole-isoxazoline hybrids using the eugenol as a precursors.

Oubella A, Taia A, Byadi S, Ait Lahcen M, Bimoussa A, Essaber M, Podlipnik C, Morjani H, Ait Itto MY, Aatif A

J Biomol Struct Dyn. 2022 Feb 17;:1-13

Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact.

Ben Arfi K, Schneider C, Bennasroune A, Bouland N, Wolak-Thierry A, Collin G, Le CC, Toussaint K, Hachet C, Lehrter V, Dedieu S, Bouché O, Morjani H, Boulagnon-Rombi C, Appert-Collin A

Cancers (Basel). 2022 Feb 13;14(4):

New 1,2,3-Triazoles from (R)-Carvone: Synthesis, DFT Mechanistic Study and In Vitro Cytotoxic Evaluation.

Oubella A, Bimoussa A, N'ait Oussidi A, Fawzi M, Auhmani A, Morjani H, Riahi A, Esseffar M, Parish C, Ait Itto MY

Molecules. 2022 Jan 25;27(3):

Cytotoxic and apoptotic effects of some (R)-carvone-isoxazoline derivatives on human fibrosarcoma and carcinoma cells: experimental evaluation for cytotoxicity, molecular docking and molecular dynamics studies.

Oubella A, Bimoussa A, Byadi S, Laamari Y, Fawzi M, N'ait Ousidi A, Oblack D, Auhmani A, Riahi A, Morjani H, Ait Itto MY

J Biomol Struct Dyn. 2022 Jan 11;:1-14

An integrated approach to investigate age-related modifications of morphological, mechanical and structural properties of type I collagen.

Gulick LV, Saby C, Jaisson S, Okwieka A, Gillery P, Dervin E, Morjani H, Beljebbar A

Acta Biomater. 2021 Oct 18;:

Thiazolidinone-linked1,2,3-triazoles with monoterpenic skeleton as new potential anticancer agents: Design, synthesis and molecular docking studies.

Oubella A, El Mansouri AE, Fawzi M, Bimoussa A, Laamari Y, Auhmani A, Morjani H, Robert A, Riahi A, Youssef Ait Itto M

Bioorg Chem. 2021 Jul 20;115:105184

Design, Hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol.

Laamari Y, Oubella A, Bimoussa A, El Mansouri AE, Ketatni EM, Mentre O, Ait Itto MY, Morjani H, Khouili M, Auhmani A

Bioorg Chem. 2021 Jul 14;115:105165

Discovery of novel furo[2,3-d]pyrimidin-2-one-1,3,4-oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis.

El Mansouri AE, Oubella A, Dânoun K, Ahmad M, Neyts J, Jochmans D, Snoeck R, Andrei G, Morjani H, Zahouily M, Lazrek HB

Arch Pharm (Weinheim). 2021 Jun 15;:e2100146

Degradation of p53 by HPV16-E6 variants isolated from cervical cancer specimens of Moroccan women.

Hadami K, Saby C, Dakka N, Collin G, Attaleb M, Khyatti M, Filali-Maltouf A, Morjani H, El Mzibri M

Gene. 2021 May 10;:145709

Investigation of squalene-doxorubicin distribution and interactions within single cancer cell using Raman microspectroscopy.

Rammal H, Al Assaad A, Dosio F, Stella B, Maksimenko A, Mura S, Van Gulick L, Callewaert M, Desmaële D, Couvreur P, Morjani H, Beljebbar A

Nanomedicine. 2021 Apr 28;:102404

Newly synthesized (R)-carvone-derived 1,2,3-triazoles: structural, mechanistic, cytotoxic and molecular docking studies.

Hachim ME, Oubella A, Byadi S, Fawzi M, Laamari Y, Bahsis L, Aboulmouhajir A, Morjani H, Podlipnik Č, Auhmani A, Ait Itto MY

J Biomol Struct Dyn. 2021 Mar 15;:1-14

Collagen and Discoidin Domain Receptor 1 Partnership: A Multifaceted Role in the Regulation of Breast Carcinoma Cell Phenotype.

Saby C, Maquoi E, Saltel F, Morjani H

Front Cell Dev Biol. 2021 ;9:808625

The N and C-termini of SPCA2 regulate differently Kv10.1 function: role in the collagen 1-induced breast cancer cell survival.

Girault A, Peretti M, Badaoui M, Hémon A, Morjani H, Ouadid-Ahidouch H

Am J Cancer Res. 2021 ;11(1):251-263

Design, synthesis, biological evaluation and molecular docking of new 1,3,4-oxadiazole homonucleosides and their double-headed analogs as antitumor agents.

El Mansouri AE, Oubella A, Mehdi A, AitItto MY, Zahouily M, Morjani H, Lazrek HB

Bioorg Chem. 2020 Dec 15;:104558

Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression.

Ouadid-Ahidouch H, Morjani H, Schnipper J, Girault A, Ahidouch A

Rev. Physiol. Biochem. Pharmacol.. 2020 Aug 7;:

Design, synthesis, biological evaluation and molecular docking of new uracil analogs-1,2,4-oxadiazole hybrids as potential anticancer agents.

El Mansouri AE, Oubella A, Maatallah M, Youssef AitItto M, MohamedZahouily,Morjani H, Lazrek HB

Bioorg. Med. Chem. Lett.. 2020 Jul 28;:127438

Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer.

Le CC, Bennasroune A, Langlois B, Salesse S, Boulagnon-Rombi C, Morjani H, Dedieu S, Appert-Collin A

Front Oncol. 2020 ;10:527

LRP-1 Promotes Colon Cancer Cell Proliferation in 3D Collagen Matrices by Mediating DDR1 Endocytosis.

Le CC, Bennasroune A, Collin G, Hachet C, Lehrter V, Rioult D, Dedieu S, Morjani H, Appert-Collin A

Front Cell Dev Biol. 2020 ;8:412

Thrombospondin-1 Receptor CD47 Overexpression Contributes to P-Glycoprotein-Mediated Multidrug Resistance Against Doxorubicin in Thyroid Carcinoma FTC-133 Cells.

Courageot MP, Duca L, Martiny L, Devarenne-Charpentier E, Morjani H, El Btaouri H

Front Oncol. 2020 ;10:551228

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model.

Sarazin T, Collin G, Buache E, Van Gulick L, Charpentier C, Terryn C, Morjani H, Saby C

Front Oncol. 2020 ;10:1593

Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia.

Bitchi MB, Magid AA, Kabran FA, Yao-Kouassi PA, Harakat D, Morjani H, Tonzibo FZ, Voutquenne-Nazabadioko L

Phytochemistry. 2019 Aug 9;167:112081

Triterpenes from Salvia argentea var. aurasiaca and their antibacterial and cytotoxic activities.

Bechkri S, Magid AA, Voutquenne-Nazabadioko L, Djemaa B, Kabouche A, Lehbili M, Lakhal H, Abedini A, Gangloff SC, Morjani H, Kabouche Z

Fitoterapia. 2019 Aug 8;:104296

Oleanane-type saponins from the roots of Parkia bicolor A. Chev.

Bitchi MB, Magid AA, Yao-Kouassi PA, Kabran FA, Harakat D, Martinez A, Morjani H, Tonzibo FZ, Voutquenne-Nazabadioko L

Fitoterapia. 2019 Jul 9;:104264

Age-related changes in molecular organization of type I collagen in tendon as probed by polarized SHG and Raman microspectroscopy.

Van Gulick L, Saby C, Morjani H, Beljebbar A

Sci Rep. 2019 May 13;9(1):7280

Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership.

Peretti M, Badaoui M, Girault A, Van Gulick L, Mabille MP, Tebbakha R, Sevestre H, Morjani H, Ouadid-Ahidouch H

Sci Rep. 2019 Feb 4;9(1):1175

DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells.

Saby C, Collin G, Sinane M, Buache E, Van Gulick L, Saltel F, Maquoi E, Morjani H

Front Pharmacol. 2019 ;10:462

Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells.

Saby C, Rammal H, Magnien K, Buache E, Brassart-Pasco S, Van-Gulick L, Jeannesson P, Maquoi E, Morjani H

Cell Adh Migr. 2018 Jun 28;:1-13

Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria.

Lehbili M, Alabdul Magid A, Kabouche A, Voutquenne-Nazabadioko L, Morjani H, Harakat D, Kabouche Z

Phytochemistry. 2018 Jun;150:40-49

Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway.

Badaoui M, Mimsy-Julienne C, Saby C, Van Gulick L, Peretti M, Jeannesson P, Morjani H, Ouadid-Ahidouch H

Oncotarget. 2018 May 15;9(37):24653-24671

Two new bis-iridoids isolated from Scabiosa stellata and their antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities.

Lehbili M, Alabdul Magid A, Hubert J, Kabouche A, Voutquenne-Nazabadioko L, Renault JH, Nuzillard JM, Morjani H, Abedini A, Gangloff SC, Kabouche Z

Fitoterapia. 2018 Mar;125:41-48

A new 2-alkylhydroquinone glucoside from Phagnalon saxatile (L.) Cass.

Cherchar H, Lehbili M, Berrehal D, Morjani H, Alabdul Magid A, Voutquenne-Nazabadioko L, Kabouche A, Kabouche Z

Nat. Prod. Res.. 2017 Sep;:1-7

Antibacterial, antioxidant and cytotoxic activities of triterpenes and flavonoids from the aerial parts of Salvia barrelieri Etl.

Lehbili M, Alabdul Magid A, Kabouche A, Voutquenne-Nazabadioko L, Abedini A, Morjani H, Gangloff SC, Kabouche Z

Nat. Prod. Res.. 2017 Sep;:1-9

Oleanane-type triterpene saponins from Calendula stellata.

Lehbili M, Alabdul Magid A, Kabouche A, Voutquenne-Nazabadioko L, Abedini A, Morjani H, Sarazin T, Gangloff SC, Kabouche Z

Phytochemistry. 2017 Sep;144:33-42

A new gallium complex inhibits tumor cell invasion and matrix metalloproteinase MMP-14 expression and activity.

Mohsen A, Collery P, Garnotel R, Brassart B, Etique N, Mohamed Sabry G, Elsherif Hassan R, Jeannesson P, Desmaële D, Morjani H

Metallomics. 2017 Aug;:

Triterpene glycosides from the aerial parts of Gouania longipetala.

Gossan DP, Alabdul Magid A, Yao-Kouassi PA, Ahibo Coffy A, Josse J, Gangloff SC, Morjani H, Voutquenne-Nazabadioko L

Phytochemistry. 2017 Feb;134:71-77

How Streptomyces anulatus Primes Grapevine Defenses to Cope with Gray Mold: A Study of the Early Responses of Cell Suspensions.

Vatsa-Portugal P, Aziz A, Rondeau M, Villaume S, Morjani H, Clément C, Ait Barka E

Front Plant Sci. 2017 ;8:1043

Isolation and characterisation of cytotoxic compounds from Euphorbia clementei Boiss.

Benmerache A, Alabdul Magid A, Labed A, Kabouche A, Voutquenne-Nazabadioko L, Hubert J, Morjani H, Kabouche Z

Nat. Prod. Res.. 2017 Jan;:1-8

Tomentosin Induces Telomere Shortening and Caspase-Dependant Apoptosis in Cervical Cancer Cells.

Merghoub N, El Btaouri H, Benbacer L, Gmouh S, Trentesaux C, Brassart B, Attaleb M, Madoulet C, Wenner T, Amzazi S, Morjani H, El Mzibri M

J. Cell. Biochem.. 2016 Dec;:

Biological study of the effect of water soluble [N-(2-hydroxybenzyl)-L-aspartato] gallium complexes on breast carcinoma and fibrosarcoma cells.

Mohsen A, Saby C, Collery P, Sabry GM, Hassan RE, Badawi A, Jeannesson P, Desmaële D, Morjani H

J. Biol. Inorg. Chem.. 2016 Oct;21(7):837-49

A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells.

Medves S, Auchter M, Chambeau L, Gazzo S, Poncet D, Grangier B, Verney A, Moussay E, Ammerlaan W, Brisou G, Morjani H, Géli V, Palissot V, Berchem G, Salles G, Wenner T

Br. J. Haematol.. 2016 Jul;174(1):57-70

Role of LRP-1 in cancer cell migration in 3-dimensional collagen matrix.

Appert-Collin A, Bennasroune A, Jeannesson P, Terryn C, Fuhrmann G, Morjani H, Dedieu S

Cell Adh Migr. 2016 Jul;:1-11

Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression.

Saby C, Buache E, Brassart-Pasco S, El Btaouri H, Courageot MP, Van Gulick L, Garnotel R, Jeannesson P, Morjani H

Oncotarget. 2016 May;7(18):24908-27

Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum.

Gossan DP, Alabdul Magid A, Yao-Kouassi PA, Josse J, Gangloff SC, Morjani H, Voutquenne-Nazabadioko L

Fitoterapia. 2016 Apr;110:89-95

Discoidin Domain Receptors: Potential Actors and Targets in Cancer.

Rammal H, Saby C, Magnien K, Van-Gulick L, Garnotel R, Buache E, El Btaouri H, Jeannesson P, Morjani H

Front Pharmacol. 2016 ;7:55

Inula Viscosa Extracts Induces Telomere Shortening and Apoptosis in Cancer Cells and Overcome Drug Resistance.

Merghoub N, El Btaouri H, Benbacer L, Gmouh S, Trentesaux C, Brassart B, Terryn C, Attaleb M, Madoulet C, Benjouad A, Amzazi S, El Mzibri M, Morjani H

Nutr Cancer. 2016 ;68(1):131-43