A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons.
Fiche publication
Date publication
février 2015
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEFORT Katia, Dr DARCQ Emmanuel
Tous les auteurs :
Chu Sin Chung P, Keyworth HL, Martin-Garcia E, Charbogne P, Darcq E, Bailey A, Filliol D, Matifas A, Scherrer G, Ouagazzal AM, Gaveriaux-Ruff C, Befort K, Maldonado R, Kitchen I, Kieffer BL
Lien Pubmed
Résumé
The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underlying DOR activities have been poorly explored by genetic approaches. We used conditional mouse mutagenesis to elucidate receptor function in GABAergic neurons of the forebrain.
Mots clés
Conditional gene knockout, Delta opioid receptor, Emotion, GABAergic forebrain neurons, Locomotion, Motivation
Référence
Biol Psychiatry. 2015 02 15;77(4):404-15