Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food.
Fiche publication
Date publication
mai 2017
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEFORT Katia, Dr DARCQ Emmanuel
Tous les auteurs :
Charbogne P, Gardon O, Martín-García E, Keyworth HL, Matsui A, Mechling AE, Bienert T, Nasseef MT, Robé A, Moquin L, Darcq E, Ben Hamida S, Robledo P, Matifas A, Befort K, Gavériaux-Ruff C, Harsan LA, von Elverfeldt D, Hennig J, Gratton A, Kitchen I, Bailey A, Alvarez VA, Maldonado R, Kieffer BL
Lien Pubmed
Résumé
Mu opioid receptors (MORs) are central to pain control, drug reward, and addictive behaviors, but underlying circuit mechanisms have been poorly explored by genetic approaches. Here we investigate the contribution of MORs expressed in gamma-aminobutyric acidergic forebrain neurons to major biological effects of opiates, and also challenge the canonical disinhibition model of opiate reward.
Mots clés
Conditional gene knockout, Dopamine, Motivation, Mu opioid receptor, Opiate, Reward
Référence
Biol Psychiatry. 2017 05 1;81(9):778-788