Can cocaine-induced neuroinflammation explain maladaptive cocaine-associated memories?
Fiche publication
Date publication
avril 2020
Journal
Neuroscience and biobehavioral reviews
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEFORT Katia
Tous les auteurs :
Correia C, Romieu P, Olmstead MC, Befort K
Lien Pubmed
Résumé
Persistent and intrusive memories define a number of psychiatric disorders, including posttraumatic stress disorder and substance use disorder. In the latter, memory for drug-paired cues plays a critical role in sustaining compulsive drug use as these are potent triggers of relapse. As with many drugs, cocaine-cue associated memory is strengthened across presentations as cues become reliable predictors of drug availability. Recently, the targeting of cocaine-associated memory through disruption of the reconsolidation process has emerged as a potential therapeutic strategy; reconsolidation reflects the active process by which memory is re-stabilized after retrieval. In addition, a separate line of work reveals that neuroinflammatory markers, regulated by cocaine intake, play a role in memory processes. Our review brings these two literatures together by summarizing recent findings on cocaine-associated reconsolidation and cocaine-induced neuroinflammation. We discuss the interactions between reconsolidation processes and neuroinflammation following cocaine use, concluding with a new perspective on treatment to decrease risk of relapse to cocaine use.
Mots clés
Addiction, Cocaine, Memory, Neuroinflammation, Reconsolidation
Référence
Neurosci Biobehav Rev. 2020 04;111:69-83