RSK2 signaling in brain habenula contributes to place aversion learning.
Fiche publication
Date publication
septembre 2011
Journal
Learning & memory (Cold Spring Harbor, N.Y.)
Auteurs
Membres identifiés du Cancéropôle Est :
Mme KOEBEL Pascale, Dr BEFORT Katia, Dr DARCQ Emmanuel
Tous les auteurs :
Darcq E, Koebel P, Del Boca C, Pannetier S, Kirstetter AS, Garnier JM, Hanauer A, Befort K, Kieffer BL
Lien Pubmed
Résumé
RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. Rsk2 gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits. We found that mrsk2 knockout mice are unable to associate an aversive stimulus with context in a lithium-induced conditioned place aversion task requiring both high-order cognition and emotional processing. Virally mediated shRNA-RSK2 knockdown in the habenula, whose involvement in cognition is receiving increasing attention, also ablated contextual conditioning. RSK2 signaling in the habenula, therefore, is essential for this task. Our study reveals a novel role for RSK2 in cognitive processes and uncovers the critical implication of an intriguing brain structure in place aversion learning.
Mots clés
Analysis of Variance, Animals, Antimanic Agents, pharmacology, Avoidance Learning, physiology, COS Cells, Chlorocebus aethiops, Conditioning, Operant, drug effects, Habenula, drug effects, Lithium Chloride, pharmacology, Luminescent Proteins, genetics, Mice, RNA, Small Interfering, genetics, Ribosomal Protein S6 Kinases, 90-kDa, deficiency, Signal Transduction, drug effects, Transfection, methods
Référence
Learn. Mem.. 2011 Sep;18(9):574-8