Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains.
Fiche publication
Date publication
juin 2015
Journal
Psychopharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LUTZ Pierre-Eric, Dr BEFORT Katia
Tous les auteurs :
Ayranci G, Befort K, Lalanne L, Kieffer BL, Lutz PE
Lien Pubmed
Résumé
Opiate addiction is a brain disorder emerging through repeated intoxication and withdrawal episodes. Epidemiological studies also indicate that chronic exposure to opiates may lead in susceptible individuals to the emergence of depressive symptoms, strongly contributing to the severity and chronicity of addiction. We recently established a mouse model of heroin abstinence, characterized by the development of depressive-like behaviors following chronic heroin exposure.
Mots clés
Animals, Arousal, drug effects, Emotions, drug effects, Heroin, pharmacology, Heroin Dependence, genetics, Male, Mice, Mice, Inbred Strains, Motor Activity, drug effects, Naloxone, pharmacology, Social Behavior, Substance Withdrawal Syndrome, genetics
Référence
Psychopharmacology (Berl). 2015 06;232(11):1957-71