How molecular modelling can better broaden the understanding of glycosylations.
Fiche publication
Date publication
juin 2022
Journal
Current opinion in structural biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DAUCHEZ Manuel, Pr BAUD Stéphanie
Tous les auteurs :
Rao RM, Dauchez M, Baud S
Lien Pubmed
Résumé
Glycosylations are among the most ubiquitous post-translational modifications (PTMs) in proteins, and the effects of their perturbations are seen in various diseases such as cancers, diabetes and arthritis to name a few. Yet they remain one of the most enigmatic aspects of protein structure and function. On the other hand, molecular modelling techniques have been rapidly bridging this knowledge gap since the last decade. In this review, we discuss how these techniques have proven to be indispensable for a better understanding of the role of glycosylations in glycoprotein structure and function.
Référence
Curr Opin Struct Biol. 2022 06 6;75:102393