Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing.
Fiche publication
Date publication
juin 2018
Journal
RSC advances
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BAGNARD Dominique, Dr REMY Jean-Serge, Dr WAGNER Alain, Dr KICHLER Antoine
Tous les auteurs :
Ripoll M, Pierdant M, Neuberg P, Bagnard D, Wagner A, Kichler A, Remy JS
Lien Pubmed
Résumé
Recently, it has been shown that the efficiency of antitumoral drugs can be enhanced when combined with therapeutic siRNAs. In the present study, an original platform based on polydiacetylenic micelles containing a cationic head group able to efficiently deliver a small interfering RNA (siRNA) targeting the PLK-1 gene while offering a hydrophobic environment for encapsulation of lipophilic drugs such as camptothecin is developed. We demonstrate that the co-delivery of these two agents with our micellar system results in a synergistic tumor cell killing of cervical and breast cancer cell lines . The combined drugs are active in a subcutaneous cancer model. Altogether, the results show that our nanometric micellar delivery system can be used for the development of new drug-siRNA combo-therapies.
Référence
RSC Adv. 2018 Jun 5;8(37):20758-20763