A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates.
Fiche publication
Date publication
mars 2022
Journal
BMC biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BARDET Anaïs, Dr WEBER Mickaël, Pr FAUQUE Patricia
Tous les auteurs :
Al Adhami H, Bardet AF, Dumas M, Cleroux E, Guibert S, Fauque P, Acloque H, Weber M
Lien Pubmed
Résumé
Cytosine DNA methylation is a heritable epigenetic mark present in most eukaryotic groups. While the patterns and functions of DNA methylation have been extensively studied in mouse and human, their conservation in other vertebrates remains poorly explored. In this study, we interrogated the distribution and function of DNA methylation in primary fibroblasts of seven vertebrate species including bio-medical models and livestock species (human, mouse, rabbit, dog, cow, pig, and chicken).
Mots clés
5mC, CpG island, DNA methylation, Genomic imprinting, Germline genes, Vertebrates
Référence
BMC Biol. 2022 Mar 23;20(1):70