Dr BARDET Anaïs

Fiche personne


coordonnées

IGBMC
1 rue Laurent Fries
BP 10142
67404 ILLKIRCH Cedex

03 88 65 35 25

anais.bardet@igbmc.fr

Territoire

Alsace

Statut

Chercheur

Recherche

Mots clés : Bioinformatique,Génomique,Facteurs de transcription,Méthylation de l'ADN


Thématique de recherche :

Multicellular organisms establish and maintain different transcriptional states in disparate cell types through complex and specific regulation of gene expression. This regulation is mediated by the cooperative binding of transcription factors (TFs) to regulatory elements through the recognition of specific DNA sequence motifs. Additionally, the physical access of TFs to DNA can be modulated by epigenetic regulation, such as DNA methylation, nucleosome positioning and histone modifications. Failure to maintain this tight regulation of gene expression results in developmental defects and various diseases including cancer. We use both computational and experimental approaches and integrate genomic data to study TF binding and its regulation in cellular systems.

Publications


Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma.

Sundaramoorthy S, Colombo DF, Sanalkumar R, Broye L, Balmas Bourloud K, Boulay G, Cironi L, Stamenkovic I, Renella R, Kuttler F, Turcatti G, Rivera MN, Mühlethaler-Mottet A, Bardet AF, Riggi N

JCI Insight. 2024 07 22;9(14):

Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells.

Al Adhami H, Vallet J, Schaal C, Schumacher P, Bardet AF, Dumas M, Chicher J, Hammann P, Daujat S, Weber M

Nucleic Acids Res. 2023 02 11;:

Pan-cancer predictions of transcription factors mediating aberrant DNA methylation.

Detilleux D, Spill YG, Balaramane D, Weber M, Bardet AF

Epigenetics Chromatin. 2022 Mar 24;15(1):10

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