Dr BARDET Anaïs
Fiche personne
coordonnées
IGBMC
1 rue Laurent Fries
BP 10142
67404 ILLKIRCH Cedex
03 88 65 32 25
Territoire
Alsace
Statut
Chercheur
équipes/plateformes
Recherche
Mots clés : Bioinformatique,Génomique,Facteurs de transcription,Méthylation de l'ADN
Thématique de recherche :
Multicellular organisms establish and maintain different transcriptional states in disparate cell types through complex and specific regulation of gene expression. This regulation is mediated by the cooperative binding of transcription factors (TFs) to regulatory elements through the recognition of specific DNA sequence motifs. Additionally, the physical access of TFs to DNA can be modulated by epigenetic regulation, such as DNA methylation, nucleosome positioning and histone modifications. Failure to maintain this tight regulation of gene expression results in developmental defects and various diseases including cancer. We use both computational and experimental approaches and integrate genomic data to study TF binding and its regulation in cellular systems.
Projets
Publications
Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells.
Al Adhami H, Vallet J, Schaal C, Schumacher P, Bardet AF, Dumas M, Chicher J, Hammann P, Daujat S, Weber M
Nucleic Acids Res. 2023 02 11;:
Pan-cancer predictions of transcription factors mediating aberrant DNA methylation.
Detilleux D, Spill YG, Balaramane D, Weber M, Bardet AF
Epigenetics Chromatin. 2022 Mar 24;15(1):10
A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates.
Al Adhami H, Bardet AF, Dumas M, Cleroux E, Guibert S, Fauque P, Acloque H, Weber M
BMC Biol. 2022 Mar 23;20(1):70