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1 rue Laurent Fries
BP 10142
67404 ILLKIRCH Cedex

03 88 65 32 25







Mots clés : Bioinformatique,Génomique,Facteurs de transcription,Méthylation de l'ADN

Thématique de recherche :

Multicellular organisms establish and maintain different transcriptional states in disparate cell types through complex and specific regulation of gene expression. This regulation is mediated by the cooperative binding of transcription factors (TFs) to regulatory elements through the recognition of specific DNA sequence motifs. Additionally, the physical access of TFs to DNA can be modulated by epigenetic regulation, such as DNA methylation, nucleosome positioning and histone modifications. Failure to maintain this tight regulation of gene expression results in developmental defects and various diseases including cancer. We use both computational and experimental approaches and integrate genomic data to study TF binding and its regulation in cellular systems.


Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells.

Al Adhami H, Vallet J, Schaal C, Schumacher P, Bardet AF, Dumas M, Chicher J, Hammann P, Daujat S, Weber M

Nucleic Acids Res. 2023 02 11;:

Pan-cancer predictions of transcription factors mediating aberrant DNA methylation.

Detilleux D, Spill YG, Balaramane D, Weber M, Bardet AF

Epigenetics Chromatin. 2022 Mar 24;15(1):10

A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates.

Al Adhami H, Bardet AF, Dumas M, Cleroux E, Guibert S, Fauque P, Acloque H, Weber M

BMC Biol. 2022 Mar 23;20(1):70

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